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1 | 2012 Angel of the North
1 | 2012 Angel of the North

... cause mortality was found to be less in the L-thyroxine treated group than in the untreated group for patients between 40 and 70  years, but not in the older patients. Importantly, atrial fibrillation was not more common in patients taking L-thyroxine, even in the older agegroup.49 Although we have ...
F W James, S Kaplan, C J Glueck, J Y... 1980;61:902-912 doi: 10.1161/01.CIR.61.5.902
F W James, S Kaplan, C J Glueck, J Y... 1980;61:902-912 doi: 10.1161/01.CIR.61.5.902

... from the parent, guardian or subject. The procedure was usually conducted in the morning with restricted food intake for at least 2 hours before the study. The bicycle protocol in this study is outlined in table 1. The protocol consists of three exercise programs for three ranges of body surface are ...
Hemodynamic sensing using subcutaneous photoplethysmography
Hemodynamic sensing using subcutaneous photoplethysmography

... doi:10.1152/ajpheart.00574.2008.—Pacemakers and implantable defibrillators presently operate without access to hemodynamic information. If available, such data would allow tailoring of delivered therapy according to perfusion status, optimization of device function, and enhancement of disease monito ...
Biventricular Pacemakers
Biventricular Pacemakers

... reported a reduction for the ICD-CRT group on the primary outcome, ie, death or acute heart failure exacerbation. The primary end point was reached by 17.2% of patients in the ICD-CRT group compared with 25.3% of patients in the ICD-alone group. The first component of the composite outcome, acute he ...
Responses of Normal Children and Young Adults to
Responses of Normal Children and Young Adults to

... from the parent, guardian or subject. The procedure was usually conducted in the morning with restricted food intake for at least 2 hours before the study. The bicycle protocol in this study is outlined in table 1. The protocol consists of three exercise programs for three ranges of body surface are ...
Print - Circulation
Print - Circulation

... subject in the resting state in order to obtain a "control" circulation time. After 3 to 5 minutes a second injection of P32 was made at the onset of the Valsalva maneuver, care being taken that the P32 was not injected before the patient had started to strain. From each two-second sample of arteria ...
Serum Levels of the Interleukin-1 Receptor Family
Serum Levels of the Interleukin-1 Receptor Family

... (Boston, Mass), where samples were maintained at ⫺70°C. Soluble ST2 was measured by a sandwich double monoclonal antibody ...
Underlying Causes and Long-Term Survival in Patients with Initially
Underlying Causes and Long-Term Survival in Patients with Initially

... reanalyzed the data using the combined end point of death or cardiac transplantation. In this alternative analysis, the associations between specific causes of cardiomyopathy and prognosis were unchanged, with the exception that cardiomyopathy due to connective-tissue disease was no longer significa ...
3434-3439-The impact of the extent and severity of coronary artery
3434-3439-The impact of the extent and severity of coronary artery

... standard for the diagnosis of coronary artery disease, but it has a limitation in evaluating the functional significance of intermediate coronary stenosis (30-70% stenosis)1-4. This limitation can cause an unnecessary myocardial revascularization5,6. Some intracoronary hemodynamical measurements can ...
The index of suspicion of RV infarction should be particularly high in
The index of suspicion of RV infarction should be particularly high in

... (M-mode colour Doppler of mitral inflow) ...
here
here

... such as cardiac MRI, even in mice with postinfarction cardiomyopathy, where volumes are larger and LV walls present fibrosis (48). In many ways, the small rodent heart has turned out to be the ideal application for this methodology. A pressure signal can be integrated with other imaging methods to o ...
Echocardiographic findings in pulmonary embolism: An important
Echocardiographic findings in pulmonary embolism: An important

... potentially fatal, caused by partial or total obstruction of the pulmonary arteries and or its branches usually by blood clots but also air, tissue and fat. The most common cause is secondary embolization from thrombosis of veins usually originating from lower extremities or pelvis. Risk factors for ...
Obstructive Sleep Apnea and its Relationship to Cardiac Arrhythmias
Obstructive Sleep Apnea and its Relationship to Cardiac Arrhythmias

... (sinus bradycardia, sinus pause, first degree, and Mobitz I second-degree AV block). These disturbances are considered physiologic and are related to normal changes in autonomic nervous system activity typical of the different sleep stages. Such a finding generally does not warrant further investiga ...
Diseases of the Cardiovascular System
Diseases of the Cardiovascular System

... and contracting to push blood forward  Relaxation phase is diastole.  Contraction phase is systole. ...
Aging-related Changes in Cardiac Extracellular Matrix: Implications
Aging-related Changes in Cardiac Extracellular Matrix: Implications

... (HTN) and myocardial infarction (MI) are the two main comorbidities leading to HF in the elderly (age ≥ 65 years). Aging is progressive and results in cardiovascular changes that lead to an aging phenotype and negatively impact disease expression and response to therapy. Aging-related changes contri ...
Full Text - European Heart Journal
Full Text - European Heart Journal

... VE/VCO2 minute ventilation – carbon dioxide production relationship V/Q ventilation/perfusion WHO-FC World Health Organization functional class WU Wood units ...
Heart Failure with Preserved Ejection Fraction
Heart Failure with Preserved Ejection Fraction

... searched using the ICD-9-CM code 428. Among this, 170 with HFPEF were selected for study. To adjust for the impact of baseline differences between the 2 cohorts on clinical outcomes, we calculated a propensity score. To establish a risk score, HFPEF patients were randomly divided into derivation gro ...
The intramyocardial left anterior descending artery
The intramyocardial left anterior descending artery

... the consequence of disease in the LAD artery.[17] The LAD artery is most commonly situated intramuscularly, although other vessels may be involved.[10,11,18-20] Clinically, the LAD artery is the most important affected vessel,[10] and in view of the routine use of the left internal mammary artery (L ...
Right ventricular failure in patients with the HeartMate
Right ventricular failure in patients with the HeartMate

... Nader Moazami, MD,i Kartik S. Sundareswaran, PhD,j and David J. Farrar, PhD,j for the HeartMate II Clinical Investigators Objective: The aim of this study was to evaluate the incidence, risk factors, and effect on outcomes of right ventricular failure in a large population of patients implanted with ...
Level of Evidence: C - Professional Heart Daily
Level of Evidence: C - Professional Heart Daily

... of patients presenting with HF should include complete blood count, urinalysis, serum electrolytes (including calcium and magnesium), blood urea nitrogen, serum creatinine, fasting blood glucose (glycohemoglobin), lipid profile, liver function tests, and thyroid-stimulating hormone. (Level of Eviden ...
European Heart Rhythm Association/Heart Failure Association joint
European Heart Rhythm Association/Heart Failure Association joint

... The two constantly growing global health problems (that is, HF and AF) often co-exist, or may precipitate one another. Recent registry-based reports show that 40% of patients hospitalized for HF already have a history of AF, up to 50% of patients have AF at baseline, and nearly 20% of patients may ...
Antiarrhythmic Drugs - LSU School of Medicine
Antiarrhythmic Drugs - LSU School of Medicine

... population—have failed, despite prolonged and dedicated efforts, to become sufficiently effective or safe for widespread use. And finally, consider that with a deeper understanding of cellular electrophysiology, drug companies are now beginning to “tailor” new compounds that might be more effective an ...
Experimental Models of Heart Failure
Experimental Models of Heart Failure

... to the wild type, in AT-2 receptor-null (–/–) mice, the 7-day survival rate after acute myocardial infarction (AMI) is significantly lower. 24 h after coronary occlusion, ventricular mRNA levels for brain natriuretic peptide, lung weights and pulmonary congestion were found to be significantly highe ...
Name of presentation
Name of presentation

... Sooner if things get worse Potassium supplementation is often necessary Untreated hypokalemia can predispose to arrhythmia, especially if on digitalis ...
Responses of cardiac natriuretic peptides after paroxysmal
Responses of cardiac natriuretic peptides after paroxysmal

... Chi-square test with Yates’ correction or Fisher’s exact test. P<0.05 was considered ...
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Antihypertensive drug



Antihypertensives are a class of drugs that are used to treat hypertension (high blood pressure). Antihypertensive therapy seeks to prevent the complications of high blood pressure, such as stroke and myocardial infarction. Evidence suggests that reduction of the blood pressure by 5 mmHg can decrease the risk of stroke by 34%, of ischaemic heart disease by 21%, and reduce the likelihood of dementia, heart failure, and mortality from cardiovascular disease. There are many classes of antihypertensives, which lower blood pressure by different means. Among the most important and most widely used drugs are thiazide diuretics, calcium channel blockers, ACE inhibitors, angiotensin II receptor antagonists (ARBs), and beta blockers.Which type of medication to use initially for hypertension has been the subject of several large studies and resulting national guidelines. The fundamental goal of treatment should be the prevention of the important endpoints of hypertension, such as heart attack, stroke and heart failure. Patient age, associated clinical conditions and end-organ damage also play a part in determining dosage and type of medication administered. The several classes of antihypertensives differ in side effect profiles, ability to prevent endpoints, and cost. The choice of more expensive agents, where cheaper ones would be equally effective, may have negative impacts on national healthcare budgets. As of 2009, the best available evidence favors the thiazide diuretics as the first-line treatment of choice for high blood pressure when drugs are necessary. Although clinical evidence shows calcium channel blockers and thiazide-type diuretics are preferred first-line treatments for most people (from both efficacy and cost points of view), an ACE inhibitor is recommended by NICE in the UK for those under 55 years old.
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