Histone modifications and exercise adaptations
... with increased CaMKII activation and MEF2 transcriptional activity and the HDAC4 translocation in response to electrical stimulation was abolished by the CaMK inhibitor KN-62 (17). Caffeine, which increases sarcoplasmic reticulum Ca2⫹ release and activates CaMK, induces HDAC5 efflux from the nucleus ...
... with increased CaMKII activation and MEF2 transcriptional activity and the HDAC4 translocation in response to electrical stimulation was abolished by the CaMK inhibitor KN-62 (17). Caffeine, which increases sarcoplasmic reticulum Ca2⫹ release and activates CaMK, induces HDAC5 efflux from the nucleus ...
The β-Globin LCR is Not Necessary for an Open Chromatin
... Hispanic thalassemia removes ~35 kb of DNA upstream resulting in failure to activate the β-globin locus at the level of transcription All five HSs form when chromosome 11 is transferred to an erythroid environment 5’HSs increase expression of β-globin genes in transfection and transgenic analyses Al ...
... Hispanic thalassemia removes ~35 kb of DNA upstream resulting in failure to activate the β-globin locus at the level of transcription All five HSs form when chromosome 11 is transferred to an erythroid environment 5’HSs increase expression of β-globin genes in transfection and transgenic analyses Al ...
Smchd1 regulates a subset of autosomal genes subject to
... samples. Magel2 was more reliably detectable in MEFs but, while its transcript levels appeared to be increased in Smchd1MommeD1/MommeD1 MEFs, the difference was not statistically significant (P = 0.081012) for the four independently derived MEF cultures used. While most genes within the Snrpn cluste ...
... samples. Magel2 was more reliably detectable in MEFs but, while its transcript levels appeared to be increased in Smchd1MommeD1/MommeD1 MEFs, the difference was not statistically significant (P = 0.081012) for the four independently derived MEF cultures used. While most genes within the Snrpn cluste ...
miRNA pptx - NUS School of Computing
... Improving miRNA Target Genes Prediction Rikky Wenang Purbojati ...
... Improving miRNA Target Genes Prediction Rikky Wenang Purbojati ...
Mapping strategies for sequence reads (with focus on RNA-seq)
... uires a set of known junctions from the reference ond, the QPALMA pipeline’s initial mapping phase ...
... uires a set of known junctions from the reference ond, the QPALMA pipeline’s initial mapping phase ...
The ECF sigma factors of Streptomyces coelicolor A3(2)
... subunit that associates with the core enzyme. This key role of in promoter recognition suggests a mechanism for the coordinate control of gene expression using alternative forms of and different subsets of promoters, an idea that was first proposed as soon as the role of was established (Burg ...
... subunit that associates with the core enzyme. This key role of in promoter recognition suggests a mechanism for the coordinate control of gene expression using alternative forms of and different subsets of promoters, an idea that was first proposed as soon as the role of was established (Burg ...
and GvpD-mediated transcription regulation of the p
... suggesting a function of GvpD in repression. To determine the DNA sequences involved in the GvpE-mediated activation, a 50-nucleotide region of the pA promoter was investigated by 4-nucleotide scanning mutagenesis. Some of these mutations affected the basal transcription, especially mutations in the ...
... suggesting a function of GvpD in repression. To determine the DNA sequences involved in the GvpE-mediated activation, a 50-nucleotide region of the pA promoter was investigated by 4-nucleotide scanning mutagenesis. Some of these mutations affected the basal transcription, especially mutations in the ...
One vitellogenin gene in an ocean of many: The molecular ecology
... the orthology of the hagfish aquaglyceroporin, so annotated it as glp. The above analyses thus revealed that at least five aquaglyceroporin paralogs are found in Cyclostomata, four in Chondrichthyes, up to five in Amphibia and Prototheria, four in Metatheria and most eutherian lineages, five in some ...
... the orthology of the hagfish aquaglyceroporin, so annotated it as glp. The above analyses thus revealed that at least five aquaglyceroporin paralogs are found in Cyclostomata, four in Chondrichthyes, up to five in Amphibia and Prototheria, four in Metatheria and most eutherian lineages, five in some ...
Chromosome structure and mutations
... Many TEs sustain deletions during transposition or repair If promoter needed for transcription is deleted, TE can not transpose again Nonautonomous elements – need activity of intact copies of same TE for movement Autonomous elements – move by themselves Most SINEs and LINEs in human genome are defe ...
... Many TEs sustain deletions during transposition or repair If promoter needed for transcription is deleted, TE can not transpose again Nonautonomous elements – need activity of intact copies of same TE for movement Autonomous elements – move by themselves Most SINEs and LINEs in human genome are defe ...
Morphology of nuclear transcription | SpringerLink
... important step. The spatial nuclear arrangement of the transcription process driven by RNA polymerases II and III is nonrandomly organized in foci, which is believed to add another regulatory layer on gene expression control. RNA polymerase I transcription takes place within a specialized organelle, ...
... important step. The spatial nuclear arrangement of the transcription process driven by RNA polymerases II and III is nonrandomly organized in foci, which is believed to add another regulatory layer on gene expression control. RNA polymerase I transcription takes place within a specialized organelle, ...
Prof. Kamakaka`s Lecture 16 Notes
... In addition to negative regulation by the lac repressor, the lac operon also required positive regulation. That is, a factor was needed for specific activation of the operon. The specific activator was called CAP ( Catabolic activator protein) produced by the gene crp (not part of the lac operon). C ...
... In addition to negative regulation by the lac repressor, the lac operon also required positive regulation. That is, a factor was needed for specific activation of the operon. The specific activator was called CAP ( Catabolic activator protein) produced by the gene crp (not part of the lac operon). C ...
Multiplex RT-PCR kit.
... This test brings IVD testing deeper into a detailed description of the exon organization of fusion genes originating from chromosome translocations. This information is important for predicting development of the disease and selection of treatment. The test is for professional use only. HemaVision- ...
... This test brings IVD testing deeper into a detailed description of the exon organization of fusion genes originating from chromosome translocations. This information is important for predicting development of the disease and selection of treatment. The test is for professional use only. HemaVision- ...
The Complete Chloroplast and Mitochondrial DNA Sequence of
... 2002b), Petersen et al. (2006) provided unequivocal support for its Streptophycean affiliation, based on the presence of a land plant–specific gapB gene and the absence of this gene in the different orders of chlorophyte green algae. However, our tree based on concatenated cp genes (fig. 1a) clearly ...
... 2002b), Petersen et al. (2006) provided unequivocal support for its Streptophycean affiliation, based on the presence of a land plant–specific gapB gene and the absence of this gene in the different orders of chlorophyte green algae. However, our tree based on concatenated cp genes (fig. 1a) clearly ...
genomebiology.com
... exons/introns from previously intronic/exonic sequences, respectively), and insertion into first and last exons. However, no extensive analysis has compared the effects of TEs on the transcriptomes of mammals, non-mammalian vertebrates and invertebrates. Results: We analyzed the influence of TEs on ...
... exons/introns from previously intronic/exonic sequences, respectively), and insertion into first and last exons. However, no extensive analysis has compared the effects of TEs on the transcriptomes of mammals, non-mammalian vertebrates and invertebrates. Results: We analyzed the influence of TEs on ...
A disproportionate role for mtDNA in DobzhanskyMuller
... Dobzhansky–Muller (DM) model nicely accounts for the evolution of such incompatibilities. Although DM incompatibilities were originally conceived as resulting of interactions between nuclear genes, recent studies have documented cases where incompatibilities have arisen between nuclear and mitochond ...
... Dobzhansky–Muller (DM) model nicely accounts for the evolution of such incompatibilities. Although DM incompatibilities were originally conceived as resulting of interactions between nuclear genes, recent studies have documented cases where incompatibilities have arisen between nuclear and mitochond ...
GENE EXPRESSION
... enes are transcribed into RNA, which, for the most part, is then translated into protein. Control mechanisms are exercised along the way. Without some control of gene expression, an Escherichia coli cell, for example, would produce all its proteins in large quantities all the time, and all the cells ...
... enes are transcribed into RNA, which, for the most part, is then translated into protein. Control mechanisms are exercised along the way. Without some control of gene expression, an Escherichia coli cell, for example, would produce all its proteins in large quantities all the time, and all the cells ...
Transcriptional Repression of the
... Typically, estrogens and androgens synthesized in response to gonadotropin stimulation repress transcription of the a- and gonadotropin b-subunit genes (4–6, 9–12). Mechanistically, negative feedback by gonadal steroids may reflect either direct regulatory effects occurring at the level of the pitui ...
... Typically, estrogens and androgens synthesized in response to gonadotropin stimulation repress transcription of the a- and gonadotropin b-subunit genes (4–6, 9–12). Mechanistically, negative feedback by gonadal steroids may reflect either direct regulatory effects occurring at the level of the pitui ...
How were introns inserted into nuclear genes?
... into a classical intron (Fig. 2b). Both types of intron have similar consensus sequences for splicing, and an identical mechanism in which the 5' end of the intron is joined to the 2' hydroxyl of an internal adenosine to form a lariat 2s.2~'. One pyrimidine to guanine substitution might effect the c ...
... into a classical intron (Fig. 2b). Both types of intron have similar consensus sequences for splicing, and an identical mechanism in which the 5' end of the intron is joined to the 2' hydroxyl of an internal adenosine to form a lariat 2s.2~'. One pyrimidine to guanine substitution might effect the c ...
Supplement Figures
... In this paper we used the tRNA adaptation index (tAI) developed by dos Reis [2] as an approximation for the codon translation speed. The tAI index was developed mainly based on optimizing the translation efficiency of highly express genes. Two recent papers [15, 16] used evolutionary selection for t ...
... In this paper we used the tRNA adaptation index (tAI) developed by dos Reis [2] as an approximation for the codon translation speed. The tAI index was developed mainly based on optimizing the translation efficiency of highly express genes. Two recent papers [15, 16] used evolutionary selection for t ...
Alu - Environmental
... Alu elements • Alu elements are only found in the primate branch • Each Alu insertion is a unique event and is inherited from each parent • Most occurred millions of years ago and are often on both pairs of chromosomes • There are Alu elements that have occurred since humans branched from other pri ...
... Alu elements • Alu elements are only found in the primate branch • Each Alu insertion is a unique event and is inherited from each parent • Most occurred millions of years ago and are often on both pairs of chromosomes • There are Alu elements that have occurred since humans branched from other pri ...
form/activity - Science of Security
... • “..and to build engines.” (propulsion) • “Inability to balance/steer [is the] problem.” (control) • “When this one feature has been worked out, the age of flying will have arrived, for all other difficulties are of minor importance.” ...
... • “..and to build engines.” (propulsion) • “Inability to balance/steer [is the] problem.” (control) • “When this one feature has been worked out, the age of flying will have arrived, for all other difficulties are of minor importance.” ...
RNA Interference and Small Interfering RNAs
... sequence-specific signals appear to spread from cell to cell via repeat genes confer potent and long-lasting specific gene plasmodesmata until they reach the vascular system and spread inactivation, including neuronally expressed genes that otherthrough the entire plant. Even though the plant cell c ...
... sequence-specific signals appear to spread from cell to cell via repeat genes confer potent and long-lasting specific gene plasmodesmata until they reach the vascular system and spread inactivation, including neuronally expressed genes that otherthrough the entire plant. Even though the plant cell c ...
Genetics of CO2 fixation in the chemoautotroph Alcaligenes eutrophus
... still unknown. All genes, except the regulatory gene cfxR that is loca,.ed within the chromosomal cluster immediately upstream of cfxLc (see below in Section 5), have the same relative orientation and are closely linked. Seq,Jence data will have to provide information as to whether the intergenic re ...
... still unknown. All genes, except the regulatory gene cfxR that is loca,.ed within the chromosomal cluster immediately upstream of cfxLc (see below in Section 5), have the same relative orientation and are closely linked. Seq,Jence data will have to provide information as to whether the intergenic re ...
Regulation of 6sg expression site transcription and switching in
... promoter manipulations at 6sg expression sites (ES) and examination of the behavior of ES promoters in ectopic locations both within the ES and at other loci. In summary, ES promoter sequences inserted into non-transcribed rRNA spacers are generally inactive, or have low activity, in bloodstream and ...
... promoter manipulations at 6sg expression sites (ES) and examination of the behavior of ES promoters in ectopic locations both within the ES and at other loci. In summary, ES promoter sequences inserted into non-transcribed rRNA spacers are generally inactive, or have low activity, in bloodstream and ...