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Science 103 (Spring 2006) – Outlines 10 & 11 Reading: Cell cycle, chromosomes, and mitosis P 423-424, 570 Importance of Cell Division 1. 2. 3. The Cell Cycle 1. Description 2. Prokaryotic Cell Cycle 3. Eukaryotic Cell Cycle The Cell Cycle in Eukaryotes is more Complex than in Prokaryotes, Why? (a) (b) (c) Eukaryotic Cell Cycle 1. Stages of the Cell Cycle (See http://www.cellsalive.com/cell_cycle.htm for an animated version). Figure 19.20 (a) Interphase: ~________ of the cell cycle. Composed of 3 phases: (i) 1 (ii) (iii) (b) Mitosis: Occurs in _______________ cells. (c) Cytokinesis: 3. Control of the Cell Cycle (a) Rate of Cell division: Important that the cell controls its rate of cell division (loss of control = __________). (b) Checkpoints: Cells use checkpoints to ensure that proper conditions have been achieved before allowing the cell to proceed to the next stage in the cell cycle. These checkpoints are at: (i) (ii) (iii) Figures (Slide) Chromosomes 1. Chromosome Number (a) Varies according to species. (b) Humans – 2. Incorrect Chromosome Number (Each chromosome has thousands of genes, all of which are important). (a) Monosomy: (b) Trisomy: 3. Chromosome Structure Figure 25.11 (a) DNA and proteins: 2 (b) Why have proteins? 4. Homologous Chromosomes (a) (b) 5. Chromosome Duplication During S phase each homologue replicates so that it is composed of 2 sister chromatids that are joined at the centromere. Mitosis 1. Definition ____________ division in ____________cells. 2. Stages *A continuous process – scientists divide it into stages to better understand it* (See http://www.cellsalive.com/mitosis.htm for animated version. Figure 19.21 The stages are: (a) (b) (c) (d) 3 3. Prophase (a) (b) (i) Animal Cells: ____________ move to opposite poles, forming __________________ (_______________) between them. (ii) Plant Cells: (c) ______________________ breaks down. (d) The ________________ attach to ________________ by their kinetochores. (i) Kinetochore: Forms at the _______________ of each _________________ and includes __________________. (ii) Kinetochore Microtubules: 4. Metaphase (a) (b) 4 5. Anaphase (a) (b) 6. Telophase (a) (b) (c) Cytoplasmic division begins with the assembly of the __________________ (in animals). 5 Cytokinesis 1. Description 2. Animal Cells (a) The cell is pinched in 2 by the contractile belt (composed of _______________). (b) A ___________________ becomes evident. 3. Plant Cells (Have _______________, so cytokinesis has to occur by a different mechanism – ). (a) A ___________________ forms across the midline of the cell: (b) (d) The _____________________ is laid down between the 2 membranes. 6 Cell death 1. Programmed Cell Death Some cells are programmed to die. eg. Why do ducks have webbed feet? 2. Human Cell Timeline (a) (b) 3. Cancer Cells 7