Differences in Sarcoplasmic Reticulum Ca2+ Leak Characteristics
... colleagues (26) have been the primary proponents of the idea that SR Ca2+ leak may be increased by RyR2 hyperphosphorylation for 10 years. They showed that phosphorylation by either protein PKA or CaMKII might increase RyR2 phosphorylation status and activity (26, 41, 42). RyR2 hyperphosphorylation ...
... colleagues (26) have been the primary proponents of the idea that SR Ca2+ leak may be increased by RyR2 hyperphosphorylation for 10 years. They showed that phosphorylation by either protein PKA or CaMKII might increase RyR2 phosphorylation status and activity (26, 41, 42). RyR2 hyperphosphorylation ...
Mechanisms With Clinical Implications for Atrial Fibrillation
... December 2010 for scheduled radiofrequency catheter ablation with coronary angiography. AF in these patients had been diagnosed in light of symptoms, 12-lead electrocardiogram, and Holter electrocardiogram. As described previously,25 PAF was defined on the basis of a history of 1 or more episodes of ...
... December 2010 for scheduled radiofrequency catheter ablation with coronary angiography. AF in these patients had been diagnosed in light of symptoms, 12-lead electrocardiogram, and Holter electrocardiogram. As described previously,25 PAF was defined on the basis of a history of 1 or more episodes of ...
Articles in PresS. Am J Physiol Heart Circ Physiol (November 20
... signaling against acute myocardial ischemia/reperfusion (MI/R) injury15, 19. In the setting of MI/R ...
... signaling against acute myocardial ischemia/reperfusion (MI/R) injury15, 19. In the setting of MI/R ...
Echocardiography in Pediatric and Congenital Heart
... results in early relaxation abnormalities and incoordinate wall motion abnormalities especially affecting the isovolumic relaxation period and early filling [13–15]. These diastolic changes have typically been observed in FSV patients who underwent a Fontan operation without a previous bidirectional ...
... results in early relaxation abnormalities and incoordinate wall motion abnormalities especially affecting the isovolumic relaxation period and early filling [13–15]. These diastolic changes have typically been observed in FSV patients who underwent a Fontan operation without a previous bidirectional ...
Document
... necessary to keep the insides of these cells relatively electronegative. These ions pass into and out of the cell through special ion channels in the cell membrane. The most common natural cause of sudden death in young persons is a disturbance in the electrical flow through the heart, called an arr ...
... necessary to keep the insides of these cells relatively electronegative. These ions pass into and out of the cell through special ion channels in the cell membrane. The most common natural cause of sudden death in young persons is a disturbance in the electrical flow through the heart, called an arr ...
2016 ACC/AHA/HFSA Focused Update on New Pharmacological
... Evidence (LOE) are derived independently of each other according to established criteria. The COR indicates the strength of recommendation, encompassing the estimated magnitude and certainty of benefit of a clinical action in proportion to risk. The LOE rates the quality of scientific evidence suppo ...
... Evidence (LOE) are derived independently of each other according to established criteria. The COR indicates the strength of recommendation, encompassing the estimated magnitude and certainty of benefit of a clinical action in proportion to risk. The LOE rates the quality of scientific evidence suppo ...
Cardiogenesis in the bovine to 35 somites - K-REx
... form the left chambers of the heart from the left primordium and the right chambers from the right heart tube. ...
... form the left chambers of the heart from the left primordium and the right chambers from the right heart tube. ...
CLINICAL AND ECHOCARDIOGRAPHIC FINDINGS OF LEFT
... Hypertension is the commonest of the cardiovascular risk factors, whose prevalence in Tanzania is high between 20-30%, among rural and urban residents respectively. Uncontrolled hypertension leads to a number of structural changes in the heart which eventually cumulates into interstitial fibrosis, m ...
... Hypertension is the commonest of the cardiovascular risk factors, whose prevalence in Tanzania is high between 20-30%, among rural and urban residents respectively. Uncontrolled hypertension leads to a number of structural changes in the heart which eventually cumulates into interstitial fibrosis, m ...
PDF - Circulation: Arrhythmia and Electrophysiology
... down the pathway to the posterior fascicle and retrograde conduction back up the conduction system to the AV node could produce a similar tachycardia with VH linking and VA dissociation. However, during atrial pacing, no evidence of pre-excitation was seen suggestive of presence of a pathway. ...
... down the pathway to the posterior fascicle and retrograde conduction back up the conduction system to the AV node could produce a similar tachycardia with VH linking and VA dissociation. However, during atrial pacing, no evidence of pre-excitation was seen suggestive of presence of a pathway. ...
Acute, ambulatory and central blood pressure measurements in diabetes Magnus Olof Wijkman
... risk for cardiovascular disease, such as stroke3 and myocardial infarction4. A meta-analysis of observational epidemiological studies revealed a close relationship between systolic or diastolic blood pressure and the risk of either fatal stroke or fatal coronary heart disease, with no evidence of a ...
... risk for cardiovascular disease, such as stroke3 and myocardial infarction4. A meta-analysis of observational epidemiological studies revealed a close relationship between systolic or diastolic blood pressure and the risk of either fatal stroke or fatal coronary heart disease, with no evidence of a ...
pressure and volume relationships in the ventricle
... Pressure measurements alone are insufficient to allow complete understanding of a system in which interactions between the contractile chambers must occur. It is important to know the extent of the volume changes occurring in different regions of the heart and whether the cardiac muscle in these reg ...
... Pressure measurements alone are insufficient to allow complete understanding of a system in which interactions between the contractile chambers must occur. It is important to know the extent of the volume changes occurring in different regions of the heart and whether the cardiac muscle in these reg ...
Cardiac Malpositions
... bilate.rally deficient. It should be noted that as used herein DORV differs from the broader use proposed by Lev,' i.e., aorta and pulmonary artery completely or almost completely arising from the right ventricle regardless of semilunar valve mitral continuity. The latter definition focuses entirely ...
... bilate.rally deficient. It should be noted that as used herein DORV differs from the broader use proposed by Lev,' i.e., aorta and pulmonary artery completely or almost completely arising from the right ventricle regardless of semilunar valve mitral continuity. The latter definition focuses entirely ...
Dextrocardia with Situs Inversus, Atrio
... Figure 4: A 2-D Echocardiogram showing the aorta connected to the right-sided left ventricle. The aortic arch is directed to the right and its first bifurcating branch is directed to the left. ...
... Figure 4: A 2-D Echocardiogram showing the aorta connected to the right-sided left ventricle. The aortic arch is directed to the right and its first bifurcating branch is directed to the left. ...
Probing the Electrophysiology of the Developing Heart
... to hatching. Zebrafish can also survive to 7 days post-fertilization despite severely compromised heart development and even with an absence of heart function [7] because the embryos can survive on ...
... to hatching. Zebrafish can also survive to 7 days post-fertilization despite severely compromised heart development and even with an absence of heart function [7] because the embryos can survive on ...
PowerPoint - Cardiovascular Radiology
... - Murmur heard on annual – left sternum • Skeletal, cranial abdomen, Lung fields, airways, Great vessels, small vessels – No abnormalities noted ...
... - Murmur heard on annual – left sternum • Skeletal, cranial abdomen, Lung fields, airways, Great vessels, small vessels – No abnormalities noted ...
Decreased Nox4 levels in the myocardium of patients with aortic
... The study population consisted of 34 patients with clinically diagnosed severe isolated AS, defined in accordance with the following criteria [18]: mean transvalvular pressure gradient 40 mmHg, aortic valve area <1 cm2 or aortic valve area index <0.6 cm2 /m2 . The patients were referred for valve r ...
... The study population consisted of 34 patients with clinically diagnosed severe isolated AS, defined in accordance with the following criteria [18]: mean transvalvular pressure gradient 40 mmHg, aortic valve area <1 cm2 or aortic valve area index <0.6 cm2 /m2 . The patients were referred for valve r ...
Mitochondria in heart failure
... antioxidant defense mechanisms, a significant increase in oxidative stress markers was described in cardiac IFM compared with SSM with age.49 Cardiac IFM are also more sensitive to diabetic damage. Experimental-induced diabetes in rats causes a decrease in CL content, oxidative phosphorylation, and ...
... antioxidant defense mechanisms, a significant increase in oxidative stress markers was described in cardiac IFM compared with SSM with age.49 Cardiac IFM are also more sensitive to diabetic damage. Experimental-induced diabetes in rats causes a decrease in CL content, oxidative phosphorylation, and ...
Poincare Plot of Heart Rate Variability Allows
... nervous system activity. The Poincarb plot is therefore a quantitative visual tool which can be applied to the analysis of R-R interval data gathered over relatively short time periods. INTRODUCTION ...
... nervous system activity. The Poincarb plot is therefore a quantitative visual tool which can be applied to the analysis of R-R interval data gathered over relatively short time periods. INTRODUCTION ...
Cardiac Resynchronization Therapy (CRT)
... implantation of a CRT device or lead(s). Some risks encountered during the implant procedure may include infection, tissue damage, bleeding, and an irregular heart rhythm. Complications do not happen very often. However, it is important that you talk with your doctor about the risks of having a CRT ...
... implantation of a CRT device or lead(s). Some risks encountered during the implant procedure may include infection, tissue damage, bleeding, and an irregular heart rhythm. Complications do not happen very often. However, it is important that you talk with your doctor about the risks of having a CRT ...
Extracorporeal Membrane Oxygenation for Cardiac Failure
... inability of the heart to fill or eject blood at a rate commensurate with the body’s requirements.1,2 Heart failure is also referred to as cardiac failure and the terms are often used interchangeably. There are two major types of heart failure: diastolic heart failure which is associated with abnorm ...
... inability of the heart to fill or eject blood at a rate commensurate with the body’s requirements.1,2 Heart failure is also referred to as cardiac failure and the terms are often used interchangeably. There are two major types of heart failure: diastolic heart failure which is associated with abnorm ...
Quantitative trait loci with sex-specific effects for internal organs
... metabolically important organs (heart, lungs, liver and gizzard), and hematocrit value in a ...
... metabolically important organs (heart, lungs, liver and gizzard), and hematocrit value in a ...
Evaluation Pulmonary Arterial End-Diastolic Pressure
... in 24 patients with normal left ventricular function and in 26 patients with left ventricular myocardial disease and elevated EDP (range 13 to 38 mm Hg; average 22 mm Hg). In patients with normal left ventricular function, the EDPs in the left ventricle and pulmonary artery were equal (range 5 to 12 ...
... in 24 patients with normal left ventricular function and in 26 patients with left ventricular myocardial disease and elevated EDP (range 13 to 38 mm Hg; average 22 mm Hg). In patients with normal left ventricular function, the EDPs in the left ventricle and pulmonary artery were equal (range 5 to 12 ...
Long-term cardiovascular adaptations to neonatal
... My research career would not have been possible without the support and mentorship of Dr. Rohlicek. For the past five years, he has opened many doors and provided me with invaluable opportunities that I would not have otherwise been afforded. From Vancouver to Montreal to Spain, it has been a pleasu ...
... My research career would not have been possible without the support and mentorship of Dr. Rohlicek. For the past five years, he has opened many doors and provided me with invaluable opportunities that I would not have otherwise been afforded. From Vancouver to Montreal to Spain, it has been a pleasu ...
Plasma Bin1 Correlates With Heart Failure And Predicts
... More recently, BIN1's influence has also been found to extend to cardiomyocytes. Our group has found that BIN1 is necessary for localizing the delivery of L-type calcium channels to T-tubules in cardiac T-tubules22, a function that is important for maintaining normal calcium transients and myocardia ...
... More recently, BIN1's influence has also been found to extend to cardiomyocytes. Our group has found that BIN1 is necessary for localizing the delivery of L-type calcium channels to T-tubules in cardiac T-tubules22, a function that is important for maintaining normal calcium transients and myocardia ...
Myocardial infarction
Myocardial infarction (MI) or acute myocardial infarction (AMI), commonly known as a heart attack, occurs when blood flow stops to a part of the heart causing damage to the heart muscle. The most common symptom is chest pain or discomfort which may travel into the shoulder, arm, back, neck, or jaw. Often it is in the center or left side of the chest and lasts for more than a few minutes. The discomfort may occasionally feel like heartburn. Other symptoms may include shortness of breath, nausea, feeling faint, a cold sweat, or feeling tired. About 30% of people have atypical symptoms, with women more likely than men to present atypically. Among those over 75 years old, about 5% have had an MI with little or no history of symptoms. An MI may cause heart failure, an irregular heartbeat, or cardiac arrest.Most MIs occur due to coronary artery disease. Risk factors include high blood pressure, smoking, diabetes, lack of exercise, obesity, high blood cholesterol, poor diet, and excessive alcohol intake, among others. The mechanism of an MI often involves the rupture of an atherosclerotic plaque, leading to complete blockage of a coronary artery. MIs are less commonly caused by coronary artery spasms, which may be due to cocaine, significant emotional stress, and extreme cold, among others. A number of tests are useful to help with diagnosis, including electrocardiograms (ECGs), blood tests, and coronary angiography. An ECG may confirm an ST elevation MI if ST elevation is present. Commonly used blood tests include troponin and less often creatine kinase MB.Aspirin is an appropriate immediate treatment for a suspected MI. Nitroglycerin or opioids may be used to help with chest pain; however, they do not improve overall outcomes. Supplemental oxygen should be used in those with low oxygen levels or shortness of breath. In ST elevation MIs treatments which attempt to restore blood flow to the heart are typically recommended and include angioplasty, where the arteries are pushed open, or thrombolysis, where the blockage is removed using medications. People who have a non-ST elevation myocardial infarction (NSTEMI) are often managed with the blood thinner heparin, with the additional use angioplasty in those at high risk. In people with blockages of multiple coronary arteries and diabetes, bypass surgery (CABG) may be recommended rather than angioplasty. After an MI, lifestyle modifications, along with long term treatment with aspirin, beta blockers, and statins, are typically recommended.Worldwide, more than 3 million people have ST elevation MIs and 4 million have NSTEMIs each year. STEMIs occur about twice as often in men as women. About one million people have an MI each year in the United States. In the developed world the risk of death in those who have had an STEMI is about 10%. Rates of MI for a given age have decreased globally between 1990 and 2010.