Title PPAR interprets a chromatin signature of - DR-NTU
... PPARb because control morpholino (Co) injection caused no anomaly and PPARb_Rescue mRNA co-injection together with PPARb MO restored a normal phenotype (Fig. 1C–D). We verified that PPARb MO disrupted gastrulation movement by selectively targeting the dorsal marginal zone with a combination of PPARb ...
... PPARb because control morpholino (Co) injection caused no anomaly and PPARb_Rescue mRNA co-injection together with PPARb MO restored a normal phenotype (Fig. 1C–D). We verified that PPARb MO disrupted gastrulation movement by selectively targeting the dorsal marginal zone with a combination of PPARb ...
Incidence of Pulmonary Fibrosis in Lungs of CUX1 Transgenic Mice
... CUX1 (CUT-like homeobox 1) genes are present in all metazoans. In humans, the CUX1 gene is a transcriptional repressor and has been shown to play a significant role in cell cycle progression (specifically G1-S phase), cell differentiation, and morphogenesis. CUX1 expression is responsible for the in ...
... CUX1 (CUT-like homeobox 1) genes are present in all metazoans. In humans, the CUX1 gene is a transcriptional repressor and has been shown to play a significant role in cell cycle progression (specifically G1-S phase), cell differentiation, and morphogenesis. CUX1 expression is responsible for the in ...
No Slide Title
... – can target recombination to specific tissues and times – can study genes that are embryonic lethal when disrupted – can use for marker eviction – can study the role of a single gene in many different tissues with a single mouse line – can use for engineering translocations and inversions on chromo ...
... – can target recombination to specific tissues and times – can study genes that are embryonic lethal when disrupted – can use for marker eviction – can study the role of a single gene in many different tissues with a single mouse line – can use for engineering translocations and inversions on chromo ...
The Bacillus subtilis clpC operon encodes DNA
... frames (Ogasawara et al., 1994). We recently showed that the six genes are cotranscribed as an operon, preceded by two promoters. One resembles promoters recognized by the vegetative RNA polymerase EoA. The other promoter was shown to be stress-inducible and dependent upon aB, the general stress a-f ...
... frames (Ogasawara et al., 1994). We recently showed that the six genes are cotranscribed as an operon, preceded by two promoters. One resembles promoters recognized by the vegetative RNA polymerase EoA. The other promoter was shown to be stress-inducible and dependent upon aB, the general stress a-f ...
Genotypes-phenotype predictions in patients diagnosed with
... variation in samples of unrelated patients with AD compared to unrelated control subjects. These GWAS have resulted in several new candidate genes that have been identified as potential risk factors (Bertram et al., 2008). Follow-up studies, further investigate associations between genetic variation ...
... variation in samples of unrelated patients with AD compared to unrelated control subjects. These GWAS have resulted in several new candidate genes that have been identified as potential risk factors (Bertram et al., 2008). Follow-up studies, further investigate associations between genetic variation ...
Insulin - Diabetes Care - American Diabetes Association
... should inspect the bottle before each use for changes (i.e., clumping, frosting, precipitation, or change in clarity or color) that may signify a loss in potency. Visual examination should reveal rapid- and short-acting insulins as well as insulin glargine to be clear and all other insulin types to ...
... should inspect the bottle before each use for changes (i.e., clumping, frosting, precipitation, or change in clarity or color) that may signify a loss in potency. Visual examination should reveal rapid- and short-acting insulins as well as insulin glargine to be clear and all other insulin types to ...
Yeast whole-genome analysis of conserved regulatory motifs
... • Enhancer networks: Regulator enhancer target gene • Ex1: Oct4 predicted activator of embryonic stem (ES) cells • Ex2: Gfi1 repressor of K562/GM cells ...
... • Enhancer networks: Regulator enhancer target gene • Ex1: Oct4 predicted activator of embryonic stem (ES) cells • Ex2: Gfi1 repressor of K562/GM cells ...
A case-control study among Chinese Han population
... inflammation has been demonstrated to play a crucial role in atherosclerosis, a major risk factor for several human diseases. Recently, human genetic studies from us and others suggest that single nucleotide polymorphisms (SNPs) in leukotriene pathway genes influence the risk of atherosclerotic dise ...
... inflammation has been demonstrated to play a crucial role in atherosclerosis, a major risk factor for several human diseases. Recently, human genetic studies from us and others suggest that single nucleotide polymorphisms (SNPs) in leukotriene pathway genes influence the risk of atherosclerotic dise ...
Beta-cell function and mass in type 2 diabetes
... which is expected to increase considerably over the coming decades (IDF, 2000). The global prevalence of the disease was reported to be approximately 150 million or 3.8% of the adult population around year 2000 and is expected to increase to around 300 million or 5.1% of the adult population by year ...
... which is expected to increase considerably over the coming decades (IDF, 2000). The global prevalence of the disease was reported to be approximately 150 million or 3.8% of the adult population around year 2000 and is expected to increase to around 300 million or 5.1% of the adult population by year ...
ABO Blood and Human Origins.indd
... higher or lower frequency for one of the alleles at the time of migration. It could also result from random genetic drift, or from a mutation that renders glycosyltransferase inactive—which would result in blood type O from type A and is likely one cause for the increase in the frequency of the O al ...
... higher or lower frequency for one of the alleles at the time of migration. It could also result from random genetic drift, or from a mutation that renders glycosyltransferase inactive—which would result in blood type O from type A and is likely one cause for the increase in the frequency of the O al ...
Imprinted gene detection in Arabidopsis thaliana
... are mature, while the effects of imprinting are mostly confined to early development. The parameters m ≥ 0 and p ≥ 0 reflect the relative mRNA contributions of the maternal and paternal alleles, respectively. For a non-imprinted gene m = p = 1, that is, all alleles are active. For an imprinted gene, ...
... are mature, while the effects of imprinting are mostly confined to early development. The parameters m ≥ 0 and p ≥ 0 reflect the relative mRNA contributions of the maternal and paternal alleles, respectively. For a non-imprinted gene m = p = 1, that is, all alleles are active. For an imprinted gene, ...
Modeling Gene Expression Networks using Fuzzy Logic
... high-throughput microarray experiments measures the amount of RNA associated with each of thousands of genes in parallel. The expression of each gene, as reflected by level of accumulation of the corresponding RNA, is not just turned on and off like a light switch. Clustering analysis has been used ...
... high-throughput microarray experiments measures the amount of RNA associated with each of thousands of genes in parallel. The expression of each gene, as reflected by level of accumulation of the corresponding RNA, is not just turned on and off like a light switch. Clustering analysis has been used ...
Soft inheritance: Challenging the Modern Synthesis
... meiotic divisions in the germline that give rise to sperm or eggs, so offspring may inherit epigenetic variations through the germline. The mechanisms that lead to cellular epigenetic inheritance can also lead to cell memory - to the persistence of functional and structural cellular states in non-di ...
... meiotic divisions in the germline that give rise to sperm or eggs, so offspring may inherit epigenetic variations through the germline. The mechanisms that lead to cellular epigenetic inheritance can also lead to cell memory - to the persistence of functional and structural cellular states in non-di ...
Autosomal monoallelic expression in the mouse
... human genes with diverse functions (nearly 10% of approximately 4,000 assessed genes) are subject to this type of random monoallelic expression [10]. For autosomal RMAE, as with X-chromosome inactivation, each cell within a given tissue reflects a choice to activate one or both alleles. Unlike the c ...
... human genes with diverse functions (nearly 10% of approximately 4,000 assessed genes) are subject to this type of random monoallelic expression [10]. For autosomal RMAE, as with X-chromosome inactivation, each cell within a given tissue reflects a choice to activate one or both alleles. Unlike the c ...
Products of Modern Biotechnology
... for the first time. Biotech companies and universities were off to the races, and the world would never be the same again. In 1978, in the laboratory of Herbert Boyer at the University of California at San Francisco, a synthetic version of the human insulin gene was constructed and inserted into the ...
... for the first time. Biotech companies and universities were off to the races, and the world would never be the same again. In 1978, in the laboratory of Herbert Boyer at the University of California at San Francisco, a synthetic version of the human insulin gene was constructed and inserted into the ...
041610_gene Regulation
... Operon is a group of structural genes whose transcription into a polycistronic mRNA is under the control of a separate regulatory gene (control gene) Transcription of the genes in the operon is coordinately regulated (All genes are turned-on or turned-off together) ...
... Operon is a group of structural genes whose transcription into a polycistronic mRNA is under the control of a separate regulatory gene (control gene) Transcription of the genes in the operon is coordinately regulated (All genes are turned-on or turned-off together) ...
FnrP interactions with the Pasteurella haemolytica leukotoxin promoter
... region of the P1 leukotoxin promoter. Binding of FnrP at either half-site could a¡ect leukotoxin expression by excluding transcription initiated at the leukotoxin P1 promoter. Binding at the downstream half-site could inhibit binding of another regulatory protein at the overlapping near-IHF site. Mo ...
... region of the P1 leukotoxin promoter. Binding of FnrP at either half-site could a¡ect leukotoxin expression by excluding transcription initiated at the leukotoxin P1 promoter. Binding at the downstream half-site could inhibit binding of another regulatory protein at the overlapping near-IHF site. Mo ...
BISC403 Genetic and Evolutionary Biology Spring, 2011 May 16
... Consider an E. coli cell which is a partial diploid due to the presence of a stable plasmid carrying the lac operon. If the genotype of this cell for these five genes is - + + + - + - c + + (I p o Z Y /I p o Z Y ), what will be the phenotype for ß-galactosidase expression? inducible constitutive abs ...
... Consider an E. coli cell which is a partial diploid due to the presence of a stable plasmid carrying the lac operon. If the genotype of this cell for these five genes is - + + + - + - c + + (I p o Z Y /I p o Z Y ), what will be the phenotype for ß-galactosidase expression? inducible constitutive abs ...
Commentary: Lamarckian inheritance and
... genes. The whole of the X chromosome in the female zygote is silenced by an X-inactivating specific RNA transcript (Xist) which coats the X-chromosome to inactivate it. The transcription of the Xist gene is in turn regulated by a DNA methyltransferase, showing the close inter relationships of genomi ...
... genes. The whole of the X chromosome in the female zygote is silenced by an X-inactivating specific RNA transcript (Xist) which coats the X-chromosome to inactivate it. The transcription of the Xist gene is in turn regulated by a DNA methyltransferase, showing the close inter relationships of genomi ...
Oviduct-specific Glycoprotein 1 Locus is Associated with Litter Size
... introns do not directly alter any amino acid residue, they may play a role in regulating gene expression and thus their constituent SNPs may be directly related to functional variation (Zhang et al., 2005). Furthermore, it should be taken into consideration that the location of OVGP1 gene on chromos ...
... introns do not directly alter any amino acid residue, they may play a role in regulating gene expression and thus their constituent SNPs may be directly related to functional variation (Zhang et al., 2005). Furthermore, it should be taken into consideration that the location of OVGP1 gene on chromos ...
ppt - Chair of Computational Biology
... This suggests that many TFs can be regulated simply by the abundance (expression levels) of the TF. However, across 1000 microarray expression experiments for yeast, the correlation between a TF’s expression and that of its ChIP-based targets was typically very low (only between 0 and 0.25). Conside ...
... This suggests that many TFs can be regulated simply by the abundance (expression levels) of the TF. However, across 1000 microarray expression experiments for yeast, the correlation between a TF’s expression and that of its ChIP-based targets was typically very low (only between 0 and 0.25). Conside ...
Molecular Cloning of Clostridium Perfringens Type B Vaccine Strain
... elements and trypsin (5). Therefore, despite the low ...
... elements and trypsin (5). Therefore, despite the low ...