PDF - Oxford Academic - Oxford University Press
... thermodynamic stability of the 3WJ is entropy driven (37). In this report, we introduce a conceptual approach to the rational design of stable RNA architectures by stretching the 60◦ AOB angle (∠) (Figure 1) of the thermodynamically stable pRNA 3WJ motif. We demonstrate that it can be stretched to w ...
... thermodynamic stability of the 3WJ is entropy driven (37). In this report, we introduce a conceptual approach to the rational design of stable RNA architectures by stretching the 60◦ AOB angle (∠) (Figure 1) of the thermodynamically stable pRNA 3WJ motif. We demonstrate that it can be stretched to w ...
HSP70 expression: does it a novel fatigue signalling factor
... previous exercise load. Apparently, systemic eHSP70 could arise from many tissues and different cell types and this may involve distinct mechanisms of release (including necrosis) and a large variety of inducing factors.40 Finally, HSP72 is clearly the major component of the secreted eHSP70 found in ...
... previous exercise load. Apparently, systemic eHSP70 could arise from many tissues and different cell types and this may involve distinct mechanisms of release (including necrosis) and a large variety of inducing factors.40 Finally, HSP72 is clearly the major component of the secreted eHSP70 found in ...
free article - University of Kansas Medical Center
... Murine retroviral vectors were among the first viral vectors to be tested for gene replacement therapy for DMD. Unfortunately, as these vectors were only capable of transducing proliferating myoblasts, the direct injection of a murine retrovirus carrying a mini-dystrophin construct into an mdx mouse ...
... Murine retroviral vectors were among the first viral vectors to be tested for gene replacement therapy for DMD. Unfortunately, as these vectors were only capable of transducing proliferating myoblasts, the direct injection of a murine retrovirus carrying a mini-dystrophin construct into an mdx mouse ...
Vaccines
... [Diphtheria CRM197 Protein]), or any diphtheria toxoid– containing vaccine. • Prevnar 13® may not protect all individuals receiving the vaccine. • Protection against ear infections is expected to be less than that for invasive disease. • Children with weakened immune systems may have a reduced immun ...
... [Diphtheria CRM197 Protein]), or any diphtheria toxoid– containing vaccine. • Prevnar 13® may not protect all individuals receiving the vaccine. • Protection against ear infections is expected to be less than that for invasive disease. • Children with weakened immune systems may have a reduced immun ...
Acute susceptibility of aged mice to infection with Candida albicans
... disease, with a marked increase in the number of mycelia in the brain and kidney, and early morbidity. Foci of myocardial necrosis were evident, but inflammatory cells were sparse. The histological picture in the aged immune mice was similar to that in the aged non-immune group, although fewer mycel ...
... disease, with a marked increase in the number of mycelia in the brain and kidney, and early morbidity. Foci of myocardial necrosis were evident, but inflammatory cells were sparse. The histological picture in the aged immune mice was similar to that in the aged non-immune group, although fewer mycel ...
B-cell depletion inhibits arthritis in a collagen
... clinical improvement remains elusive.20 Given that B cells exist as lymphoid aggregates within the synovium of patients with RA, it is reasonable to assume that B-cell functions other than antibody production (eg, cytokine production, antigen presentation, provision of costimulatory signals to T cel ...
... clinical improvement remains elusive.20 Given that B cells exist as lymphoid aggregates within the synovium of patients with RA, it is reasonable to assume that B-cell functions other than antibody production (eg, cytokine production, antigen presentation, provision of costimulatory signals to T cel ...
hag expression in Bacillus subtilis is both negatively
... ml21 and incubation continued for 2.5 h. Cells were harvested by centrifugation and the pellet was washed with 1 ml buffer containing 25 mM Tris/HCl, pH 7.4. The pellet was resuspended in 500 ml buffer containing 25 mM Tris/HCl, pH 7.4, and cells were lysed by lysozyme treatment at 30 uC for 15 min, ...
... ml21 and incubation continued for 2.5 h. Cells were harvested by centrifugation and the pellet was washed with 1 ml buffer containing 25 mM Tris/HCl, pH 7.4. The pellet was resuspended in 500 ml buffer containing 25 mM Tris/HCl, pH 7.4, and cells were lysed by lysozyme treatment at 30 uC for 15 min, ...
Structure, expression and chromosomal location of the Oct
... restriction enzymes failed to identify a RFLP between the relevant parental t-haplotypes. This lack of polymorphism was not unexpected because all t-haplotypes are generally believed to be descended from a single ancestral chromosome. Another approach to examine the relationship between Oct-4 and t ...
... restriction enzymes failed to identify a RFLP between the relevant parental t-haplotypes. This lack of polymorphism was not unexpected because all t-haplotypes are generally believed to be descended from a single ancestral chromosome. Another approach to examine the relationship between Oct-4 and t ...
Molecular cloning, characterization and expression analysis of
... Macrophage migration inhibitory factor (MIF) as a multi-functional cytokine mediating both innate and adaptive immune responses, however, their function within the innate immune system of invertebrates remains largely unknown. Therefore, we investigated the immune functionality of MIF in Chinese mit ...
... Macrophage migration inhibitory factor (MIF) as a multi-functional cytokine mediating both innate and adaptive immune responses, however, their function within the innate immune system of invertebrates remains largely unknown. Therefore, we investigated the immune functionality of MIF in Chinese mit ...
Pathogenesis of 2009 Pandemic Influenza A Virus (H1N1) Infection
... innate immune molecules, like cytokines and chemokines, induced by different cell types in the lungs. In the study IV, we studied the induction of different innate immune molecules in different lung anatomic compartments (bronchiolar, alveolar and vascular), in response to pandemic H1N1 infection in ...
... innate immune molecules, like cytokines and chemokines, induced by different cell types in the lungs. In the study IV, we studied the induction of different innate immune molecules in different lung anatomic compartments (bronchiolar, alveolar and vascular), in response to pandemic H1N1 infection in ...
... domains (NOD)-like receptors (NLRs) and retionid acid-inducable gene I (RIG-I)-like receptors are two recently identified cytosolic PRR that recognize PAMPs in the intracellular compartments [3]. Toll-like receptors (TLRs) are the most studied PRRs. They recognize a wide range of microbial motifs at ...
Biological basis for the clinical use of interferon
... Variables affecting response to interferon The specific type of viral infection may influence the role of, and response to, interferon. Viruses that kill the cell before being released usually cause very acute infections and are not good targets for interferon. Viruses that mature on the cell surfac ...
... Variables affecting response to interferon The specific type of viral infection may influence the role of, and response to, interferon. Viruses that kill the cell before being released usually cause very acute infections and are not good targets for interferon. Viruses that mature on the cell surfac ...
Cytokine hypothesis of overtraining: a physiological adaptation to
... appetite. However, it is the decline in performance frequently associated with an increased volume or load of training, that captures the attention of the athlete and coach. A large number of symptoms associated with overtraining, have been reported in the literature. Fry et. al. (27) have categoriz ...
... appetite. However, it is the decline in performance frequently associated with an increased volume or load of training, that captures the attention of the athlete and coach. A large number of symptoms associated with overtraining, have been reported in the literature. Fry et. al. (27) have categoriz ...
Relationships between a new type IV secretion system and the icm
... secretion systems was performed, we found that from the seven conserved proteins (VirB4, -B7, -B8, -B9, -B10, -B11 and -D4) of type IV secretion systems, four of the L. pneumophila Lvh proteins (LvhB4, -B9, -B11 and -D4) contain the highest degree of homology to their homologues from the type IV sec ...
... secretion systems was performed, we found that from the seven conserved proteins (VirB4, -B7, -B8, -B9, -B10, -B11 and -D4) of type IV secretion systems, four of the L. pneumophila Lvh proteins (LvhB4, -B9, -B11 and -D4) contain the highest degree of homology to their homologues from the type IV sec ...
Pigs immunized with Chinese highly pathogenic PRRS virus
... most countries in East Asia including Cambodia, Laos, Philippines, Bhutan, Myanmar, Thailand, South Korea, and Russia [11]. JXA-1 (GenBank ID: EF112445.1), one of the earliest HP-PRRSV strains, was isolated in 2006 and shares 91% homology with the genome of VR-2332 (GenBank ID: AY150564.1). However, ...
... most countries in East Asia including Cambodia, Laos, Philippines, Bhutan, Myanmar, Thailand, South Korea, and Russia [11]. JXA-1 (GenBank ID: EF112445.1), one of the earliest HP-PRRSV strains, was isolated in 2006 and shares 91% homology with the genome of VR-2332 (GenBank ID: AY150564.1). However, ...
Exercise and the Immune System – Focusing on the Effect of
... effect on serum immunoglobulin's and sub-types of IgG {IgG1, IgG2, IgG3 and IgG4} (Table 2). No differences were observed between gymnasts and untrained girls (46). The changes observed were similar to those found in adults (40). Our laboratory for leukocyte functions focused within the last 30 year ...
... effect on serum immunoglobulin's and sub-types of IgG {IgG1, IgG2, IgG3 and IgG4} (Table 2). No differences were observed between gymnasts and untrained girls (46). The changes observed were similar to those found in adults (40). Our laboratory for leukocyte functions focused within the last 30 year ...
Epitope Masking in a Murine Model Independently from Red Cell
... fetal red cells. Much of our information on how anti-D may prevent immunization to D+ RBCs has come from seminal studies dating back to the 1960s on human male D2 volunteers immunized with D+ RBCs. In many of these studies and others that have followed, it was noticed that the dose of anti-D that ca ...
... fetal red cells. Much of our information on how anti-D may prevent immunization to D+ RBCs has come from seminal studies dating back to the 1960s on human male D2 volunteers immunized with D+ RBCs. In many of these studies and others that have followed, it was noticed that the dose of anti-D that ca ...
Article Mitochondrial DNA turnover occurs during preimplantation
... either be inherited, or generated de novo by adverse environmental factors that disturb mitochondrial DNA synthesis or destabilize mtDNA. The preimplantation period of development in mammals was thought to be relatively immune from environmentally induced changes to mtDNA, since no replication of mt ...
... either be inherited, or generated de novo by adverse environmental factors that disturb mitochondrial DNA synthesis or destabilize mtDNA. The preimplantation period of development in mammals was thought to be relatively immune from environmentally induced changes to mtDNA, since no replication of mt ...
• - Utrecht University Repository
... and release histamine into the surrounding tissue, with the allergic symptoms such as red eyes and wheezing as a result [1,4]. An important factor is the Th1/Th2 balance, largely determining the amount of IgE produced in a patient. A delicate balance between Th1 and Th2 cells exists in the body. Th1 ...
... and release histamine into the surrounding tissue, with the allergic symptoms such as red eyes and wheezing as a result [1,4]. An important factor is the Th1/Th2 balance, largely determining the amount of IgE produced in a patient. A delicate balance between Th1 and Th2 cells exists in the body. Th1 ...
Effects of Ionizing Radiation — UNSCEAR 2006 Report, Volume II
... 3. Remarks concerning organs and tissues of the immune system . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . C. Cells and molecules of the immune system. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . ...
... 3. Remarks concerning organs and tissues of the immune system . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . C. Cells and molecules of the immune system. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . ...
Annual Report 2011 - Davos - Swiss Institute of Allergy and Asthma
... und Mitglied der Life Science Zurich Graduate School. 1905 Tuberculosis Research Institute Davos Medical Society Davos, Community of Davos, K. Turban 1907 Physical-Meteorological Observatory Davos, C. Dorno 1922 Swiss Research Institute for High Altitude Climate and Tuberculosis 1922-1933 A. L ...
... und Mitglied der Life Science Zurich Graduate School. 1905 Tuberculosis Research Institute Davos Medical Society Davos, Community of Davos, K. Turban 1907 Physical-Meteorological Observatory Davos, C. Dorno 1922 Swiss Research Institute for High Altitude Climate and Tuberculosis 1922-1933 A. L ...
Activation of the Inflammatory Response by Fungal
... Vertabrates have a two-tiered immune system consisting of innate immunity and adaptive immunity. Their purpose is to protect the body from disease-causing microorganisms, physical stress or tissue damage. The innate immune system is the first to be activated; it facilitates the direct elimination of ...
... Vertabrates have a two-tiered immune system consisting of innate immunity and adaptive immunity. Their purpose is to protect the body from disease-causing microorganisms, physical stress or tissue damage. The innate immune system is the first to be activated; it facilitates the direct elimination of ...
as a PDF
... response to vaccine, although in a few studies immunological responses have been found to be impaired with large quantities of nutrients. Studies using low-dose supplementation of zinc alone (Boukaiba et al, 1993) or zinc associated with selenium (Girodon et al, 1999) in elderly patients, provide a ...
... response to vaccine, although in a few studies immunological responses have been found to be impaired with large quantities of nutrients. Studies using low-dose supplementation of zinc alone (Boukaiba et al, 1993) or zinc associated with selenium (Girodon et al, 1999) in elderly patients, provide a ...
DNA vaccination
DNA vaccination is a technique for protecting an animal against disease by injecting it with genetically engineered DNA so cells directly produce an antigen, resulting in a protective immunological response. Several DNA vaccines have been released for veterinary use, and there has been promising research using the vaccines for viral, bacterial and parasitic diseases, as well as to several tumour types. Although only one DNA vaccine has been approved for human use, DNA vaccines may have a number of potential advantages over conventional vaccines, including the ability to induce a wider range of immune response types.