Utility of metabolic exercise testing in distinguishing
... Hypertrophic cardiomyopathy (HCM) is the most common cause of exercise related sudden cardiac death in athletes (1–5). The identification of HCM in athletes can be problematic because some athletes develop substantial physiologic left ventricular hypertrophy (LVH) (13 mm to 16 mm) during intense phy ...
... Hypertrophic cardiomyopathy (HCM) is the most common cause of exercise related sudden cardiac death in athletes (1–5). The identification of HCM in athletes can be problematic because some athletes develop substantial physiologic left ventricular hypertrophy (LVH) (13 mm to 16 mm) during intense phy ...
Plasma Bin1 Correlates With Heart Failure And Predicts
... More recently, BIN1's influence has also been found to extend to cardiomyocytes. Our group has found that BIN1 is necessary for localizing the delivery of L-type calcium channels to T-tubules in cardiac T-tubules22, a function that is important for maintaining normal calcium transients and myocardia ...
... More recently, BIN1's influence has also been found to extend to cardiomyocytes. Our group has found that BIN1 is necessary for localizing the delivery of L-type calcium channels to T-tubules in cardiac T-tubules22, a function that is important for maintaining normal calcium transients and myocardia ...
Myocardial ischaemia and the cardiac nervous system
... sensory field increased the activity that this neurone generated. The estimated conduction velocity of its axon was 2.4 m / s. Vertical calibration bars beside neuronal activity50.2 mV. (D) Power spectral analysis of the activity generated by this neurone displayed one peak at about 2 Hz, which conc ...
... sensory field increased the activity that this neurone generated. The estimated conduction velocity of its axon was 2.4 m / s. Vertical calibration bars beside neuronal activity50.2 mV. (D) Power spectral analysis of the activity generated by this neurone displayed one peak at about 2 Hz, which conc ...
Preview the material
... provides an overview of cardiac arrhythmias in terms of pathogenesis and clinical presentation. Overview of Arrhythmias Arrhythmias are relatively common in the pediatric cardiac intensive care unit. One study revealed 59% of neonates and 79% of older children have arrhythmias within 24 hours of sur ...
... provides an overview of cardiac arrhythmias in terms of pathogenesis and clinical presentation. Overview of Arrhythmias Arrhythmias are relatively common in the pediatric cardiac intensive care unit. One study revealed 59% of neonates and 79% of older children have arrhythmias within 24 hours of sur ...
Left Ventricular Volume and Evaluation of Heart Murmurs
... With prolonged squatting the lower arteries (e.g. femoral) are compressed. This maneuver raises the afterload or systemic vascular resistance. As a result of increased TPR (afterload) the left ventricular pressure also increases. The rise in left ventricular pressure acts as an impediment to free fl ...
... With prolonged squatting the lower arteries (e.g. femoral) are compressed. This maneuver raises the afterload or systemic vascular resistance. As a result of increased TPR (afterload) the left ventricular pressure also increases. The rise in left ventricular pressure acts as an impediment to free fl ...
Syncope: A Guideline for Primary Care Physicians
... until his/her urine is clear and frequent is a way to ensure that adequate hydration has been achieved. Increasing salt intake can be achieved by adding salt to food. In extreme cases salt supplementation can be given (2 gm up to three times per day); of note, salt supplementation can cause gastric ...
... until his/her urine is clear and frequent is a way to ensure that adequate hydration has been achieved. Increasing salt intake can be achieved by adding salt to food. In extreme cases salt supplementation can be given (2 gm up to three times per day); of note, salt supplementation can cause gastric ...
2016 ACC/AHA/HFSA Focused Update on New Pharmacological
... HF, with or without coronary artery disease (9-14). Data suggest that there are no differences among available ACE inhibitors in their effects on symptoms or survival (25). ACE inhibitors should be started at low doses and titrated upward to doses shown to reduce the risk of cardiovascular events in ...
... HF, with or without coronary artery disease (9-14). Data suggest that there are no differences among available ACE inhibitors in their effects on symptoms or survival (25). ACE inhibitors should be started at low doses and titrated upward to doses shown to reduce the risk of cardiovascular events in ...
How to Distinguish Between Innocent and Pathologic Murmurs in
... The most commonly used classitration in the grading of systolic murmurs i s h a t proposed by S a m k v i n e 7 many years ago. The Grade 1 murmur is a faint murmur that you have to listen to w e h l l y to appreciate. It is usually heard under optimal conditions such as a quiet room, with a well-be ...
... The most commonly used classitration in the grading of systolic murmurs i s h a t proposed by S a m k v i n e 7 many years ago. The Grade 1 murmur is a faint murmur that you have to listen to w e h l l y to appreciate. It is usually heard under optimal conditions such as a quiet room, with a well-be ...
Cholesterol - Network of Care
... Good Cholesterol (HDL Cholesterol) Good (HDL) cholesterol helps remove extra cholesterol from the body. When your good cholesterol is higher, your chance of heart disease is lower. If your good cholesterol is 60 or higher, that helps protect against heart attacks and strokes. ...
... Good Cholesterol (HDL Cholesterol) Good (HDL) cholesterol helps remove extra cholesterol from the body. When your good cholesterol is higher, your chance of heart disease is lower. If your good cholesterol is 60 or higher, that helps protect against heart attacks and strokes. ...
The Prognostic Role of QTc Interval in Acute Myocarditis
... duration, which is significantly affected by changes in the sympathetic nervous system and sympathetic tone19 and by ischemia that results in increased intracellular calcium levels during the cardiac action potential, inhibiting the repolarizing potassium current.20 QT interval prolongation has also ...
... duration, which is significantly affected by changes in the sympathetic nervous system and sympathetic tone19 and by ischemia that results in increased intracellular calcium levels during the cardiac action potential, inhibiting the repolarizing potassium current.20 QT interval prolongation has also ...
Treating High Cholesterol
... Good Cholesterol (HDL Cholesterol) Good (HDL) cholesterol helps remove extra cholesterol from the body. When your good cholesterol is higher, your chance of heart disease is lower. If your good cholesterol is 60 or higher, that helps protect against heart attacks and strokes. ...
... Good Cholesterol (HDL Cholesterol) Good (HDL) cholesterol helps remove extra cholesterol from the body. When your good cholesterol is higher, your chance of heart disease is lower. If your good cholesterol is 60 or higher, that helps protect against heart attacks and strokes. ...
View Full Page PDF - Advances in Physiology Education
... This laboratory exercise, along with two similar exercises examining the cardiopulmonary changes associated with aging and congestive heart failure, was presented at an Educational Materials Workshop at the annual meeting of the American College of Sports Medicine in Indianapolis, IN, in 1994. The E ...
... This laboratory exercise, along with two similar exercises examining the cardiopulmonary changes associated with aging and congestive heart failure, was presented at an Educational Materials Workshop at the annual meeting of the American College of Sports Medicine in Indianapolis, IN, in 1994. The E ...
Intracardiac Flow Patterns in Early Embryonic Life
... lasting for 2-5 seconds each time. The total volume injected into each embryo was not determined. However, this was estimated roughly to be less than 0.02 fi\ in the young embryos (H-H stages 14-16), or not more than 0.2 n\ in the older ones (H-H stages 17-22). The dye-containing stream was observed ...
... lasting for 2-5 seconds each time. The total volume injected into each embryo was not determined. However, this was estimated roughly to be less than 0.02 fi\ in the young embryos (H-H stages 14-16), or not more than 0.2 n\ in the older ones (H-H stages 17-22). The dye-containing stream was observed ...
Exercise and Blood Pressure
... were studied before and after 5 weeks of 1-legged knee-extensor training and 2 weeks of deconditioning of the other leg (leg cast). Hemodynamics and muscle interstitial nucleotides were determined during exercise with the (1) deconditioned leg, (2) trained leg, and (3) trained leg with atrial pacing ...
... were studied before and after 5 weeks of 1-legged knee-extensor training and 2 weeks of deconditioning of the other leg (leg cast). Hemodynamics and muscle interstitial nucleotides were determined during exercise with the (1) deconditioned leg, (2) trained leg, and (3) trained leg with atrial pacing ...
The Hand1 and Hand2 transcription factors regulate
... 1998), was used to generate the Hand1loxP targeting vector. A 2.9 kb fragment extending upstream from the Hand1 5′-UTR (long arm of homology) was amplified by high-fidelity PCR (Stratagene Pfu Turbo) and digested with XhoI. An EcoRI restriction site was engineered into the Hand1 5′UTR to facilitate ...
... 1998), was used to generate the Hand1loxP targeting vector. A 2.9 kb fragment extending upstream from the Hand1 5′-UTR (long arm of homology) was amplified by high-fidelity PCR (Stratagene Pfu Turbo) and digested with XhoI. An EcoRI restriction site was engineered into the Hand1 5′UTR to facilitate ...
Primary Prevention ICD / CRT Task Force Report
... Since 2002, seven clinical trials (MADIT II, CAT, AMIOVERT, COMPANION, DEFINITE, SCD-HeFT, DINAMIT) have reported on prophylactic or ‘preventive’ ICD use in individuals with ischemic and non-ischemic heart disease and impaired heart function. Two trials in particular (MADIT II and SCD-HeFT) reported ...
... Since 2002, seven clinical trials (MADIT II, CAT, AMIOVERT, COMPANION, DEFINITE, SCD-HeFT, DINAMIT) have reported on prophylactic or ‘preventive’ ICD use in individuals with ischemic and non-ischemic heart disease and impaired heart function. Two trials in particular (MADIT II and SCD-HeFT) reported ...
PATIENT EDUCATION TOOLS The following tools can be used to
... • Blockages in the arteries of your heart, producing chest pain and/or a heart attack • Damaged heart valves • A history of diabetes • A family history of any of these conditions A complete physical exam can help diagnose heart failure. During a physical exam, your doctor or nurse will check your bl ...
... • Blockages in the arteries of your heart, producing chest pain and/or a heart attack • Damaged heart valves • A history of diabetes • A family history of any of these conditions A complete physical exam can help diagnose heart failure. During a physical exam, your doctor or nurse will check your bl ...
SYNERGY™ - Patient Information Guide
... designed to allow for a consistent and controlled release of the drug from the stent surface into the artery walls. Both the amount of drug and the drug release rate have been selected so that healing can occur while minimizing the processes leading to restenosis (recurrent blockage of the artery), ...
... designed to allow for a consistent and controlled release of the drug from the stent surface into the artery walls. Both the amount of drug and the drug release rate have been selected so that healing can occur while minimizing the processes leading to restenosis (recurrent blockage of the artery), ...
Neurocardiogenic Syncope
... 2) Patient with neurological events when transientatrial fibrillation or flutter is suspected 3) Patients with symptoms such as syncope, near syncope, episodic dizziness, or palpitation in whom a probable cause other than an arrhyhmia has been identified but in whom symptoms persists despite treatme ...
... 2) Patient with neurological events when transientatrial fibrillation or flutter is suspected 3) Patients with symptoms such as syncope, near syncope, episodic dizziness, or palpitation in whom a probable cause other than an arrhyhmia has been identified but in whom symptoms persists despite treatme ...
J. Hypertension 252185-2192 (2007).doc
... supported by two facts: (1) subjects with essential hypertension are at increased risk for a particular form of chronic kidney disease (e.g. nephroangiosclerosis) [77], and (2) the kidney ...
... supported by two facts: (1) subjects with essential hypertension are at increased risk for a particular form of chronic kidney disease (e.g. nephroangiosclerosis) [77], and (2) the kidney ...
AHEART July 46/1 - AJP
... delays the onset and slows down the rate of relaxation, whereas an increase in afterload late in systole abbreviates contraction time and increases the rate of relaxation (5). In isolated heart studies, interventions designed to increase afterload immediately after aortic valve opening increased the ...
... delays the onset and slows down the rate of relaxation, whereas an increase in afterload late in systole abbreviates contraction time and increases the rate of relaxation (5). In isolated heart studies, interventions designed to increase afterload immediately after aortic valve opening increased the ...
Is right ventricular outflow tract pacing superior to right ventricular
... this conclusion. This might be caused by the development of systolic and diastolic dyssynchrony through separate mechanisms [17, 18]. In our study, different from the conclusion by Hemayat S et al [14], MR and TR of both groups worsened between pre-operation and longterm follow-up. Increased TR resu ...
... this conclusion. This might be caused by the development of systolic and diastolic dyssynchrony through separate mechanisms [17, 18]. In our study, different from the conclusion by Hemayat S et al [14], MR and TR of both groups worsened between pre-operation and longterm follow-up. Increased TR resu ...
Atrial Fibrillation Management: 2005
... of substrate both important (wavelet mechanism) • New technique: left atrial ablation, wide area circumferential ablation, circumferential left atrial pulmonary vein ablation (Pappone, Morady, and others) • Increased success by isolating/encircling outside of the ...
... of substrate both important (wavelet mechanism) • New technique: left atrial ablation, wide area circumferential ablation, circumferential left atrial pulmonary vein ablation (Pappone, Morady, and others) • Increased success by isolating/encircling outside of the ...
Myocardial infarction
Myocardial infarction (MI) or acute myocardial infarction (AMI), commonly known as a heart attack, occurs when blood flow stops to a part of the heart causing damage to the heart muscle. The most common symptom is chest pain or discomfort which may travel into the shoulder, arm, back, neck, or jaw. Often it is in the center or left side of the chest and lasts for more than a few minutes. The discomfort may occasionally feel like heartburn. Other symptoms may include shortness of breath, nausea, feeling faint, a cold sweat, or feeling tired. About 30% of people have atypical symptoms, with women more likely than men to present atypically. Among those over 75 years old, about 5% have had an MI with little or no history of symptoms. An MI may cause heart failure, an irregular heartbeat, or cardiac arrest.Most MIs occur due to coronary artery disease. Risk factors include high blood pressure, smoking, diabetes, lack of exercise, obesity, high blood cholesterol, poor diet, and excessive alcohol intake, among others. The mechanism of an MI often involves the rupture of an atherosclerotic plaque, leading to complete blockage of a coronary artery. MIs are less commonly caused by coronary artery spasms, which may be due to cocaine, significant emotional stress, and extreme cold, among others. A number of tests are useful to help with diagnosis, including electrocardiograms (ECGs), blood tests, and coronary angiography. An ECG may confirm an ST elevation MI if ST elevation is present. Commonly used blood tests include troponin and less often creatine kinase MB.Aspirin is an appropriate immediate treatment for a suspected MI. Nitroglycerin or opioids may be used to help with chest pain; however, they do not improve overall outcomes. Supplemental oxygen should be used in those with low oxygen levels or shortness of breath. In ST elevation MIs treatments which attempt to restore blood flow to the heart are typically recommended and include angioplasty, where the arteries are pushed open, or thrombolysis, where the blockage is removed using medications. People who have a non-ST elevation myocardial infarction (NSTEMI) are often managed with the blood thinner heparin, with the additional use angioplasty in those at high risk. In people with blockages of multiple coronary arteries and diabetes, bypass surgery (CABG) may be recommended rather than angioplasty. After an MI, lifestyle modifications, along with long term treatment with aspirin, beta blockers, and statins, are typically recommended.Worldwide, more than 3 million people have ST elevation MIs and 4 million have NSTEMIs each year. STEMIs occur about twice as often in men as women. About one million people have an MI each year in the United States. In the developed world the risk of death in those who have had an STEMI is about 10%. Rates of MI for a given age have decreased globally between 1990 and 2010.