IOSR Journal of Dental and Medical Sciences (JDMS)
... the dose of 10 mg/kg, significantly increased sleeping time. Wieland et al., (1997) stated that, tolerance has not been observed to the anxiolytic and sedative effects of the synthetic neuroactive steroids ganaxolone, which supports our finding that ganaxolone possess anti anxiety activity & sedativ ...
... the dose of 10 mg/kg, significantly increased sleeping time. Wieland et al., (1997) stated that, tolerance has not been observed to the anxiolytic and sedative effects of the synthetic neuroactive steroids ganaxolone, which supports our finding that ganaxolone possess anti anxiety activity & sedativ ...
RAJIV GANDHI UNIVERSITY OF HEALTH SCIENCES,
... 4) Evaluation of oxidative status in described models. ...
... 4) Evaluation of oxidative status in described models. ...
IOSR Journal of Agriculture and Veterinary Science (IOSR-JAVS)
... the word. Most striking reasons for the use of xylazine include its safe sedative efficacy, easy availability and economical price [5].Alpha-2-adrenergic agonists are also used in combination with ketamine at reduced doses as compared to their individual doses to induce a good quality general anesth ...
... the word. Most striking reasons for the use of xylazine include its safe sedative efficacy, easy availability and economical price [5].Alpha-2-adrenergic agonists are also used in combination with ketamine at reduced doses as compared to their individual doses to induce a good quality general anesth ...
Power and Precision Manual
... These three factors, together with power, form a closed system—once any three are established, the fourth is completely determined. The goal of a power analysis is to find an appropriate balance among these factors by taking into account the substantive goals of the study, and the resources availabl ...
... These three factors, together with power, form a closed system—once any three are established, the fourth is completely determined. The goal of a power analysis is to find an appropriate balance among these factors by taking into account the substantive goals of the study, and the resources availabl ...
EMBELIA TSJERIAM COTTAM. Research Article
... rat paw oedema and cotton pellet induced granuloma (chronic) models. The ethanolic extract of Embelia tsjeriam cottam (EEETC) exhibited significant anti-inflammatory effect at the dose 75 and 150 mg/kg. Maximum inhibition (37.68 %) was noted at the dose of 150 mg/kg after 3 hr. of drug treatment in ...
... rat paw oedema and cotton pellet induced granuloma (chronic) models. The ethanolic extract of Embelia tsjeriam cottam (EEETC) exhibited significant anti-inflammatory effect at the dose 75 and 150 mg/kg. Maximum inhibition (37.68 %) was noted at the dose of 150 mg/kg after 3 hr. of drug treatment in ...
Tham-Potential_abortifacient_effects_of_BCPs_and_MAPs
... also because of its effect on tubal peristalsis However in COC’s this is also demonstrated. Objections: controls are pregnant (in the ...
... also because of its effect on tubal peristalsis However in COC’s this is also demonstrated. Objections: controls are pregnant (in the ...
... was followed by blood pressure, pulse and FEV1 readings over a period of 2 h to assess safety. After 9.5 days of dosing with drug or placebo, histamine challenge was repeated 2 and 6 h after the final treatment dose, patients being allowed a rescue dose of inhaled salbutamol 200 µg from a metered-do ...
novinky v léčbě chronického srdečního selhání na prahu
... • Heterogenous group of drugs which are able to increase diuresis and excretion of electrolytes • Main indications: • fluid retention (heart failure, pulmonary congestion, edemas, ascites, hydrothorax) • hypertension • Main clinical effects: • in heart failure they improve the quality of life, but w ...
... • Heterogenous group of drugs which are able to increase diuresis and excretion of electrolytes • Main indications: • fluid retention (heart failure, pulmonary congestion, edemas, ascites, hydrothorax) • hypertension • Main clinical effects: • in heart failure they improve the quality of life, but w ...
PASS assisted search and evaluation of some azetidin-2
... Evaluation of anti-anxiety activity: The anti-anxiety effect of test compound 5a was assessed using the mirrored chamber paradigm in Laka mice (9). This mirror chamber paradigm measures approach-conflict behavior of animals. Group-housed mice were brought into the testing room and allowed to acclima ...
... Evaluation of anti-anxiety activity: The anti-anxiety effect of test compound 5a was assessed using the mirrored chamber paradigm in Laka mice (9). This mirror chamber paradigm measures approach-conflict behavior of animals. Group-housed mice were brought into the testing room and allowed to acclima ...
induction of etorphine immobilization in blue Accelerated
... Prior to the start of the study, the animals were allocated part-randomly to treatment so that each period always had two animals per treatment group. For every subsequent phase the treatments were changed such that all animals had received the four treatments by the study end. Animals were immobi- ...
... Prior to the start of the study, the animals were allocated part-randomly to treatment so that each period always had two animals per treatment group. For every subsequent phase the treatments were changed such that all animals had received the four treatments by the study end. Animals were immobi- ...
Repeated Measures ANOVA
... is not the case in a repeated measures design because data for different conditions have come from the same people. This means that data from different experimental conditions will be related; because of this we have to make an additional assumption to those of the independ ...
... is not the case in a repeated measures design because data for different conditions have come from the same people. This means that data from different experimental conditions will be related; because of this we have to make an additional assumption to those of the independ ...
Point Estimate
... Confidence Interval for μ (σ Unknown) If the population standard deviation σ is unknown, we can substitute the sample standard deviation, S This introduces extra uncertainty, since S is variable from sample to sample ...
... Confidence Interval for μ (σ Unknown) If the population standard deviation σ is unknown, we can substitute the sample standard deviation, S This introduces extra uncertainty, since S is variable from sample to sample ...
Here
... Confidence Interval for μ (σ Unknown) If the population standard deviation σ is unknown, we can substitute the sample standard deviation, S This introduces extra uncertainty, since S is variable from sample to sample ...
... Confidence Interval for μ (σ Unknown) If the population standard deviation σ is unknown, we can substitute the sample standard deviation, S This introduces extra uncertainty, since S is variable from sample to sample ...
presentation
... Thorough ECG studies can be performed in patients with advanced-stage Parkinson’s disease and, therefore, probably also in other patient populations with diseases that have profound effects on the quality of ECG recordings - or other pharmacological compounds that are not tolerable in healthy ...
... Thorough ECG studies can be performed in patients with advanced-stage Parkinson’s disease and, therefore, probably also in other patient populations with diseases that have profound effects on the quality of ECG recordings - or other pharmacological compounds that are not tolerable in healthy ...
Ketaset-Rompun Anesthesia Induces a Conditioned Taste Aversion
... the scope of this study, the subjects did appear to be behaviorally "back to normal" by the time of testing. With the volume of anesthetic injected in the present experiments, the rats typically regained the righting reflex within 1.5 to 2 hr of administration of the drug and displayed normal behavi ...
... the scope of this study, the subjects did appear to be behaviorally "back to normal" by the time of testing. With the volume of anesthetic injected in the present experiments, the rats typically regained the righting reflex within 1.5 to 2 hr of administration of the drug and displayed normal behavi ...
Antinociceptive, anti-inflammatory and central nervous system
... the percentage protection against it which was taken as an index of analgesia. It was calculated as: % Inhibition=[(Nc -Nt) / Nc ]× 100 Where, Nc = number of writhing of the control group, Nt = number of writhing of the treated group Tail immersion test Tail immersion test was done by the method des ...
... the percentage protection against it which was taken as an index of analgesia. It was calculated as: % Inhibition=[(Nc -Nt) / Nc ]× 100 Where, Nc = number of writhing of the control group, Nt = number of writhing of the treated group Tail immersion test Tail immersion test was done by the method des ...
Synergistic Interaction between the Two Mechanisms of Action of
... Isobolographic analysis is a method traditionally used to establish whether an interaction of two agonist drugs is subadditive, additive, or supra-additive/synergistic. In such applications the individual compounds are administered in graded doses by themselves and subsequently in dose combinations ...
... Isobolographic analysis is a method traditionally used to establish whether an interaction of two agonist drugs is subadditive, additive, or supra-additive/synergistic. In such applications the individual compounds are administered in graded doses by themselves and subsequently in dose combinations ...
Revisiting the Isobole and Related Quantitative Methods for
... this one I have an additional purpose, namely to show that this approach is useful for developing optimal combinations of fixed-dose combinations. In addition, I will show how the theoretical basis of the isobologram relates to another method for studying drug combinations, one that views the result ...
... this one I have an additional purpose, namely to show that this approach is useful for developing optimal combinations of fixed-dose combinations. In addition, I will show how the theoretical basis of the isobologram relates to another method for studying drug combinations, one that views the result ...
IJEB 48(3) 289-293
... was used as standard. P<0.05 as compared to *vehicle, aVPAEO (20 mg/kg) per se, bDCME (20 mg/kg) per se, caspirin (5 mg/kg, i.p) per se. [Values are expressed Mean± SE of 6 independent observations in each group]. ...
... was used as standard. P<0.05 as compared to *vehicle, aVPAEO (20 mg/kg) per se, bDCME (20 mg/kg) per se, caspirin (5 mg/kg, i.p) per se. [Values are expressed Mean± SE of 6 independent observations in each group]. ...
6 Synergy and polyvalence: paradigms to explain the activity of herbal products
... generated is to explain the effects seen in terms of ingredients detected which, on their own as single compounds, have relatively weak activity. Such explanations are often couched in terms of synergy and polyvalence, but the meaning of these terms is often not fully understood, with consequent con ...
... generated is to explain the effects seen in terms of ingredients detected which, on their own as single compounds, have relatively weak activity. Such explanations are often couched in terms of synergy and polyvalence, but the meaning of these terms is often not fully understood, with consequent con ...
Design of Engineering Experiments Part 2
... • An engineer is interested in investigating the relationship between the RF power setting and the etch rate for this tool. The objective of an experiment like this is to model the relationship between etch rate and RF power, and to specify the power setting that will give a desired target etch rate ...
... • An engineer is interested in investigating the relationship between the RF power setting and the etch rate for this tool. The objective of an experiment like this is to model the relationship between etch rate and RF power, and to specify the power setting that will give a desired target etch rate ...
Title Improving clinical trial efficiency by biomarker
... improve the efficiency of clinical trials [16]. Predictive markers enable selection of patient subgroups for whom the expected effect of treatment (as compared to control) is particularly beneficial. Restricting randomization to this subgroup could reduce the sample size requirements to establish tr ...
... improve the efficiency of clinical trials [16]. Predictive markers enable selection of patient subgroups for whom the expected effect of treatment (as compared to control) is particularly beneficial. Restricting randomization to this subgroup could reduce the sample size requirements to establish tr ...