Brugada Syndrome - Department of Medicine | Columbia University
... Fig 3. Examples of 2 different mutations in SCN5A leading to a loss of function of the sodium (Na) channel. A, Mutation I1660V, producing a trafficking defect of the Na channel, and thus a decrease of Na channels present in the sarcolemma. Mutant and WT Na channels have been expressed in TSA201 cell ...
... Fig 3. Examples of 2 different mutations in SCN5A leading to a loss of function of the sodium (Na) channel. A, Mutation I1660V, producing a trafficking defect of the Na channel, and thus a decrease of Na channels present in the sarcolemma. Mutant and WT Na channels have been expressed in TSA201 cell ...
What Do You Mean by Aortic Valve Area: Geometric Orifice Area
... Doppler echocardiography provides the lowest AVA value As discussed above, AVA may reflect the EOA, Gorlin area or anatomic area (GOA), depending on the technique used to assess stenosis severity (Table II). The differences between these three AVA values depend mainly on the valve inflow shape and t ...
... Doppler echocardiography provides the lowest AVA value As discussed above, AVA may reflect the EOA, Gorlin area or anatomic area (GOA), depending on the technique used to assess stenosis severity (Table II). The differences between these three AVA values depend mainly on the valve inflow shape and t ...
Corrigan`s Disease
... by the standard works on the treatment of heart disease". T o prove his point he quotes from the works of Corvisart, Laennec, and Bertin in which bleeding, blistering, starvation, and purging are advocated. He paints out that the cardiac hypertrophy ofaorticregurgitation is "a provision of nature to ...
... by the standard works on the treatment of heart disease". T o prove his point he quotes from the works of Corvisart, Laennec, and Bertin in which bleeding, blistering, starvation, and purging are advocated. He paints out that the cardiac hypertrophy ofaorticregurgitation is "a provision of nature to ...
Atsuyoshi Takao
... the syndrome,4 and microdeletion of this region was confirmed in 1991 and 1992.5,6 Conotruncal anomaly face syndrome had first been reported in 1976.7 In the early 1970s, Atsuyoshi Takao had begun to recognize a characteristic facial appearance, with a flat nasal bridge, a small mouth, a nasal voic ...
... the syndrome,4 and microdeletion of this region was confirmed in 1991 and 1992.5,6 Conotruncal anomaly face syndrome had first been reported in 1976.7 In the early 1970s, Atsuyoshi Takao had begun to recognize a characteristic facial appearance, with a flat nasal bridge, a small mouth, a nasal voic ...
Fluid–structure interaction modeling of aortic valve stenosis at
... the fluid velocity is equal to the structural timedependent deformation and the forces on the solid are induced through flow conditions [11–32]. Donea et al. [10] used an Arbitrary-Lagrange–Euler (ALE) mesh to discretize governing equations in their transient FSI modeling. According to the presented ...
... the fluid velocity is equal to the structural timedependent deformation and the forces on the solid are induced through flow conditions [11–32]. Donea et al. [10] used an Arbitrary-Lagrange–Euler (ALE) mesh to discretize governing equations in their transient FSI modeling. According to the presented ...
Bicuspid Aortic Valve Is Associated With Altered Wall Shear Stress
... significantly elevated WSS occurred for both the nonstenotic and the stenotic RL BAV patient groups compared with the age/ size controls. All RL BAV subgroups were significantly elevated compared with the age/size controls for the circumferentially averaged WSSsystole (P<0.001) and WSSt_avg (P<0.05 ...
... significantly elevated WSS occurred for both the nonstenotic and the stenotic RL BAV patient groups compared with the age/ size controls. All RL BAV subgroups were significantly elevated compared with the age/size controls for the circumferentially averaged WSSsystole (P<0.001) and WSSt_avg (P<0.05 ...
PDF Article
... Determination of the prevalence of T2 among members of families with long QT syndrome . To avoid bias, the ECG for each member of families with long QT syndrome enrolled in the study was read without knowledge of whether the family member was a blood relative or an unrelated spouse and without knowl ...
... Determination of the prevalence of T2 among members of families with long QT syndrome . To avoid bias, the ECG for each member of families with long QT syndrome enrolled in the study was read without knowledge of whether the family member was a blood relative or an unrelated spouse and without knowl ...
Echocardiography Evaluation of Ventricular Septal Defect
... VSD’s persisting into adulthood • Usually perimembranous and small • Eisenmenger’s complex now rare • Endocarditis most serious complication. Closure of VSD reduces endocarditis risk by 50%. • May develop left heart dilation, aortic regurgitation, or PHTN as patients age • Need to be aware of doubl ...
... VSD’s persisting into adulthood • Usually perimembranous and small • Eisenmenger’s complex now rare • Endocarditis most serious complication. Closure of VSD reduces endocarditis risk by 50%. • May develop left heart dilation, aortic regurgitation, or PHTN as patients age • Need to be aware of doubl ...
TRANSCATHETER AORTIC VALVE IMPLANTATION: REVIEW AND
... The Edwards SAPIEN THV™ prosthesis is a balloon expandable valve, consisting of a cylindrical frame of a cobalt chromium alloy. In this stent, three valve cusps of bovine pericardial tissue are sealed. The lower part of the stent frame is covered with a skirt of polyethylene terephthalate. This biop ...
... The Edwards SAPIEN THV™ prosthesis is a balloon expandable valve, consisting of a cylindrical frame of a cobalt chromium alloy. In this stent, three valve cusps of bovine pericardial tissue are sealed. The lower part of the stent frame is covered with a skirt of polyethylene terephthalate. This biop ...
Imaging for Transcatheter Aortic Valve Replacement
... Planning at the aortic valve plane involves multiple measurements for accurate device sizing. These include measurements of the left ventricular outflow tract (LVOT) and interventricular septum, aortic annulus, sinuses of Valsalva, sinotubular junction, ascending aorta, coronary leaflets, and corona ...
... Planning at the aortic valve plane involves multiple measurements for accurate device sizing. These include measurements of the left ventricular outflow tract (LVOT) and interventricular septum, aortic annulus, sinuses of Valsalva, sinotubular junction, ascending aorta, coronary leaflets, and corona ...
Fig. 11 - JACC: Cardiovascular Imaging
... rings, planes, and a crownlike ring can be recognized, and all of these originate from the aortic valve leaflets, which are attached throughout the length of the aortic root. The aortic valve annulus typically represents the tightest part of the aortic root and is defined as a virtual ring with 3 an ...
... rings, planes, and a crownlike ring can be recognized, and all of these originate from the aortic valve leaflets, which are attached throughout the length of the aortic root. The aortic valve annulus typically represents the tightest part of the aortic root and is defined as a virtual ring with 3 an ...
2014 Life threatening causes of syncope
... should be performed in all patients presenting with syncope (Brignole et al., 2004), as an abnormal ECG in the presence of syncope carries a poor prognosis and may elucidate the syncope mechanism (Colivicchi et al., 2003; Rose et al., 2009). The ECG should be inspected for evidence of sinus or AV no ...
... should be performed in all patients presenting with syncope (Brignole et al., 2004), as an abnormal ECG in the presence of syncope carries a poor prognosis and may elucidate the syncope mechanism (Colivicchi et al., 2003; Rose et al., 2009). The ECG should be inspected for evidence of sinus or AV no ...
Translating Novel Imaging Technologies Into Clinical Applications
... driven by progressive myocyte death and myocardial fibrosis.4–6 Therefore, it is important to consider aortic stenosis as a condition that affects both the valve and the myocardium.5,6 Indeed, contemporary guidelines recommend aortic valve replacement in patients with severe aortic stenosis and evid ...
... driven by progressive myocyte death and myocardial fibrosis.4–6 Therefore, it is important to consider aortic stenosis as a condition that affects both the valve and the myocardium.5,6 Indeed, contemporary guidelines recommend aortic valve replacement in patients with severe aortic stenosis and evid ...
Acute Aortic Syndromes and Thoracic Aortic Aneurysm
... In addition to these 3 major connective-tissue disorders, aortic dissection and aneurysm, unaccompanied by other Marfan-like properties, have been reported in family members with FBN sequence variations.13 In addition, the Loeys-Dietz syndrome, phenotypically similar to vascular EDS, was recently id ...
... In addition to these 3 major connective-tissue disorders, aortic dissection and aneurysm, unaccompanied by other Marfan-like properties, have been reported in family members with FBN sequence variations.13 In addition, the Loeys-Dietz syndrome, phenotypically similar to vascular EDS, was recently id ...
OBSTETRICS. A Whole Lot of Nothing or A little Bit of Not Much
... Ventricular and Atrial Septal Defects. This is a hole in the wall that separates the two ventricular and atrial chambers. This is also known as an endocardial cushion defect or an AV canal defect. When this is present the risk for Down syndrome is 50%. ...
... Ventricular and Atrial Septal Defects. This is a hole in the wall that separates the two ventricular and atrial chambers. This is also known as an endocardial cushion defect or an AV canal defect. When this is present the risk for Down syndrome is 50%. ...
Congenital Aneurysms of the Aortic Sinuses with
... in two of this group. More recently, Dubilier, Taylor, and Steinberg” have reported three cases of coarctation associated with generalized dilatation of all three sinuses; they state that the increased pressure in the aorta proximal to the coarctation magnifies the congenital weakness of the elastic ...
... in two of this group. More recently, Dubilier, Taylor, and Steinberg” have reported three cases of coarctation associated with generalized dilatation of all three sinuses; they state that the increased pressure in the aorta proximal to the coarctation magnifies the congenital weakness of the elastic ...
Flow Characteristics of the Medtronic CoreValve: Difficulties
... less-invasive alternative for patients with severe symptomatic aortic stenosis who are at high-risk for surgical AVR2,3. Survival after TAVI is higher compared to medical therapy alone4, and is comparable with surgical AVR at 1-year5. The need for accurate follow-up assessment of TAVI devices is the ...
... less-invasive alternative for patients with severe symptomatic aortic stenosis who are at high-risk for surgical AVR2,3. Survival after TAVI is higher compared to medical therapy alone4, and is comparable with surgical AVR at 1-year5. The need for accurate follow-up assessment of TAVI devices is the ...
Impacts of aortic stenosis and hypertension on left ventricular
... It has been reported that 30–40% of patients with aortic stenosis are hypertensive. In such patients, the left ventricle faces a double (i.e. valvular and vascular) pressure overload, which results in subsequent wall volume hypertrophy. From a clinical standpoint, it is difficult to separate the resp ...
... It has been reported that 30–40% of patients with aortic stenosis are hypertensive. In such patients, the left ventricle faces a double (i.e. valvular and vascular) pressure overload, which results in subsequent wall volume hypertrophy. From a clinical standpoint, it is difficult to separate the resp ...
Proximal Aortic Distensibility Is an Independent Predictor of All
... as a marker of early arterial damage may be important. Although the usual onset of ...
... as a marker of early arterial damage may be important. Although the usual onset of ...
Asymptomatic Aortic Stenosis-Prognosis, Risk Stratification and
... hemodynamics, the left ventricular response to chronic pressure overload, aortic dilatation and associated valve disease. Only in certain circumstances, a transoesophageal or a 3Dechocardiography is needed, e.g. for improved analysis of valve anatomy (bicuspid valve, planimetry of valve area) or pre ...
... hemodynamics, the left ventricular response to chronic pressure overload, aortic dilatation and associated valve disease. Only in certain circumstances, a transoesophageal or a 3Dechocardiography is needed, e.g. for improved analysis of valve anatomy (bicuspid valve, planimetry of valve area) or pre ...
Aortic-Valve Stenosis — From Patients at Risk to Severe Valve
... Copyright © 2014 Massachusetts Medical Society. All rights reserved. ...
... Copyright © 2014 Massachusetts Medical Society. All rights reserved. ...
Aortic-Valve Stenosis - American College of Cardiology
... Copyright © 2014 Massachusetts Medical Society. All rights reserved. ...
... Copyright © 2014 Massachusetts Medical Society. All rights reserved. ...
Part II: Chapter 8
... Consecutive patients with DM1 were recruited from the local outpatient clinic. All subjects were within the age range of 30-80 years and underwent MRI imaging between February 2008 and January 2010. Forty-one patients with DM1 were included in the study (25 men and 16 women ; mean age ± standard ...
... Consecutive patients with DM1 were recruited from the local outpatient clinic. All subjects were within the age range of 30-80 years and underwent MRI imaging between February 2008 and January 2010. Forty-one patients with DM1 were included in the study (25 men and 16 women ; mean age ± standard ...
Aortic Stenosis: Diagnosis and Treatment
... coexisting abnormalities of other valves. Guidelines for In symptomatic patients with echocardiographic mearelating these hemodynamic measures to severity of aor- sures consistent with severe aortic stenosis, symptoms tic stenosis are presented in Table 1.19 Isolated aortic ste- must be presumed to ...
... coexisting abnormalities of other valves. Guidelines for In symptomatic patients with echocardiographic mearelating these hemodynamic measures to severity of aor- sures consistent with severe aortic stenosis, symptoms tic stenosis are presented in Table 1.19 Isolated aortic ste- must be presumed to ...
Turner syndrome
Turner syndrome (TS) also known as Ullrich–Turner syndrome, gonadal dysgenesis, and 45,X, is a condition in which a female is partly or completely missing an X chromosome. Signs and symptoms vary among those affected. Often, a short and webbed neck, low-set ears, low hairline at the back of the neck, short stature, and swollen hands and feet are seen at birth. Typically they are without menstrual periods, do not develop breasts, and are unable to have children. Heart defects, diabetes, and low thyroid hormone occur more frequently. Most people with TS have normal intelligence. Many, however, have troubles with spatial visualization such as that needed for mathematics. Vision and hearing problems occur more often.Turner syndrome is not usually inherited from a person's parents. No environmental risks are known and the mother's age does not play a role. Turner syndrome is due to a chromosomal abnormality in which all or part of one of the X chromosomes is missing or altered. While most people have 46 chromosomes, people with TS usually only have 45. The chromosomal abnormality may be present in just some cells in which case it is known as TS with mosaicism. In these cases, the symptoms are usually fewer and possibly none occur at all. Diagnosis is based on physical signs and genetic testing.No cure for Turner syndrome is known. Treatment, however, may help with symptoms. Human growth hormone injections during childhood may increase adult height. Estrogen replacement therapy can promote development of the breasts and hips. Medical care is often required to manage other health problems with which TS is associated.Turner syndrome occurs in between one in 2000 and one in 5000 females at birth. All regions of the world and cultures are affected about equally. People with TS have a shorter life expectancy, mostly due to heart problems and diabetes. Henry Turner first described the condition in 1938. In 1964, it was determined to be due to a chromosomal abnormality.