Download Role of Vitamin K in Clotting

FUNCTIONS OF BLOOD

Define the transportation, regulation, and protection functions of the blood.
PHYSICAL CHARACTERISTICS OF BLOOD


What are the values for the physical parameters of the blood and some of the systems that help maintain
them?
What are the techniques for withdrawing blood for laboratory testing?
COMPONENTS OF BLOOD



Illustrate the proportions of the major components of the blood plasma and cells.
What are the components of plasma and explain their importance?
What are the varieties and relative number of formed elements in blood?
FORMATION OF BLOOD CELLS


Explain the formation of blood cells from the pluripotent stem cells to the final formed elements.
Identify the hemopoietic growth factors that regulate the differentiation and proliferation of particular
progenitor cells.
RED BLOOD CELLS

Identify the basic properties of red blood cells as well as the normal quantity and rate of production.
RBC Anatomy

Describe the structure and content of red blood cells, the presence of membrane antigens, and the usual
concentrations of hemoglobin.
RBC Physiology


What are the structural features that make RBCs highly specialized for O2 transport?
What is the role of hemoglobin in oxygen transport and blood pressure regulation?
RBC Life Cycle


Describe the steps in the processing of RBCs once they have started to degenerate and are trapped by
macrophages in the spleen and liver.
Explain the consequences of iron buildup in the plasma.
Erythropoiesis: Production of RBCs

Describe the stages of RBC development, the conditions and hormones that regulate their production
through negative feedback, and nutrients required for their construction.
WHITE BLOOD CELLS
WBC Anatomy and Types



Identify the types of white blood cells.
Identify the three types of granular leukocytes.
Identify the two types of agranular leukocytes .
Function of WBCs


Discuss the usual WBC range in number, distribution, emigration, response to chemotaxis, and differing
functions in reaction to tissue damage and/or pathogen invasion.
Describe some uses for a differential white blood cell count.
STEM CELL TRANSPLANTS FROM BONE MARROW AND CORD BLOOD

Discuss the steps required for a bone marrow transplant.
PLATELETS


Trace the development of thrombocytes from the megakaryocyte stage and review the functions they
perform in blood clotting.
Discuss what is included in a complete blood count.
HEMOSTASIS

State the three general criteria for a hemostatic response to blood vessel rupture or damage.
Vascular Spasm

Discuss the timing for the effect of vascular spasm on bleeding.
Platelet Plug Formation

Discuss the chemical contents of the two types of granules in platelets and their role in the three steps of
plug formation.
Blood Clotting

Identify the principal stages involved in blood clotting and explain the general actions of the various
factors that promote and inhibit blood clotting.
Role of Vitamin K in Clotting

Establish how vitamin K is involved with factors of the coagulation pathway.
Hemostatic Control Mechanisms



Show how fibrinolysis works through plasmin enzymes to prevent the inappropriate formation and
expansion of blood clots.
List the actions of physical conditions, chemicals, enzymes, and factors that control the extent of clot
growth.
Discuss the medical uses of anticoagulants.
Intravascular Clotting


Discuss the conditions that may precipitate formation of a blood clot in an undamaged vessel, and the
consequences of its enlargement or becoming free floating in the veins or arteries.
Discuss the use of aspirin and thrombolytic agents in patients who are at risk of forming blood clots.
BLOOD GROUPS AND BLOOD TYPES
ABO Blood Groups


Discuss how the two genes for RBC isoantigens are able to produce four blood types.
Summarize the reactions between blood antigens and antibodies.
Transfusions

Describe the impact of isoantibodies on cells of a blood transfusion and the effect of an immune
response on the body as a whole.
Blood Group

Explain the basis of Rh grouping.
Hemolytic Disease of the Newborn

Describe how Rh isoantigens of a first fetus and the mother’s immune response to them can lead to
hemolytic disease of the next newborn.
DISORDERS: HOMEOSTATIC IMBALANCES
Anemia

Define anemia, identify various types of anemia, and describe the symptoms of anemia.
Sickle-Cell Disease

Discuss sickle-cell disease in terms of cause, symptoms, and treatment.
Hemophilia


Define hemophilia and describe some types of hemophilia.
Discuss what causes disseminated intravascular clotting.
Leukemia

.
Distinguish between acute and chronic leukemia.