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Left Ventricular Untwisting Is an Important Determinant of Early
Left Ventricular Untwisting Is an Important Determinant of Early

Diminished stroke volume during inspiration
Diminished stroke volume during inspiration

... connectors prevented ventricular hemorrhage and pneumothorax. The aortic flow probes were coupled to a sine-wave flowmeter (Statham, M4001, Los Angeles). The performance characteristics of these instruments have been described previously.22 25 ...
Several of the cells have drop down menus with them – if you see an
Several of the cells have drop down menus with them – if you see an

... Pre BiV HCTZ TDD (mg/kg-day): Total daily dose in mg/kg/day of hydrochlorothiazide in the 24 hours prior to BiV placement Pre BiV other diuretics & TDD: Total daily dose in mg/kg/day and name of any other diuretic in the 24 hours prior to BiV placement Pre BiV transplant status (Not listed, 1a,1b,2, ...
S1 Table. A list of DDN features
S1 Table. A list of DDN features

... decrease sleep latency ...
Left Ventricular Eccentric Remodeling and Matrix Loss Are Mediated
Left Ventricular Eccentric Remodeling and Matrix Loss Are Mediated

... because end-systolic stress is normal in a compensated volume overload (1,2). During the compensated phase of volume overload, forward cardiac output is maintained by a greater-than-normal fractional shortening and stroke volume (2). In fact, normal or slightly reduced fractional shortSee page 822 ...
Aortic Stenosis: Pathophysiology, Diagnosis, and Medical Management of
Aortic Stenosis: Pathophysiology, Diagnosis, and Medical Management of

... 50 years old.1 Calcification of the aortic valve is the most common cause of aortic stenosis in adults in industrialized countries and affects more than 4% of North American and Europeans more than 75 years old.2 In a study3 of 338 North American patients with severe asymptomatic aortic stenosis, th ...
A Guide For Patients: Patent Foramen Ovale
A Guide For Patients: Patent Foramen Ovale

... involve incisions in the chest, the heart being stopped, or the prolonged recovery needed after open-heart surgery. Rather the heart is reached via the insertion of catheters typically in a leg vein, maneuvered to the heart, and then used to insert or implant a medical device. The heart remains beat ...
The University of Birmingham Na+/Ca2+ exchange and Na+/K+
The University of Birmingham Na+/Ca2+ exchange and Na+/K+

... mechanism is elusive. One hypothesis is that the binding of Na+ to its transport site drives the exchanger into an inactivated state (Hilgemann et al. 1992). However, mutagenesis studies have shown that a region within the large cytoplasmic loop is also involved in this process (Matsuoka et al. 1995 ...
Atrial fibrillation management
Atrial fibrillation management

... and this burden will avalanche in the next decades. Primary prevention of AF can currently only target classical modifiable cardiovascular risk factors that are known to be associated with AF occurrence, such as obesity, hypertension, diabetes and excessive alcohol intake.16,35-37 The SAFE study sho ...
The Treatment of Atrial Fibrillation
The Treatment of Atrial Fibrillation

... effects, and an adjustment of the dosage or a change to another medication is often necessary because of side effects. There are some important points to keep in mind about medications: 1. Atrial fibrillation always eventually returns despite treatment with a medication. The goal of therapy is not t ...
Extracorporeal membrane oxygenation: coming to an ICU near you
Extracorporeal membrane oxygenation: coming to an ICU near you

... observed mortality rate to the patients’ young age, favourable survival outcome associated with ARDS secondary to viral pneumonia and to improvements in ECMO technology and staff training. Although these case series did not show survival benefit for ECMO patients over patients who did not receive th ...
DYNAMIC AUSCULTATION
DYNAMIC AUSCULTATION

...  Accentuate AR and PR murmur (mechanical) ...
CV - Division of Cardiology
CV - Division of Cardiology

... (6 sessions x medical students, annually) Physician Shadowing: Hosted countless premed and accelerated track WSU (MEDSTART) medical students as part of shadowing experience to expose trainees to the daily routine of an attending physician over the course of the year. MENTORING: (includes clinical re ...
guideline-for-prevention-of-ais-in-patients-with-stroke-or-tia
guideline-for-prevention-of-ais-in-patients-with-stroke-or-tia

... fatal stroke and vascular death. These results were seen in studies that recruited patients regardless of whether they had hypertension. Data on the relative benefits of specific antihypertensive regimens for secondary stroke prevention are largely lacking. A meta-analysis showed a significant reduc ...
Percutaneous Left Atrial Appendage Closure Devices for Stroke
Percutaneous Left Atrial Appendage Closure Devices for Stroke

... typical ischemic stroke, and causes higher rates of mortality and disability. As a result, stroke prevention is one of the main goals of atrial fibrillation treatment. Stroke in AF occurs primarily as a result of thromboembolism from the left atrium. The lack of atrial contractions in atrial fibrill ...
The effect of cyclooxygenase inhibition on vasomotion
The effect of cyclooxygenase inhibition on vasomotion

... indomethacin there was a progressive reduction in cross-sectional area of the LAD by 60. 90, and 105 min (37%, 42%, and 50%, respectively, p < .05). No significant change in the dimensions of the undamaged left circumflex artery was noted after the administration of indomethacin. The effect of anoth ...
PFO Closure: Will They Ever Get Any RESPECT?
PFO Closure: Will They Ever Get Any RESPECT?

... • PFOs have been conduits for trouble as recognized for centuries. • The most recent trials regarding cryptogenic stroke suggest the high risk groups ( ASA/ large PFO) benefit from closure. • The CVA type reduced by the device is the type seen from embolic events. • Certain indications exist for clo ...
Cellular Biology
Cellular Biology

... Right Heart Failure ...
Increases Left-to-Right Ventricular Systolic Interaction
Increases Left-to-Right Ventricular Systolic Interaction

... ventricular interaction is especially important as a determinant of right heart function since it is known that a substantial portion of RV pressure generation is contributed by the left ventricle.31'34'35 Ventricular interaction can be quantitated by interaction "gains," which are ratios of changes ...
Antiarrhythmic Effect of Nifekalant on Atrial Tachyarrhythmia in Four
Antiarrhythmic Effect of Nifekalant on Atrial Tachyarrhythmia in Four

... Objectives. Nifekalant is a class Ⅲ antiarrhythmic drug, which prolongs the refractory period of the atrial and ventricular myocardium, without negative inotropic action. Intravenous nifekalant was administered in four patients with atrial tachyarrhythmia and severe heart failure to terminate or pre ...
2013 ESC guidelines on the management of stable coronary artery
2013 ESC guidelines on the management of stable coronary artery

... No recurrence of chest pain at rest No signs of heart failure No abnormalities in the initial electrocardiogram (ECG) or a second ECG (at 6–9 hours). No rise in troponin levels (at arrival and after 6– 9 hours) Low risk as defined by the Global Registry of Acute Cardiac Events (GRACE, ≤108) or Throm ...
Scientific Evidence Underlying the ACC/AHA Clinical Practice
Scientific Evidence Underlying the ACC/AHA Clinical Practice

... about appropriate health care for specific patients’ circumstances.1 Guidelines are often assumed to be the epitome of evidence-based medicine. Yet, guideline recommendations imply not only an evaluation of the evidence but also a value judgment based on personal or organizational preferences regard ...
Full Text
Full Text

... humans for centuries. Prospective cohort studies and retrospective observational studies over the past several decades have contributed to a growing evidence base supporting an association between increased resting heart rate and adverse all-cause and cardiovascular outcomes.1,2 Recent randomized cl ...
Impact of exercise training on arterial wall
Impact of exercise training on arterial wall

... artery [25,26], in which plaque formation/rupture is not typically observed. The presence of arterial wall thickening in atherosclerosis-prone and -resistant vessels supports the idea that wall thickening occurs systemically [27]. Whether an age-related increase in wall thickness in these vessels re ...
PRESCRIBING INFORMATION CATHEJELLTM Jelly 2% 20 mg/mL
PRESCRIBING INFORMATION CATHEJELLTM Jelly 2% 20 mg/mL

... Debilitated patients, acutely ill patients, and patients with sepsis should be given reduced doses commensurate with their age, weight and physical condition because they may be more sensitive to systemic effects due to increased blood levels of lidocaine following repeated doses. Pregnant Women: Th ...
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Antihypertensive drug



Antihypertensives are a class of drugs that are used to treat hypertension (high blood pressure). Antihypertensive therapy seeks to prevent the complications of high blood pressure, such as stroke and myocardial infarction. Evidence suggests that reduction of the blood pressure by 5 mmHg can decrease the risk of stroke by 34%, of ischaemic heart disease by 21%, and reduce the likelihood of dementia, heart failure, and mortality from cardiovascular disease. There are many classes of antihypertensives, which lower blood pressure by different means. Among the most important and most widely used drugs are thiazide diuretics, calcium channel blockers, ACE inhibitors, angiotensin II receptor antagonists (ARBs), and beta blockers.Which type of medication to use initially for hypertension has been the subject of several large studies and resulting national guidelines. The fundamental goal of treatment should be the prevention of the important endpoints of hypertension, such as heart attack, stroke and heart failure. Patient age, associated clinical conditions and end-organ damage also play a part in determining dosage and type of medication administered. The several classes of antihypertensives differ in side effect profiles, ability to prevent endpoints, and cost. The choice of more expensive agents, where cheaper ones would be equally effective, may have negative impacts on national healthcare budgets. As of 2009, the best available evidence favors the thiazide diuretics as the first-line treatment of choice for high blood pressure when drugs are necessary. Although clinical evidence shows calcium channel blockers and thiazide-type diuretics are preferred first-line treatments for most people (from both efficacy and cost points of view), an ACE inhibitor is recommended by NICE in the UK for those under 55 years old.
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