DNA Microarrays (Gene Chips) and Cancer - URMC
... expressed (turned on) in different cells under different conditions. When a gene is expressed, the genetic instructions coded in its DNA are transcribed (copied) to make messenger RNA (mRNA) molecules; then the coded instructions in messenger RNA are translated by the ribosome to make a specific pro ...
... expressed (turned on) in different cells under different conditions. When a gene is expressed, the genetic instructions coded in its DNA are transcribed (copied) to make messenger RNA (mRNA) molecules; then the coded instructions in messenger RNA are translated by the ribosome to make a specific pro ...
PcGs and Hox genes - Development
... et al., 1995; Justice et al., 1995). This phenotype is not observed for clones of any of the other PcG mutants. We find that in the absence of Psc-Su(z)2 or ph function, imaginal disc cells are larger than wild-type cells (data not shown) but additional studies will be needed to establish how cell g ...
... et al., 1995; Justice et al., 1995). This phenotype is not observed for clones of any of the other PcG mutants. We find that in the absence of Psc-Su(z)2 or ph function, imaginal disc cells are larger than wild-type cells (data not shown) but additional studies will be needed to establish how cell g ...
Microarrays and Cancer - URMC
... expressed (turned on) in different cells under different conditions. When a gene is expressed, the genetic instructions coded in its DNA are transcribed (copied) to make messenger RNA (mRNA) molecules; then the coded instructions in messenger RNA are translated by the ribosome to make a specific pro ...
... expressed (turned on) in different cells under different conditions. When a gene is expressed, the genetic instructions coded in its DNA are transcribed (copied) to make messenger RNA (mRNA) molecules; then the coded instructions in messenger RNA are translated by the ribosome to make a specific pro ...
New Phytologist Supporting Information Notes S1 Populus trichocarpa
... Fig. B Gene expression values were more similar between tissues than between individuals sampled. Higher expression values were reported within the leaf samples compared to the xylem samples (a and c). As expected, FPKM values were more similar between tissues than between individuals, and the simi ...
... Fig. B Gene expression values were more similar between tissues than between individuals sampled. Higher expression values were reported within the leaf samples compared to the xylem samples (a and c). As expected, FPKM values were more similar between tissues than between individuals, and the simi ...
Molecular genetics of macular dystrophies
... short arm of chromosome 1 in eight families.' This result is consistent with genetic homogeneity and suggests that possibly only one gene is involved in this form of the disorder. In contrast, several different genes have been implicated in the autosomal dominant form of the disease. Of families stu ...
... short arm of chromosome 1 in eight families.' This result is consistent with genetic homogeneity and suggests that possibly only one gene is involved in this form of the disorder. In contrast, several different genes have been implicated in the autosomal dominant form of the disease. Of families stu ...
Networks in leaf development
... of the promoter of one YABBY gene, FILAMENTOUS FLOWER (FIL), has revealed independent cis-acting sequences that promote the expression of FIL throughout the leaf primordium and repress FIL expression on the adaxial side of the leaf primordium. This demonstrates that FIL is actively excluded from the ...
... of the promoter of one YABBY gene, FILAMENTOUS FLOWER (FIL), has revealed independent cis-acting sequences that promote the expression of FIL throughout the leaf primordium and repress FIL expression on the adaxial side of the leaf primordium. This demonstrates that FIL is actively excluded from the ...
Autonomic regulation of islet hormone secretion
... vagus nerve releases acetylcholine from the preganglionic terminals in the ganglia which activates nicotinic receptors on the nerve cell bodies of the postganglionic nerves. This implies a nicotonic mechanism mediates vagally induced insulin secretion. Verification came from findings that nicotinic ...
... vagus nerve releases acetylcholine from the preganglionic terminals in the ganglia which activates nicotinic receptors on the nerve cell bodies of the postganglionic nerves. This implies a nicotonic mechanism mediates vagally induced insulin secretion. Verification came from findings that nicotinic ...
JunctionSeq Package User Manual
... broader array of isoform-regulation phenomena, as well as vastly improving the detection of differentials in unannotated isoforms. JunctionSeq is not designed to detect changes in overall gene expression. Gene-level differential expression is best detected with tools designed specifically for that p ...
... broader array of isoform-regulation phenomena, as well as vastly improving the detection of differentials in unannotated isoforms. JunctionSeq is not designed to detect changes in overall gene expression. Gene-level differential expression is best detected with tools designed specifically for that p ...
Mutations in type I collagen genes resulting in osteogenesis
... than their normal counterparts (Baker et al., 1989). Another consistent observation is the overmodification of the portions of the a-chains N-terminal to the mutation (Lehmann et al., 1995) as judged by the lower electrophoretic mobility of the collagen chains on SDS/PAGE (Fig. 2). Since post-transl ...
... than their normal counterparts (Baker et al., 1989). Another consistent observation is the overmodification of the portions of the a-chains N-terminal to the mutation (Lehmann et al., 1995) as judged by the lower electrophoretic mobility of the collagen chains on SDS/PAGE (Fig. 2). Since post-transl ...
Fig. 1 - Repositorio Académico
... Signaling of Dpp and Scw through Type I and Type II receptors leads to the phosphorylation of the Smad transcription factor, Mothers-againstdpp (Mad). Phosphorylated Mad forms a complex with a co-Smad, known as Medea, and both translocate into the nucleus to activate transcription of a number of dow ...
... Signaling of Dpp and Scw through Type I and Type II receptors leads to the phosphorylation of the Smad transcription factor, Mothers-againstdpp (Mad). Phosphorylated Mad forms a complex with a co-Smad, known as Medea, and both translocate into the nucleus to activate transcription of a number of dow ...
Factors Affecting synonymous codon Usage Bias in chloroplast
... plant nuclear genes and in chloroplasts.32 Chloroplasts differ from the nuclear genome of higher plants in that they encode only 30 tRNA species. Since chloroplasts have restricted their tRNA genes, the use of preferred codons by chloroplast encoded proteins appears more extreme. However, a positive ...
... plant nuclear genes and in chloroplasts.32 Chloroplasts differ from the nuclear genome of higher plants in that they encode only 30 tRNA species. Since chloroplasts have restricted their tRNA genes, the use of preferred codons by chloroplast encoded proteins appears more extreme. However, a positive ...
Gadd45g Is Essential for Primary Sex Determination, Male
... other intracellular proteins, including p21 [1,2], PCNA [1,2], CRIF [3], CDK1 [4] and the MAP kinases p38 [5] and MAP3K4 [6]. They are implicated in the regulation of apoptosis, survival, senescence, cell cycle control, DNA repair and the response to physiological or environmental stress in mammalia ...
... other intracellular proteins, including p21 [1,2], PCNA [1,2], CRIF [3], CDK1 [4] and the MAP kinases p38 [5] and MAP3K4 [6]. They are implicated in the regulation of apoptosis, survival, senescence, cell cycle control, DNA repair and the response to physiological or environmental stress in mammalia ...
Analysis continued Each TopHat run will result in four files: a list of
... an exon that was predicted by the output from CuffLinks was actually seen in the reference. The Sn and Sp columns calculate sensitivity (the proportion of exons, for example, that have been correctly identified) and specificity (the proportion of predicted exons that are annotated as such in the ref ...
... an exon that was predicted by the output from CuffLinks was actually seen in the reference. The Sn and Sp columns calculate sensitivity (the proportion of exons, for example, that have been correctly identified) and specificity (the proportion of predicted exons that are annotated as such in the ref ...
PDF
... che-1 and nhr-67 reporter genes were created using λ-Red-mediated recombineering in bacteria as described (Dolphin and Hope, 2006; Tursun et al., 2009). Briefly, the che-1-containing fosmid (WRM066bC03) and the nhr-67-containing fosmid (WRM0613bE08) were each electroporated and maintained in the E. ...
... che-1 and nhr-67 reporter genes were created using λ-Red-mediated recombineering in bacteria as described (Dolphin and Hope, 2006; Tursun et al., 2009). Briefly, the che-1-containing fosmid (WRM066bC03) and the nhr-67-containing fosmid (WRM0613bE08) were each electroporated and maintained in the E. ...
Association between IGF1R / i16 / TaqI and IGF1 / SnaBI
... understandable. Comparing the sequences of primers designed by Moody et al. [1996] with NCBI reference sequence AC_000178.1 revealed that primers flanking the 625 bp fragment of bovine IGF1R gene are located in the exon 12 (forward primer) and 13 (reverse primer) and that polymorphism mentioned is l ...
... understandable. Comparing the sequences of primers designed by Moody et al. [1996] with NCBI reference sequence AC_000178.1 revealed that primers flanking the 625 bp fragment of bovine IGF1R gene are located in the exon 12 (forward primer) and 13 (reverse primer) and that polymorphism mentioned is l ...
Physiological Genomics of Antidepressant Targets: Keeping the
... proteins in cotransfection studies, perhaps explaining how the heterozygosity of our probands results in such a profound phenotype (M. Hahn and R. D. Blakely, unpublished observations). We suspect that other subjects with OI-like phenotypes may harbor additional nonsynonymous NET mutations or have a ...
... proteins in cotransfection studies, perhaps explaining how the heterozygosity of our probands results in such a profound phenotype (M. Hahn and R. D. Blakely, unpublished observations). We suspect that other subjects with OI-like phenotypes may harbor additional nonsynonymous NET mutations or have a ...
Clinical and genetic patterns ofneurofibromatosis 1 and 2
... The NF 1 gene is one of the largest genes to code for a disease in humans, spanning 300 kb of genomic DNA (see Fig 5). The NF1 promoter region consists of a CpG rich region characteristic of housekeeping genes. The NFl gene contains 49 exons (coding portions) which, after transcription, form a messe ...
... The NF 1 gene is one of the largest genes to code for a disease in humans, spanning 300 kb of genomic DNA (see Fig 5). The NF1 promoter region consists of a CpG rich region characteristic of housekeeping genes. The NFl gene contains 49 exons (coding portions) which, after transcription, form a messe ...
Evaluation of TMPRSS2-ERG Fusion Protein in
... The incidence of prostate cancer is 30 times more prevalent in North American vs. Asian populations. Chromosomal translocations involving the ETS transcription factors, such as ERG and ETV1, are frequent events in human prostate cancer pathogenesis. In particular, the TMPRSS2-ERG fusion gene has rec ...
... The incidence of prostate cancer is 30 times more prevalent in North American vs. Asian populations. Chromosomal translocations involving the ETS transcription factors, such as ERG and ETV1, are frequent events in human prostate cancer pathogenesis. In particular, the TMPRSS2-ERG fusion gene has rec ...
The Genetics of Beta-galactosidase
... The lac Operon from a Historical Perspective The operon model defined by Jacob and Monod (1961) was a significant development. The suggestion that there can be coordinated control of the expression of multiple genes led researchers to search for similar genetic units controlling other enzyme systems ...
... The lac Operon from a Historical Perspective The operon model defined by Jacob and Monod (1961) was a significant development. The suggestion that there can be coordinated control of the expression of multiple genes led researchers to search for similar genetic units controlling other enzyme systems ...
Hypertriglyceridemia - London Health Sciences Centre
... Inhibit HMG-CoA reductae, not 1st line with TG >5 mmol/L as monotherapy Safety profile appropriate combo with fibrate as FIELD showed no ...
... Inhibit HMG-CoA reductae, not 1st line with TG >5 mmol/L as monotherapy Safety profile appropriate combo with fibrate as FIELD showed no ...
fragile x dna testing: a guide for physicians and families
... of many sizes using certain enzymes, which recognize and cleave at specific DNA sequences. Among the millions of DNA fragments that result are some containing the section of the FMR1 gene with the CGG repeat. When there is no mutation, these FMR1 fragments are of a single known size. If a mutation i ...
... of many sizes using certain enzymes, which recognize and cleave at specific DNA sequences. Among the millions of DNA fragments that result are some containing the section of the FMR1 gene with the CGG repeat. When there is no mutation, these FMR1 fragments are of a single known size. If a mutation i ...
Xylitol production using recombinant Saccharomyces
... 40 copies of the XYL1 gene on the chromosome, was obtained by a sequential transformation using a dominant selection marker neo r and an auxotrophic marker URA3. The multiple XYL1 genes were stably maintained on the chromosome even after 21 and 10 days in the non-selective sequential batch and chemo ...
... 40 copies of the XYL1 gene on the chromosome, was obtained by a sequential transformation using a dominant selection marker neo r and an auxotrophic marker URA3. The multiple XYL1 genes were stably maintained on the chromosome even after 21 and 10 days in the non-selective sequential batch and chemo ...
A genome-wide association study identifies an osteoarthritis
... authors and do not necessarily represent the official position or policies of the Tufts Clinical and Translational Science Institute. Supported by the Research Institute for Diseases in the Elderly (RIDE2) (014-93-015), The Netherlands Genomics Initiative (NGI)/Netherlands Organization for Scientifi ...
... authors and do not necessarily represent the official position or policies of the Tufts Clinical and Translational Science Institute. Supported by the Research Institute for Diseases in the Elderly (RIDE2) (014-93-015), The Netherlands Genomics Initiative (NGI)/Netherlands Organization for Scientifi ...
Detection of mutation status of IgVH genes and minimal residual
... disease. The fact that overall survival was inferior for the subgroups with unmutated IgVH, 11q-, or 17p-, suggests that response to therapy may be different in genetic subgroups[19-21]. In particular, the deletion 17p- and -possibly- abnormalities of the p53 gene involved in this aberration have be ...
... disease. The fact that overall survival was inferior for the subgroups with unmutated IgVH, 11q-, or 17p-, suggests that response to therapy may be different in genetic subgroups[19-21]. In particular, the deletion 17p- and -possibly- abnormalities of the p53 gene involved in this aberration have be ...
Ehlers-Danlos syndrome type VIIA and VIIB result from splice
... the pepsin-sensitive site (Phe-Ala; Fig. 5). At the genomic level, this cell strain contained a point mutation in the splice acceptor site (AG→GG; Fig. 5), which allowed the use of the cryptic 38-splice site (AG) at position 14,15 of the exon (Fig. 6). The mutation in this family resulted in loss of ...
... the pepsin-sensitive site (Phe-Ala; Fig. 5). At the genomic level, this cell strain contained a point mutation in the splice acceptor site (AG→GG; Fig. 5), which allowed the use of the cryptic 38-splice site (AG) at position 14,15 of the exon (Fig. 6). The mutation in this family resulted in loss of ...