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Recognition of Acute Coronary Syndrome in the Clinical Setting
Recognition of Acute Coronary Syndrome in the Clinical Setting

... Recognition of Acute Coronary Syndrome in the Clinical Setting The recognition of acute coronary syndrome (ACS), and of stable and unstable angina in any care setting, requires a thorough knowledge of not only the obvious, but also and especially of the not so obvious electrocardiographic (ECG) patt ...
document
document

... • RUQ pain • Hepatojugular Reflex • Ascites – Puddle sign ...
Acute heart failure in the intensive care unit - Area
Acute heart failure in the intensive care unit - Area

... months, with a substantially higher inhospital mortality for those with cardiogenic shock (Fig. 1). Drug Therapy. Many of the patients are already on disease-modifying therapy at the time of hospitalization—with high usage of diuretics, ␤-blockers, and angiotensin converting enzyme inhibitors/ angio ...
IOSR Journal of Dental and Medical Sciences (IOSR-JDMS)
IOSR Journal of Dental and Medical Sciences (IOSR-JDMS)

... The pressor response to laryngoscopy and intubation has been a cause of concern for anaesthesiologist especially in high risk patients. Similarly, controlling intraocular pressure in paediatric patients with acute glaucoma (congenital/ acquired) and penetrating eye injuries needs attention of the an ...
Infective Endocarditis
Infective Endocarditis

... Who is at risk of infective endocarditis? You are more likely to get infective endocarditis if you already have a heart condition or heart valve damage. It is best to ask your cardiologist if you are more at risk of infective endocarditis. However, generally, your risk for developing infective endoc ...
Cardiac Arrhythmias in the Intensive Care Unit
Cardiac Arrhythmias in the Intensive Care Unit

... step in treatment is establishing the diagnosis because VT is more ominous than SVT with aberrancy. VT is defined by three or more consecutive ventricular beats. Sustained VT is defined as more than 30 seconds of ventricular beats at a rate of more than 100 bpm.27,28 Initial evaluation should include ...
Efficacy, safety and tolerability of metoprolol CR/XL in patients with
Efficacy, safety and tolerability of metoprolol CR/XL in patients with

... After a single, blind, placebo run-in phase of 2 weeks, patients were randomized to metoprolol CR/XL or placebo, with starting doses of 12.5 mg (NYHA classes III and IV) or 25 mg once daily. It was recommended that the dose be doubled every 2 weeks to a target dose of 200 mg once daily, or the highe ...
Word 2MB - Australian Commission on Safety and Quality in Health
Word 2MB - Australian Commission on Safety and Quality in Health

... for three days or more, stays of one day or less are more frequent in all age groups than they were in the late 1990s, due in part to advances in medical procedures.8 Nonetheless, one-third of patients admitted for CHD are readmitted within 24 months, with readmissions accounting for up to a third o ...
Atrial septostomy benefits severe pulmonary - AJP
Atrial septostomy benefits severe pulmonary - AJP

... Biomedical Engineering, Maastricht Univ., P.O. Box 616, 6200 MD, Maastricht, The Netherlands (e-mail: [email protected]). H2654 ...
anomalous pulmonary venous return with stenosis in
anomalous pulmonary venous return with stenosis in

... channel. This applies for example to vertical veins draining into the vein innaminate, in the course of the left bronchus and the left branch of the pulmonary artery, pulmonary vein, or the outlet of the R-SVC (due to stenosis at the branch running between the right lung and trachea). In the infradi ...
Venous return
Venous return

... Lichtwarck-Aschoff et al. Intensive Care Med1992; 18:142-147 ...
The Management of Patients with Premature Ventricular Contractions
The Management of Patients with Premature Ventricular Contractions

... It is essential that patients have a baseline monitoring or exercise study (whichever demonstrated the PVCs) prior to therapy and again after institution of therapy in conjunction with blood levels of the drug, when available, to evaluate the effectiveness of the antiarrhythmic therapy. It also shou ...
G-protein-coupled receptor kinase activity in human heart failure
G-protein-coupled receptor kinase activity in human heart failure

... The biopsy samples taken from explanted human hearts revealed that GRK2 activity was inversely correlated with beta-AR-mediated cyclic adenosine monophosphate (cAMP) production, while further analysis showed that GRK2 activity and beta-AR density combined to regulate catecholamine-sensitive cAMP. Cr ...
Cardiopulmonary Physiology
Cardiopulmonary Physiology

... pressure (about 6 l/min and 2 mm Hg in young adults). This equilibrium point is a balancing act between the cardiac performance curve and the vascular performance curve. If cardiac output increases, venous pressure decreases, cardiac output then drops, venous pressure increases, .. etc. Alterations ...
Activation of cytokines as a mechanism of disease progression in
Activation of cytokines as a mechanism of disease progression in

... used as a therapeutic tool in treating patients with heart failure. Another potentially important pharmacological method for suppressing cytokine production is through the use of agents that increase cAMP levels, such as dobutamine, which as noted above, will suppress TNF production.42 It is therefo ...
Diastolic heart failure: diagnosis and therapy
Diastolic heart failure: diagnosis and therapy

... II receptor blockers, angiotensin-converting enzyme inhibitors, aldosterone antagonists, b-blockers, digoxin, and sildenafil (Fig. 2). Mineralocorticoid antagonists have been investigated for the treatment of DHF based on the participation of the renin–angiotensin–aldosterone system in the pathogene ...
Prognostic Significance of Premature Atrial Complexes Burden in
Prognostic Significance of Premature Atrial Complexes Burden in

... determine the optimal cut-off point for all-cause death (Youden index). The final results indicated an optimal cut-off point of 76 beats of PACs on 24-hour ECG monitoring (76 beats per day) as a predictor for an adverse outcome. Baseline characteristics of the patients with a PAC burden >76 beats per ...
Increasing survival in SCA: The Role of ICD and CRT
Increasing survival in SCA: The Role of ICD and CRT

... are in NHYA Class II or III • Nonischemic DCM who have an LVEF < 35% and who are in NYHA Class II or III • LV dysfunction due to prior MI how are at least 40 days post-MI; have an LVEF < 30%; and are in NHYA Class I CRT-D Class I Guideline • LVEF < 35%; a QRS duration > 0.12 seconds; and sinus rhyth ...
Czech Technical University in Prague Faculty of Electrical
Czech Technical University in Prague Faculty of Electrical

... in patients of dierent size. Hereby, I try to prove basic concept, that substantially larger VAD stroke volume, than to what the patient is used to, would lead to hypertension. This concept has been already multiple times considered (for instance in [39, 35]). There are discussed general properties ...
CIMC Medical-Surgical Nursing I Practical Nursing
CIMC Medical-Surgical Nursing I Practical Nursing

... As the electrical impulse leaves the SA node, it quickly travels down the internodal pathways, causing contraction of the atria. This contraction causes the blood contained within the atria to be emptied into the awaiting ventricles. As the electrical impulse reaches the bundle of HIS, it is still t ...
A study to evaluate the effectiveness of video assisted teaching
A study to evaluate the effectiveness of video assisted teaching

... with incident cardiovascular disease in United States of America among people 45 to 64 years. The researchers used data from atherosclerosis risk in communities study cohort to estimate the prevalence of ideal cardiovascular health and the corresponding incidence rates of cardiovascular disease. Amo ...
1. What Bisoprolol fumarate 5 mg is and what it is used for 2. Before
1. What Bisoprolol fumarate 5 mg is and what it is used for 2. Before

... The tablets should preferably be taken in the morning with some fluids (for example water) without chewing. The following doses generally apply: Adults The starting dose is as low as possible. The usual dose is 10 mg per day, with a maximum dose of 20 mg per day. Use in patients with reduced kidney ...
Heart failure with a preserved ejection fraction additive value of an
Heart failure with a preserved ejection fraction additive value of an

... and control groups (sub-maximal exercise test to reach the predefined target HR ,120). Stroke volume at rest and during exercise and its increase during exercise, were not statistically different between study groups (Table 3). During exercise, however, aortic outflow velocity time integral did not ...
12. What type of tissue carries small electrical currents to the muscles?
12. What type of tissue carries small electrical currents to the muscles?

... blood around the body. Normal adult heart rates at rest are between 50 and 75 beats per minute. Females’ heart rates are usually higher than males. Also heart rates are fastest at birth and then slow with age. There are other situations that will cause an increase in heart rate. Increased heart rate ...
kinins and kinin receptors in the pathogenesis of heart - E
kinins and kinin receptors in the pathogenesis of heart - E

... 1.1.2. Degradation of bradykinin by human cardiac membranes (I) .............................. 1.1.3. Comparison normal and failing hearts in their ability to degrade KD and BK (I) 1.1.4. Inhibition of kallidin and bradykinin degradation by enzyme inhibitors (I)......... 1.1.5. The role of ACE in he ...
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Antihypertensive drug



Antihypertensives are a class of drugs that are used to treat hypertension (high blood pressure). Antihypertensive therapy seeks to prevent the complications of high blood pressure, such as stroke and myocardial infarction. Evidence suggests that reduction of the blood pressure by 5 mmHg can decrease the risk of stroke by 34%, of ischaemic heart disease by 21%, and reduce the likelihood of dementia, heart failure, and mortality from cardiovascular disease. There are many classes of antihypertensives, which lower blood pressure by different means. Among the most important and most widely used drugs are thiazide diuretics, calcium channel blockers, ACE inhibitors, angiotensin II receptor antagonists (ARBs), and beta blockers.Which type of medication to use initially for hypertension has been the subject of several large studies and resulting national guidelines. The fundamental goal of treatment should be the prevention of the important endpoints of hypertension, such as heart attack, stroke and heart failure. Patient age, associated clinical conditions and end-organ damage also play a part in determining dosage and type of medication administered. The several classes of antihypertensives differ in side effect profiles, ability to prevent endpoints, and cost. The choice of more expensive agents, where cheaper ones would be equally effective, may have negative impacts on national healthcare budgets. As of 2009, the best available evidence favors the thiazide diuretics as the first-line treatment of choice for high blood pressure when drugs are necessary. Although clinical evidence shows calcium channel blockers and thiazide-type diuretics are preferred first-line treatments for most people (from both efficacy and cost points of view), an ACE inhibitor is recommended by NICE in the UK for those under 55 years old.
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