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Dr. Sukhbinder Dhesy-Thind
Juravinski Cancer Centre
699 Concession Street
Hamilton, ON, L8V 5C2
Telephone: 905-387-9495 x64602
Fax: 905-575-6326
E-mail: [email protected]
Dr. Michael McLean
Editor-In-Chief
Current Oncology
Princess Margaret Hospital
610 University Avenue
Toronto, ON, M5G 2M9
RE: Submitted manuscript “Generalizability of toxicity data from oncology clinical
trials to clinical practice: Toxicity of irinotecan-based regimens in patients with
metastatic colorectal cancer”
Dear Editor,
Please find enclosed our manuscript “Generalizability of toxicity data from oncology
clinical trials to clinical practice: Toxicity of irinotecan-based regimens in patients with
metastatic colorectal cancer” for submission to your respected journal. This is an original
article that has not been published and is not being considered for publication elsewhere.
We feel our article is suitable for publication in Current Oncology. Our article would be
of significant interest to your readers given the overall importance of our results. We
have determined that the toxicity rates of chemotherapy administered to non-trial patients
are not significantly different compared to those quoted in published clinical trials. This
provides further evidence for the generalizability of clinical trial results to clinical
practice.
All four authors declare that we have read and approved the submitted manuscript. The
authors also declare that we do not have any competing interests.
Thank you for your attention.
Sincerely,
Dr. Vincent Tam
Dr. Sara Rask
Dr. Tulay Koru-Sengul
Dr. Sukhbinder Dhesy-Thind