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JOB DESCRIPTION
This form summarises the purpose of the job and lists its key tasks.
It may be varied from time to time at the discretion of the College in consultation with the postholder.
Job Title: Post-doctoral Research Assistant
Job ref no: CBS/0069/17
Grade: 6
Department: Comparative Biomedical Sciences
Accountable to: Professors Jonathan Elliott/Caroline WheelerJones
Responsible for: N/A
Job summary:
This two year post-doctoral research assistant post offers an exciting opportunity for a talented cell and molecular biologist
to gain experience in applying their knowledge and skills to comparative research into the pathogenesis of chronic kidney
disease. The research has applications to both human and veterinary medicine. Cell pathways involved in the response of
proximal convoluted tubule epithelial cells (PTECs) to stimuli that are relevant to the disease initiation and progression
will be studied. Primary cultures of feline PTECs will be compared to human cells lines which retain PTEC phenotype.
Training will be offered in a range of relevant techniques and in the background physiology and disease pathophysiology
within a supportive vibrant group. Interaction with an industry partner will ensure the successful candidate gains an
appreciation of the research and development process in a commercial organisation.
Competency: Analysis and Research
Key tasks
 To isolate and culture proximal tubular epithelial cells from feline kidneys obtained at post-mortem examination
in our veterinary hospitals
 To design experiments to determine the responses of these cells to a variety of external stimuli relevant to chronic
kidney disease (CKD) initiation and progression
 To analyse protein and gene expression and undertake pathway analysis to determine the interaction of key
pathways driving fibrosis in CKD in response to external stimuli
 To present and publish results at international conferences and in high quality journals
Competency: Communication
Key tasks:
 To communicate effectively with all relevant team members (technicians, PhD students, veterinary nurses,
clinicians and, potentially, cat owners) and industry scientists and professionals
 Train undergraduate students working in the laboratory how to undertake techniques relevant to their project
work
 Communicate results in oral and written format to a range of audiences with different levels of knowledge
Competency: Knowledge and Experience
Key tasks:

To undertake personal continuing professional development in order to keep abreast of current best practice in
research and teaching.
Competency: Planning and Organising
Key tasks:

Organise systems to maximise the chances of getting viable tissue for primary cell culture

Plan and organise experiments around tissue availability

Work to meet deadlines for reporting to the sponsor and abstract submission for meetings
Competency: Liaison and Networking
Key tasks:

Attend meetings and effectively network with the clinical community in the College

Interact closely with the feline research group to gain an understanding of feline CKD, its clinical progression and
owner-related concerns

Attend international conferences to network with scientists working in the fields of cell biology in general and
nephrology in particular

Make industry contacts to increase your awareness of how this research may have impact in development of novel
therapeutics in the future
Competency: Work Environment
Key tasks:
 To assist in maintaining a safe working environment by:
- Attending basic and specialist health and safety training, as required
- Following local procedures for safe working practices and the College’s Health and Safety Policy
Flexibility: The post holder may be required to perform non-specified, complementary work in response to the changing
needs of the position.