
Valsalva Sinus Aneurysms: Findings at CT and MR Imaging
... may lead to impaired function of the tricuspid or mitral valve, depending on the cardiac chamber into which the aneurysm extends and the proximity of the aneurysm to the valve. Nonruptured Valsalva sinus aneurysms, depending on their size and the consequent mass effect on adjacent cardiac structures ...
... may lead to impaired function of the tricuspid or mitral valve, depending on the cardiac chamber into which the aneurysm extends and the proximity of the aneurysm to the valve. Nonruptured Valsalva sinus aneurysms, depending on their size and the consequent mass effect on adjacent cardiac structures ...
Aortic Valve and Ascending Aorta Guidelines for Management and
... represent a major step forward in improving and standardizing quality of care, there are fundamental weaknesses in the underpinnings of these guidelines. Unlike many other areas of cardiovascular disease, such as secondary prevention, acute coronary syndromes and heart failure, there is a major scar ...
... represent a major step forward in improving and standardizing quality of care, there are fundamental weaknesses in the underpinnings of these guidelines. Unlike many other areas of cardiovascular disease, such as secondary prevention, acute coronary syndromes and heart failure, there is a major scar ...
Congenital malformations of the mitral valve
... phenotype. It is a diffuse disease process, probably due to structural protein defects in cardiac tissues (fibrillin 1), which explains the concomitant illness of the aortic root and mitral valve. MVP most commonly involves both leaflets and is symmetrical in Marfan syndrome, whereas it more frequentl ...
... phenotype. It is a diffuse disease process, probably due to structural protein defects in cardiac tissues (fibrillin 1), which explains the concomitant illness of the aortic root and mitral valve. MVP most commonly involves both leaflets and is symmetrical in Marfan syndrome, whereas it more frequentl ...
Cardiac Surgery Simulation Curriculum
... Richard H. Feins, M.D., University of North Carolina at Chapel Hill, Chapel Hill, NC (Principal Investigator) Harold M. Burkhart, M.D., Mayo Clinic, Rochester, MN Daniel N. Coore, Ph.D., University of the West Indies, Mona, Jamaica John V. Conte, M.D., Johns Hopkins University, Baltimore, MD James I ...
... Richard H. Feins, M.D., University of North Carolina at Chapel Hill, Chapel Hill, NC (Principal Investigator) Harold M. Burkhart, M.D., Mayo Clinic, Rochester, MN Daniel N. Coore, Ph.D., University of the West Indies, Mona, Jamaica John V. Conte, M.D., Johns Hopkins University, Baltimore, MD James I ...
stabilization of extracellular matrix components in
... 1.1 Anatomy of the Heart The cardiovascular system can be divided into two parts: the heart and the vasculature. The human heart is a four chambered biomechanical pump which provides continuous blood flow to the rest of the body [1]. The vasculature is a highly complex branched network of blood vess ...
... 1.1 Anatomy of the Heart The cardiovascular system can be divided into two parts: the heart and the vasculature. The human heart is a four chambered biomechanical pump which provides continuous blood flow to the rest of the body [1]. The vasculature is a highly complex branched network of blood vess ...
Vertical gaze palsy
... affecting either upgaze alone or both upgaze and downgaze, sparing vestibuloocular response range, with a variable number of other signs (Keane 1990). These include light-near pupillary dissociation, with loss of the pupillary light reactions from damage to the pretectum, Collier lid retraction sign ...
... affecting either upgaze alone or both upgaze and downgaze, sparing vestibuloocular response range, with a variable number of other signs (Keane 1990). These include light-near pupillary dissociation, with loss of the pupillary light reactions from damage to the pretectum, Collier lid retraction sign ...
Prosthetic Heart Valves in the Aortic Position: A Review Hadi
... construction. If more or less blood is required to be circulated through the body (depending on the physical or mental conditions), the heart rate needs to increase or decrease [10]. The regulation of heart rate is directly controlled by the neural network, which is achieved specifically by the symp ...
... construction. If more or less blood is required to be circulated through the body (depending on the physical or mental conditions), the heart rate needs to increase or decrease [10]. The regulation of heart rate is directly controlled by the neural network, which is achieved specifically by the symp ...
Mitral valve anatomy for Transcatheter techniques
... systole, reaching its maximum (10.0!2.2 cm2) at mitral valve opening. Aortic annulus projected area was 4.1!1.2 ...
... systole, reaching its maximum (10.0!2.2 cm2) at mitral valve opening. Aortic annulus projected area was 4.1!1.2 ...
Congenital Aneurysm of the Sinus of Valsalva
... • Aneurysms usually arise from the right coronary sinus and extend into the right ventricle or right atrium. • Aneurysmal rupture into the right heart results in a large left-to-right shunt , which, in turn, can lead to congestive heart failure. • Unruptured aneurysms extending into the right heart ...
... • Aneurysms usually arise from the right coronary sinus and extend into the right ventricle or right atrium. • Aneurysmal rupture into the right heart results in a large left-to-right shunt , which, in turn, can lead to congestive heart failure. • Unruptured aneurysms extending into the right heart ...
Right-sided Aorta
... with situs solitus of the viscera, the venous atrium is usually located on the right side, and the aortic arch is, as a rule, situated on the left, e.g. opposite the cardiac apex. In our series this occurred in 15 of 17 cases (88%). In a previous report by Arcilla and Gasul (1961) the aortic arch wa ...
... with situs solitus of the viscera, the venous atrium is usually located on the right side, and the aortic arch is, as a rule, situated on the left, e.g. opposite the cardiac apex. In our series this occurred in 15 of 17 cases (88%). In a previous report by Arcilla and Gasul (1961) the aortic arch wa ...
Late Systolic Murmurs and Non-Ejection - Heart
... billowing posterior leaflet of the mitral valve constitutes a specific syndrome (Barlow, 1965; Barlow and Bosman, 1966). In this paper we present an analysis of 90 subjects with either a late systolic murmur, a nonejection click, or both. The intracardiac origin of these murmurs and clicks is reaffi ...
... billowing posterior leaflet of the mitral valve constitutes a specific syndrome (Barlow, 1965; Barlow and Bosman, 1966). In this paper we present an analysis of 90 subjects with either a late systolic murmur, a nonejection click, or both. The intracardiac origin of these murmurs and clicks is reaffi ...
ENDOCARDIAL SCLEROSIS IN INFANTS AND CHILDREN* We
... authors who regard endocardial sclerosis as an inflammatory lesion. The most authentic evidence presented has been the microscopic findings. Monckeberg23 regarded the microscopic changes as inflammatory in nature because he had not seen such changes even in the most severe malformations. Abbott 1,2 ...
... authors who regard endocardial sclerosis as an inflammatory lesion. The most authentic evidence presented has been the microscopic findings. Monckeberg23 regarded the microscopic changes as inflammatory in nature because he had not seen such changes even in the most severe malformations. Abbott 1,2 ...
Aneurysms of the Sinuses of Valsalva
... which is normally adjacent to the right ventricular outflow tract, usually rupture into the right ventricle (75%), less commonly into the right atrium (19%), left atrium/ ventricle (6%), and very rarely into the pulmonary trunk (less than 1% of cases) [7, 52]. Unruptured aneurysms of the right sinus ...
... which is normally adjacent to the right ventricular outflow tract, usually rupture into the right ventricle (75%), less commonly into the right atrium (19%), left atrium/ ventricle (6%), and very rarely into the pulmonary trunk (less than 1% of cases) [7, 52]. Unruptured aneurysms of the right sinus ...
Sinus of Valsalva Aneurysm with Rupturing into the Right Atrium ¾ A
... the right atrium. Patients may remain asymptomatic for several years even if the sinus of Valsalva aneurysms has ruptured. However, dyspnea and exercise intolerance may develop because of the increased shunting and volume overloading. Sudden massive rupture may result in acute chest pain and dyspnea ...
... the right atrium. Patients may remain asymptomatic for several years even if the sinus of Valsalva aneurysms has ruptured. However, dyspnea and exercise intolerance may develop because of the increased shunting and volume overloading. Sudden massive rupture may result in acute chest pain and dyspnea ...
CURRICULUM VITAE John Alex Elefteriades, M.D. Date of Revision
... ventricular aneurysmectomy, and artificial heart implantation. Dr. Elefteriades directs the Aortic Institute at Yale-New Haven Hospital, one of the nation's largest facilities for treatment of the dilated thoracic aorta. He conducts laboratory research in new techniques of heart transplantation. Amo ...
... ventricular aneurysmectomy, and artificial heart implantation. Dr. Elefteriades directs the Aortic Institute at Yale-New Haven Hospital, one of the nation's largest facilities for treatment of the dilated thoracic aorta. He conducts laboratory research in new techniques of heart transplantation. Amo ...
Heart Activities
... A wide split S2 may be caused by any of the following except: (a) pulmonic stenosis. (b) a right bundle branch block. (c) mitral regurgitation. (d) a left bundle branch block. Answer: d Rationale: The wide split is caused by the aortic valve closing early and the pulmonic valve closing late, indicat ...
... A wide split S2 may be caused by any of the following except: (a) pulmonic stenosis. (b) a right bundle branch block. (c) mitral regurgitation. (d) a left bundle branch block. Answer: d Rationale: The wide split is caused by the aortic valve closing early and the pulmonic valve closing late, indicat ...
Computational Modeling of Aortic Heart Valves
... of the valve. Li et al. [33] also compared isotropic and anisotropic models of the aortic valve, in this case a static trileaflet model of porcine aortic leaflets, assumed to be attached to a rigid stent. Li found differing results in leaflet deformations and stress magnitudes and distributions betw ...
... of the valve. Li et al. [33] also compared isotropic and anisotropic models of the aortic valve, in this case a static trileaflet model of porcine aortic leaflets, assumed to be attached to a rigid stent. Li found differing results in leaflet deformations and stress magnitudes and distributions betw ...
European Association of Echocardiography recommendations for
... Valve assessment: recommendations (1) TTE is recommended as the first-line imaging modality in valvular regurgitation. (2) TEE is advocated when TTE is of nondiagnostic value or when further diagnostic refinement is required. (3) 3D TEE or TTE is reasonable to provide additional information in patie ...
... Valve assessment: recommendations (1) TTE is recommended as the first-line imaging modality in valvular regurgitation. (2) TEE is advocated when TTE is of nondiagnostic value or when further diagnostic refinement is required. (3) 3D TEE or TTE is reasonable to provide additional information in patie ...
Assessment of valvular regurgitation. Part 1: aortic and pulmonary
... Valve assessment: recommendations (1) TTE is recommended as the first-line imaging modality in valvular regurgitation. (2) TEE is advocated when TTE is of nondiagnostic value or when further diagnostic refinement is required. (3) 3D TEE or TTE is reasonable to provide additional information in patie ...
... Valve assessment: recommendations (1) TTE is recommended as the first-line imaging modality in valvular regurgitation. (2) TEE is advocated when TTE is of nondiagnostic value or when further diagnostic refinement is required. (3) 3D TEE or TTE is reasonable to provide additional information in patie ...
Applied Neuro-Ophthalmology – Web References © 2009
... syndrome and Koerber-Salus-Elschning syndrome. May be simulated by myasthenia gravis, Lambert-Eaton myasthenic syndrome, thyroid eye disease, or Miller Fisher variant of Gullain-Barre syndrome. Workup Isolated impairment of upward gaze in elderly is commonly physiologic and requires no work up. If v ...
... syndrome and Koerber-Salus-Elschning syndrome. May be simulated by myasthenia gravis, Lambert-Eaton myasthenic syndrome, thyroid eye disease, or Miller Fisher variant of Gullain-Barre syndrome. Workup Isolated impairment of upward gaze in elderly is commonly physiologic and requires no work up. If v ...
Aortic Stenosis In The Elderly
... Cardiac catheterization should be reserved mainly for the evaluation of possible concomitant coronary artery disease prior to cardiac surgery. Aortic valve replacement represents the only proven treatment modality for symptomatic, hemodynamically significant aortic stenosis. Advanced age is not a co ...
... Cardiac catheterization should be reserved mainly for the evaluation of possible concomitant coronary artery disease prior to cardiac surgery. Aortic valve replacement represents the only proven treatment modality for symptomatic, hemodynamically significant aortic stenosis. Advanced age is not a co ...
The Brugada ECG Pattern - Circulation: Arrhythmia and
... fibrillation (VF) in the absence of structural heart disease.1 The typical ECG anomaly is currently known as the Brugada ECG pattern and the conglomerate of features as the Brugada syndrome. Over the years, the Brugada syndrome has been recognized as an important cause of sudden cardiac death in you ...
... fibrillation (VF) in the absence of structural heart disease.1 The typical ECG anomaly is currently known as the Brugada ECG pattern and the conglomerate of features as the Brugada syndrome. Over the years, the Brugada syndrome has been recognized as an important cause of sudden cardiac death in you ...
Transcatheter Aortic Valve Replacement: A Review Article Juan A
... be affected by peripheral artery diseases. Moreover, the catheter would need to travel through the aortic arch in a retrograde fashion, and at any rate, the patient could still be at the risk of strokes caused by calcium emboli. The CoreValve device could be repositioned or removed surgically, simil ...
... be affected by peripheral artery diseases. Moreover, the catheter would need to travel through the aortic arch in a retrograde fashion, and at any rate, the patient could still be at the risk of strokes caused by calcium emboli. The CoreValve device could be repositioned or removed surgically, simil ...
Floppy mitral valve/mitral valve prolapse/mitral valvular
... FMV surface phenomena may lead to methods preventing the progress to significant mitral valve dysfunction. The genetic association between FMV/MVP and the FMV/MVP syndrome remains to be defined. Floppy mitral valve/mitral valve prolapse: Frequency in relation to other cardiovascular abnormalities In ...
... FMV surface phenomena may lead to methods preventing the progress to significant mitral valve dysfunction. The genetic association between FMV/MVP and the FMV/MVP syndrome remains to be defined. Floppy mitral valve/mitral valve prolapse: Frequency in relation to other cardiovascular abnormalities In ...
Invasive Hemodynamic Characteristics of Low Gradient
... group (by echo: 48 ⫾ 16 ml vs. 53 ⫾ 15 ml, respectively, p ⫽ 0.14; by catheterization [oxymetry]: 50 ⫾ 15 ml vs. 51 ⫾ 12 ml, respectively, p ⫽ 0.65). Left ventricular mass index was lower in “paradoxic” aortic stenosis. Left ventricular volumes, ejection fraction, and relative wall thicknesses were ...
... group (by echo: 48 ⫾ 16 ml vs. 53 ⫾ 15 ml, respectively, p ⫽ 0.14; by catheterization [oxymetry]: 50 ⫾ 15 ml vs. 51 ⫾ 12 ml, respectively, p ⫽ 0.65). Left ventricular mass index was lower in “paradoxic” aortic stenosis. Left ventricular volumes, ejection fraction, and relative wall thicknesses were ...
Marfan syndrome

Marfan syndrome (also called Marfan's syndrome) is a genetic disorder of connective tissue. It has a variable clinical presentation, ranging from mild to severe systemic disease. The most serious manifestations involve defects of the heart valves and aorta, which may lead to early death if not properly managed. The syndrome also may affect the lungs, eyes, dural sac surrounding the spinal cord, the skeleton, and the hard palate. People with Marfan syndrome tend to be unusually tall, with long limbs and long, thin fingers and toes.The syndrome is caused by the misfolding of fibrillin-1, a glycoprotein which forms elastic fibers in connective tissue and contributes to cell signaling activity by binding to and sequestering transforming growth factor beta (TGF-β). The mutated fibrillin binds poorly to TGF-β, which results in an accumulation of excess TGF-β in the lungs, heart valves, and aorta. This in turn causes abnormal structure and function of vascular smooth muscle and reduced integrity of the extracellular matrix, which weaken the tissues and cause the features of Marfan syndrome.Named after Antoine Marfan, the French pediatrician who first described the condition in 1896, the disease is an autosomal dominant disorder. Management often includes the use of angiotensin II receptor antagonists (ARBs) and beta blockers.