Risk assessment - Office of the Gene Technology Regulator
... that do not lead to an adverse outcome, or could not reasonably occur, do not advance in the risk assessment process. Sixteen events were identified and assessed whereby the release of the GM sugarcane lines might give rise to harm to people or the environment. These 16 events included consideration ...
... that do not lead to an adverse outcome, or could not reasonably occur, do not advance in the risk assessment process. Sixteen events were identified and assessed whereby the release of the GM sugarcane lines might give rise to harm to people or the environment. These 16 events included consideration ...
The amelogenin gene
... protein is now well characterized from the data of amino acid sequences which have been shown to be at a high degree of homology between all species investigated to date. The gene structure of this protein has been demonstrated and it is confirmed that there are two amelogenin genes, one on the X.ch ...
... protein is now well characterized from the data of amino acid sequences which have been shown to be at a high degree of homology between all species investigated to date. The gene structure of this protein has been demonstrated and it is confirmed that there are two amelogenin genes, one on the X.ch ...
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... - Linkages occur where loci do not assort independently. Generally loci do assort independently, with crossover events common (eg, the recessive white gene assorts independently from the Pea Comb gene, as no linkage between their loci). For there to be a linkage between loci, they must be on the sam ...
... - Linkages occur where loci do not assort independently. Generally loci do assort independently, with crossover events common (eg, the recessive white gene assorts independently from the Pea Comb gene, as no linkage between their loci). For there to be a linkage between loci, they must be on the sam ...
Hox, ParaHox, ProtoHox: facts and guesses
... posterior region that account for the present-day composition of the complexes (reviewed in de Rosa et al, 1999; Ferrier and Minguillón, 2003). The Hox cluster was believed to originate by tandem duplication from an ancestral ‘central’ Hox gene until 1998, with the discovery of the ParaHox cluster ...
... posterior region that account for the present-day composition of the complexes (reviewed in de Rosa et al, 1999; Ferrier and Minguillón, 2003). The Hox cluster was believed to originate by tandem duplication from an ancestral ‘central’ Hox gene until 1998, with the discovery of the ParaHox cluster ...
PDF - Ruhr-Universität Bochum
... of autonomy from the DNA-level. Thus epigenetics challenges gene centrism and asks for a broader notion of heredity that should be taken into consideration for inheritance and evolution. Epigenetic inheritance systems, like chromatin-marking systems (Suzuki and Bird 2008) or RNA-mediated gene silenc ...
... of autonomy from the DNA-level. Thus epigenetics challenges gene centrism and asks for a broader notion of heredity that should be taken into consideration for inheritance and evolution. Epigenetic inheritance systems, like chromatin-marking systems (Suzuki and Bird 2008) or RNA-mediated gene silenc ...
Systematic Studies on the Family Cucurbitaceae
... for light green (55). However, this model does not seem to apply in all watermelon cultivars. Furthermore, the inheritance of some rind colors such as gray or mediumgreen have not been published, even though these have been two common colors during the last century of watermelon breeding. The geneti ...
... for light green (55). However, this model does not seem to apply in all watermelon cultivars. Furthermore, the inheritance of some rind colors such as gray or mediumgreen have not been published, even though these have been two common colors during the last century of watermelon breeding. The geneti ...
Quantitative analysis of SMN1 and SMN2 genes based on DHPLC
... patients gaining the ability to walk. A locus for the three clinical types of SMA was mapped to chromosome 5q13 by linkage analysis [Scheffer et al., 2001; Wirth, 2000] and was refined to the location of the survival motor neuron (SMN) gene [Lefebvre et al., 1995]. Two almost identical copies of the ...
... patients gaining the ability to walk. A locus for the three clinical types of SMA was mapped to chromosome 5q13 by linkage analysis [Scheffer et al., 2001; Wirth, 2000] and was refined to the location of the survival motor neuron (SMN) gene [Lefebvre et al., 1995]. Two almost identical copies of the ...
Exam Questions from Exam 1 – Basic Genetic Tests
... Mice homozygous for alleles that block the production of enzyme A (genotype a/a) do not make either antigen 1 or antigen 2. Mice homozygous for defects in the gene encoding enzyme B (genotype b/b) do not make antigen 1. Mice homozygous for defects in the gene encoding enzyme C (genotype c/c) do not ...
... Mice homozygous for alleles that block the production of enzyme A (genotype a/a) do not make either antigen 1 or antigen 2. Mice homozygous for defects in the gene encoding enzyme B (genotype b/b) do not make antigen 1. Mice homozygous for defects in the gene encoding enzyme C (genotype c/c) do not ...
Genetic analysis of the floral initiation process (FLIP) in Arabidopsis
... such as APETALA2 (AP2) in Arabidopsis, act in whorls one and two, Class B genes, such as PISTILLATA (PI) and APETALA3 (AP3) act in whorls two and three, and Class C genes, such as AGAMOUS (AG) act in whorls three and four. Secondly, the model states that the expression of Class A and C genes are mut ...
... such as APETALA2 (AP2) in Arabidopsis, act in whorls one and two, Class B genes, such as PISTILLATA (PI) and APETALA3 (AP3) act in whorls two and three, and Class C genes, such as AGAMOUS (AG) act in whorls three and four. Secondly, the model states that the expression of Class A and C genes are mut ...
Cold-induced silencing by long antisense transcripts of an
... In summary, our study has demonstrated the environmental induction of long, non-coding, antisense transcripts covering an entire gene. These were found to be sufficient to induce silencing of a linked reporter. In the context of endogenous FLC silencing we propose that COOLAIR is involved in early, ...
... In summary, our study has demonstrated the environmental induction of long, non-coding, antisense transcripts covering an entire gene. These were found to be sufficient to induce silencing of a linked reporter. In the context of endogenous FLC silencing we propose that COOLAIR is involved in early, ...
Premature stop codons involved in muscular dystrophies
... antibiotic is currently used in human therapy against bacterial infections, and its pharmacokinetics properties and side effects are well characterized.17 However, one cannot exclude that a long-term use of gentamicin may induce other types of side effects due to generalized readthrough of normal te ...
... antibiotic is currently used in human therapy against bacterial infections, and its pharmacokinetics properties and side effects are well characterized.17 However, one cannot exclude that a long-term use of gentamicin may induce other types of side effects due to generalized readthrough of normal te ...
Table 3 - HAL Descartes
... are found in WS4 probands, while heterozygous family members occasionally present with some of the features 11-14; 4; 15-17. Dominant mutations of SOX10 have also been identified in WS4 18. SOX10 is a key transcription factor of neural crest development. It is crucial for the survival and maintenanc ...
... are found in WS4 probands, while heterozygous family members occasionally present with some of the features 11-14; 4; 15-17. Dominant mutations of SOX10 have also been identified in WS4 18. SOX10 is a key transcription factor of neural crest development. It is crucial for the survival and maintenanc ...
Ethanol exposure affects gene expression in the embryonic
... including microphthalmia. Using Xenopus embryos as a model developmental system, we show that ethanol exposure recapitulates many aspects of FAS, including a shortened rostro–caudal axis, microcephally and microphthalmia. Temporal analysis revealed that Xenopus embryos are most sensitive to ethanol ...
... including microphthalmia. Using Xenopus embryos as a model developmental system, we show that ethanol exposure recapitulates many aspects of FAS, including a shortened rostro–caudal axis, microcephally and microphthalmia. Temporal analysis revealed that Xenopus embryos are most sensitive to ethanol ...
Histological classification and molecular genetics of meningiomas
... progesterone receptor, but this remains unproven.4,5 Another well-defined cause in those with young onset and no sex predilection is neurofibromatosis type 2 (NF2). Meningiomas (besides schwannomas) are hallmark features of this autosomal dominant disorder caused by germline mutations in the NF2 gene ...
... progesterone receptor, but this remains unproven.4,5 Another well-defined cause in those with young onset and no sex predilection is neurofibromatosis type 2 (NF2). Meningiomas (besides schwannomas) are hallmark features of this autosomal dominant disorder caused by germline mutations in the NF2 gene ...
Hox patterning of the vertebrate axial skeleton
... Hoxb1, Hoxa2, Hoxb2) turn on during early gastrulation stages and more 5⬘ genes are expressed later in the tail bud, after anterior somites have formed. Comparisons between Hox gene expression patterns consistently demonstrated that the temporal delay of 5⬘ Hox gene expression, along with progressiv ...
... Hoxb1, Hoxa2, Hoxb2) turn on during early gastrulation stages and more 5⬘ genes are expressed later in the tail bud, after anterior somites have formed. Comparisons between Hox gene expression patterns consistently demonstrated that the temporal delay of 5⬘ Hox gene expression, along with progressiv ...
MOLECULAR BIOLOGY OF FRUIT MATURATION AND
... Fruit are an integral part of this endeavor and can be narrowly defined as mature carpels. This definition accurately describes the fruits of tomato, melons, and stone fruits, to name just a few. A more accurate and inclusive definition encompasses extracarpellary tissues that are included at the ma ...
... Fruit are an integral part of this endeavor and can be narrowly defined as mature carpels. This definition accurately describes the fruits of tomato, melons, and stone fruits, to name just a few. A more accurate and inclusive definition encompasses extracarpellary tissues that are included at the ma ...
Pharmacogenetics of warfarin: current status and future
... S-warfarin may also be metabolized by CYP2C8, CYP2C18 and CYP2C19 to form 4-hydroxywarfarin, although these are minor pathways.28 The genes encoding these P450 isoforms contain many functional polymorphisms. Two studies have so far found no effect of the CYP2C19*2 variant allele on warfarin therapy. ...
... S-warfarin may also be metabolized by CYP2C8, CYP2C18 and CYP2C19 to form 4-hydroxywarfarin, although these are minor pathways.28 The genes encoding these P450 isoforms contain many functional polymorphisms. Two studies have so far found no effect of the CYP2C19*2 variant allele on warfarin therapy. ...
Selection for TnlO Tet Repressor Binding to tet Operator
... We have constructed a genetic assay which selects positively for a functional interaction between Tet repressor and its cognate operator in Escherichia coli. In this strain Tet repressor blocks expression of lacl and lacZ. This leads to derepression of a lacPO controlled galK gene. The strain can be ...
... We have constructed a genetic assay which selects positively for a functional interaction between Tet repressor and its cognate operator in Escherichia coli. In this strain Tet repressor blocks expression of lacl and lacZ. This leads to derepression of a lacPO controlled galK gene. The strain can be ...
Loss of heterozygosity at D8S262: an early genetic event of
... genome-wide abnormalities, such as copy number changes that include loss of heterozygosity (LOH), deletions, and gene amplification events in various types of cancer, and localization of the regions of many oncogens and tumor suppressor genes (TSGs) [12–14]. Notably, the inactivation of TSGs has b ...
... genome-wide abnormalities, such as copy number changes that include loss of heterozygosity (LOH), deletions, and gene amplification events in various types of cancer, and localization of the regions of many oncogens and tumor suppressor genes (TSGs) [12–14]. Notably, the inactivation of TSGs has b ...
The Wnt code: cnidarians signal the way
... was introduced by the pioneering work of Cadet Hand (Hand and Uhlinger, 1992). Recent EST projects in these and some other cnidarian taxa have revealed an astonishing and unexpected genetic complexity of cnidarians. Analyses of ESTs from the anthozoans Acropora millepora and Nematostella vectensis h ...
... was introduced by the pioneering work of Cadet Hand (Hand and Uhlinger, 1992). Recent EST projects in these and some other cnidarian taxa have revealed an astonishing and unexpected genetic complexity of cnidarians. Analyses of ESTs from the anthozoans Acropora millepora and Nematostella vectensis h ...
Functional Interactions of Genes Mediating Convergent Extension
... least four members in the mouse, chick, and zebrafish, encode secreted signaling proteins that function in multiple patterning processes during animal embryogenesis (for review, see Hammerschmidt et al., 1997). Among the above family members, sonic hedgehog (shh) expression has been found in axial m ...
... least four members in the mouse, chick, and zebrafish, encode secreted signaling proteins that function in multiple patterning processes during animal embryogenesis (for review, see Hammerschmidt et al., 1997). Among the above family members, sonic hedgehog (shh) expression has been found in axial m ...
The Arabidopsis Protein SHI Represses
... but are generally poorly characterized at the genetic and molecular level. One exception is the response to GA in germinating cereal grains. The key response is the production of the hydrolytic enzyme ␣-amylase, which is synthesized in the aleurone cells during germination for breakdown and mobiliza ...
... but are generally poorly characterized at the genetic and molecular level. One exception is the response to GA in germinating cereal grains. The key response is the production of the hydrolytic enzyme ␣-amylase, which is synthesized in the aleurone cells during germination for breakdown and mobiliza ...
Role of two-component systems in the virulence of Streptococcus
... membrane-associated sensor histidine kinase (HK) and a cytoplasmic cognate response regulator (RR). Upon receipt of a specific external stimulus the kinase domain of the HK sensor protein is activated to autophosphorylate a conserved histidine residue. HK proteins tend to be found as homodimers that ...
... membrane-associated sensor histidine kinase (HK) and a cytoplasmic cognate response regulator (RR). Upon receipt of a specific external stimulus the kinase domain of the HK sensor protein is activated to autophosphorylate a conserved histidine residue. HK proteins tend to be found as homodimers that ...
Developing a Bioassay for Triclosan Toxicity Abstract
... impairment of cardiac and skeletal muscle observed by Cherednichenko et al (). Furthermore, the decrease of actin can also affect cell growth. Actin plays a critical role in the cytoskeleton and cell division. Actin’s interaction with myosin allows the microtubules to contract during cytokinesis. Th ...
... impairment of cardiac and skeletal muscle observed by Cherednichenko et al (). Furthermore, the decrease of actin can also affect cell growth. Actin plays a critical role in the cytoskeleton and cell division. Actin’s interaction with myosin allows the microtubules to contract during cytokinesis. Th ...
Exocrine Pancreatic Function
... days, and then fasted for 24 hours, refeeding for 15 minutes resulted in a small decrease in amino acid incorporation into protein in vivo 45 minutes after the meal, followed by a small increase 90 to 105 minutes after the meal (21). Other studies indicated that refeeding after prolonged fasting (48 ...
... days, and then fasted for 24 hours, refeeding for 15 minutes resulted in a small decrease in amino acid incorporation into protein in vivo 45 minutes after the meal, followed by a small increase 90 to 105 minutes after the meal (21). Other studies indicated that refeeding after prolonged fasting (48 ...