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Guideline on clinical investigation of medicinal - EMA
Guideline on clinical investigation of medicinal - EMA

... The severity of the target COPD population should be defined a priori. Severity is classified on the basis of airflow limitation, symptoms, risk of exacerbation and presence of comorbidities (GOLD 2011). The most widely accepted classification of the spirometric severity of COPD is according to the ...
Essentials of Clinical Neurology: Diseases of Muscle and Neuromuscular Junction 17-1
Essentials of Clinical Neurology: Diseases of Muscle and Neuromuscular Junction 17-1

... connective tissue disorders, lupus erythematosus, poly-arteritis nodosa, or Sjögren's syndrome). Clinical features such as arthritis, sclerosis of skin, renal disease, multiple mononeuropathies, or salivary gland enlargement should suggest associated connective tissue disorder. Viral Polymyositis. V ...
Morbidity and Mortality Weekly Report
Morbidity and Mortality Weekly Report

... Editorial Note: The results in this report suggest that vaccination with recent (2005–2009) seasonal influenza vaccines is unlikely to provide protection against the novel influenza A (H1N1) virus. Although vaccination of adults with seasonal TIV generally resulted in a small increase in antibodies ...
Parkinson`s - Innovative Educational Services
Parkinson`s - Innovative Educational Services

... the body, such as pulse and blood pressure. The loss of norepinephrine might help explain several of the non-motor features seen in PS, including fatigue and abnormalities of blood pressure regulation. Many brain cells of people with PD contain Lewy bodies – unusual deposits or clumps of the protein ...
Nutrition Guideline: Renal
Nutrition Guideline: Renal

... The target hemoglobin A1c (HbA1c) for people with diabetes should be less than 7.0%, even in patients with advanced kidney disease.4,5 Micro- and macroalbuminuria, which are small and large losses of albumin in the urine, can both be seen in diabetic nephropathy, and improve with better blood glucos ...
NRC OI Viral - WordPress.com
NRC OI Viral - WordPress.com

...  Double-stranded DNA virus, herpes virus family  Disseminated or localized disease  Occurs in patients with advanced immunosuppression (CD4 count typically <50 cells/µL)  Other risk factors: patient not on ART, previous opportunistic infections, high level of CMV viremia, high plasma HIV RNA (>1 ...
Diagnosis and treatment of Wilson disease: An update
Diagnosis and treatment of Wilson disease: An update

... Only consensus opinion of experts, case studies, or standard-of-care. ...
1 Contents 1) Glaucoma 2 2) Lens 6 3) Uveitis and Iris 8 4) Retina
1 Contents 1) Glaucoma 2 2) Lens 6 3) Uveitis and Iris 8 4) Retina

... DDx of vitreous opacities 1) pars planitis 2) sarcoidosis 3) Candida endophthalmitis 4) asteroid 5) synchisis scintillans 6) amyloidosis 7) Whipple’s disease 8) tumor cells Types of endophthalmitis 1) Acute: < 2 weeks a) mild: Staph epi, sterile b) severe: S aureus, strep, G 2) Chronic: > 2 weeks - ...
Sleep and Parkinson`s Disease
Sleep and Parkinson`s Disease

... obstructive sleep apnoea, 5% have troublesome insomnia, at least 2-3 % of adults have some form of parasomnia and the prevalence figures for all these conditions double for those over 65 or those with severe psychiatric disease. However symptoms are often attributed to other daytime conditions rathe ...
No Slide Title
No Slide Title

... outdoors in snow in her bare feet; opening the door of a moving car to get out; driving surreptitiously when told not to [she rented a car without telling anyone]), and 5) reduced/erratic sleep patterns. ...
hypertension
hypertension

... Despite compelling evidence that hypertension is a public health concern that we cannot ignore, it often fails to attract significant attention. Known as the “silent killer”, hypertension rarely causes symptoms and many people go undiagnosed for years, with few, if any symptoms of discomfort. Sympto ...
hypertension
hypertension

... Despite compelling evidence that hypertension is a public health concern that we cannot ignore, it often fails to attract significant attention. Known as the “silent killer”, hypertension rarely causes symptoms and many people go undiagnosed for years, with few, if any symptoms of discomfort. Sympto ...
Incidence and Risk Factors of Cerebrovascular Events Following
Incidence and Risk Factors of Cerebrovascular Events Following

... CI [1.12 to 4.33], P=0.021). An additional analysis excluded any temporal change of CVE rates but demonstrated a significant increase of all high-risk patient features. Conclusion-—In a single-center, retrospective assessment over nearly 20 years, cardiac catheterization-related CVEs were very rare a ...
Incidence and Risk Factors of Cerebrovascular Events Following
Incidence and Risk Factors of Cerebrovascular Events Following

... CI [1.12 to 4.33], P=0.021). An additional analysis excluded any temporal change of CVE rates but demonstrated a significant increase of all high-risk patient features. Conclusion-—In a single-center, retrospective assessment over nearly 20 years, cardiac catheterization-related CVEs were very rare a ...
Slide 1
Slide 1

... the elderly age well! Most of our images are based on the frail sub-set who frequently use medical services. Generally normal aging in associated with a reduction in functional reserve capacity in tissues and organs Proportion with abnormal aging increases with age ...
Context Module 2
Context Module 2

... Theme 6 Breech presentation. Malpresentations. Contracted pelvis Theme 7 Abnormalities of conceptus’ development. Multifetal pregnancy. Malpresentations of fetus. Theme 8 Diagnostic methods of well-being of fetus. Placental insufficiency. Theme 9 Rh-izoimmunisation of fetus. Disorders of neonatal pe ...
Diagnosing PSC - PSC Partners Seeking a Cure
Diagnosing PSC - PSC Partners Seeking a Cure

... •Chills and fever - signs of bacterial infections in bile ducts requiring immediate medical attention including administering antibiotics. what other diseases are associated with psc? ...
CHD - Islington Council
CHD - Islington Council

... Diagnosing CHD early is important in ensuring that potentially fatal events such as heart attacks can be prevented. Early diagnosis also helps primary care professionals work with patients to control key risk factors such as high blood pressure and cholesterol by prescribing medications such as stat ...
Report of the first WHO stakeholders meeting on rhodesiense
Report of the first WHO stakeholders meeting on rhodesiense

... frontiers or boundaries. Dotted lines on maps represent approximate border lines for which there may not yet be full agreement. ...
Amyloidosis Information A General Overview for Patients
Amyloidosis Information A General Overview for Patients

... the mutation (we call this autosomal dominant) but not all people with a mutated gene will necessarily get sick (we call this incomplete penetrance). Some individuals only develop a small amount of amyloid in their body and some people may not accumulate any amyloid at all. The non-inherited form of ...
Alpha – 1 Antitrypsin (AAT) Deficiency
Alpha – 1 Antitrypsin (AAT) Deficiency

... Imbalance between neutrophil elastase in the lung which destroys elaste and elastase inhibitor AAT which protects against proteolytic degradation of elastin ...
Polycystic Kidney Disease - National Institute of Diabetes and
Polycystic Kidney Disease - National Institute of Diabetes and

... numerous cysts in the kidneys. The kidneys are two organs, each about the size of a fist, located in the upper part of a person’s abdomen, toward the back. The kidneys filter wastes and extra fluid from the blood to form urine. They also regulate amounts of certain vital substances in the body. When ...
disease - The Gut Foundation
disease - The Gut Foundation

... ulcerative colitis, is termed a complex disease. Its cause is not due to a single gene abnormality, but rather multiple genes and the environment interact with each other to determine the overall disease risk to the person. These illnesses have dramatically increased in prevalence in the past half-c ...
Chronic musculoskeletal pain
Chronic musculoskeletal pain

... Musculoskeletal pain affects the locomotor system and is mainly associated with loss of function, disability and, in appropriate populations, reduced work productivity. The functional properties vary according to the specific disease and are specified at the level of the particular entities. Disabil ...
section description
section description

... i. Anorexia, epigastric fullness or pain, N/V, dyspepsia ii. Hematemesis, melena, pallor Classification & risk factors in terms of: i. Acute gastritis 1. Risk factors including: a. Aspirin, steroid, alcohol or NSAID use; smoking b. History of trauma or burns to GI tract c. Stress – decreased blood f ...
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Disease



A disease is a particular abnormal condition, a disorder of a structure or function, that affects part or all of an organism. The causal study of disease is called pathology. Disease is often construed as a medical condition associated with specific symptoms and signs. It may be caused by factors originally from an external source, such as infectious disease, or it may be caused by internal dysfunctions, such as autoimmune diseases. In humans, ""disease"" is often used more broadly to refer to any condition that causes pain, dysfunction, distress, social problems, or death to the person afflicted, or similar problems for those in contact with the person. In this broader sense, it sometimes includes injuries, disabilities, disorders, syndromes, infections, isolated symptoms, deviant behaviors, and atypical variations of structure and function, while in other contexts and for other purposes these may be considered distinguishable categories. Diseases usually affect people not only physically, but also emotionally, as contracting and living with a disease can alter one's perspective on life, and one's personality.Death due to disease is called death by natural causes. There are four main types of disease: pathogenic disease, deficiency disease, hereditary disease, and physiological disease. Diseases can also be classified as communicable and non-communicable. The deadliest disease in humans is ischemic heart disease (blood flow obstruction), followed by cerebrovascular disease and lower respiratory infections respectively.
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