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Chapter 26
Chapter 26

... However, for the patients suffering from autoimmune diseases, the immune system mistakes the body tissues as foreign antigens and produces antibodies against them. Many of the patients receive immunosuppressive medications to control their diseases. ...
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... such as dendritic cells, and they serve as the primary viral sensors for IFN production in plasmacytoid dendritic cells (pDC), cells that are capable of producing very high levels of IFN and are therefore critical for antiviral defense [50]. pDCs express only 2 types of TLRs, 7 and 9, that bind sing ...
DNA Shape Dominates Sequence Affinity in Nucleosome Formation
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... base steps to the center of the protein, and the angle brackets denote an average over base steps at the −15, −5, þ5, and þ15 positions relative to the dyad [cf. Fig. 1(c)]. The positive sign is chosen if ðP × BÞ · D ≤ 0 (negative if > 0), where D is a vector in the 5’ to 3’ direction along the sens ...
DNA – The Molecule of Life
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Entry Pattern Recognition Receptors, and Viral IFN Regulatory

... inflammatory response, indicates that pathology may be due to maladaptive immune responses. One important difference between the hantavirus-human disease model, compared with many other viral disease models, is that humans are an incidental and terminal host for hantaviruses and that neither the vir ...
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... Env (Fig. 1B). The IFN-␥-producing cells were lymphocytes (based on forward and side scatter criteria) but were CD3, CD4, and CD8 negative and, hence, not T lymphocytes. We subsequently demonstrated that these responses were maximal after a 5-h incubation, were not present without antigen stimulatio ...
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... 8. a. antibody b. bone marrow c. plasma 9. a. antigens b. antigen-binding site c. combine with antigens and mark them for destruction 10. a. A, O b. A, AB c. B, O d. B, AB e. A, B, AB, O f. AB g. O h. A, B, AB, O 11. a 12. a. secretes cytokines that stimulate other immune cells b. destroys cells bea ...
Chapter 24 powerpoint file
Chapter 24 powerpoint file

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Cellular Immune Response

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Geometrical ordering of DNA in bacteria

... Figure 1. Average subcellular position of genes as function of their position on the chromosome in C. crescentus and E. coli as obtained from numerical simulations of compacted DNA. (A and B) show the position of genes along the cell axis as function of their position on the chromosomal map for an a ...
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DNA vaccination



DNA vaccination is a technique for protecting an animal against disease by injecting it with genetically engineered DNA so cells directly produce an antigen, resulting in a protective immunological response. Several DNA vaccines have been released for veterinary use, and there has been promising research using the vaccines for viral, bacterial and parasitic diseases, as well as to several tumour types. Although only one DNA vaccine has been approved for human use, DNA vaccines may have a number of potential advantages over conventional vaccines, including the ability to induce a wider range of immune response types.
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