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Chronic vagus nerve stimulation improves left ventricular function in
Chronic vagus nerve stimulation improves left ventricular function in

... from the implantation procedure. At the month 3, consistent contractile dysfunction was observed in all 12 animals, which is consistent with previous reports [9]. The VNS therapy were turned on in the animals of VNS group from the month 3 to month 6, while the VNS therapy were kept off in the animal ...
Expert Consensus Statement
Expert Consensus Statement

... to diagnose, and there is no easy way to assess disease activity or severity.6 Although CS is a known inflammatory disease and despite 450 years of the use of corticosteroids for treatment, there is no proof of survival benefit from this treatment.7 There are also conflicting data on the efficacy of cor ...
HRS Expert Consensus Statement on the Diagnosis
HRS Expert Consensus Statement on the Diagnosis

... to diagnose, and there is no easy way to assess disease activity or severity.6 Although CS is a known inflammatory disease and despite 450 years of the use of corticosteroids for treatment, there is no proof of survival benefit from this treatment.7 There are also conflicting data on the efficacy of cor ...
ventricular septaldefect with shunt from left ventricle to right atrium
ventricular septaldefect with shunt from left ventricle to right atrium

... artery was 21/12, the right ventricle 22/2, and right atrium 5 mm. Hg. The course of the catheter during a repeat catheterization at 8 years of age was from right atrium to right ventricle to left ventricle to aorta. Angiocardiography performed with injection into the right ventricular outflow tract ...
PDF-1 - RUcore - Rutgers University
PDF-1 - RUcore - Rutgers University

... Specifically, can the body be overloaded with a catecholamine response when exercising in combination with continued drug therapy? What negative outcomes could arise from stressing the human system (i.e. exercise) while at the same time creating an increased adrenergic response due to medication? Th ...
Percutaneous Closure of Left Ventricular Pseudoaneurysm
Percutaneous Closure of Left Ventricular Pseudoaneurysm

... by the pericardium. In many cases, cardiac rupture results in cardiac tamponade and death.1 In left ventricular pseudoaneurysm, however, this rupture is contained by pericardial adhesions or a new thrombus, preventing exsanguination.1– 6 The true incidence of left ventricular pseudoaneurysms is unkn ...
Cardiac malpositions and syndromes with right or left atrial isomerism
Cardiac malpositions and syndromes with right or left atrial isomerism

... structures such as the inferior vena cava and the right atrium with sinus node are absent or may have developed abnormally. Therefore, two leading signs in left isomerism can be expected: first, the ‘interruption’ of the inferior vena cava in its intrahepatic part and its persistence as the azygos ( ...
- Wiley Online Library
- Wiley Online Library

... LVO group but also in the control group, because only the dipole from the left ventricle could be detected. Tsunakawa et aL3 used moving dipole from isopotential map in patients with left bundle-branch block with and without myocardial infarction and found that the single dipole approximation is app ...
Prioritizing functional capacity as a principal end point
Prioritizing functional capacity as a principal end point

... programmed cell death in cardiomyocytes or other tissue.30 In addition, cellular mitochondrial quality control mechanisms such as autophagy and ubiquitin-protease system, which removes damaged mitochondria or protein to maintain a functional mitochondrial network, become impaired with aging, resulti ...
Full Paper - Daniel Burkhoff MD PhD
Full Paper - Daniel Burkhoff MD PhD

... Representative pressure and calcium transients measured during steady-state ejecting beats and on the first isovolumic beat of variously timed volume clamps are shown in Fig. 2. As shown in Fig. 2D, there is an approximately linear relationship (dotted line) between peak pressure and volume on the t ...
PHYSIOLOGY OF ADVENTURE RACING
PHYSIOLOGY OF ADVENTURE RACING

... The overall aims of this thesis were to elucidate the circulatory responses to ultra-endurance exercise (Adventure Racing), and furthermore, to contribute to the clarification of the so called “exercise-induced cardiac fatigue” in relation to said exercise. An Adventure race (AR) varies in duration ...
Compression of interventricular septum during right - AJP
Compression of interventricular septum during right - AJP

... Large deformation was also accounted for by invoking geometric nonlinearity into the analysis. In so-called linear geometric problems, equilibrium equations may be written with respect to the original undeformed configuration because the deformations are minimal (i.e., the configuration remains esse ...
Permanent cardiac pacemaker: an emergency perspective
Permanent cardiac pacemaker: an emergency perspective

... Infectious complication is not common but may occasionally be severe and life threatening. Patients with diabetes, malignancy, on steroid or anticoagulant therapy are at higher risk. It is also more common in longer procedures, reoperation and in patients with a temporary pacing lead in situ.10 Infe ...
Standards for Physical Activity and Exercise In the Cardiac
Standards for Physical Activity and Exercise In the Cardiac

... when individuals expend greater than 4.3 kcal/kilogram (kg) of body mass per day above their basal metabolic requirements, there is a decline in the incidence of CVD which is due to either a reduction in risk factors or in part from an actual improvement in endothelial status and/or a regression in ...
Detection of Pulmonic and Tricuspid Valvular
Detection of Pulmonic and Tricuspid Valvular

... defect, pulmonary hypertension and a typical Graham Steell murmur; the presence of pulmonic regurgitation was confirmed at the time of operative closure of the defect when a distinct jet of blood was felt in the right ventricle during diastole. In only 3 (W.J., J.K., M.B.) of these 7 patients was th ...
Natriuretic Peptides in the Regulation of Cardiovascular Physiology
Natriuretic Peptides in the Regulation of Cardiovascular Physiology

Left Ventricular Assist Device as Destination Therapy
Left Ventricular Assist Device as Destination Therapy

... pulmonary hypertension (defined as pulmonary arterial systolic pressure greater than 60 mm Hg, transpulmonary gradient greater than 15 mm Hg, or pulmonary vascular resistance greater than 6 Wood units, while unresponsive to treatment with pulmonary vasodilators) are very high risk candidates for car ...
Cardiovascular Magnetic Resonance Pocket Guide
Cardiovascular Magnetic Resonance Pocket Guide

... Bernhard A. Herzog Ananth Kidambi George Ballard The Cardiovascular Magnetic Resonance Pocket Guide represents the views of the ESC Working Group on Cardiovascular Magnetic Resonance and was arrived at after careful consideration of the available evidence at the time it was written. Health professio ...
ENDOCARDIAL SCLEROSIS IN INFANTS AND CHILDREN* We
ENDOCARDIAL SCLEROSIS IN INFANTS AND CHILDREN* We

... inflammatory are complete or partial occlusion of the blood vessels, atrophy associated with hyaline or fatty degeneration of muscle fibers, fibroblastic proliferation, thickening of the endocardium, and cicatrization near the atretic valves7,28. Farber and Hubbard suggested that the gross valvular ...
Pulmonary Arterial Hypertension: A Two
Pulmonary Arterial Hypertension: A Two

... major limitations of TAPSE is that the value can be falsely elevated in a failing RV (10). Also, in severe tricuspid regurgitation, TAPSE could be falsely elevated because of volumedriven, hyperdynamic state perhaps providing a supraphysiological stroke output. The differential diagnosis of lower TA ...
Cardiac Pacing Site Optimization
Cardiac Pacing Site Optimization

... a pacing strategy has not yet been shown to protect or improve LV performance in patients requiring pacing for bradyarrhythmias. In an ongoing clinical trial, dogs with naturally occurring thirddegree or complete heart block in need of pacing therapy are being randomly assigned to three treatment gr ...
the relationship between electrical and mechanical - Heart
the relationship between electrical and mechanical - Heart

... needle, and recording of pressures has been previously described (Cournand and Ranges, 1941; Cournand et al., 1944; and Bloomfield et al., 1946). In some instances a double lumen catheter was used (Cournand et al., 1945), permitting the simultaneous recording of pressures in the right auricle and ve ...
11.1 Cardiovascular Anatomy
11.1 Cardiovascular Anatomy

...  From right atrium, through the tricuspid valve, blood travels to the right ventricle  From the right ventricle, blood leaves the heart as it passes through the pulmonary semilunar valve into the pulmonary trunk  Pulmonary trunk splits into right and left pulmonary arteries that carry blood to th ...
Analysis of the Characteristics of the Flow Velocity Waveforms in Left
Analysis of the Characteristics of the Flow Velocity Waveforms in Left

... volume flow rate was underestimated by about 10%. The correlation coefficients between the blood velocity measured by the LDV method and the timed-collected blood flow rate in the other two dogs were also significantly high (r=0.99, p<0.01; r=0.96, /><0.01). These results indicate that our method ac ...
Living with Congestive Heart Failure - Providence
Living with Congestive Heart Failure - Providence

... evaluate any abnormal heart rhythm • Chest X-ray to look for fluid buildup around your heart and lungs and to see if your heart is enlarged • Echocardiogram to look at the heart valves and to determine how efficiently your heart is pumping • Exercise stress test to see what your heart does ...
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Myocardial infarction



Myocardial infarction (MI) or acute myocardial infarction (AMI), commonly known as a heart attack, occurs when blood flow stops to a part of the heart causing damage to the heart muscle. The most common symptom is chest pain or discomfort which may travel into the shoulder, arm, back, neck, or jaw. Often it is in the center or left side of the chest and lasts for more than a few minutes. The discomfort may occasionally feel like heartburn. Other symptoms may include shortness of breath, nausea, feeling faint, a cold sweat, or feeling tired. About 30% of people have atypical symptoms, with women more likely than men to present atypically. Among those over 75 years old, about 5% have had an MI with little or no history of symptoms. An MI may cause heart failure, an irregular heartbeat, or cardiac arrest.Most MIs occur due to coronary artery disease. Risk factors include high blood pressure, smoking, diabetes, lack of exercise, obesity, high blood cholesterol, poor diet, and excessive alcohol intake, among others. The mechanism of an MI often involves the rupture of an atherosclerotic plaque, leading to complete blockage of a coronary artery. MIs are less commonly caused by coronary artery spasms, which may be due to cocaine, significant emotional stress, and extreme cold, among others. A number of tests are useful to help with diagnosis, including electrocardiograms (ECGs), blood tests, and coronary angiography. An ECG may confirm an ST elevation MI if ST elevation is present. Commonly used blood tests include troponin and less often creatine kinase MB.Aspirin is an appropriate immediate treatment for a suspected MI. Nitroglycerin or opioids may be used to help with chest pain; however, they do not improve overall outcomes. Supplemental oxygen should be used in those with low oxygen levels or shortness of breath. In ST elevation MIs treatments which attempt to restore blood flow to the heart are typically recommended and include angioplasty, where the arteries are pushed open, or thrombolysis, where the blockage is removed using medications. People who have a non-ST elevation myocardial infarction (NSTEMI) are often managed with the blood thinner heparin, with the additional use angioplasty in those at high risk. In people with blockages of multiple coronary arteries and diabetes, bypass surgery (CABG) may be recommended rather than angioplasty. After an MI, lifestyle modifications, along with long term treatment with aspirin, beta blockers, and statins, are typically recommended.Worldwide, more than 3 million people have ST elevation MIs and 4 million have NSTEMIs each year. STEMIs occur about twice as often in men as women. About one million people have an MI each year in the United States. In the developed world the risk of death in those who have had an STEMI is about 10%. Rates of MI for a given age have decreased globally between 1990 and 2010.
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