Efficient Ends-Out Gene Targeting In Drosophila
... although for long-term stock maintenance, we recommend 18ºC. Males of Y.hs-hid are slightly weaker due to having two copies of hs-hid genes, so culturing stocks under 25ºC is not recommended. It is important to keep vials and bottles from being overcrowded since Y.hs-hid males may not survive very w ...
... although for long-term stock maintenance, we recommend 18ºC. Males of Y.hs-hid are slightly weaker due to having two copies of hs-hid genes, so culturing stocks under 25ºC is not recommended. It is important to keep vials and bottles from being overcrowded since Y.hs-hid males may not survive very w ...
BROWSING GENES AND GENOMES WITH ENSEMBL
... Oct;41(10):1116-21.) the following twelve variants are shown to be associated with prostate cancer susceptibility: rs10993994, rs2735839, rs4242384, rs6983267, rs7931342, rs7501939, rs9364554, rs6465657, rs5945619, rs2660753, rs1016343, rs1859962. Use BioMart to generate a list of the genes to which ...
... Oct;41(10):1116-21.) the following twelve variants are shown to be associated with prostate cancer susceptibility: rs10993994, rs2735839, rs4242384, rs6983267, rs7931342, rs7501939, rs9364554, rs6465657, rs5945619, rs2660753, rs1016343, rs1859962. Use BioMart to generate a list of the genes to which ...
Adverse Effects of Excessive Leucine Intake Depend on Dietary
... adverse effects of excessive leucine (Leu) in Sprague-Dawley rats by DNA microarray. It has long been known that the adverse effects of excessive amino acid intake depend on dietary protein levels. Male rats were divided into 12 groups (n56) and fed for 1 wk a diet containing low (6%), moderate (12% ...
... adverse effects of excessive leucine (Leu) in Sprague-Dawley rats by DNA microarray. It has long been known that the adverse effects of excessive amino acid intake depend on dietary protein levels. Male rats were divided into 12 groups (n56) and fed for 1 wk a diet containing low (6%), moderate (12% ...
Plant–nematode interactions
... roles in plant parasitism are likely to be those with homology to microbial genes or that have no homologs in current databases. At present, genetic analysis is not a viable approach for determining the role of these genes but other techniques have promise. In situ hybridization has been applied ext ...
... roles in plant parasitism are likely to be those with homology to microbial genes or that have no homologs in current databases. At present, genetic analysis is not a viable approach for determining the role of these genes but other techniques have promise. In situ hybridization has been applied ext ...
Connective Tissue Disorders 61 Gene Panel
... Depending on which organs and tissues are affected, the signs and symptoms of cutis laxa can range from mild to life-threatening. Ehlers-Danlos Syndromes (EDS) are a group of disorders which share common features including easy bruising, loose joints, skin that stretches easily and weakness of tissu ...
... Depending on which organs and tissues are affected, the signs and symptoms of cutis laxa can range from mild to life-threatening. Ehlers-Danlos Syndromes (EDS) are a group of disorders which share common features including easy bruising, loose joints, skin that stretches easily and weakness of tissu ...
answers
... in lecture to test why Ubx showed different expression patterns in the two species. In that case we used the Artemia and Homarus enhancers to control the expression of lacZ. Imagine instead that we replace both copies of the endogenous Ubx gene (that includes the coding region plus enhancers) with t ...
... in lecture to test why Ubx showed different expression patterns in the two species. In that case we used the Artemia and Homarus enhancers to control the expression of lacZ. Imagine instead that we replace both copies of the endogenous Ubx gene (that includes the coding region plus enhancers) with t ...
Somatic MEN1 gene mutation does not contribute
... sequence of MEN1 (10). Recently, in a sample of 31 sporadic tumours, Tanaka et al. detected only 1 nonsense mutation in a GH/PRL adenoma with LOH in 11q13 (11). These results are disturbing taking into account that Boggild et al. found LOH on chromosome 11 in as many as about 20% of 88 sporadic aden ...
... sequence of MEN1 (10). Recently, in a sample of 31 sporadic tumours, Tanaka et al. detected only 1 nonsense mutation in a GH/PRL adenoma with LOH in 11q13 (11). These results are disturbing taking into account that Boggild et al. found LOH on chromosome 11 in as many as about 20% of 88 sporadic aden ...
Structural maintenance of chromosome complexes and bone
... estrogen-responsive genes, pointing out a possible collaboration between it and ESR1. Furthermore, depletion of the cohesin subunit SMC3 significantly impaired the estrogenregulated transcriptome.43 Taken together, these findings suggest that cohesin modifies the higher-order structure of chromatin ...
... estrogen-responsive genes, pointing out a possible collaboration between it and ESR1. Furthermore, depletion of the cohesin subunit SMC3 significantly impaired the estrogenregulated transcriptome.43 Taken together, these findings suggest that cohesin modifies the higher-order structure of chromatin ...
A Maize Glutaredoxin Gene, Abphyl2, Regulates
... are predominantly expressed throughout the SAM, except in incipient leaf primordia (Jackson et al., 1994; Long et al., 1996). Mutations in KNOX genes lead to smaller or terminated meristems (Long et al., 1996; Kerstetter et al., 1997; Vollbrecht et al., 2000), demonstrating their positive roles in m ...
... are predominantly expressed throughout the SAM, except in incipient leaf primordia (Jackson et al., 1994; Long et al., 1996). Mutations in KNOX genes lead to smaller or terminated meristems (Long et al., 1996; Kerstetter et al., 1997; Vollbrecht et al., 2000), demonstrating their positive roles in m ...
Identification and Microsatellite Markers of a Resistance Gene to
... identified. Genetic analysis of resistance to powdery mildew in BC3F2 population and derived BC3F3 families indicated a single dominant gene controlled the resistance. By bulk segregation analysis, two microsatellite markers, Xgwm311 and Xgwm382, were identified to be closely linked to the resistanc ...
... identified. Genetic analysis of resistance to powdery mildew in BC3F2 population and derived BC3F3 families indicated a single dominant gene controlled the resistance. By bulk segregation analysis, two microsatellite markers, Xgwm311 and Xgwm382, were identified to be closely linked to the resistanc ...
Mendelian and Non-Mendelian Regulation of Gene Expression in
... between the population and the parents. We first focused on the expression levels of 22,242 genes that were detected in both parents and at least 90% of the IBM RILs. The mean expression levels in the RILs were similar to the mid-parent values for most genes (Figure 1B). Transgressive segregation, d ...
... between the population and the parents. We first focused on the expression levels of 22,242 genes that were detected in both parents and at least 90% of the IBM RILs. The mean expression levels in the RILs were similar to the mid-parent values for most genes (Figure 1B). Transgressive segregation, d ...
beautiful bicolours - tuxedo and magpie cats
... conditions in some rabbits upholds this). Black feet could indicate a black domain that has been pushed to the foot extremity by the expansion of the ventral region at the same time that the limbs are being formed. Many cats have patches which look as though they could be fitted together like jigsa ...
... conditions in some rabbits upholds this). Black feet could indicate a black domain that has been pushed to the foot extremity by the expansion of the ventral region at the same time that the limbs are being formed. Many cats have patches which look as though they could be fitted together like jigsa ...
Divergent evolution of oxidosqualene cyclases in plants
... metabolism (e.g. cytochrome P450s, glycosyltransferases, acyltransferases, prenyltransferases) have commonly expanded, and the different members have acquired new functions by shifting or broadening substrate and ⁄ or product specificity (Vogt & Jones, 2000; Suzuki et al., 2004; Matsuno et al., 2009 ...
... metabolism (e.g. cytochrome P450s, glycosyltransferases, acyltransferases, prenyltransferases) have commonly expanded, and the different members have acquired new functions by shifting or broadening substrate and ⁄ or product specificity (Vogt & Jones, 2000; Suzuki et al., 2004; Matsuno et al., 2009 ...
VegT activates Bix4 to specify endodermal
... within the oocyte. Prominent among these are the RNAs encoding Vg1, a member of the TGF-β family (Rebagliati et al., 1985; Weeks and Melton, 1987), and VegT (Horb and Thomsen, 1997; Lustig et al., 1996; Stennard et al., 1996; Zhang and King, 1996) a member of the T-box family of transcription factor ...
... within the oocyte. Prominent among these are the RNAs encoding Vg1, a member of the TGF-β family (Rebagliati et al., 1985; Weeks and Melton, 1987), and VegT (Horb and Thomsen, 1997; Lustig et al., 1996; Stennard et al., 1996; Zhang and King, 1996) a member of the T-box family of transcription factor ...
The Jumping SHOX Gene—Crossover in the Pseudoautosomal
... percentage could be due to the fact that males with LWD are overrepresented in the families. The possibility of a crossing over seems not to be dependent on the kind of abnormality in PAR1. Flanagan et al. (16) described one family with at least a deletion of the whole SHOX gene and one family with ...
... percentage could be due to the fact that males with LWD are overrepresented in the families. The possibility of a crossing over seems not to be dependent on the kind of abnormality in PAR1. Flanagan et al. (16) described one family with at least a deletion of the whole SHOX gene and one family with ...
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... Sin3, SMRT (silencing mediator of retinoic acid and thyroid hormone receptor) or NCoR (nuclear receptor co-repressor) [14–18]. Recruitment of HDAC by these factors results in deacetylation of histone tails and transcriptional repression. Recently I characterized a transcriptional repressor for rat v ...
... Sin3, SMRT (silencing mediator of retinoic acid and thyroid hormone receptor) or NCoR (nuclear receptor co-repressor) [14–18]. Recruitment of HDAC by these factors results in deacetylation of histone tails and transcriptional repression. Recently I characterized a transcriptional repressor for rat v ...
Divergent evolution of oxidosqualene cyclases in plants
... metabolism (e.g. cytochrome P450s, glycosyltransferases, acyltransferases, prenyltransferases) have commonly expanded, and the different members have acquired new functions by shifting or broadening substrate and ⁄ or product specificity (Vogt & Jones, 2000; Suzuki et al., 2004; Matsuno et al., 2009 ...
... metabolism (e.g. cytochrome P450s, glycosyltransferases, acyltransferases, prenyltransferases) have commonly expanded, and the different members have acquired new functions by shifting or broadening substrate and ⁄ or product specificity (Vogt & Jones, 2000; Suzuki et al., 2004; Matsuno et al., 2009 ...
TBK1 Gene Duplication and Normal
... determined by examination with a CGH microarray. The duplication encompasses 370 kilobase pairs (kbp), extends from 64 563 to 64 933 kbp, and spans the TBK1 gene and part of the XPOT gene (Figure 1). ...
... determined by examination with a CGH microarray. The duplication encompasses 370 kilobase pairs (kbp), extends from 64 563 to 64 933 kbp, and spans the TBK1 gene and part of the XPOT gene (Figure 1). ...
Turning floral organs into leaves, leaves into floral organs Koji Goto
... Smyth [20••] have demonstrated that CRABS CLAW (CRC) and SPATULA (SPT) act in an AG-independent manner to promote several aspects of carpel differentiation. Both spt and crc mutations have a phenotypic effect in an ABC triple mutant background, reducing the amount and type of carpel tissues that dev ...
... Smyth [20••] have demonstrated that CRABS CLAW (CRC) and SPATULA (SPT) act in an AG-independent manner to promote several aspects of carpel differentiation. Both spt and crc mutations have a phenotypic effect in an ABC triple mutant background, reducing the amount and type of carpel tissues that dev ...
Is HP1 an RNA detector that functions both in repression and
... repressed sites. Nuclease hypersensitivity mapping studies on transgenes inserted into heterochromatin support this assumption (Wallrath and Elgin, 1995; Cryderman et al., 1999). However, the majority of studies of HP1 regulation have relied on phenotypic assays (such as position effect variegation) ...
... repressed sites. Nuclease hypersensitivity mapping studies on transgenes inserted into heterochromatin support this assumption (Wallrath and Elgin, 1995; Cryderman et al., 1999). However, the majority of studies of HP1 regulation have relied on phenotypic assays (such as position effect variegation) ...
You Light Up My Life
... • Alleles at a single locus may have effects on two or more traits • Classic example is the effects of the mutant allele at the beta-globin locus that gives rise to sickle-cell anemia ...
... • Alleles at a single locus may have effects on two or more traits • Classic example is the effects of the mutant allele at the beta-globin locus that gives rise to sickle-cell anemia ...
CHAPTER 2 Genome Sequence Acquisition and
... Epidemiologic studies suggest that 30 to 70% of the variation in body weight may be attributable to genetic factors. Hager et al. (1998) undertook a genomewide scan in affected sib pairs to identify chromosomal regions linked to obesity in a collection of French families. Model-free multipoint linka ...
... Epidemiologic studies suggest that 30 to 70% of the variation in body weight may be attributable to genetic factors. Hager et al. (1998) undertook a genomewide scan in affected sib pairs to identify chromosomal regions linked to obesity in a collection of French families. Model-free multipoint linka ...
Transgene inheritance in plants
... a low copy number and the transgenes are transmitted to progeny according to Mendelian (HORSCH et al. 1984, BUDAR et al. 1986) and in some cases non-Mendelian inheritance (DEROLES, GARDNER 1988). The characteristic features of the transgene integration pattern resulting from DNA delivery through par ...
... a low copy number and the transgenes are transmitted to progeny according to Mendelian (HORSCH et al. 1984, BUDAR et al. 1986) and in some cases non-Mendelian inheritance (DEROLES, GARDNER 1988). The characteristic features of the transgene integration pattern resulting from DNA delivery through par ...
reproductive cell fate transition in plants - Development
... during MMC specification (Olmedo-Monfil et al., 2010; Singh et al., 2011) and later for the initiation of female gametophyte development (Tucker et al., 2012). In addition, SMC differentiation is characterized by elevated transcriptional levels for many of the enzymes that participate in epigenetic ...
... during MMC specification (Olmedo-Monfil et al., 2010; Singh et al., 2011) and later for the initiation of female gametophyte development (Tucker et al., 2012). In addition, SMC differentiation is characterized by elevated transcriptional levels for many of the enzymes that participate in epigenetic ...
Xdbx inhibits neurogenesis - Development
... Regionalized X-Ngnr1 expression defines domains of early neurogenesis. Are there negative effectors that similarly define neural progenitor domains in the embryo? The homeodomaincontaining gene Xiro3 is expressed at highest levels in neural progenitors and when overexpressed, Xiro3 inhibits neuronal ...
... Regionalized X-Ngnr1 expression defines domains of early neurogenesis. Are there negative effectors that similarly define neural progenitor domains in the embryo? The homeodomaincontaining gene Xiro3 is expressed at highest levels in neural progenitors and when overexpressed, Xiro3 inhibits neuronal ...