Pathophysiology in the Treatment of Type 2
... – In in vitro assays, exendin-4 and GLP-1 have equivalent binding affinities for the GLP-1 receptor2-4 – In in vitro studies, the degree of GLP-1 receptor activation by exenatide is at least equivalent to that of native GLP-15,6 1. Nielsen LL, et al. Regul Pept. 2004;117:77-88; 2. Raufman JP. Regul ...
... – In in vitro assays, exendin-4 and GLP-1 have equivalent binding affinities for the GLP-1 receptor2-4 – In in vitro studies, the degree of GLP-1 receptor activation by exenatide is at least equivalent to that of native GLP-15,6 1. Nielsen LL, et al. Regul Pept. 2004;117:77-88; 2. Raufman JP. Regul ...
P otective effects of inhaled ipratropium ... on bronchoconstriction induced by adenosine
... The mode of action of adenosine-induced bronchoconstriction in asthma remains to be clarified. Current evidence strongly supports a central role for the airway mast cell in the response to adenosine. In vitro, adenosine potentiates the release of beta-hexosaminidase and histamine from the granules o ...
... The mode of action of adenosine-induced bronchoconstriction in asthma remains to be clarified. Current evidence strongly supports a central role for the airway mast cell in the response to adenosine. In vitro, adenosine potentiates the release of beta-hexosaminidase and histamine from the granules o ...
ANTIULCEROGENIC AND FREE RADICAL SCAVENGING ACTIVITY OF FLAVONOID FRACTION PSIDIUM GUAJAVA
... Wistar rats (150-200 gms) of either sex were fasted for 18 hours but water ad libitum. Just one hour before the experiment, water was withdrawn. Under light ether anaesthesia the abdomen was opened by a midline incision below the sternum. Pylorus was lifted and ligated carefully with the help of sil ...
... Wistar rats (150-200 gms) of either sex were fasted for 18 hours but water ad libitum. Just one hour before the experiment, water was withdrawn. Under light ether anaesthesia the abdomen was opened by a midline incision below the sternum. Pylorus was lifted and ligated carefully with the help of sil ...
Antinociceptive effect of Ferula assa-foetida oleo-gum
... the behavioral responses. Data were analyzed using repeated measure one-way ANOVA and P<0.05 was considered as the significant level. According to our findings, asafoetida exhibited a significant antinociceptive effect on chronic and acute pain in mice. These effects probably involve central opioid ...
... the behavioral responses. Data were analyzed using repeated measure one-way ANOVA and P<0.05 was considered as the significant level. According to our findings, asafoetida exhibited a significant antinociceptive effect on chronic and acute pain in mice. These effects probably involve central opioid ...
DODONAEA VISCOSA NORMAL AND STZDIABETIC RATS Research Article
... kingdom has become a target for the search by multinational drug and biologically active lead compounds 1. Ethnobotanical information indicates that more than 800 plants are used as traditional remedies for the treatment of diabetes 2, 3. The hypoglycaemic acti ...
... kingdom has become a target for the search by multinational drug and biologically active lead compounds 1. Ethnobotanical information indicates that more than 800 plants are used as traditional remedies for the treatment of diabetes 2, 3. The hypoglycaemic acti ...
A Rapid New Assay to Detect RNA Editing Reveals Antipsychotic
... clustering (Kirkwood and Sterne, 2003a). GEE was used in the analyses of data generated in the current study. We applied GEE models to clustered binary-dependent variables, a modeling framework that has not been used in previous studies of 5-HT2C RNA editing. We modeled the effects of drug treatment ...
... clustering (Kirkwood and Sterne, 2003a). GEE was used in the analyses of data generated in the current study. We applied GEE models to clustered binary-dependent variables, a modeling framework that has not been used in previous studies of 5-HT2C RNA editing. We modeled the effects of drug treatment ...
The Muscarinic Receptor Agonist Xanomeline Has an Antipsychotic
... of the front panel of the operant chamber, 2 cm above the grid floor. Coulbourn animal test cage grid floor shockers were used to deliver shock (0.4 mA, 0.5 s) to the grid floors (model E-10-10SF). Formula P Noyes food pellets (45 mg) could be delivered to the food magazine centered on the front wal ...
... of the front panel of the operant chamber, 2 cm above the grid floor. Coulbourn animal test cage grid floor shockers were used to deliver shock (0.4 mA, 0.5 s) to the grid floors (model E-10-10SF). Formula P Noyes food pellets (45 mg) could be delivered to the food magazine centered on the front wal ...
CASSIA ALATA Research Article MULHAM ALFATAMA, KAUSAR AHMAD, FARAHIDAH MOHAMED
... concentrations on C. alata- loaded PLGA microsphere. Two types of surfactants (Tween 20 and Span 20) and a stabilizer, PVA were selected to be investigated on the basis of they are commonly employed in other fabrication of microspheres by solvent-evaporation. The concentrations of surfactants (Tween ...
... concentrations on C. alata- loaded PLGA microsphere. Two types of surfactants (Tween 20 and Span 20) and a stabilizer, PVA were selected to be investigated on the basis of they are commonly employed in other fabrication of microspheres by solvent-evaporation. The concentrations of surfactants (Tween ...
Evidence for the roles of ... mediators in exercise-induced asthma: the ...
... the hnal pre-study exercise tests with those on the placebo study days [12] (table 4). The mean bias was 2.5±2.9% (Ns) with the coefficient of repeatability being ±19.3% (for example, and disregarding bias, for an observed maximum fall of 30%, a repeated test would give a fall with a 95% likelihood ...
... the hnal pre-study exercise tests with those on the placebo study days [12] (table 4). The mean bias was 2.5±2.9% (Ns) with the coefficient of repeatability being ±19.3% (for example, and disregarding bias, for an observed maximum fall of 30%, a repeated test would give a fall with a 95% likelihood ...
... of treatment. MAP was analysed in two ways: the peak change within 6 min after instillation i.t. of drugs was calculated as per cent of baseline MAP prior to drug instillation i.t. (% baseline) and the change in MAP was also calculated as AUC to assess the total effect throughout the observation per ...
this PDF file
... observed in this study was higher than that produced by the extract of the root of Capparis zeylanica (Mishra et al., 2011). In that study, the values obtained were 14.9, 27.8, and 51.7 minutes using 100 mg/kg, 200 mg/kg and 400 mg/kg respectively. The observed difference could be due to the differe ...
... observed in this study was higher than that produced by the extract of the root of Capparis zeylanica (Mishra et al., 2011). In that study, the values obtained were 14.9, 27.8, and 51.7 minutes using 100 mg/kg, 200 mg/kg and 400 mg/kg respectively. The observed difference could be due to the differe ...
comparative study of the effect of sucralose and sugar on some
... which are stable to more hydrolysis and degradation because chlorinated sucrose and its conversion into sucralose cause some changes in molecule conformation and makes it resistant to glycoside enzymes of digestive tract, which normally causes the breakdown of carbohydrates (SCF/CS/ADDS/EDUL/190 Fin ...
... which are stable to more hydrolysis and degradation because chlorinated sucrose and its conversion into sucralose cause some changes in molecule conformation and makes it resistant to glycoside enzymes of digestive tract, which normally causes the breakdown of carbohydrates (SCF/CS/ADDS/EDUL/190 Fin ...
Meloxicam (Mobic) - Texas Department of State Health Services
... Meloxicam, a partially selective NSAID, was associated with similar pain reduction relative to nonselective NSAIDs. In multiple double-blinded studies comparing meloxicam 7.5 mg and 15 mg to other NSAIDs, there were generally no differences in efficacy. A multicenter, double-blind, randomized trial ...
... Meloxicam, a partially selective NSAID, was associated with similar pain reduction relative to nonselective NSAIDs. In multiple double-blinded studies comparing meloxicam 7.5 mg and 15 mg to other NSAIDs, there were generally no differences in efficacy. A multicenter, double-blind, randomized trial ...
A study with cumulative doses of formoterol and salbutamol in
... improve the FEV1 further, indicating that the maximum effect had been obtained by the greatest dose of each drug. There was no statistically significant difference between the two drugs at any dose level. For both drugs there was a highly significant (p=0.001) increase in FEV1 with increasing doses, ...
... improve the FEV1 further, indicating that the maximum effect had been obtained by the greatest dose of each drug. There was no statistically significant difference between the two drugs at any dose level. For both drugs there was a highly significant (p=0.001) increase in FEV1 with increasing doses, ...
Lecture 18 - 97 - School of Public Health
... showing that the response to two or more treatments differs by an amount which is clinically unimportant (active control). • Non-inferiority trial – a trial with the primary objective of showing that the response to the investigational product is not clinically inferior (or not unacceptably inferior ...
... showing that the response to two or more treatments differs by an amount which is clinically unimportant (active control). • Non-inferiority trial – a trial with the primary objective of showing that the response to the investigational product is not clinically inferior (or not unacceptably inferior ...
Bleeding and Blood Transfusion Issues Among Patients with Acute
... Not usually powered for clinical endpoints Unusual to see statistically significant differences in clinical outcomes An overwhelmingly positive Phase 2 trial is a ...
... Not usually powered for clinical endpoints Unusual to see statistically significant differences in clinical outcomes An overwhelmingly positive Phase 2 trial is a ...
ANALGESIC AND ANTHELMINTIC ACTIVITY OF VARIOUS EXTRACTS OF ANDROGRAPHIS Research Article
... test groups were recorded and tabulated in Table 1. Acetic-acid induced writhing method In the writhing test adult Swiss albino mice(25-30 g) of either sex were used in six groups of 6each. Diclofenac sodium (50 mg/kg, p.o.) was usedas standard. 1% w/v gum acacia was used as controland 95% ethanolic ...
... test groups were recorded and tabulated in Table 1. Acetic-acid induced writhing method In the writhing test adult Swiss albino mice(25-30 g) of either sex were used in six groups of 6each. Diclofenac sodium (50 mg/kg, p.o.) was usedas standard. 1% w/v gum acacia was used as controland 95% ethanolic ...
Buspirone and Pindolol Effects on the EEG Frequency Spectrum in
... 2. Smith C.E., Ware C.J., & Cowen P.J. (1991) Pindolol decreases prolactin and growth hormone responses to intravenous L-tryptophan. Psychopharm. 103, 140-142. 3. Blier P., Seletti B., Young S.N., Benkelfat C., & de Montigny C. (1994) Serotonin 1A receptor activation and hypothermia: Evidence for a ...
... 2. Smith C.E., Ware C.J., & Cowen P.J. (1991) Pindolol decreases prolactin and growth hormone responses to intravenous L-tryptophan. Psychopharm. 103, 140-142. 3. Blier P., Seletti B., Young S.N., Benkelfat C., & de Montigny C. (1994) Serotonin 1A receptor activation and hypothermia: Evidence for a ...
Study on The Effect of Paliurus spina
... hypercholesterol diet (group 3) significantly increased cholesterol and triglyceride levels and decreased the ratio of HDL/TG compared with group 1; Nevertheless, in all cases it had no significant effect on the HDL level (Table 2). When hypercholesterol diet was coadministered with different doses ...
... hypercholesterol diet (group 3) significantly increased cholesterol and triglyceride levels and decreased the ratio of HDL/TG compared with group 1; Nevertheless, in all cases it had no significant effect on the HDL level (Table 2). When hypercholesterol diet was coadministered with different doses ...
ANNONA SQUAMOSA INDUCED GASTRIC ULCER IN ALBINO RATS. Full Proceeding Paper
... wide range of drugs are being used for the treatment of ulcer, many of these do not fulfill all the requirements and reported to have side effects like sedation, indigestion, headache, bowl upset, confusions, anti androgenic effect. These factors have prompted the researchers to investigate the phar ...
... wide range of drugs are being used for the treatment of ulcer, many of these do not fulfill all the requirements and reported to have side effects like sedation, indigestion, headache, bowl upset, confusions, anti androgenic effect. These factors have prompted the researchers to investigate the phar ...
on murine uterine contractility. : 0 Vol. 22, No. 1 , 2010 by Alawa
... the uterine muscle and its degree of activity is related to the physiological state of the uterus, which is greatest during the last stages of pregnancy (Hopkins, 1993). ...
... the uterine muscle and its degree of activity is related to the physiological state of the uterus, which is greatest during the last stages of pregnancy (Hopkins, 1993). ...
Analysing the effect of I1 imidazoline receptor ligands on DSS
... effects as well. For example, clonidine and its structural analog (Holsapple et al. 1984; Kulkarni et al. 1986) as well as rilmenidine (Gyires et al. 2009) inhibited acute paw edema in rats, which was likely mediated by alpha2-adrenoceptors (Gyires et al. 2009; Kulkarni et al. 1986). Moxonidine redu ...
... effects as well. For example, clonidine and its structural analog (Holsapple et al. 1984; Kulkarni et al. 1986) as well as rilmenidine (Gyires et al. 2009) inhibited acute paw edema in rats, which was likely mediated by alpha2-adrenoceptors (Gyires et al. 2009; Kulkarni et al. 1986). Moxonidine redu ...
IOSR Journal of Pharmacy and Biological Sciences (IOSR-JPBS)
... smoking is only a form of self-medication in people with psychotic symptoms rather than a causative factor in development of psychosis [5]. Recently, there seems to be an increase in the number of reports lending support to cannabis psychosis. Further, a review of the evidence surrounding the acute ...
... smoking is only a form of self-medication in people with psychotic symptoms rather than a causative factor in development of psychosis [5]. Recently, there seems to be an increase in the number of reports lending support to cannabis psychosis. Further, a review of the evidence surrounding the acute ...
descriptive statistics i
... The alternative hypothesis, denoted by Ha, is the opposite of what is stated in the null hypothesis. The alternative hypothesis is what the test is ...
... The alternative hypothesis, denoted by Ha, is the opposite of what is stated in the null hypothesis. The alternative hypothesis is what the test is ...
4730 - Emerson Statistics Home
... sex is not in the causal pathway of interest, it is likely that sex is a confounder within this data set, at least in so far as an association between bilirubin levels and all-cause mortality is concerned. b. A cursory glance of the data suggests that there is no association between serum bilirubin ...
... sex is not in the causal pathway of interest, it is likely that sex is a confounder within this data set, at least in so far as an association between bilirubin levels and all-cause mortality is concerned. b. A cursory glance of the data suggests that there is no association between serum bilirubin ...