The role of duplications in the evolution of genomes highlights the
... the history of various lineages are difficult to detect because of subsequent remodeling of the genome through gene losses and recombinations. Ancient genome polyploidization (termed paleopolyploidization) has, for example, occurred in yeasts, angiosperms and teleost fishes [10]. Polyploidization ca ...
... the history of various lineages are difficult to detect because of subsequent remodeling of the genome through gene losses and recombinations. Ancient genome polyploidization (termed paleopolyploidization) has, for example, occurred in yeasts, angiosperms and teleost fishes [10]. Polyploidization ca ...
Warren, ST: Trinucleotide repetition and fragile X syndrome. Hospital Practice 32:73 - 98 (1997). cover illustration.
... length in the normal chromosome but also on the number and position of cryptic interruptions. The available data suggest a multistep history in which a normal allele becomes a predisposed allele, which eventually becomes a premutation, which then expands into full mutation. At the outset, safety res ...
... length in the normal chromosome but also on the number and position of cryptic interruptions. The available data suggest a multistep history in which a normal allele becomes a predisposed allele, which eventually becomes a premutation, which then expands into full mutation. At the outset, safety res ...
Initial Stages in Creating a lacI Knockout in Escherichia coli C29
... the genome of the C29 cells, for only under an endogenous promoter would expression of the kanamycin gene be observed. Supporting this observation is the activation of β-galactosidase (β-gal) in the absence of IPTG, for the cells expressed a blue phenotype when grown in LB/X-gal solid media. The blu ...
... the genome of the C29 cells, for only under an endogenous promoter would expression of the kanamycin gene be observed. Supporting this observation is the activation of β-galactosidase (β-gal) in the absence of IPTG, for the cells expressed a blue phenotype when grown in LB/X-gal solid media. The blu ...
Type XVII collagen gene mutations in junctional epidermolysis
... biological consequences of mutations in the COL17A1 gene has shown that most patients lack type XVII collagen mRNA due to nonsense-mediated mRNA decay. Patients with these mutations can therefore be a target for corrective gene therapy using vectors coding for full-length type XVII collagen. Proof o ...
... biological consequences of mutations in the COL17A1 gene has shown that most patients lack type XVII collagen mRNA due to nonsense-mediated mRNA decay. Patients with these mutations can therefore be a target for corrective gene therapy using vectors coding for full-length type XVII collagen. Proof o ...
The Catabolic Action of Insulin in the Brain Is Mediated
... than that of the level in the fasted saline rats (Tukey’s post hoc test; p ⬍ 0.05) and not significantly different from the level in the fed controls. Hence, the local administration of insulin greatly attenuated the reduction of ARC POMC caused by fasting. Percentage of change data were analyzed wi ...
... than that of the level in the fasted saline rats (Tukey’s post hoc test; p ⬍ 0.05) and not significantly different from the level in the fed controls. Hence, the local administration of insulin greatly attenuated the reduction of ARC POMC caused by fasting. Percentage of change data were analyzed wi ...
Deletions of ultraconserved elements have no obvious phenotype
... tend to cluster in regions that are enriched for transcription factors and developmental genes [3], and a limited number of functional studies suggest a role for some of these noncoding elements in gene regulation [4–6]. Several hypotheses have been proposed to explain the extreme sequence constrain ...
... tend to cluster in regions that are enriched for transcription factors and developmental genes [3], and a limited number of functional studies suggest a role for some of these noncoding elements in gene regulation [4–6]. Several hypotheses have been proposed to explain the extreme sequence constrain ...
-Chain Gene Promoter ζ Antigen Receptor Elf
... several potential binding sites for T cell-specific transcription factors within the z promoter, including three GATA-3 binding sites (12, 13) between 2268 and 2247 and two canonical Ets-family binding sites (14) at 2135 and 252. Members of the Ets proto-oncogene family share a high degree of homolo ...
... several potential binding sites for T cell-specific transcription factors within the z promoter, including three GATA-3 binding sites (12, 13) between 2268 and 2247 and two canonical Ets-family binding sites (14) at 2135 and 252. Members of the Ets proto-oncogene family share a high degree of homolo ...
Saccharomyces Genome Database.
... Registry form (http:l/genome-www4.stanford.edu/cgi-binlSGDIregistry/geneRegistry). In 1994 Robert Mortimer transferred the task of maintaining the nomenclature orS. cerevisiae genes, the Gene Name Registry, to SGD. Yeast researchers can reserve a gene name or register a published gene name by submit ...
... Registry form (http:l/genome-www4.stanford.edu/cgi-binlSGDIregistry/geneRegistry). In 1994 Robert Mortimer transferred the task of maintaining the nomenclature orS. cerevisiae genes, the Gene Name Registry, to SGD. Yeast researchers can reserve a gene name or register a published gene name by submit ...
Text S1. Supporting Information Supporting Information Figure
... Figure S5: Scatter plot of ORF Depth vs measured nucleotide diversity: For all ORFs, the depth from high throughput sequence data is compared to the calculated nucleotide diversity. The red line represents the linear regression through the data. Equation for linear regression: y = (1.153 10-5)x + 0. ...
... Figure S5: Scatter plot of ORF Depth vs measured nucleotide diversity: For all ORFs, the depth from high throughput sequence data is compared to the calculated nucleotide diversity. The red line represents the linear regression through the data. Equation for linear regression: y = (1.153 10-5)x + 0. ...
Plant Molecular Biology
... degradation of substrate proteins required for cell cycle progression (Tyers and Jorgensen, 2000), signal transduction, and the execution of tumor suppressor The nucleotide sequence data reported will appear in the GenBank Database under the accession number AF417491 (MsRH2-1 gene). ...
... degradation of substrate proteins required for cell cycle progression (Tyers and Jorgensen, 2000), signal transduction, and the execution of tumor suppressor The nucleotide sequence data reported will appear in the GenBank Database under the accession number AF417491 (MsRH2-1 gene). ...
幻灯片 1
... approaches have led to the discovery of numerous molecules involved in embryouterine interactions; however, the precise sequence and details of the signaling cascades for many of these molecules have not yet been defined. • We attempts to focus on a select number of signaling molecules and pathways ...
... approaches have led to the discovery of numerous molecules involved in embryouterine interactions; however, the precise sequence and details of the signaling cascades for many of these molecules have not yet been defined. • We attempts to focus on a select number of signaling molecules and pathways ...
![[ 19] Saccharomyces Genome Database - SGD-Wiki](http://s1.studyres.com/store/data/012906934_1-a4c322e0bc64d409034f1882ecf44124-300x300.png)
[ 19] Saccharomyces Genome Database - SGD-Wiki
... Registry form (http:l/genome-www4.stanford.edu/cgi-binlSGDIregistry/geneRegistry). In 1994 Robert Mortimer transferred the task of maintaining the nomenclature orS. cerevisiae genes, the Gene Name Registry, to SGD. Yeast researchers can reserve a gene name or register a published gene name by submit ...
... Registry form (http:l/genome-www4.stanford.edu/cgi-binlSGDIregistry/geneRegistry). In 1994 Robert Mortimer transferred the task of maintaining the nomenclature orS. cerevisiae genes, the Gene Name Registry, to SGD. Yeast researchers can reserve a gene name or register a published gene name by submit ...
Genes and physical fitness
... minutes to a few hours) depend on the amount of ATP from the oxidation of glycogen and free fatty acids as well as the rate of glucose recovery in gluconeogenesis. The reserves of fatty acids are large enough so their losses during a day-long work are insignificant. On the other hand, the glycogen st ...
... minutes to a few hours) depend on the amount of ATP from the oxidation of glycogen and free fatty acids as well as the rate of glucose recovery in gluconeogenesis. The reserves of fatty acids are large enough so their losses during a day-long work are insignificant. On the other hand, the glycogen st ...
Single-step generation of rabbits carrying a targeted allele of the
... short palindromic repeat (CRISPR) and CRISPR-associated protein (Cas) have been developed as an efficient gene targeting system [10]. In such type II systems, the complex of a CRISPR RNA (crRNA) annealed to a transactivating crRNA is sufficient to guide the Cas9 endonuclease to a specific genomic se ...
... short palindromic repeat (CRISPR) and CRISPR-associated protein (Cas) have been developed as an efficient gene targeting system [10]. In such type II systems, the complex of a CRISPR RNA (crRNA) annealed to a transactivating crRNA is sufficient to guide the Cas9 endonuclease to a specific genomic se ...
Investigation of the role of ANKH in ankylosing spondylitis
... occurs in ⬃40% of cases, and inflammation may also involve extraarticular sites such as the uvea, tendon insertions, aorta, lungs, and kidneys. Genetic factors play a major role in AS: the heritability of susceptibility to AS assessed in twins is ⬎90% (2), and disease activity and functional impairm ...
... occurs in ⬃40% of cases, and inflammation may also involve extraarticular sites such as the uvea, tendon insertions, aorta, lungs, and kidneys. Genetic factors play a major role in AS: the heritability of susceptibility to AS assessed in twins is ⬎90% (2), and disease activity and functional impairm ...
Inheritance of Color And The Polled Trait
... Most traits involve large numbers of different genes. Very complex genes are responsible for a trait like weaning weight, (Environmental factors like nutrition must also be taken into account) but the polled trait depends on just one gene, expressed by the symbol “P”. The opposite condition, the pre ...
... Most traits involve large numbers of different genes. Very complex genes are responsible for a trait like weaning weight, (Environmental factors like nutrition must also be taken into account) but the polled trait depends on just one gene, expressed by the symbol “P”. The opposite condition, the pre ...
Glutathione S-transferase copy number variation alters lung gene expression M.W. Butler*
... Labeling Kit, followed by additional clean-up and quantification of the biotin-labelled copy (c)RNA yield using a spectrophotometer (all reagents from Affymetrix). In accordance with Affymetrix protocols, the test microarrays were first hybridised and, if quality control was acceptable, hybridisatio ...
... Labeling Kit, followed by additional clean-up and quantification of the biotin-labelled copy (c)RNA yield using a spectrophotometer (all reagents from Affymetrix). In accordance with Affymetrix protocols, the test microarrays were first hybridised and, if quality control was acceptable, hybridisatio ...
Protocol
... RNAi, the synthetic siRNAs are expensive and only mediate transient knockdown effect. In contrast, the promoter driven expression of short hairpin RNAs (shRNAs) in cells is more cost-effective, and the effect of gene silence can possibly persist for a long period of time by stable selection of the a ...
... RNAi, the synthetic siRNAs are expensive and only mediate transient knockdown effect. In contrast, the promoter driven expression of short hairpin RNAs (shRNAs) in cells is more cost-effective, and the effect of gene silence can possibly persist for a long period of time by stable selection of the a ...
A Sunflower Helianthinin Gene Upstream Sequence
... in both embryonic and somatic tissues. Interestingly,binding competition experiments revealed that these proteins also bind to the French bean phaseolin and the carrot DcG3 genes, both of which also are expressed in plant embryos. A helianthinin 404-bp DNA sequence ensemble, including the detected n ...
... in both embryonic and somatic tissues. Interestingly,binding competition experiments revealed that these proteins also bind to the French bean phaseolin and the carrot DcG3 genes, both of which also are expressed in plant embryos. A helianthinin 404-bp DNA sequence ensemble, including the detected n ...
Three Allele Combinations Associated with
... situated at chromosomes 2, 3, 6 and 19 (Table 1). The allelic carriership (phenotypic frequency) in case of biallelic candidate loci (Figure 1) did not differ significantly in MS patients and controls. The allelic distributions of polymorphic candidate loci showed a positive association of MS with a ...
... situated at chromosomes 2, 3, 6 and 19 (Table 1). The allelic carriership (phenotypic frequency) in case of biallelic candidate loci (Figure 1) did not differ significantly in MS patients and controls. The allelic distributions of polymorphic candidate loci showed a positive association of MS with a ...
Technologies to keep an eye on: alternative hosts for protein
... entries recording a yeast expression system for their production (1658 protein chains or 2.20%) (Figure 1a). These dominant expression platforms share widespread use and a wealth of available resources (material and knowledge) and their performance has been demonstrated for many heterologous protein ...
... entries recording a yeast expression system for their production (1658 protein chains or 2.20%) (Figure 1a). These dominant expression platforms share widespread use and a wealth of available resources (material and knowledge) and their performance has been demonstrated for many heterologous protein ...
Frequent Loss of Heterozygosity at the TEL Gene Locus
... results in unregulated ABL tyrosine kinase activity.‘” Chimeric transcription factors such as the E2A-PBX1 fusion arising from the t(1; 19)(q23;p13) translocation inpre-B ALL have been shown to act as dominant transforming proteins in cell culture and animal A number of fusion partners have also bee ...
... results in unregulated ABL tyrosine kinase activity.‘” Chimeric transcription factors such as the E2A-PBX1 fusion arising from the t(1; 19)(q23;p13) translocation inpre-B ALL have been shown to act as dominant transforming proteins in cell culture and animal A number of fusion partners have also bee ...
Incomplete Dominance, Codominance, and ABO Blood Types
... the hair color trait- red and blue What would be the resulting phenotype of a heterozygous pair if the alleles showed codominance? A. B. C. D. ...
... the hair color trait- red and blue What would be the resulting phenotype of a heterozygous pair if the alleles showed codominance? A. B. C. D. ...
A Symbolic and Graphical Gene Regulation Model of the lac Operon
... included into the DNA strand. The lacZ gene, with its associated control complex is incorporated into the DNA structure. In addition, the lacI gene along with its control complex is also part of the visualization. All other interactive elements including RNA polymerase, repressor molecules, and b-ga ...
... included into the DNA strand. The lacZ gene, with its associated control complex is incorporated into the DNA structure. In addition, the lacI gene along with its control complex is also part of the visualization. All other interactive elements including RNA polymerase, repressor molecules, and b-ga ...
![2610//16 1 Allele-specific expression, ASE [1] Defini8on of allele](http://s1.studyres.com/store/data/006248723_1-82195dc62ecf1cc4d0499f4ecaf3249f-300x300.png)
2610//16 1 Allele-specific expression, ASE [1] Defini8on of allele
... Map reads to diploid genome (or transcriptome) Requires that you either have or construct the diploid genome (or transcriptome) of the individual. E.g., Turro et al. (2011) (transcriptome). ...
... Map reads to diploid genome (or transcriptome) Requires that you either have or construct the diploid genome (or transcriptome) of the individual. E.g., Turro et al. (2011) (transcriptome). ...