Genetic polymorphisms and drug interactions modulating
... Time-effect curves were generated by arithmetic means of effect values at each sample time. Area under the drug effecttime curves (AUEC) were calculated with the trapezoidal method. The statistical software package SPSS for Windows (version 15, Chicago, IL, USA) was used for the statistical pharmaco ...
... Time-effect curves were generated by arithmetic means of effect values at each sample time. Area under the drug effecttime curves (AUEC) were calculated with the trapezoidal method. The statistical software package SPSS for Windows (version 15, Chicago, IL, USA) was used for the statistical pharmaco ...
Amiodarone Inhibits the Na -K Pump in Rabbit Cardiac Myocytes
... Treatment protocols. Male New Zealand White rabbits, weighing 2.5 to 3.0 kg, were used in the study. Amiodarone was supplied in its hydrochloride powder form. In experiments examining the effects of chronic treatment, gelatin capsules containing appropriate quantities of amiodarone were made up at t ...
... Treatment protocols. Male New Zealand White rabbits, weighing 2.5 to 3.0 kg, were used in the study. Amiodarone was supplied in its hydrochloride powder form. In experiments examining the effects of chronic treatment, gelatin capsules containing appropriate quantities of amiodarone were made up at t ...
Prescribing Framework for Phenelzine (MAOI) in the treatment of
... hallucinations and paranoid delusions. If possible MAOIs should be withdrawn slowly. MAOIs inhibit monoamine oxidase, thereby causing an accumulation of amine neurotransmitters. The metabolism of some amine drugs such as indirect-acting sympathomimetics (present in many cough and decongestant prepar ...
... hallucinations and paranoid delusions. If possible MAOIs should be withdrawn slowly. MAOIs inhibit monoamine oxidase, thereby causing an accumulation of amine neurotransmitters. The metabolism of some amine drugs such as indirect-acting sympathomimetics (present in many cough and decongestant prepar ...
Effect of Subconjunctivally Injected, Liposome
... All continuous variables were expressed as the mean ⫾ SD. The differences in the amount of size decreases of subconjunctival hemorrhages between groups were tested with repeated-measures ANOVA. The baseline sizes and mean elapsed times for the complete resorption of subconjunctival hemorrhages were ...
... All continuous variables were expressed as the mean ⫾ SD. The differences in the amount of size decreases of subconjunctival hemorrhages between groups were tested with repeated-measures ANOVA. The baseline sizes and mean elapsed times for the complete resorption of subconjunctival hemorrhages were ...
Stability and aerosolization of pressurized metered dose inhalers
... The ability of nanoparticles to disperse and form a physically stable suspension in propellant used is one of the major properties related to dose reproducibility in a suspension-type pMDI (Byron, 1992). Unstable suspensions can result in uncontrolled emitted dose and size characteristics, which lea ...
... The ability of nanoparticles to disperse and form a physically stable suspension in propellant used is one of the major properties related to dose reproducibility in a suspension-type pMDI (Byron, 1992). Unstable suspensions can result in uncontrolled emitted dose and size characteristics, which lea ...
Pharmacogenetic Determinants of Codeine Induction by Rifampin
... Inter- and intraphenotypic comparisons were carried out by twoway ANOVA with repeated measurements, followed if appropriate by paired or unpaired Student’s t test or nonparametric test (Wilcoxon signed rank test), as indicated. Linear and Spearman correlation tests were used to evaluate the relation ...
... Inter- and intraphenotypic comparisons were carried out by twoway ANOVA with repeated measurements, followed if appropriate by paired or unpaired Student’s t test or nonparametric test (Wilcoxon signed rank test), as indicated. Linear and Spearman correlation tests were used to evaluate the relation ...
evaluation for flushing, safety and tolerability of niacin
... (subjects)-DRQS and a short form of the Addiction Research Inventory (ARCI), at completion, subjects completed the Treatment Enjoyment Assessment Questionnaire. The maximum scale response to the question “Do you dislike the drug effect you are feeling now?” or Disliking Score in the DRQS is the prim ...
... (subjects)-DRQS and a short form of the Addiction Research Inventory (ARCI), at completion, subjects completed the Treatment Enjoyment Assessment Questionnaire. The maximum scale response to the question “Do you dislike the drug effect you are feeling now?” or Disliking Score in the DRQS is the prim ...
Placebo Effects in Guidelines, Practice, and Patient Choice:
... For much of the modern era of medicine, the placebo has been largely viewed as a useful control in clinical trials. However, clinical research has demonstrated that placebo has powerful effects of its own. Despite this mounting evidence, providers rarely consider placebo effects in clinical manageme ...
... For much of the modern era of medicine, the placebo has been largely viewed as a useful control in clinical trials. However, clinical research has demonstrated that placebo has powerful effects of its own. Despite this mounting evidence, providers rarely consider placebo effects in clinical manageme ...
Pharmaceutical Development Case Study: “ACE Tablets”
... Foreword The last decade has seen a significant transformation in pharmaceutical quality regulation from an empirical process to a more science and risk based approach. This case study is an extremely important document for helping guide FDA and the industry toward the “desired state” of pharmaceu ...
... Foreword The last decade has seen a significant transformation in pharmaceutical quality regulation from an empirical process to a more science and risk based approach. This case study is an extremely important document for helping guide FDA and the industry toward the “desired state” of pharmaceu ...
ARE STATINS NEPHROPROTECTIVE?:A DOSE DEPENDENT STUDY IN ALBINO RATS Research Article
... haemotoxylin and eosin and histomorphological features were examined under high power. Statistical analysis Descriptive statistics had been presented as mean value ± SEM. Statistical analysis was done by using one way ANOVA with post Hoc comparisons using Tukey HSD tests. In one way ANOVA; F test wa ...
... haemotoxylin and eosin and histomorphological features were examined under high power. Statistical analysis Descriptive statistics had been presented as mean value ± SEM. Statistical analysis was done by using one way ANOVA with post Hoc comparisons using Tukey HSD tests. In one way ANOVA; F test wa ...
Title
... activities of the aqueous extract of the leaves have been investigated on different isolated tissue preparations in our laboratory (3). Here, the results of the effects of the aqueous extract on neuromuscular transmission using the isolated toad rectus abdominis and rat phrenic nerve-diaphragm muscl ...
... activities of the aqueous extract of the leaves have been investigated on different isolated tissue preparations in our laboratory (3). Here, the results of the effects of the aqueous extract on neuromuscular transmission using the isolated toad rectus abdominis and rat phrenic nerve-diaphragm muscl ...
Abstract Ethnopharmacological relevance Achillea millefolium L
... The elevated plus maze, marble-burying, and open-field data were analyzed by oneway (treatment) analysis of variance (ANOVA) for independent samples followed by the Duncan test, with the exception of the total number of arm entries in the elevated plus maze and number of fecal boluses in the open-fi ...
... The elevated plus maze, marble-burying, and open-field data were analyzed by oneway (treatment) analysis of variance (ANOVA) for independent samples followed by the Duncan test, with the exception of the total number of arm entries in the elevated plus maze and number of fecal boluses in the open-fi ...
Therapeutic and pharmacological potential of Foeniculum vulgare Mill
... mg of ethanol and watery extracts respectively had the 99.1% and 77.5% of antioxidant activity which was greater than the alpha-tocopherol (36.1%) antioxidant properties with the same dose (45). Anti-inflammatory activity Of the pharmacological effects of fennel plant, antiinflammatory activity can ...
... mg of ethanol and watery extracts respectively had the 99.1% and 77.5% of antioxidant activity which was greater than the alpha-tocopherol (36.1%) antioxidant properties with the same dose (45). Anti-inflammatory activity Of the pharmacological effects of fennel plant, antiinflammatory activity can ...
Pharmacokinetic Drug Interactions of Antimicrobial Drugs: A
... extent of severity and clinical relevance. Not only co-medication, but also food and herbal medicine can interact with antimicrobial drugs and vice versa. The nature of these interactions can be of pharmacodynamic (PD) and/or pharmacokinetic (PK) origin. A PD interaction consists of an alteration of ...
... extent of severity and clinical relevance. Not only co-medication, but also food and herbal medicine can interact with antimicrobial drugs and vice versa. The nature of these interactions can be of pharmacodynamic (PD) and/or pharmacokinetic (PK) origin. A PD interaction consists of an alteration of ...
Effect of `Mentat` on the pharmacokinetics of single and multiple
... Analysis: Phenytoin concentrations in plasma samples were estimated by HPLC technique8 which was standardized in our laboratory and the intra-assay and inter-assay coefficient of variation was 3.7% and 4.6% respectively. Pharmacokinetic Parameters: Peak plasma phenytoin concentration (Cmax) and time ...
... Analysis: Phenytoin concentrations in plasma samples were estimated by HPLC technique8 which was standardized in our laboratory and the intra-assay and inter-assay coefficient of variation was 3.7% and 4.6% respectively. Pharmacokinetic Parameters: Peak plasma phenytoin concentration (Cmax) and time ...
(1) - PhUSE Wiki
... This paper attempts to give recommendations for difficult decisions related to the analysis of difficult topics such as QT interval correction, baseline, and PK/PD analysis. Since there are on-going discussions regarding these topics the recommendations made here are mainly based on the authors expe ...
... This paper attempts to give recommendations for difficult decisions related to the analysis of difficult topics such as QT interval correction, baseline, and PK/PD analysis. Since there are on-going discussions regarding these topics the recommendations made here are mainly based on the authors expe ...
O A
... NMDA receptor blockers are drugs with explicit CNS depression effect so that Ketamine is typical drug in this group. It is a suitable injectable anesthetic in human and animal that has a low intestinal absorption rate. It's bioavailability in cat with rectal administration is %43.5±61 and in human w ...
... NMDA receptor blockers are drugs with explicit CNS depression effect so that Ketamine is typical drug in this group. It is a suitable injectable anesthetic in human and animal that has a low intestinal absorption rate. It's bioavailability in cat with rectal administration is %43.5±61 and in human w ...
Ischemic Heart Disease - students 2012 [Read
... discomfort at other sites: • epigastrum • shoulders/arms • neck/jaw ...
... discomfort at other sites: • epigastrum • shoulders/arms • neck/jaw ...
Effect of Khat chewing on the bioavailability of ampicillin and
... maximum time taken to reach the peak (TTP, h) following oral administration of the antibiotic at different times with respect to Khat chewing are shown in Table I. In comparison with the control, A, the mean PDE%, MPE and TTP were significantly altered in B, C, D and E (P < 0.05) but not in F, where ...
... maximum time taken to reach the peak (TTP, h) following oral administration of the antibiotic at different times with respect to Khat chewing are shown in Table I. In comparison with the control, A, the mean PDE%, MPE and TTP were significantly altered in B, C, D and E (P < 0.05) but not in F, where ...
- EBioMedicine
... The study design, regulatory approvals, and the summary pharmacokinetic parameter results of the PHATISA study have been published in the past (Hiruy et al., 2015). Clinical and demographic factors were recorded. Malnutrition was measured using Z scores for height-forage, weight-for-age, and weight- ...
... The study design, regulatory approvals, and the summary pharmacokinetic parameter results of the PHATISA study have been published in the past (Hiruy et al., 2015). Clinical and demographic factors were recorded. Malnutrition was measured using Z scores for height-forage, weight-for-age, and weight- ...
EFFECT OF SEPTILIN - A HERBAL PREPARATION ON
... (Csa=') and also Cmax and Tmax for single dose study were calculated from actual plasma data of each rabbit. The area under the time-plasma ...
... (Csa=') and also Cmax and Tmax for single dose study were calculated from actual plasma data of each rabbit. The area under the time-plasma ...
2013 Accomplishments
... ‘‘predict,’’ ‘‘project,’’ ‘‘target,’’ ‘‘potential,’’ ‘‘will,’’ ‘‘would,’’ ‘‘could,’’ ‘‘should,’’ ‘‘continue,’’ and similar expressions are intended to identify forward-looking statements, although not all forward-looking statements contain these identifying words. We may not actually achieve the pla ...
... ‘‘predict,’’ ‘‘project,’’ ‘‘target,’’ ‘‘potential,’’ ‘‘will,’’ ‘‘would,’’ ‘‘could,’’ ‘‘should,’’ ‘‘continue,’’ and similar expressions are intended to identify forward-looking statements, although not all forward-looking statements contain these identifying words. We may not actually achieve the pla ...
Title page
... DMSO inhibits microsomal formation of NAPQI in competitive manner [19]. Therefore, we hypothesized that experimental model in which microsomal enzymes are induced prior to APAP administration will be less sensitive to DMSO. However, our results show that model, in which microsomal enzymes are induce ...
... DMSO inhibits microsomal formation of NAPQI in competitive manner [19]. Therefore, we hypothesized that experimental model in which microsomal enzymes are induced prior to APAP administration will be less sensitive to DMSO. However, our results show that model, in which microsomal enzymes are induce ...
The effect of oral midazolam ... on respiration in normal subjects
... reversed the sedation. It may be argued that the failure of our study to detect a depressant effect on the HVR is due to intrasubject variability; the coefficient of variation (COV) of repeated studies being about 20- 30%. Indeed, in our laboratory, the HVR was repeated three times within the same d ...
... reversed the sedation. It may be argued that the failure of our study to detect a depressant effect on the HVR is due to intrasubject variability; the coefficient of variation (COV) of repeated studies being about 20- 30%. Indeed, in our laboratory, the HVR was repeated three times within the same d ...