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Cancer A group of diseases characterized by the _________________ and spread of _______________ Cancer Development Process 1. Cancer _________: various factors that cause changes in a cells DNA (genetic code) - Spontaneous error - genetic mutations - Carcinogens - Oncogenes: present and dormant at birth 2. Cancer __________: the stimulation of excessive growth of cells that have been altered by a cancer initiator - Estrogen - Immunosuppressant drugs 3. Cancer ___________: occurs when a tumor releases growth factors that stimulate the growth of new blood vessels to provide the tumor with a blood supply. This process is called ______________. Tumors – clumping of new growth (neoplasmic) cells __________ Tumor (noncancerous) - cells enclosed in a fiberous capsule ____________ Tumor (cancerous) a. Invasion: when cells invade surrounding tissues b. ______________: when cells break away from site of origin, enter blood stream or lymph system and are carried to other sites Classification of Cancers – type of tissues they affect Carcinoma: Epithelial tissues (body surfaces, line body cavities) - skin, breast, lung, GI tract, reproductive organs Sarcoma: Middle layers of tissues - connective tissues: bone, muscle, ligaments, fascia Classification of Cancers – type of tissues they effect Lymphomas: lymphatic system Leukemia: affects blood - proliferation of white blood cells - bone marrow and spleen Cancer Statistics 2nd leading cause of death in U.S. 555,000 deaths annually Four major cancers account for most cancer deaths Lung Cancer Risk factors 1. Cigarette smoking (nearly 90%) 2. Certain chemicals Colorectal Cancer Risk Factors 1. Heredity 2. Low intake of fruits, vegs, whole grains 3. Alcohol consumption 4. Excess body fat 5. Sedentary lifestyle Dietary Intervention: Breast Cancer Risk Factors 1. Heredity (about 10%) 2. Alcohol consumption 3. Obesity (especially abdominal deposition) 4. Never having children 5. Early menstruation or late menopause 6. Sedentary lifestyle 7. HRT and birth control pills Dietary Intervention: A woman’s chance of being diagnosed with breast cancer is: From From From From Ever age age age age 30 40 50 60 to to to to age age age age 40 50 60 70 1 1 1 1 1 out out out out out of of of of of 252 68 35 27 8 Average age of breast cancer diagnosis is 64 Prostate Cancer Risk factors 1. Age 2. Low fruit & vegetable intake Dietary Intervention: 7 Cancer Warning Signs Preventing Cancer “Things to avoid or limit” Tobacco & alcohol Saturated fat and meat intake Exposure to UV radiation Charred, smoked, preserved meats Environmental carcinogens Obesity Preventing Cancer “Things to do” Increase intake of _______, ___________, ______________, and _________ - Curciferous vegs - Citrus fruits & berries - Dark-green leafy vegs - Dark red, yellow, orange fruits/vegs Exercise regularly Next to prevention, early identification and treatment offers the best chance for a _____ Breast Cancer Self-Breast Exam ____% lumps found) - Perform __________ Physician Clinical Breast Exam - Age 20-39: every 3 years - 40+: yearly Mammogram: yearly after age 40 Testicular Cancer Most common cancer in men age 20-35 Men with undescended testicles are at increased risk – surgical treatment early Testicular self-exam: perform _______