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12/10/06 Gene Ontology Too Specific 32279 (Asymmetric Synapse) + 32280 (Symmetric Synapse) Since both are too specific, create a node called: "Synapse Morphology" Then place these 2 nodes underneath. 6033 (Chitin Localization) Since it has to do with the cell wall, create a node called: “Cell Wall Localization” and place 6033 under it. 43056 (Forward Locomotion) + 43057 (Backward Locomotion) Create a node called “Unidirectional locomotion (along A/P axis)” and place the two nodes under it. 43108 (Pilus Retraction) Create a node called “Bacterial Cell Conjugation” and put this under it. 32364 (Oxygen Homeostasis) Create a node called “Gas Homeostasis” and put this under it. We can do this b/c there are peer nodes called “Ion homeostasis” and “Tissue homeostasis”… larger groupings than the individuals. 128 (Flocculation) Move under 51705 “Behavioral interaction with other organisms” 51703 (Intraspecies Interaction Between Organisms) delete 44419 move 0044011 to under 44403 move 0042710 under symbiosis 43473 (Pigmentation) – potentially old – Under "multicellular organismal process" (32501), there is a "pigment accumulation in tissues. Delete that. And in its place, put Pigmentation (43473). Because "pigment accumulation in tissues" is under "pigmentation" already and it looks good there. Too General The ion binding suggestions from before have already been suggested (i.e. Deleting “Ion Binding” (43167) and moving all its child nodes up). 51539 (4 iron, 4 sulfur cluster binding) Delete the parent node 51536 (Iron-Sulfur Cluster Binding) because it is the only child of the grandparent “Metal Cluster Binding” 6388 (tRNA Splicing) Consider deleting parent of this node and children of that parent (due to having 0 genes in them) including 6388 itself. This would effectively “move it up a level” because 6388 is elsewhere in tree at a higher level. 30097 2521 2573 30316 2761 30183 45619 2294 'hemopoiesis' 'leukocyte differentiation' 'myeloid leukocyte differentiation' 'osteoclast differentiation' 'regulation of myeloid leukocyte differentiation' 'B cell differentiation' 'regulation of lymphocyte differentiation' 'CD4-positive, alpha-beta T cell differentiation during immune response' Rename 48534 (Hemopoietic or lymphoid organ development) to “Lymphoid Organ Development.” Then move its child node “Hemopoiesis” up a level, out from directly under 48534. This moves all of hemopoiesis up a level because it is too general. This fixes a bunch of nodes (above) and more.