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Topics to Review
Topics to Review

... – relates the depolarization and repolarization of the atria and the ventricles with respect to time – since depolarization initiates contraction, these electrical events can be associated with the systole and diastole of the heart chambers • The 3 major electrical events of an ECG repeat each time ...
Downloaded
Downloaded

... therapy, including a selective aldosterone inhibitor eplerenone, on neurohumoral profile in patients with left ventricular (LV) systolic dysfunction following an acute myocardial infarction (MI). We also assessed the effect of multiple neuroendocrine inhibitors therapy on renal function and explored ...
The Heart
The Heart

... – relates the depolarization and repolarization of the atria and the ventricles with respect to time – since depolarization initiates contraction, these electrical events can be associated with the systole and diastole of the heart chambers • The 3 major electrical events of an ECG repeat each time ...
Murmurs on Murmurs, When to ECHO, When to Refer
Murmurs on Murmurs, When to ECHO, When to Refer

... and diastolic backwash causes a large pulse pressure and very high amplitude pulses. The LV apex is dramatically enlarged while heart sounds may show an S4 and S3 from increased LV volume and mass. The murmur of aortic insufficiency starts with S2 and goes into S1, usually high pitched, at the base, ...
Three‑year survival of patients with chronic systolic heart failure due
Three‑year survival of patients with chronic systolic heart failure due

... Introduction   Despite advances in medicine, chronic systolic heart failure (CHF) due to hypertension still constitutes a serious clinical challenge. Objectives   The aim of the study was to determine risk mortality factors in a 3‑year follow‑up of patients with CHF due to hypertension. Patients and ...
File - Josephine Carlos
File - Josephine Carlos

... • GLP-1 infusion improved regional and global LV function in patients with AMI and severe systolic dysfunction after successful primary angioplasty. • rGLP-1 may contribute to improved outcomes through non–glucose-dependent mechanisms. These include reductions in plasma NEFA levels that have been im ...
Cardiovascular System Notes
Cardiovascular System Notes

... has a low oxygen content from the right ventricle to the lungs.  Systemic arteries transport oxygenated blood from the left ventricle to the body ...
Increasing plasma potassium with amiloride shortens the QT interval
Increasing plasma potassium with amiloride shortens the QT interval

... the added effect of blocking aldosterone. In both of the above papers,6 7 the authors did not differentiate between potassium sparing agents; therefore it is difficult to know whether this beneficial effect was indeed caused by increasing potassium per se or whether aldosterone blockade contributed. ...
The Circulatory System
The Circulatory System

... chain causes, small, pale, and short-lived RBCs ...
Outpatient Heart Failure Management
Outpatient Heart Failure Management

... • Too many subgroups? • Definition of DM in the analysis? • Aliskiren should not be used or used with caution when added to other agents that block RAAS axis • ATMOSPHERE trial on-going to evaluate ACEi monotherapy versus Aliskiren monotherapy versus combination therapy ...
pathogenisis of coronary artery disease
pathogenisis of coronary artery disease

... Diagnosis and Treatment  Take detail history of pain (rule out non coronary causes e.g. esophageal reflux or musculo skeletal disorder)  Look for risk factors e.g. hypertension, ...
Research Article Impact of Transcendental Meditation on Left
Research Article Impact of Transcendental Meditation on Left

... The current findings should be interpreted cautiously due to the relatively small sample size. Loss to follow-up was not unexpected in this type of study, and this loss ...
The Circulatory System
The Circulatory System

... chain causes, small, pale, and short-lived RBCs ...
functional capacity
functional capacity

... Heart chronically works against excessive resistance to blood flow No "recuperation" periods to induce training effect (like RT or endurance training) Constant tension weakens left ventricle "Hypertrophied" heart becomes enlarged, distended, and functionally inadequate to deliver blood to tissues ...
Neonatology
Neonatology

... –Pallor continues after oxygenation –Pulses weak after oxygenation –Response to resuscitation poor –History of hemorrhage from maternal/fetal unit •10cc/kg LR or NS over 5 - 10 minutes ...
Arrhythmias and conduction disturbances in EDITORIAL Fre
Arrhythmias and conduction disturbances in EDITORIAL Fre

... demonstrate the role played by sleep-related respiratory diseases in the field. Controlled trials have demonstrated that OSA causes hypertension, and prospective epidemiological studies have indicated that OSA might be an independent risk factor for stroke [10] and myocardial infarction [11]. Studie ...
sanofi-aventis, plavix
sanofi-aventis, plavix

... ACTIVE-A specifically addressed the efficacy and safety of dual antiplatelet therapy (Plavix® plus aspirin) versus aspirin alone in patients with atrial fibrillation who were at increased risk for stroke and could not take an OAC. ACTIVE-I, a trial of irbesartan in patients participating in ACTIVE-A ...
Circulatory System
Circulatory System

... thick – so it’s easy to exchange materials between the blood and body cells through diffusion  They’re so small that red blood cells move single-file through them, but they can expand if needed (when exercising for ...
Sheep Heart Dissection
Sheep Heart Dissection

... each chamber, there are valves that prevent the backflow of blood. Blood is carried away from the heart by blood vessels called arteries and carried back toward the heart by blood vessels called veins. Arteries and veins are connected by capillaries. Arteries have muscular, elastic walls to help mov ...
a Powerpoint of this Presentation
a Powerpoint of this Presentation

... Pump Thrombosis Over Extended Periods HeartMate II uses customized texturing that has been refined and proven throughout decades of clinical experience. Rose et al. found that despite the low levels in anticoagulation (including patients with no anticoagulation regimen), only 3.5% of patients had th ...
Genome-Wide Scan for Pulse Pressure in the
Genome-Wide Scan for Pulse Pressure in the

... was defined using 2-stage analysis. First, the difference between systolic and diastolic blood pressure was averaged over all qualifying clinic examinations. In the second stage, mean PP was adjusted for mean age, time period of examination, and body mass index by regression analysis. PP values were ...
Practical approaches and novel technology to optimize left main
Practical approaches and novel technology to optimize left main

... • A single stent strategy whenever possible may help to reduce major adverse cardiac events (MACE)2 • Among two-stent techniques, there seems to be no difference between the treatment approaches2 ...
Clinical Medicine Reviews in Vascular Health Efficacy and Safety of
Clinical Medicine Reviews in Vascular Health Efficacy and Safety of

... (HR, 0.70; 95% CI, 0.63–0.78; P , 0.0001). ALLHAT (Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial)42 compared lisinopril-based therapy with amlodipine-based therapy in hypertensive patients and found that the risks for coronary events were similar; however, the risks wer ...
Distance Learning Program Anatomy of the Human Heart/Pig Heart Dissection
Distance Learning Program Anatomy of the Human Heart/Pig Heart Dissection

... Coronary sinus - a vein which drains blood from the myocardium and routes it into the right atrium. SA node - specialized myocardial cells in the wall of the right atrium that generate electrical impulses. The pacemaker of the heart. Right ventricle - inferiorly-located chamber on the right side of ...
Duration of Action
Duration of Action

... minutes to a maximum of 30 mg ■ Caution when using nifedipine with magnesium sulfate, can see precipitous blood pressure drop ■ Short-acting nifedipine is not approved by the Food and Drug Administration for managing hypertension ...
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Antihypertensive drug



Antihypertensives are a class of drugs that are used to treat hypertension (high blood pressure). Antihypertensive therapy seeks to prevent the complications of high blood pressure, such as stroke and myocardial infarction. Evidence suggests that reduction of the blood pressure by 5 mmHg can decrease the risk of stroke by 34%, of ischaemic heart disease by 21%, and reduce the likelihood of dementia, heart failure, and mortality from cardiovascular disease. There are many classes of antihypertensives, which lower blood pressure by different means. Among the most important and most widely used drugs are thiazide diuretics, calcium channel blockers, ACE inhibitors, angiotensin II receptor antagonists (ARBs), and beta blockers.Which type of medication to use initially for hypertension has been the subject of several large studies and resulting national guidelines. The fundamental goal of treatment should be the prevention of the important endpoints of hypertension, such as heart attack, stroke and heart failure. Patient age, associated clinical conditions and end-organ damage also play a part in determining dosage and type of medication administered. The several classes of antihypertensives differ in side effect profiles, ability to prevent endpoints, and cost. The choice of more expensive agents, where cheaper ones would be equally effective, may have negative impacts on national healthcare budgets. As of 2009, the best available evidence favors the thiazide diuretics as the first-line treatment of choice for high blood pressure when drugs are necessary. Although clinical evidence shows calcium channel blockers and thiazide-type diuretics are preferred first-line treatments for most people (from both efficacy and cost points of view), an ACE inhibitor is recommended by NICE in the UK for those under 55 years old.
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