Leukaemia Section dic(9;20)(p11 13;q11) -
... occur within the PAX5 gene and result in aberrant fusion sequences with regions of chromosome 20. Breakpoint cloning experiments have shown PAX5 sequence juxtaposed to several genes on 20q including ASXL1, C20ORF112 and KIF3B (Figure 3). The genes involved in these fusion sequences are either in opp ...
... occur within the PAX5 gene and result in aberrant fusion sequences with regions of chromosome 20. Breakpoint cloning experiments have shown PAX5 sequence juxtaposed to several genes on 20q including ASXL1, C20ORF112 and KIF3B (Figure 3). The genes involved in these fusion sequences are either in opp ...
Gene mapping - Australian Mathematical Sciences Institute
... An allele is one of two or more versions of a gene. An individual inherits two alleles for each gene, one from each parent. If the two alleles are the same, the individual is homozygous for that gene. If the alleles are different, the individual is heterozygous. We discuss the alleles for pea colour ...
... An allele is one of two or more versions of a gene. An individual inherits two alleles for each gene, one from each parent. If the two alleles are the same, the individual is homozygous for that gene. If the alleles are different, the individual is heterozygous. We discuss the alleles for pea colour ...
Molecular Plant-Microbe Interacttions
... ments of interest were eluted, re-amplified by PCR with the same set of primers, and subsequently cloned into the pCR-2 vector plasmid. To minimize the number of false positives, a hybridization screen method was employed (Consalez et al. 1996). Six insert sequences scored positive. The sequences o ...
... ments of interest were eluted, re-amplified by PCR with the same set of primers, and subsequently cloned into the pCR-2 vector plasmid. To minimize the number of false positives, a hybridization screen method was employed (Consalez et al. 1996). Six insert sequences scored positive. The sequences o ...
genetics of susceptibility to infectious diseases: tuberculosis and
... intragenic polymorphisms of possible biological significance. Candidate genes can also be derived based on experiments in mouse models of infectious diseases thereby exploiting the identification of murine resistance/susceptibility loci. Variants within a candidate gene can be analyzed in linkage st ...
... intragenic polymorphisms of possible biological significance. Candidate genes can also be derived based on experiments in mouse models of infectious diseases thereby exploiting the identification of murine resistance/susceptibility loci. Variants within a candidate gene can be analyzed in linkage st ...
Harnessing gene expression to identify the genetic basis of drug
... credited. Creation of derivative works is permitted but the resulting work may be distributed only under the same or similar licence to this one. This licence does not permit commercial exploitation without specific permission. ...
... credited. Creation of derivative works is permitted but the resulting work may be distributed only under the same or similar licence to this one. This licence does not permit commercial exploitation without specific permission. ...
Control of the acetamidase gene of Mycobacterium smegmatis by
... Suicide (non-replicating) delivery vectors were constructed to generate amiC and amiD mutants using a rapid cloning system [9] (Fig. 1). For the amiC deletion construct a 1.4-kb BamHI^HindIII region was cloned into p2NIL and the central 0.4-kb XhoI fragment was deleted to give pURR55. For the amiD d ...
... Suicide (non-replicating) delivery vectors were constructed to generate amiC and amiD mutants using a rapid cloning system [9] (Fig. 1). For the amiC deletion construct a 1.4-kb BamHI^HindIII region was cloned into p2NIL and the central 0.4-kb XhoI fragment was deleted to give pURR55. For the amiD d ...
Two enhancer regions in the mouse En-2 locus
... CNS, En-2 is expressed in cells surrounding the developing pituitary (Davis et al., 1988, 1991). In addition, immunohistochemical analysis using a polyclonal antiserum (aEnhb-1) that detects both En-1 and En-2 protein has shown that one or both genes are expressed in presumptive myoblasts within the ...
... CNS, En-2 is expressed in cells surrounding the developing pituitary (Davis et al., 1988, 1991). In addition, immunohistochemical analysis using a polyclonal antiserum (aEnhb-1) that detects both En-1 and En-2 protein has shown that one or both genes are expressed in presumptive myoblasts within the ...
Ribosome reinitiation at leader peptides increases translation of
... reviewer for setting out the former distance problem in the context of the distance between neighboring genes in general in bacterial operons. We have bioinformatics data relevant to the latter distance problem. Several examples of this kind composed the new Additional file 4: the distances between ...
... reviewer for setting out the former distance problem in the context of the distance between neighboring genes in general in bacterial operons. We have bioinformatics data relevant to the latter distance problem. Several examples of this kind composed the new Additional file 4: the distances between ...
Harnessing gene expression to identify the genetic basis of drug
... credited. Creation of derivative works is permitted but the resulting work may be distributed only under the same or similar licence to this one. This licence does not permit commercial exploitation without specific permission. ...
... credited. Creation of derivative works is permitted but the resulting work may be distributed only under the same or similar licence to this one. This licence does not permit commercial exploitation without specific permission. ...
Hepatic Transporter Expression in Metabolic Syndrome: Phenotype
... manufacturer’s protocol. The optimal RNA input was determined prior to running the assay. Briefly, 500 ng of total RNA was incubated overnight at 53C with xMAP beads containing oligonucleotide capture-probes, label extenders, and blockers. On the next day, beads and bound target RNA were washed and ...
... manufacturer’s protocol. The optimal RNA input was determined prior to running the assay. Briefly, 500 ng of total RNA was incubated overnight at 53C with xMAP beads containing oligonucleotide capture-probes, label extenders, and blockers. On the next day, beads and bound target RNA were washed and ...
Novel Molecular Methods for Discovery and Engineering of
... genes. If the properties are different from those of the known biocatalysts available in the databases, it means that the cloned genes and corresponding biocatalysts are newly found, which are not reported yet previously. In the case that a functional gene is located in the same single DNA insert as ...
... genes. If the properties are different from those of the known biocatalysts available in the databases, it means that the cloned genes and corresponding biocatalysts are newly found, which are not reported yet previously. In the case that a functional gene is located in the same single DNA insert as ...
Genetic basis for Schizophrenia, Bipolar 1 Disorder, Tourette`s
... 3-In a new study, a family in which the father and all eight offspring (six sons and two daughters) have the syndrome. Extensive genetic detective work led them to a mutation in a gene called HDC, which encodes L-histidine decarboxylase, an enzyme involved in the production of histamine, a signalin ...
... 3-In a new study, a family in which the father and all eight offspring (six sons and two daughters) have the syndrome. Extensive genetic detective work led them to a mutation in a gene called HDC, which encodes L-histidine decarboxylase, an enzyme involved in the production of histamine, a signalin ...
PPT - Bioinformatics.ca
... • Ex 1. Homologues of human genes are often present in Fugu rubripes in more condensed form (with shorter introns). Is this true for the gene PTEN, a tumor suppressor often mutated in advanced cancers? – Try MultiContigView; can you think of another way to get this information as well? ...
... • Ex 1. Homologues of human genes are often present in Fugu rubripes in more condensed form (with shorter introns). Is this true for the gene PTEN, a tumor suppressor often mutated in advanced cancers? – Try MultiContigView; can you think of another way to get this information as well? ...
Qualitative Analysis of Regulatory Graphs: A Computational Tool
... level of gene gi corresponds to a threshold from which an interaction (with source gi ) becomes functional (thus for each gene, the maximum level equals at most the number of interactions exerted by this gene). Let Ij be the set of incoming interactions (or inputs set) of gj . For any gene gj , a su ...
... level of gene gi corresponds to a threshold from which an interaction (with source gi ) becomes functional (thus for each gene, the maximum level equals at most the number of interactions exerted by this gene). Let Ij be the set of incoming interactions (or inputs set) of gj . For any gene gj , a su ...
Raised Haemoglobin F (HbF) Level in Haemoglobinopathies: an
... [41],[44]. HbF (α2γ2) is formed by two α- and two γ-globin chains consisting of 141 and 146 amino acid residues, respectively. Changes in this ratio were observed in some hemoglobin disorders[45]-[46]. The developmental switch from foetal (α2γ2) to adult (α2 β2) haemoglobin (Hb) occurs just before b ...
... [41],[44]. HbF (α2γ2) is formed by two α- and two γ-globin chains consisting of 141 and 146 amino acid residues, respectively. Changes in this ratio were observed in some hemoglobin disorders[45]-[46]. The developmental switch from foetal (α2γ2) to adult (α2 β2) haemoglobin (Hb) occurs just before b ...
Apolipoprotein A5, a Newly Identified Gene That Affects Plasma
... Abstract—Apolipoprotein A5 (APOA5) is a newly described member of the apolipoprotein gene family whose initial discovery arose from comparative sequence analysis of the mammalian APOA1/C3/A4 gene cluster. Functional studies in mice indicated that alteration in the level of APOA5 significantly affect ...
... Abstract—Apolipoprotein A5 (APOA5) is a newly described member of the apolipoprotein gene family whose initial discovery arose from comparative sequence analysis of the mammalian APOA1/C3/A4 gene cluster. Functional studies in mice indicated that alteration in the level of APOA5 significantly affect ...
Apolipoprotein A5, a Newly Identified Gene That Affects Plasma
... Abstract—Apolipoprotein A5 (APOA5) is a newly described member of the apolipoprotein gene family whose initial discovery arose from comparative sequence analysis of the mammalian APOA1/C3/A4 gene cluster. Functional studies in mice indicated that alteration in the level of APOA5 significantly affect ...
... Abstract—Apolipoprotein A5 (APOA5) is a newly described member of the apolipoprotein gene family whose initial discovery arose from comparative sequence analysis of the mammalian APOA1/C3/A4 gene cluster. Functional studies in mice indicated that alteration in the level of APOA5 significantly affect ...
Consultation process for this DIR application
... Expression of each of these genes will be under the control of one of a number of constitutive, inducible (drought, cold or salt) or root specific promoters derived variously from cauliflower mosaic virus (CaMV), maize, rice, barley or wheat. Other short regulatory sequences that contribute to contr ...
... Expression of each of these genes will be under the control of one of a number of constitutive, inducible (drought, cold or salt) or root specific promoters derived variously from cauliflower mosaic virus (CaMV), maize, rice, barley or wheat. Other short regulatory sequences that contribute to contr ...
Predisposition of genetic disease by modestly decreased
... level of the enzyme partially (e.g. 50%), the DRD patient with recessive mutations might have typical DRD symptoms as shown in patients with a single dominant mutation. Our result of the decreased mRNA level into a half in a R198W mutant strand should be a typical example. So far six different autos ...
... level of the enzyme partially (e.g. 50%), the DRD patient with recessive mutations might have typical DRD symptoms as shown in patients with a single dominant mutation. Our result of the decreased mRNA level into a half in a R198W mutant strand should be a typical example. So far six different autos ...
Gene Regulatory Network of Ikaros in T cell development and
... Fig. 3. Screening of the functional sites along the enhancer-H by in situ mutagenesis on endogenous enhancer locus. ...
... Fig. 3. Screening of the functional sites along the enhancer-H by in situ mutagenesis on endogenous enhancer locus. ...
gene duplication in the evolution of sexual dimorphism
... whole-body hybridizations. The detection of sex-bias depends on the statistical approach and power of a given experimental design, which may partly explain differences among studies in the number of sex-biased genes identified. Furthermore, because evolutionarily recent gene duplicates are expected ...
... whole-body hybridizations. The detection of sex-bias depends on the statistical approach and power of a given experimental design, which may partly explain differences among studies in the number of sex-biased genes identified. Furthermore, because evolutionarily recent gene duplicates are expected ...
Hypotonic infants and the Prader-Willi Syndrome
... nature remains unknown.2 During the past few years, the genetic base of PWS has been extensively investigated; still, the clinical diagnosis of this disorder is complex, considering that some characteristics change according to the age and can be present in other syndromes as well. PWS can be define ...
... nature remains unknown.2 During the past few years, the genetic base of PWS has been extensively investigated; still, the clinical diagnosis of this disorder is complex, considering that some characteristics change according to the age and can be present in other syndromes as well. PWS can be define ...
serious asthma should focus on the possible confounding role
... others acquire asthma later in life. Still other patients develop the disease in early childhood and suffer from asthma their entire life. In addition, ethnicity, sex and age affect asthma susceptibility and severity [8, 9]. How can we explain these different patterns? A challenging hypothesis may b ...
... others acquire asthma later in life. Still other patients develop the disease in early childhood and suffer from asthma their entire life. In addition, ethnicity, sex and age affect asthma susceptibility and severity [8, 9]. How can we explain these different patterns? A challenging hypothesis may b ...
Hox Genes in Development and Disease – Lecture 2
... Drosophila paired. Aniridia is a human mutation in which the iris is lost and the retina is hypoplastic in heterozygotes (OMIM # 106210). In homozygotes there is fetal lethality and complete loss of eyes and olfactory epithelium. The aniridia gene was cloned by positional cloning and found to be the ...
... Drosophila paired. Aniridia is a human mutation in which the iris is lost and the retina is hypoplastic in heterozygotes (OMIM # 106210). In homozygotes there is fetal lethality and complete loss of eyes and olfactory epithelium. The aniridia gene was cloned by positional cloning and found to be the ...
No Slide Title
... – can target recombination to specific tissues and times – can study genes that are embryonic lethal when disrupted – can use for marker eviction – can study the role of a single gene in many different tissues with a single mouse line – can use for engineering translocations and inversions on chromo ...
... – can target recombination to specific tissues and times – can study genes that are embryonic lethal when disrupted – can use for marker eviction – can study the role of a single gene in many different tissues with a single mouse line – can use for engineering translocations and inversions on chromo ...