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Thalamus and basal ganglia Eunice Abrams PGY4 Neurology U of Michigan • Diencephalon: • Thalamus • Hypothalamus • epithalamus Thalamus(Greek:inner chamber) • Relay center • Sensory • Cerebellum, basal ganglia • Limbic inputs • Modulatory inputs for behavioral and sleep-wake cycles. Thalamic nuclei and function • • • • lateral geniculate nucleus (LGN): thalamic nucleus for vision medial geniculate nucleus (MGN): thalamic nucleus for hearing pulvinar: association thalamic nucleus ventral posterolateral (VPL) nucleus: nucleus for processing somatosensory information from the body • ventral posteromedial (VPM) nucleus: nucleus for processing somatosensory information from the face; contains a medial parvocellular part for taste • internal medullary lamina: partition between groups of thalamic nuclei; consists of bundles of axons for intrathalamic communication • centromedian nucleus: an intralaminar nucleus embedded in the internal medullary lamina • related to the basal ganglia • receives input from the ascending reticular activating system (ARAS) & projects impulses to widespread areas of the cerebral cortex for arousal. Thalamic nuclei and function • internal medullary lamina: axonal partition between thalamic nuclei • external medullary lamina: outer capsule of thalamus; consists of fibers traveling to & from thalamic nuclei • reticular nucleus: scattered cells in the external medullary lamina • - receives impulses from & projects impulses to other thalamic nuclei • - inhibits other thalamocortical circuits (attention) • dorsomedial nucleus: component of the limbic system • anterior nucleus: part of the limbic system; involved in declarative memory storage. Thalamic nuclei • Thalamic nuclei <------> CORTEX • Corticothalamic projections > thalamocortical projections. Main noncortical inputs to the different thalamic nuclei Major reciprocal connections between thalamus and cortex Vascular supply Thalamic infarction • Paramedian territory(off basilar comm a.) • Clinical triad: somnolent apathy, memory loss, and abnormalities of vertical gaze. • Thalamogeniculate a.: VPN, VL, subthalamic • Contralateral-Hemianesthesia, slight hemiparesis, hemiataxia-hypesthesia, disequilibrium, choreoathetoid movements, athetoid posture, paroxysmal pain syndrome, homonymous hemianopia. • Tuberothalamic/polar a.: • Facial paresis for emotional movement, hemiparesis, visual field defects, dysphasia with left sided lesions, hemineglect, impaired visuo-spatial processing(right sided lesions). • Bilat polar a: abulia, apathy, frontal lobe deficits, lethargy, impaired memory. • Post choroidal a.: lat geniculate body • Contralateral Partial hemianopsia, assymetric optokinetic visual fields. Question 1.Which vessels provide the main blood supply of the thalamus? 2.The amygdala sends fibers to which part of the thalamus? 3.Which thalamic nucleus only projects to other thalamic nuclei? Basal ganglia • Neostriatum: Caudate and putamen • Substantia Nigra • Globus pallidus • Subthalamic nucleus • Nucleus accumbens Function • Control posture and movement. • Execution of learned motor plans(subconscious) • Anticipating rewards(nucleus accumbens)-involved in addiction. Information processing • Motor channel: cortex-putamen; Globus pallidus internal, substantia nigra-thalamus(VL, VA)-supplementary motor, premotor cortex, primary motor cortex. • Oculomotor channel-higher control of eye movements: • body of caudate nucleus-frontal eyefields, supplementary eyefields(frontal lobes). • Prefrontal channel-cognition involving frontal lobe. • Head of caudate-prefrontal cortex. • Limbic channel(regulation of emotions, and motivational drives) • Limbic system-nucleus accumbens, ventral striatum • Ventral pallidum-thalamic mediodorsal and ventral anterior nuclei. Inputs to striatum • Cortical efferent fibers to caudate and putamen(corticostriate)ipsilateral-topographic pattern • Cortex to substantia nigra • Thalamostriatal: intralaminar nuclei/centrum mediumstriatum • Nigrostriatal projections: substantia nigrastriatum, globus pallidum. • Brain stem raphe nucleiascending fibers to striatum. • Orbitofrontal cortex, and limbic systemNucleus accumbens Striatal efferents • Striatumglobus pallidus(internal, and external segments) • Striatumsubstantia nigra Pallidal afferents • Substantia nigraGlobus pallidus • SubthalamusGlobus pallidus(medial or internal) • Striatuminternal and external globus pallidus Pallidal efferents • Globus pallidus(internal)→Thalamus(VA, VL)premotor, motor cortex/influence motor system • Globus pallidus(int)Thalamus(centrum medianum)putamen(closed circuit) • Globus pallidus(int)lateral habernacular nucleus • Globus pallidus(external)internal pallidum, subthalamic nucleusGpi, Gpe(closed circuit) • Globus pallidussubstantia nigra, red nucleus, mesencephalic reticular formation Nigral afferents and efferents • Cerebral cortex • Globus pallidus Pars reticularis Substantia nigra • Subthalamic nucleus • Striatum • Pars reticularisVA, VL, reticular formation and superior colliculus. • Pars compacta(dopaminergic fibers)caudate, putamen • Excitatory direct pathway • Inhibitory-indirect pathway Direct and indirect pathway • Direct pathway: • Pars compacta(SN)excitatorycaudate & putamen inhibitory(GABA+P) GPi, and pars reticularis(SN)inhibitorythalamus(ventral nucleus)cortical excitation • Indirect pathway: • Pars compacta(SN)(-) caudate & putamen(-)(GABA+E)GPe()subthalmus(+)GPi(-) thalamus(ventral nucleus)cortical inhibition Lesions of the basal ganglia • Subthalamic nucleus: contralateral hemiballismus • Caudate(anteroventral): choreoathetosis • Caudate and putamen degeneration: Huntington disease • Bilateral pallidal lesions: akinesia • Substantia nigra: parkinsonism • Unilateral basal ganglia(pallidal-putaminal) • Falling to contralateral side, slow tilting movements • Substantia nigra pars compacta degeneration: Parkinson’s disease Questions • 1. True or false: Globus pallidus externa is part of the direct pathway. • 2. Which of these sensor modalities bypass the thalamus: Gustatory, auditory, visual, nociception, olfactory.