PPTX - Bioinformatics.ca
... depends on the # of tests that you do, so, no matter what, the more tests you do, the more sensitive the test needs to be • Can control the stringency by reducing the number of tests: e.g. use GO slim; restrict testing to the appropriate GO annotations; or select only larger GO categories. Module 2 ...
... depends on the # of tests that you do, so, no matter what, the more tests you do, the more sensitive the test needs to be • Can control the stringency by reducing the number of tests: e.g. use GO slim; restrict testing to the appropriate GO annotations; or select only larger GO categories. Module 2 ...
Candidate Genetic Risk Factors of Stroke: Results of a Multilocus
... patients who suffered an acute ischemic stroke (n ⫽ 358; 80%) or TIA (n ⫽ 92; 20%) before the age of 60 years [168 female, 282 male; median age 52 years; interquartile range (IQR) 45–57 years] who were documented in the Vienna Stroke Registry (7, 8 ). Diagnoses were established clinically (9 ), and ...
... patients who suffered an acute ischemic stroke (n ⫽ 358; 80%) or TIA (n ⫽ 92; 20%) before the age of 60 years [168 female, 282 male; median age 52 years; interquartile range (IQR) 45–57 years] who were documented in the Vienna Stroke Registry (7, 8 ). Diagnoses were established clinically (9 ), and ...
SHORT COMMUNICATION One-step multiplex RT-PCR
... The patient who was negative for BCR/ABL had clinical features and peripheral blood film suggestive of chronic myeloproliferative disease. Her condition was complicated by carcinoma of the breast that developed later. The use of conventional cytogenetic analysis has complemented PCR at initial diagn ...
... The patient who was negative for BCR/ABL had clinical features and peripheral blood film suggestive of chronic myeloproliferative disease. Her condition was complicated by carcinoma of the breast that developed later. The use of conventional cytogenetic analysis has complemented PCR at initial diagn ...
Overexpression of a Knotted-Like Homeobox Gene of Potato Alters
... elements in regulatory regions of the GA 20-oxidase gene of tobacco to suppress its activity (Sakamoto et al., 2001). The results of this study demonstrate that a potato (Solanum tuberosum) homeobox gene, POTH1, is involved in vegetative pattern formation, accompanied by a decrease in GA levels. On ...
... elements in regulatory regions of the GA 20-oxidase gene of tobacco to suppress its activity (Sakamoto et al., 2001). The results of this study demonstrate that a potato (Solanum tuberosum) homeobox gene, POTH1, is involved in vegetative pattern formation, accompanied by a decrease in GA levels. On ...
The Gene Gateway Workbook
... - Learn about the genetic disorder and its associated gene. - Identify mutations that cause the disorder. Online Mendelian Inheritance in Man (OMIM) OMIM is a large, searchable, up-to-date database of human genes, genetic traits, and disorders created and edited by researchers at Johns Hopkins Unive ...
... - Learn about the genetic disorder and its associated gene. - Identify mutations that cause the disorder. Online Mendelian Inheritance in Man (OMIM) OMIM is a large, searchable, up-to-date database of human genes, genetic traits, and disorders created and edited by researchers at Johns Hopkins Unive ...
Document
... Very small RNAs are gene regulators in many eukaryotes. The first example was discovered in the nematode C. elegans as the result of the interaction between the regulator gene lin4 and its target gene, lin14 (Fig. 13.19). The lin4 RNA is an example of a microRNA (miRNA). There are ~80 genes i ...
... Very small RNAs are gene regulators in many eukaryotes. The first example was discovered in the nematode C. elegans as the result of the interaction between the regulator gene lin4 and its target gene, lin14 (Fig. 13.19). The lin4 RNA is an example of a microRNA (miRNA). There are ~80 genes i ...
Structure, expression differentiation and evolution of duplicated fiber
... G. hirsutum while simultaneously maintaining its high fiber yield [4]. The cotton fiber is a single cell without the complex cell division and multicellular development that develops from ovule’s epidermal cells. Fiber development occurs in four distinct, but overlapping stages: initiation, elongati ...
... G. hirsutum while simultaneously maintaining its high fiber yield [4]. The cotton fiber is a single cell without the complex cell division and multicellular development that develops from ovule’s epidermal cells. Fiber development occurs in four distinct, but overlapping stages: initiation, elongati ...
Origin of New Genes: Evidence from Experimental
... ficant coding potential. The coding ability inherited from the parental gene has been rapidly eliminated by a series of sequence changes, including a change in the start codon, introduction of a stop codon in the original reading frame, and several deletions causing frameshift mutations. Second, it ...
... ficant coding potential. The coding ability inherited from the parental gene has been rapidly eliminated by a series of sequence changes, including a change in the start codon, introduction of a stop codon in the original reading frame, and several deletions causing frameshift mutations. Second, it ...
Multifactorial Traits - U
... then eye color might be a candidate. One model of how different eye colors arise considers two genes with two alleles each, that interact additively to produce five eye colors—light blue, deep blue or green, light brown, medium brown, and dark brown/black. (It seems that manufacturers of mascara foll ...
... then eye color might be a candidate. One model of how different eye colors arise considers two genes with two alleles each, that interact additively to produce five eye colors—light blue, deep blue or green, light brown, medium brown, and dark brown/black. (It seems that manufacturers of mascara foll ...
Touring Ensembl: A practical guide to genome browsing Open Access
... [12-14]. Within only 200 bp upstream of the translational start site, binding sites for proteins such as NF-κB, AP-1, and NFAT (nuclear factor of activated T-cells), DNase I hypersensitive sites and a TATA box can all be found. These regions have been shown to be involved in the control of T-cell me ...
... [12-14]. Within only 200 bp upstream of the translational start site, binding sites for proteins such as NF-κB, AP-1, and NFAT (nuclear factor of activated T-cells), DNase I hypersensitive sites and a TATA box can all be found. These regions have been shown to be involved in the control of T-cell me ...
GENE EXPRESSION
... the most part, is then translated into protein. Control mechanisms are exercised along the way. Without some control of gene expression, an Escherichia coli cell, for example, would produce all its proteins in large quantities all the time, and all the cells in a eukaryotic organism would be identic ...
... the most part, is then translated into protein. Control mechanisms are exercised along the way. Without some control of gene expression, an Escherichia coli cell, for example, would produce all its proteins in large quantities all the time, and all the cells in a eukaryotic organism would be identic ...
High mutation rates in human and ape pseudoautosomal genes
... ectopic recombination with homologous sequences in the subtelomeric regions of the other chromosomes (Mefford and Trask, 2002). Human X and Y chromosomes pair and recombine in two small pseudoautosomal regions (PARs) at both ends of the sex chromosomes (Cooke et al., 1985; Freije et al., 1992). The ...
... ectopic recombination with homologous sequences in the subtelomeric regions of the other chromosomes (Mefford and Trask, 2002). Human X and Y chromosomes pair and recombine in two small pseudoautosomal regions (PARs) at both ends of the sex chromosomes (Cooke et al., 1985; Freije et al., 1992). The ...
Gene Section USF1 (upstream transcription factor 1) Atlas of Genetics and Cytogenetics
... characteristically show elevation of both cholesterol and triglycerides in the blood, which is due to increased VLDL and LDL levels. This is often accompanied by elevated apoB100 and low HDL levels, and a preponderance of small dense LDL particles (Naukkarinen et al., 2006). FCHL is genetically hete ...
... characteristically show elevation of both cholesterol and triglycerides in the blood, which is due to increased VLDL and LDL levels. This is often accompanied by elevated apoB100 and low HDL levels, and a preponderance of small dense LDL particles (Naukkarinen et al., 2006). FCHL is genetically hete ...
Comparison between Human and Mouse genomes
... Automated partial DNA sequencing was conducted on more than 600 randomly selected human brain complementary DNA (cDNA) clones to generate expressed sequence tags (ESTs). ESTs have applications in the discovery of new human genes, mapping of the human genome, and identification of coding regions in g ...
... Automated partial DNA sequencing was conducted on more than 600 randomly selected human brain complementary DNA (cDNA) clones to generate expressed sequence tags (ESTs). ESTs have applications in the discovery of new human genes, mapping of the human genome, and identification of coding regions in g ...
Allelic Frequencies of Hla-A, Hla-B and Hla
... The definitive treatment of patients with ACT is surgical resection, and the prognosis correlates negatively with the size of the tumor [4,9]. The increased incidence of childhood ACT in the South and Southeast regions of Brazil has been widely documented. However, the factors associated with thi ...
... The definitive treatment of patients with ACT is surgical resection, and the prognosis correlates negatively with the size of the tumor [4,9]. The increased incidence of childhood ACT in the South and Southeast regions of Brazil has been widely documented. However, the factors associated with thi ...
PDF
... that Wingless has two functions in the leg disc. In the specification of ventral fate, our data indicate that Wingless does not function as a morphogen but instead appears to collaborate with other factors. In addition to its role in ventral fate specification, Wingless inhibits the commitment of do ...
... that Wingless has two functions in the leg disc. In the specification of ventral fate, our data indicate that Wingless does not function as a morphogen but instead appears to collaborate with other factors. In addition to its role in ventral fate specification, Wingless inhibits the commitment of do ...
Boundary elements and nuclear organization
... in Grewal and Moazed, 2003). On the other hand, the euchromatic or transcriptionally competent state is associated with hyperacetylation of H3 lysines 9 and 14 and methylation of H3 lysine 4. Hyperacetylation of histones is thus correlated with transcriptional activation and is thought to aid in the ...
... in Grewal and Moazed, 2003). On the other hand, the euchromatic or transcriptionally competent state is associated with hyperacetylation of H3 lysines 9 and 14 and methylation of H3 lysine 4. Hyperacetylation of histones is thus correlated with transcriptional activation and is thought to aid in the ...
5_triiodothyronine-down-regulates-thyrotropin-releasing
... on islet ppTRH messenger RNA (mRNA) concentrations, the TRH and pTRH-(160 –169) contents and secretions, together with the concomitant regulation of insulin synthesis and secretion. Materials and Methods Preparation of islets Fetal islets were prepared as described by Hellerström et al. (19). Brief ...
... on islet ppTRH messenger RNA (mRNA) concentrations, the TRH and pTRH-(160 –169) contents and secretions, together with the concomitant regulation of insulin synthesis and secretion. Materials and Methods Preparation of islets Fetal islets were prepared as described by Hellerström et al. (19). Brief ...
Waleed Abdellatief Abd elhleem _paper manuscript
... In our study when we analyzed the genotypic distribution among the different degrees of activity of SLE, TNF-α genotypes showed significant differences between various SLEDAI activity grades and these results were in accordance with a study done by Santos and colleagues (2011) [21] in Portuguese pop ...
... In our study when we analyzed the genotypic distribution among the different degrees of activity of SLE, TNF-α genotypes showed significant differences between various SLEDAI activity grades and these results were in accordance with a study done by Santos and colleagues (2011) [21] in Portuguese pop ...
Vectors: The carriers of DNA molecules DNA vectors and their
... replication. This region of phage can be deleted or replaced without seriously impairing the phage growth cycle. Using this non-essential region of phage ë, several phage vector derivatives have been constructed for efficient gene cloning. Types of phage vectors Wild type phage DNA itself cannot be ...
... replication. This region of phage can be deleted or replaced without seriously impairing the phage growth cycle. Using this non-essential region of phage ë, several phage vector derivatives have been constructed for efficient gene cloning. Types of phage vectors Wild type phage DNA itself cannot be ...
Leukaemia Section t(3;12)(q26;p13) ETV6/MECOM / t(3;12)(q26;p13) ETV6/EVI1 Atlas of Genetics and Cytogenetics
... MECOM is a "complex entity" made of two genes, EVI1 and MDS1. EVI1 has 16 exons, of which 14 are coding, the start ATG codons being in exon 3. MDS1 has 4 exons, exon 4 being located in the vicinity of exon 1 of EVI1. Splicing of the second exon of MDS1 to the second exon of EVI1 leads to a MDS1-EVI1 ...
... MECOM is a "complex entity" made of two genes, EVI1 and MDS1. EVI1 has 16 exons, of which 14 are coding, the start ATG codons being in exon 3. MDS1 has 4 exons, exon 4 being located in the vicinity of exon 1 of EVI1. Splicing of the second exon of MDS1 to the second exon of EVI1 leads to a MDS1-EVI1 ...
The chromatin remodelling factor Brg1 interacts with catenin to
... mediates transcriptional activation by virtue of potent transactivation domains present in the C-terminus of b-catenin (van de Wetering et al., 1997; Hecht et al., 1999). In the absence of nuclear b-catenin, Tcf factors occupy target gene promoters in a complex with p300/ CBP, CtBP and members of th ...
... mediates transcriptional activation by virtue of potent transactivation domains present in the C-terminus of b-catenin (van de Wetering et al., 1997; Hecht et al., 1999). In the absence of nuclear b-catenin, Tcf factors occupy target gene promoters in a complex with p300/ CBP, CtBP and members of th ...
Gene tree reconstruction and orthology analysis based on
... and reconciliation, are problems important in multigenomebased comparative genomics and biology in general. In the present paper, we advance the frontier of these areas in several respects and provide important computational tools. First, exact algorithms are given for several probabilistic reconcil ...
... and reconciliation, are problems important in multigenomebased comparative genomics and biology in general. In the present paper, we advance the frontier of these areas in several respects and provide important computational tools. First, exact algorithms are given for several probabilistic reconcil ...
Genomic Research to Identify Novel Pathways in the Development
... 2.1. Candidate Gene Approaches. The “common-disease common-variant” hypothesis poses that common complex diseases arise from the accumulation of genetic variants, each with a modest effect on risk (low penetrance) and environmental risk factors [22, 23]. It is this hypothesis that has underpinned the ...
... 2.1. Candidate Gene Approaches. The “common-disease common-variant” hypothesis poses that common complex diseases arise from the accumulation of genetic variants, each with a modest effect on risk (low penetrance) and environmental risk factors [22, 23]. It is this hypothesis that has underpinned the ...