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epinephrine injection, USP auto-injector
epinephrine injection, USP auto-injector

... arrhythmias, coronary artery or organic heart disease, hypertension, or in patients who are on medications that may sensitize the heart to arrhythmias, e.g., digitalis, diuretics, or anti-arrhythmics. In such patients, epinephrine may precipitate or aggravate angina pectoris as well as produce ventr ...
Pulmonary Vascular Resistance as Assessed by Bicycle Stress
Pulmonary Vascular Resistance as Assessed by Bicycle Stress

... patients also causes shear stress on the endothelium, inducing progressive pulmonary vascular lesions.1 The earlier stages of shunt-induced pulmonary vascular disease, as first described by Heath and Edwards, present with medial hypertrophy and/or intimal proliferation and are largely reversible aft ...
Sarah E. Nelson, Gautam R. Shroff, Shuling Li and Charles A
Sarah E. Nelson, Gautam R. Shroff, Shuling Li and Charles A

... incidence of AF was 12.2% for patients with CKD stages 1 and 2, 14.4% for stages 3 to 5, and 13.4% for unknown stage, compared with 7.5% for patients without CKD (P<0.0001). The median follow-up time for incident AF was 24 months for patients without CKD and for each subgroup of patients with CKD. T ...
818-2787-1-RV
818-2787-1-RV

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818-2787-2-RV

... necrosis and loss of systolic function compared with an untreated control group. Combination treatment has the potential to improve the results of cardiac surgery, however further improvements are needed before clinical application. In one study, sodium-proton exchange inhibition with cariporide dec ...
Articles in PresS. Am J Physiol Heart Circ Physiol (January 22, 2016
Articles in PresS. Am J Physiol Heart Circ Physiol (January 22, 2016

Articles in PresS. Am J Physiol Heart Circ Physiol (January 22, 2016
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... 33) in comparison to sea level inhabitants that is characterized in adult Sherpa by lower ...
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CARDIOVASCULAR BASIC DATA SET - International Spinal Cord
CARDIOVASCULAR BASIC DATA SET - International Spinal Cord

... non-noxious stimuli below the level of injury defined by an increase in systolic blood pressure (> 20mm Hg above baseline), and which may include one of the following symptoms: headache, flushing and sweating above the level of the lesion, vasoconstriction below the level of the lesion, and dysrhyth ...
reviews
reviews

... Sudden cardiac death is associated with common cardiac diseases and conditions, most notably heart failure (roughly 50% of heart failure patients die from fatal ventricular arrhythmias). However, fatal arrhythmias can also occur in young and otherwise healthy individuals without known structural hea ...
Wall thickness of coronary vessels varies transmurally in the LV but
Wall thickness of coronary vessels varies transmurally in the LV but

... LV, much more than in the RV. Five normal Yorkshire swine were used in this study. The major coronary arteries were cannulated through the aorta and perfusion fixed with 6.25% glutaraldehyde and casted with a catalyzed silicone-elastomer solution. Arterial and venous vessels were obtained from diffe ...
Aortic Aneurysm Guide
Aortic Aneurysm Guide

... What does “watch and wait” mean if I have been diagnosed with an aortic aneurysm? The goal in treating aneurysms is to reduce the risk of rupture, which increases with aneurysm size. If you have a small aneurysm, your doctor will check it every six to 12 months by CT or ultrasound to determine if i ...
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Review Treatment of tachyarrhythmias during pregnancy and lactation

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ESC Guidelines - Dansk Cardiologisk Selskab
ESC Guidelines - Dansk Cardiologisk Selskab

... Associations: European Association of Echocardiography (EAE), European Association of Percutaneous Cardiovascular Interventions (EAPCI), European Heart Rhythm Association (EHRA), Heart Failure Association (HFA) Working Groups: Acute Cardiac Care, e-Cardiology, Cardiovascular Pharmacology and Drug Th ...
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Heart Disease - John Appleton

... cardiovascular conditions, including what I consider to be the top five most deadly: coronary artery disease, angina, arrhythmia, atrial fibrillation, and congestive heart failure. Many of them have survived either a heart attack or a stroke. And many of them are enjoying the same activities as they ...
European Guidelines on cardiovascular disease prevention in clinical practice (version 2012)
European Guidelines on cardiovascular disease prevention in clinical practice (version 2012)

... Associations: European Association of Echocardiography (EAE), European Association of Percutaneous Cardiovascular Interventions (EAPCI), European Heart Rhythm Association (EHRA), Heart Failure Association (HFA) Working Groups: Acute Cardiac Care, e-Cardiology, Cardiovascular Pharmacology and Drug Th ...
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Full Topic PDF

... be adjusted according to the patient’s creatinine clearance. Smaller amounts of the drug are excreted in bile, with enterohepatic recycling occurring. Serum digoxin levels may be decreased in the setting of concomitant use of drugs that reduce its clearance or volume of distribution, such as alpraxo ...
The Cardiovascular System: The Heart
The Cardiovascular System: The Heart

... The ancient Greeks believed the heart was the seat of intelligence. Others thought it was the source of emotions. While these theories have proved false, we do know that emotions affect heart rate. When your heart pounds or occasionally skips a beat, you become acutely aware of how much you depend o ...
Heart and Vascular System Practice Questions
Heart and Vascular System Practice Questions

... 85. If blood pressure increases above normal, the response from the medulla oblongata will be to A. increase heart rate and dilate the arterioles. B. increase heart rate and constrict the arterioles. C. decrease heart rate and dilate the arterioles. D. decrease heart rate and constrict the arteriol ...
Guidelines on the management of stable angina pectoris
Guidelines on the management of stable angina pectoris

... disorders of the oesophagus, lungs, or chest wall. Although the most common cause of myocardial ischaemia is atherosclerotic CAD, demonstrable myocardial ischaemia may be induced by hypertrophic or dilated cardiomyopathy, aortic stenosis, or other rare cardiac conditions in the absence of obstructiv ...
Pulmonary arterial hypertension in children
Pulmonary arterial hypertension in children

... The definition of primary pulmonary hypertension in children is the same as for adult patients. It is defined as a mean pulmonary artery pressure o25 mmHg at rest or o30 mmHg during exercise, with a normal pulmonary artery wedge pressure and the absence of related or associated conditions. The inclu ...
Learning to Live with Heart Failure
Learning to Live with Heart Failure

... All patients who have an EF < 40% should take an angiotensin-converting enzyme (ACE) inhibitor or an angiotensin receptor blocker (ARB) plus a beta blocker. These medications make people live longer, feel better, and stay out of the hospital. If you have swelling in your legs or fluid in your lungs, ...
Contained myocardial rupture: a variant linking complete and
Contained myocardial rupture: a variant linking complete and

- Journal of Clinical Investigation
- Journal of Clinical Investigation

... Wiggers (1925) has compared cardiac failure in man to the conditions in animals poisoned by cliloroform or other drugs which "depress" the heart. He believed that "back-pressure," when it occurred was secondary to decreased output due to myocardial weakness. Gibson (1927) believed that both diminish ...
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Antihypertensive drug



Antihypertensives are a class of drugs that are used to treat hypertension (high blood pressure). Antihypertensive therapy seeks to prevent the complications of high blood pressure, such as stroke and myocardial infarction. Evidence suggests that reduction of the blood pressure by 5 mmHg can decrease the risk of stroke by 34%, of ischaemic heart disease by 21%, and reduce the likelihood of dementia, heart failure, and mortality from cardiovascular disease. There are many classes of antihypertensives, which lower blood pressure by different means. Among the most important and most widely used drugs are thiazide diuretics, calcium channel blockers, ACE inhibitors, angiotensin II receptor antagonists (ARBs), and beta blockers.Which type of medication to use initially for hypertension has been the subject of several large studies and resulting national guidelines. The fundamental goal of treatment should be the prevention of the important endpoints of hypertension, such as heart attack, stroke and heart failure. Patient age, associated clinical conditions and end-organ damage also play a part in determining dosage and type of medication administered. The several classes of antihypertensives differ in side effect profiles, ability to prevent endpoints, and cost. The choice of more expensive agents, where cheaper ones would be equally effective, may have negative impacts on national healthcare budgets. As of 2009, the best available evidence favors the thiazide diuretics as the first-line treatment of choice for high blood pressure when drugs are necessary. Although clinical evidence shows calcium channel blockers and thiazide-type diuretics are preferred first-line treatments for most people (from both efficacy and cost points of view), an ACE inhibitor is recommended by NICE in the UK for those under 55 years old.
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