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A RARE KEL17/KEL(IVS3+1G>A) COMPOUND HETEROZYGOUS
A RARE KEL17/KEL(IVS3+1G>A) COMPOUND HETEROZYGOUS

... groups know. Among them Kell(KEL1), Kp (KEL3), and Js (KEL6) are well known. The antithetic antigens KEL11/17 further contribute to this list. However, KEL17 is considered as very rare, with an approximte frequency of one KEL17 homozygote among 30’000 Europeans only (Daniels G, Human Blood Groups, 2 ...
Classification of plant-pathogenic mycoplasma
Classification of plant-pathogenic mycoplasma

... parasitic prQkaryotes of the class Mollicutes associated with diseases of several hundred plant species (McCoy et al., 1989). Until recently, differentiation and characterization was mainly based on host range and the symptoms induced in natural hosts and in the experimental host Catharanthus roseus ...
Chapter 1: Masters Thesis Literature Review
Chapter 1: Masters Thesis Literature Review

... animal models used for studying M. tuberculosis infection are; the mouse, rabbit, guinea pig and non-human primate [17]. While none are perfect models, they each have their advantages and disadvantages. The murine model is by far the most commonly used within research and during early drug testing. ...
DNA Methylation Analysis
DNA Methylation Analysis

Hannah Akuffo Publications 1990 to 1999
Hannah Akuffo Publications 1990 to 1999

... promastigotes. Scand J Immunol Suppl. 1992;11:179-84. 43. Akuffo HO. Cytokine responses to parasite antigens: in vitro cytokine production to promastigotes of L. aethiopica by cells from non-Leishmania exposed donors may influence disease establishment. Scand J Immunol Suppl. 1992;11:161-6. 44. Meng ...
to TCR Ligand Potency Within MHC Molecule or Antigenic Peptide
to TCR Ligand Potency Within MHC Molecule or Antigenic Peptide

... 3 to 10 amino acids in length (B). The mean cpm and SD of triplicate experiments are shown. The data represent one of three experiments yielding similar results. ...
Hall - Autism Speaks
Hall - Autism Speaks

... of autism and significantly increase susceptibility to adverse effects of environmental toxicants. This hypothesis is based on evidence from the Pessah lab that organic mercury, polychlorinated biphenyls, and flame retardants (PBDEs) can alter the intracellular Ca2+ signals generated by ryanodine re ...
Phagocytosis, a cellular immune response in insects
Phagocytosis, a cellular immune response in insects

... active antimicrobial and proinflammatory phenotype. This change is known as activation of phagocytic cells. The signals delivered to the cell by the various receptors determine the final activation stage of the leukocyte. At later times, these activated leukocytes can process and present antigens to ...
Host–pathogen interactions in sepsis
Host–pathogen interactions in sepsis

DNA cytosine methylation in plant development
DNA cytosine methylation in plant development

The heterogeneity of lung macrophages in the susceptibility to disease
The heterogeneity of lung macrophages in the susceptibility to disease

Full-Text PDF
Full-Text PDF

... extensively studied using animal models, as mice are naturally susceptible to both sheep scrapie and bovine spongiform encephalopathy (BSE). Following natural peripheral exposure to prion agents, infection is usually sequestered to lymphoid organs prior to invasion of the nervous system (termed neur ...
Food allergy: separating the science from the mythology
Food allergy: separating the science from the mythology

... latter strategy is called oral tolerance when induced via the gut. Homeostatic mechanisms also dampen immune responses to commensal bacteria. The mucosal epithelial barrier and immunoregulatory network are poorly developed in newborns. The perinatal period is, therefore, critical with regard to the ...
A tandem repeat in decay accelerating factor 1 induced autoimmunity
A tandem repeat in decay accelerating factor 1 induced autoimmunity

... 15], prostaglandin PGE2 [16], and tissue specific factors [17]. Although there is evidence that DAF mRNA stability can be affected by tissue specific factors [17] and inflammation [18], most studies suggest that expression is primarily modulated at transcription [15–17, 19, 20]. The human DAF promot ...
Epidemic Pertussis in 2012 — The Resurgence of a Vaccine
Epidemic Pertussis in 2012 — The Resurgence of a Vaccine

... was 500 per 100,000 population (PCR) assays have begun to be in the first study and 370 per used for diagnosis, and a major 100,000 population in the second. contributor to the difference in Although the studies were not the reported sizes of the 2005 conducted during known epidem- and 2010 epidemic ...
basic immunology
basic immunology

... Our interactions with bacteria drive processes in the body. A good example [maybe, jury still out] is that interactions with various bacteria probably drives and molds the type of responses we are capable of making under certain circumstances, making us less likely to make a more inappropriate respo ...
The Effect of OmpA Expression on Hfr Conjugation Efficiency
The Effect of OmpA Expression on Hfr Conjugation Efficiency

... between bacteria. OmpA, a highly abundant protein in the outer membrane of Escherichia coli, is a critical component required for conjugation. In order to investigate the effect of OmpA expression on Hfr conjugation, the conjugation efficiencies of E. coli strains expressing varying degrees of funct ...
CHK2 kinase: cancer susceptibility and cancer therapy – two sides
CHK2 kinase: cancer susceptibility and cancer therapy – two sides

... with a number of other substrates. In particular, in response to etoposide-induced double-strand breaks, CHK2 phosphorylates S364 of the E2F1 transcription factor (from the E2F family), resulting in its stabilization, transcriptional activation and induction of apoptosis through a p53-independent me ...
Effect of Proliferating Cell Nuclear Antigen
Effect of Proliferating Cell Nuclear Antigen

... Cells were plated at 5 ⫻ 105 cells/3-cm dish (MatTek, Ashland, MA) for at least 48 h before imaging. The cells were monitored under the microscope in a temperature-controlled chamber in 5% CO2 atmosphere. All the FRAP analysis was performed on an LSM510 confocal microscope (Carl Zeiss, Jena, Germany ...
Complement and its role in innate and adaptive immune
Complement and its role in innate and adaptive immune

... viability. The incredible complexity of mammalian immune systems is required to provide adequate defense in spite of the impressive number of pathogens and host processes that cause disease. Immune processes have traditionally been divided into two broad, but interconnected, subsystems on the basis ...


... could also be a key to the missing heritability of T2DM [73–75], given the major role of environmental factors in this disease. As said before, it is also possible that the poor phenotypic resolution of calling T2DM a number of different IR and IS phenotypes, which disregards the phenotypic complexit ...
Collaborative Bioinspired Algorithms
Collaborative Bioinspired Algorithms

... Use this idea to generate attribute strings that represent receptors Antibody production through a random concatenation from gene ...
The Immune System Drugs in Fish: Immune Function, Immunoassay
The Immune System Drugs in Fish: Immune Function, Immunoassay

... Fig. 1. The relationship of various factors in fish health status. In addition, in the Food and Drug Administration (FDA) and the European Union (EU) member states, although a limited number of antimicrobial agents are licensed for use in fin fish culture, various drugs such as chemotherapeutics hav ...
Prevention of Hepatitis A with the Hepatitis A Vaccine
Prevention of Hepatitis A with the Hepatitis A Vaccine

... injection site in 18 to 39 percent of persons, headache (in 15 percent), and fever (in less than 10 percent).10-14,22 By 1999, more than 65 million doses of hepatitis A vaccine had been administered worldwide; investigators who reviewed data from multiple sources could not identify any serious adver ...
Strains to Theiler`s Virus Persistent Infection the Difference of
Strains to Theiler`s Virus Persistent Infection the Difference of

... accompanied by chronic inflammation and primary demyelination. This late disease is studied as a model for multiple sclerosis (1, 2). Genetically resistant strains of mice clear the infection after the first 2 wk following inoculation and do not present with demyelination. Resistance/susceptibility ...
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DNA vaccination



DNA vaccination is a technique for protecting an animal against disease by injecting it with genetically engineered DNA so cells directly produce an antigen, resulting in a protective immunological response. Several DNA vaccines have been released for veterinary use, and there has been promising research using the vaccines for viral, bacterial and parasitic diseases, as well as to several tumour types. Although only one DNA vaccine has been approved for human use, DNA vaccines may have a number of potential advantages over conventional vaccines, including the ability to induce a wider range of immune response types.
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