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8 15 17 `Working round my heart transplant gave me more to focus on`
8 15 17 `Working round my heart transplant gave me more to focus on`

... You may have been recently diagnosed with the condition, or have been off work because of a spell of poor health. The diagnosis itself, or the severity and type of symptoms, may make you doubt if you will ever be able to return to work. But it’s important not to rush a decision. Once you are establi ...
Evaluation of Diastolic Function: How Practical Is it?
Evaluation of Diastolic Function: How Practical Is it?

Apical Right Ventricular Hypertrophic Cardiomyopathy—A Case
Apical Right Ventricular Hypertrophic Cardiomyopathy—A Case

... gene) had been identified in these families. A family history is more common in patients with asymmetric septal hypertrophy than with apical hypertrophic cardiomyopathy. Morphologically apical HCM is divided into 3 types; pure focal, pure diffuse and mixed, of which pure focal is most common [4]. Ot ...
time-resolved fluorescence spectroscopy of the heart
time-resolved fluorescence spectroscopy of the heart

... calculate the fractional components of the fluorescence intensity that could help to determine the relative amounts of these components in different heart tissues, which could be useful for its differentiation. 2. Materials and methods The experiments were performed on the specimens prepared from a ...
American College of Radiology ACR Appropriateness
American College of Radiology ACR Appropriateness

Regional ejection fraction and regional area strain for left ventricular
Regional ejection fraction and regional area strain for left ventricular

... regions after MI as the contribution of that region to the pumping efficacy of the LV is decreased due to reduced deformation of the endocardial surface. Taken together, the REF and RAS can be used for improving the diagnosis, disease stratification and estimation of prognosis after MI. The novelty ...
Carrent issues of the aortic functional morphology
Carrent issues of the aortic functional morphology

... surface of the arch (T. A. Grigorieva, 1948, 1954) near the point of arterial ligament attachment, at the base of the brachiocephalic trunk and bronchial branches. The opinion on the depth of location of sensitive nerve endings in the aortic wall differ [2,3,9,12,16,20,29]. So, A. Abraham (1950, 19 ...
Scintigraphic imaging of neuroadrenergic
Scintigraphic imaging of neuroadrenergic

... emerged from the few studies that have been conducted are often discordant, in part due to the different experimental models used [5-9]. A greater understanding of the mechanisms underlying the uptake of this tracer is essential since a number of controversial issues recently emerged, especially in ...
I IIaIIbIII - Ochsner Health System
I IIaIIbIII - Ochsner Health System

... for SND in asymptomatic patients. Permanent pacemaker implantation is not indicated for SND in patients for whom the symptoms suggestive of bradycardia have been clearly documented to occur in the absence of bradycardia. Permanent pacemaker implantation is not indicated for SND with symptomatic brad ...
Advances in Arrhythmia and Electrophysiology
Advances in Arrhythmia and Electrophysiology

... exceptionally thin, an area noted by McAlpine2 as the “unprotected” area at risk of perforation. The posterior wall of the left atrium, including its inferior part, is related to the esophagus and its nerves (vagal nerves), the thoracic aorta, and the coronary sinus (Figure 1C). Its mean thickness i ...
Linking Cx43 and fibrosis
Linking Cx43 and fibrosis

Temporary epicardial pacing after cardiac surgery
Temporary epicardial pacing after cardiac surgery

... Specific electrophysiological conditions that may benefit from temporary pacing are listed in Table 1. Whereas many ...
AHA Scientific Statement - The Institute for Collegiate Sports Medicine
AHA Scientific Statement - The Institute for Collegiate Sports Medicine

... udden deaths of young competitive athletes are tragic events that continue to have a considerable impact on the lay and medical communities.1–17 These deaths are usually due to a variety of unsuspected cardiovascular diseases and have been reported with increasing frequency in both the United States ...
DOI: 10.1161/CIRCULATIONAHA.107.181423 published online Mar
DOI: 10.1161/CIRCULATIONAHA.107.181423 published online Mar

... udden deaths of young competitive athletes are tragic events that continue to have a considerable impact on the lay and medical communities.1–17 These deaths are usually due to a variety of unsuspected cardiovascular diseases and have been reported with increasing frequency in both the United States ...
ppt - Cardiovascular Division Heart Rate Variability Laboratory
ppt - Cardiovascular Division Heart Rate Variability Laboratory

... NE blinds to the beta-receptor (Alpha subunit of G-protein). After binding, G protein links to second messenger (adenyl cyclase) which converts ATP to cAMP. cAMP activates protein kinase A which breaks ATP to ADP+phosphate which phosphorylates the pacemaker channels and increases HR ...
Spatiotemporal electrophysiological changes in a murine ablation
Spatiotemporal electrophysiological changes in a murine ablation

... the acute and chronic electrophysiological changes that occur following cardiac ablation. Studies in rabbit hearts during and immediately after application of energy have suggested that cardiac ablation results in significant decreases in effective refractory period (ERP) and action potential durati ...
Rheology of discrete subaortic stenosis - Heart
Rheology of discrete subaortic stenosis - Heart

... development of which is poorly understood. It has become apparent in recent years that this is an acquired lesion that is rarely seen in the newborn or neonatal period.1–4 Recent theories about the pathophysiological mechanism of its formation suggest an abnormal underlying endothelial substrate tha ...
Diagnosis of Supraventricular Tachycardia
Diagnosis of Supraventricular Tachycardia

... irregular QRS complexes with no defined P wave. Atrial flutter (AFl): AFl may be a stable rhythm or a bridge arrhythmia between sinus rhythm and atrial fibrillation. It is an arrhythmia most commonly seen in men, the elderly and individuals with preexisting structural heart disease or chronic obstru ...
The effect of connexin40 deficiency on ventricular conduction
The effect of connexin40 deficiency on ventricular conduction

... endocardium. (C) This pattern is similar at ED11.5, where a rich network of the pectinate muscles could be seen in both atrial appendages. White dots indicate the position of the PIR, devoid of Cx40, corresponding externally to forming interventricular groove. (A, B, C) Tissue autofluorescence in th ...
Electromechanical wave imaging (EWI) validation in all four cardiac
Electromechanical wave imaging (EWI) validation in all four cardiac

... (Some figures may appear in colour only in the online journal) Introduction Arrhythmias such as atrial and ventricular tachycardia, atrial flutter, and atrial fibrillation affect millions of people worldwide (Mozaffarian et al 2015). These arrhythmias are the result of abnormal electrical activation ...
A clinical approach to the assessment of left ventricular diastolic
A clinical approach to the assessment of left ventricular diastolic

... Thus cellular diastole may actually begin while left ventricular pressure is still rising. Dysfunction at the cellular level is mediated principally via decreased ATP hydrolysis and/or impaired uptake of the intracellular calcium. When the actin2myosin interaction is prolonged, there is a delay and ...
Slide Set - Professional Heart Daily
Slide Set - Professional Heart Daily

... for SND in asymptomatic patients. Permanent pacemaker implantation is not indicated for SND in patients for whom the symptoms suggestive of bradycardia have been clearly documented to occur in the absence of bradycardia. Permanent pacemaker implantation is not indicated for SND with symptomatic brad ...
Prognostic Impact of Blood Urea Nitrogen Changes During - J
Prognostic Impact of Blood Urea Nitrogen Changes During - J

... inner medullary collecting duct.1 Thus, an elevated blood urea nitrogen (BUN) level could be regarded as a surrogate marker for neurohumoral activation in HF patients. Several studies have reported that elevated BUN levels are associated with adverse outcomes in HF patients, especially in ...
Tumours of the Heart
Tumours of the Heart

... of secondary tumours {1116}. However, these data may have a high referral bias and may not reflect population-based incidence rates {2079}. At the Mayo Clinic, the autopsy incidence of primary cardiac tumours from 1915 to 1931 was 0.05%, but more than tripled to 0.17% between 1954 and 1970 {2165}; a ...
Real-time phase-contrast flow MRI of the ascending aorta and
Real-time phase-contrast flow MRI of the ascending aorta and

... velocity-encoded phase-contrast flow MRI6–8 allows for a noninvasive quantification of blood flow in all major heart vessels.9,10 So far, however, a fundamental limitation of current cine MRI techniques is their dependency on the electrocardiogram (ECG), either for triggering or retrospective sorting o ...
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Myocardial infarction



Myocardial infarction (MI) or acute myocardial infarction (AMI), commonly known as a heart attack, occurs when blood flow stops to a part of the heart causing damage to the heart muscle. The most common symptom is chest pain or discomfort which may travel into the shoulder, arm, back, neck, or jaw. Often it is in the center or left side of the chest and lasts for more than a few minutes. The discomfort may occasionally feel like heartburn. Other symptoms may include shortness of breath, nausea, feeling faint, a cold sweat, or feeling tired. About 30% of people have atypical symptoms, with women more likely than men to present atypically. Among those over 75 years old, about 5% have had an MI with little or no history of symptoms. An MI may cause heart failure, an irregular heartbeat, or cardiac arrest.Most MIs occur due to coronary artery disease. Risk factors include high blood pressure, smoking, diabetes, lack of exercise, obesity, high blood cholesterol, poor diet, and excessive alcohol intake, among others. The mechanism of an MI often involves the rupture of an atherosclerotic plaque, leading to complete blockage of a coronary artery. MIs are less commonly caused by coronary artery spasms, which may be due to cocaine, significant emotional stress, and extreme cold, among others. A number of tests are useful to help with diagnosis, including electrocardiograms (ECGs), blood tests, and coronary angiography. An ECG may confirm an ST elevation MI if ST elevation is present. Commonly used blood tests include troponin and less often creatine kinase MB.Aspirin is an appropriate immediate treatment for a suspected MI. Nitroglycerin or opioids may be used to help with chest pain; however, they do not improve overall outcomes. Supplemental oxygen should be used in those with low oxygen levels or shortness of breath. In ST elevation MIs treatments which attempt to restore blood flow to the heart are typically recommended and include angioplasty, where the arteries are pushed open, or thrombolysis, where the blockage is removed using medications. People who have a non-ST elevation myocardial infarction (NSTEMI) are often managed with the blood thinner heparin, with the additional use angioplasty in those at high risk. In people with blockages of multiple coronary arteries and diabetes, bypass surgery (CABG) may be recommended rather than angioplasty. After an MI, lifestyle modifications, along with long term treatment with aspirin, beta blockers, and statins, are typically recommended.Worldwide, more than 3 million people have ST elevation MIs and 4 million have NSTEMIs each year. STEMIs occur about twice as often in men as women. About one million people have an MI each year in the United States. In the developed world the risk of death in those who have had an STEMI is about 10%. Rates of MI for a given age have decreased globally between 1990 and 2010.
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