Beads on a string Bowater Biochem Soc Trans 2012
... for the interaction of ISW1 on a unit of two nucleosome particles and showed how ISW1 could set the spacing between adjacent nucleosomes. The data from the Richmond laboratory provide support for ATP-dependent remodelling factors as the important driver of nucleosome positioning. The location of nuc ...
... for the interaction of ISW1 on a unit of two nucleosome particles and showed how ISW1 could set the spacing between adjacent nucleosomes. The data from the Richmond laboratory provide support for ATP-dependent remodelling factors as the important driver of nucleosome positioning. The location of nuc ...
AN INTEGRATED MAP OF CATTLE CANDIDATE GENES FOR
... affecting functional traits such as mastitis (Schwerin et al., 2003). QTLs cover large chromosomal regions on average spreading from 10 to 40 cM (Stella and Boettcher, 2004), involving hundreds or thousands of genes. The ultimate goal of the QTL analysis is identification of causal gene itself, ther ...
... affecting functional traits such as mastitis (Schwerin et al., 2003). QTLs cover large chromosomal regions on average spreading from 10 to 40 cM (Stella and Boettcher, 2004), involving hundreds or thousands of genes. The ultimate goal of the QTL analysis is identification of causal gene itself, ther ...
Genetic Evidence that the Operator Locus is Distinct from the z gene
... manuscript in preparation). If the luc and trp operons are fused and the z structural gene is intact, we should see an increase in the rate of /3-galactosidase synthesis. In fact, the derepression of trp by the trpR- allele, results /in a 17 times increase in the rate of /?-galactosidase synthesis ( ...
... manuscript in preparation). If the luc and trp operons are fused and the z structural gene is intact, we should see an increase in the rate of /3-galactosidase synthesis. In fact, the derepression of trp by the trpR- allele, results /in a 17 times increase in the rate of /?-galactosidase synthesis ( ...
reviews
... happen primarily at the level of gene regulation rather than protein function20,21. So, a likely way for sub-functionalization to occur is through complementary changes in regulatory elements, perhaps leading to two separate expression domains that together recapitulate the more complex single expre ...
... happen primarily at the level of gene regulation rather than protein function20,21. So, a likely way for sub-functionalization to occur is through complementary changes in regulatory elements, perhaps leading to two separate expression domains that together recapitulate the more complex single expre ...
The importance of MTHFR gene mutation detection in patient with
... Homocysteine is an amino acid serving as an intermediate in methionine metabolism. It is reported that after auto-oxidation of homocysteine it might form biologically reactive products that are associated with increased cell toxicity. Also, homocysteine has been identified to participate in four ess ...
... Homocysteine is an amino acid serving as an intermediate in methionine metabolism. It is reported that after auto-oxidation of homocysteine it might form biologically reactive products that are associated with increased cell toxicity. Also, homocysteine has been identified to participate in four ess ...
Transposable elements, genes and recombination in a 215
... REAL kits (Qiagen) were used to prepare DNA minipreps from 1.3-ml cultures grown in deep 96-well plates for 14–18 h at 37°C shaking at 300 rpm. DNA was typically resuspended in 50 µl water, with 4 µl used for each sequencing reaction. Clones were sequenced from both directions using Big Dye Terminat ...
... REAL kits (Qiagen) were used to prepare DNA minipreps from 1.3-ml cultures grown in deep 96-well plates for 14–18 h at 37°C shaking at 300 rpm. DNA was typically resuspended in 50 µl water, with 4 µl used for each sequencing reaction. Clones were sequenced from both directions using Big Dye Terminat ...
2) TF Gene-Disease Association Property Predictions
... recruitment of other transcription initiation factors as well as causing DNA conformational change. They can also act as part of protein complexes. Brain diseases are a broad disease area, encompassing a wide range of complex, abnormal phenotypes, including combinations of lethality, neurodegenerati ...
... recruitment of other transcription initiation factors as well as causing DNA conformational change. They can also act as part of protein complexes. Brain diseases are a broad disease area, encompassing a wide range of complex, abnormal phenotypes, including combinations of lethality, neurodegenerati ...
CDKN2 (p16/MTS1) Gene Deletion or CDK4
... The distance between the CDKN2 gene and its flanking loci, MTS2 and 1063. 7 has been estimated to be between 20 and 30 kilobases (7). In this study, breakpoints have been demonstrated within this rela tively short distance in a number of the tumors. Breakpoints occurred between the MTS2 locus and th ...
... The distance between the CDKN2 gene and its flanking loci, MTS2 and 1063. 7 has been estimated to be between 20 and 30 kilobases (7). In this study, breakpoints have been demonstrated within this rela tively short distance in a number of the tumors. Breakpoints occurred between the MTS2 locus and th ...
Transcriptional Repression of the
... Typically, estrogens and androgens synthesized in response to gonadotropin stimulation repress transcription of the a- and gonadotropin b-subunit genes (4–6, 9–12). Mechanistically, negative feedback by gonadal steroids may reflect either direct regulatory effects occurring at the level of the pitui ...
... Typically, estrogens and androgens synthesized in response to gonadotropin stimulation repress transcription of the a- and gonadotropin b-subunit genes (4–6, 9–12). Mechanistically, negative feedback by gonadal steroids may reflect either direct regulatory effects occurring at the level of the pitui ...
Chapter 18 Regulation of Gene Expression Multiple-Choice
... A) Eukaryotic mRNAs get 5ʹ caps and 3ʹ tails. B) Prokaryotic genes are expressed as mRNA, which is more stable in the cell. C) Eukaryotic exons may be spliced in alternative patterns. D) Prokaryotes use ribosomes of different structure and size. E) Eukaryotic coded polypeptides often require cleavin ...
... A) Eukaryotic mRNAs get 5ʹ caps and 3ʹ tails. B) Prokaryotic genes are expressed as mRNA, which is more stable in the cell. C) Eukaryotic exons may be spliced in alternative patterns. D) Prokaryotes use ribosomes of different structure and size. E) Eukaryotic coded polypeptides often require cleavin ...
General background text Pharmacogenetics
... There is also great variation in metabolic capacity within the IM and EM groups. The PM phenotype particularly leads to a strong increase in cellular concentration of the active metabolites (thioguanine nucleotides), which almost always leads to serious side effects such as bone marrow depression at ...
... There is also great variation in metabolic capacity within the IM and EM groups. The PM phenotype particularly leads to a strong increase in cellular concentration of the active metabolites (thioguanine nucleotides), which almost always leads to serious side effects such as bone marrow depression at ...
Gene Section PYY (peptide YY) Atlas of Genetics and Cytogenetics
... Common polymorphisms: Arg72Thr, which has been associated with type-2 diabetes and in some cases with enhanced body mass. Other variants: Gln62Pro and Leu73Pro associated with body mass and obesity, respectively as well as A-23G,C888T and 3' UTR variant C+1134A. The latter has been related to enhanc ...
... Common polymorphisms: Arg72Thr, which has been associated with type-2 diabetes and in some cases with enhanced body mass. Other variants: Gln62Pro and Leu73Pro associated with body mass and obesity, respectively as well as A-23G,C888T and 3' UTR variant C+1134A. The latter has been related to enhanc ...
Supplementary Data The complete 12 Mb genome and
... reported by contrasting rpoB(R)N426H strain to wild type strain data. Gene-sets with Normalized Enrichment Score (NES) > 1.70 and False Discovery Rate (FDR) < 0.1 in at least one of the contrasts are reported. Green and red colors indicate, respectively, up-regulation and down-regulation in test str ...
... reported by contrasting rpoB(R)N426H strain to wild type strain data. Gene-sets with Normalized Enrichment Score (NES) > 1.70 and False Discovery Rate (FDR) < 0.1 in at least one of the contrasts are reported. Green and red colors indicate, respectively, up-regulation and down-regulation in test str ...
Effects of adenovirus delivered Flt
... The expression of genes encoding antioxidative and Phase II detoxification enzymes is induced in cells exposed to electrophilic compounds and phenolic antioxidants. Induction of these enzymes is regulated at the transcriptional level and is mediated by a specific enhancer, the antioxidant response e ...
... The expression of genes encoding antioxidative and Phase II detoxification enzymes is induced in cells exposed to electrophilic compounds and phenolic antioxidants. Induction of these enzymes is regulated at the transcriptional level and is mediated by a specific enhancer, the antioxidant response e ...
Mining Gene Expression Data Using PCA Based Clustering
... is available. To address this problem, PCA has been applied to analyze gene expression data. PCA is a classical statistic technique to reduce the dimensionality of the data by transforming to a set of variables that summarize the features of the data without much loss of information [22]. Principal ...
... is available. To address this problem, PCA has been applied to analyze gene expression data. PCA is a classical statistic technique to reduce the dimensionality of the data by transforming to a set of variables that summarize the features of the data without much loss of information [22]. Principal ...
goodman_01_09_03
... All standard Santa Cruz information visible here, too Based on GBrowse – collaboration with L. Stein ...
... All standard Santa Cruz information visible here, too Based on GBrowse – collaboration with L. Stein ...
Chapter 8
... strongly conserved secondary and tertiary structures. Because the structure of snRNAs in the spliceosome complex resembles that of group II introns (Fig. 8.14), it is speculated that the spliceosome machinery evolved from group II introns. Early in evolutionary history, when catalytic RNAs may have ...
... strongly conserved secondary and tertiary structures. Because the structure of snRNAs in the spliceosome complex resembles that of group II introns (Fig. 8.14), it is speculated that the spliceosome machinery evolved from group II introns. Early in evolutionary history, when catalytic RNAs may have ...
Association of MMP-3 (-1612 5A/6A) polymorphism with knee
... The genetic etiology of OA is not entirely known. Previously, OA was recognized as a noninflammatory arthropathy. However, recent studies have shown that an inflammatory process plays a part in the pathogenesis of OA [2, 3]. Pro-inflammatory cytokines are implicated as potential mediators in the dis ...
... The genetic etiology of OA is not entirely known. Previously, OA was recognized as a noninflammatory arthropathy. However, recent studies have shown that an inflammatory process plays a part in the pathogenesis of OA [2, 3]. Pro-inflammatory cytokines are implicated as potential mediators in the dis ...
Gene Regulation in Development and Evolution
... Nanog—were particularly potent in converting or reprogramming fibroblasts into iPS cells. These reprogrammed cells have most or all of the properties of bona fide ICM cells. The iPS cells can be induced to form just about any cell type, such as cardiomyocytes (heart muscle). In a further remarkable ...
... Nanog—were particularly potent in converting or reprogramming fibroblasts into iPS cells. These reprogrammed cells have most or all of the properties of bona fide ICM cells. The iPS cells can be induced to form just about any cell type, such as cardiomyocytes (heart muscle). In a further remarkable ...
X linked
... If someone in the family has an X linked condition or is a carrier, you may wish to discuss this with other family members. This gives other female family members the opportunity to have a blood test to see if they are also carriers, if they wish. This information may also be useful in helping diagn ...
... If someone in the family has an X linked condition or is a carrier, you may wish to discuss this with other family members. This gives other female family members the opportunity to have a blood test to see if they are also carriers, if they wish. This information may also be useful in helping diagn ...
Abnormalities of epidermal differentiation associated with
... is involved. Viral D N A replication is detectable only in the suprabasal layers; however it appears likely that the viral episome is present within cells of the basal layer, where early gene products might act to interfere with the normal control of cell proliferation and differentiation (Pfister, ...
... is involved. Viral D N A replication is detectable only in the suprabasal layers; however it appears likely that the viral episome is present within cells of the basal layer, where early gene products might act to interfere with the normal control of cell proliferation and differentiation (Pfister, ...
Implications of DNA replication for eukaryotic gene expression
... antagonism between transcription and replication on efficiently replicating SV40 molecules (Lebkowski et al. 1985; Lewis and Manley, 1985). Replication forks invade the transcriptionally active ribosomal RNA genes in yeast (Saffer and Miller, 1986). The disruption of transcription complexes by repli ...
... antagonism between transcription and replication on efficiently replicating SV40 molecules (Lebkowski et al. 1985; Lewis and Manley, 1985). Replication forks invade the transcriptionally active ribosomal RNA genes in yeast (Saffer and Miller, 1986). The disruption of transcription complexes by repli ...
Chromatin: A sticky silence
... nucleus may vary in a regulated manner during development. In support of this idea, the strength of heterochromatin-mediated silencing in Drosophila was observed to decrease during differentiation [21]. In contrast, variegated expression of multiple copies of a globin gene in mice was seen to increa ...
... nucleus may vary in a regulated manner during development. In support of this idea, the strength of heterochromatin-mediated silencing in Drosophila was observed to decrease during differentiation [21]. In contrast, variegated expression of multiple copies of a globin gene in mice was seen to increa ...
Advances in Environmental Biology IL-11 play important role in scoliosis patients
... believed to be multifactorial, including such factors as growth, hormonal secretion and gravity [2-5]. However, none of these parameters has been shown individually to play a causative role. Burner, Badger and Sherman [6, 7] first noted an association between osteopenia and AIS using the Singh index ...
... believed to be multifactorial, including such factors as growth, hormonal secretion and gravity [2-5]. However, none of these parameters has been shown individually to play a causative role. Burner, Badger and Sherman [6, 7] first noted an association between osteopenia and AIS using the Singh index ...
Journal of Molecular Biology
... 1980). The phoM gene product acts as an activator that can partially replace tIhe activator function of the phoR gene product’ (Wanner & Latterell, 1980). In addition, mutations in any of the genes phoS, ph,oT or pst result in t,he constibut)ivc synthesis of the PhoE protein (Tommassen 8: Lugtenberg ...
... 1980). The phoM gene product acts as an activator that can partially replace tIhe activator function of the phoR gene product’ (Wanner & Latterell, 1980). In addition, mutations in any of the genes phoS, ph,oT or pst result in t,he constibut)ivc synthesis of the PhoE protein (Tommassen 8: Lugtenberg ...