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2 Johnson MK, Smith RP, Morrison D, et al. Large lung... central role in the pathogenesis of digital clubbing. J Pathol
2 Johnson MK, Smith RP, Morrison D, et al. Large lung... central role in the pathogenesis of digital clubbing. J Pathol

... continuously in the air and on the mucous membranes cause respiratory tract infections that are more likely in cold weather. Compared with the stability of blood pH, changes o0.5 may occur in the pH of EBC and probably, therefore, the airway surface lining fluid. A relative important change in pH ma ...
Double pumping of intravenous vasoactive drugs in the critical care
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... undertaken within the general critical care department at St. Georges Healthcare NHS Trust. Given the minimal published research available these guidelines have been developed based on the audit undertaken with the UCLH NHS foundation trust and general consensus amongst the practice development team ...
HFNEF, HFpEF, HF-PEF, or DHF
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... It has been recognized for a long time that there is a group of patients who present with symptoms suggestive of heart failure (HF) but whose left ventricular ejection fraction (LVEF) is normal. Many of these patients are elderly, have long-standing hypertension, may have diabetes, and usually have ...
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... Temporal Sequence: activity/fitness is measured first—before the outcome appears—higher activity—lower CHD risk. Thus, proper temporal sequence. ...
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(1). heart rate ↑→cardiac output
(1). heart rate ↑→cardiac output

... Importance of the heterometric regulation • In general, heterometric regulation plays only a shorttime role, such as during the body posture change, artery pressure increase, and unbalance between the left and the right ventricular outputs. • In other conditions, such as exercise, cardiac output is ...
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Vulnerable Brain and Ventricular Assist Devices

... stroke, has not decreased in the contemporary era. This must posit, therefore, that the underlying reasons for strokes may be changing as a function of device era, with causative factors that may have more to do with vascular biology than simply anticoagulation strategies. Other studies have reached ...
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... In recognized MIs, Q-waves were traditionally thought to represent transmural infarctions. This view was based primarily on animal studies conducted .50 years ago.24 The advent of magnetic resonance imaging (MRI) has enabled researchers to perform studies of electrocardiographic changes in vivo, and ...
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Beyond arterial remodelling: pulmonary venous and

... haemodynamic parameters. They found that circulating NTproBNP levels were significantly increased in patients with SSc-PAH compared with idiopathic PAH patients, despite less severe haemodynamic impairment, as measured by right heart catheterisation. They also showed that haemodynamic indices closel ...
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this PDF file - The Southwest Respiratory and Critical

... ablation may be needed in these patients. Intravenous amiodarone is the drug of choice; for ischemic ...
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Antihypertensive drug



Antihypertensives are a class of drugs that are used to treat hypertension (high blood pressure). Antihypertensive therapy seeks to prevent the complications of high blood pressure, such as stroke and myocardial infarction. Evidence suggests that reduction of the blood pressure by 5 mmHg can decrease the risk of stroke by 34%, of ischaemic heart disease by 21%, and reduce the likelihood of dementia, heart failure, and mortality from cardiovascular disease. There are many classes of antihypertensives, which lower blood pressure by different means. Among the most important and most widely used drugs are thiazide diuretics, calcium channel blockers, ACE inhibitors, angiotensin II receptor antagonists (ARBs), and beta blockers.Which type of medication to use initially for hypertension has been the subject of several large studies and resulting national guidelines. The fundamental goal of treatment should be the prevention of the important endpoints of hypertension, such as heart attack, stroke and heart failure. Patient age, associated clinical conditions and end-organ damage also play a part in determining dosage and type of medication administered. The several classes of antihypertensives differ in side effect profiles, ability to prevent endpoints, and cost. The choice of more expensive agents, where cheaper ones would be equally effective, may have negative impacts on national healthcare budgets. As of 2009, the best available evidence favors the thiazide diuretics as the first-line treatment of choice for high blood pressure when drugs are necessary. Although clinical evidence shows calcium channel blockers and thiazide-type diuretics are preferred first-line treatments for most people (from both efficacy and cost points of view), an ACE inhibitor is recommended by NICE in the UK for those under 55 years old.
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