Reconstruction of a Functional Human Gene Network, with an
... The completion of various genome-sequencing projects and large-scale genomic studies has led to a wealth of available biological data. It is anticipated that this information will revolutionize our insight into the molecular basis of most common diseases by making it easier and quicker to identify g ...
... The completion of various genome-sequencing projects and large-scale genomic studies has led to a wealth of available biological data. It is anticipated that this information will revolutionize our insight into the molecular basis of most common diseases by making it easier and quicker to identify g ...
A genome screen for linkage in Australian sibling-pairs with
... a number of interesting immunological candidates. For example, IL-2 and IL-21 which are both involved in T and B cell proliferation map to chromosome 4q26-27, while the cluster of genes for the immunoglobulin kappa light chain and CD8 are encoded at chromosome 2p12. These candidates are worthy of fu ...
... a number of interesting immunological candidates. For example, IL-2 and IL-21 which are both involved in T and B cell proliferation map to chromosome 4q26-27, while the cluster of genes for the immunoglobulin kappa light chain and CD8 are encoded at chromosome 2p12. These candidates are worthy of fu ...
Genome-wide characteristics of sequence coverage by next
... “The most likely explanation for why genes for common diseases have not been found is that, with few exceptions, they do not exist. …., if inherited genes are not to blame for our commonest illnesses, can we find out what is? “ ...
... “The most likely explanation for why genes for common diseases have not been found is that, with few exceptions, they do not exist. …., if inherited genes are not to blame for our commonest illnesses, can we find out what is? “ ...
Application of rpoB sequence similarity analysis, REP‐PCR and
... have been suggested and used instead of or in supplement to 16S rRNA, because it is believed that a combination of multiple genetic markers can increase the accuracy and reliability of a phylogenetic scheme (Ko et al. 2003; Konstantinidis and Tiedje 2005). According to Zeigler (2003), a gene used as ...
... have been suggested and used instead of or in supplement to 16S rRNA, because it is believed that a combination of multiple genetic markers can increase the accuracy and reliability of a phylogenetic scheme (Ko et al. 2003; Konstantinidis and Tiedje 2005). According to Zeigler (2003), a gene used as ...
The CNS midline cells and spitz class genes are required for proper
... of Chemistry, Konkuk University, Seoul, Korea and 2 Department of Biochemistry and Biophysics, School of Medicine, University of North Carolina at Chapel Hill, North Carolina, USA ...
... of Chemistry, Konkuk University, Seoul, Korea and 2 Department of Biochemistry and Biophysics, School of Medicine, University of North Carolina at Chapel Hill, North Carolina, USA ...
Forkhead Transcription Factors: Key Players in Development and
... functions, such as DNA binding, trans-activation or transrepression, are often contained within separable domains. DNA-binding domains tend to be particularly well conserved and can be used as the basis for a classification that reflects phylogenetic relationships. Transcription factors with the sam ...
... functions, such as DNA binding, trans-activation or transrepression, are often contained within separable domains. DNA-binding domains tend to be particularly well conserved and can be used as the basis for a classification that reflects phylogenetic relationships. Transcription factors with the sam ...
Requirements for Driving Antipathogen Effector Genes into
... reduces the fitness of the mosquito and does not contribute to the drive, then loss-of-function mutations in the effector will eventually replace functional copies, but protection may nonetheless persist sufficiently long to provide a public health benefit. Here, we present a quantitative model allowin ...
... reduces the fitness of the mosquito and does not contribute to the drive, then loss-of-function mutations in the effector will eventually replace functional copies, but protection may nonetheless persist sufficiently long to provide a public health benefit. Here, we present a quantitative model allowin ...
Full Text
... a high dose of Cs-HNF3 mRNA was injected, the expression of AChE was suppressed (Fig. 4F), indicating that HNF-3 overexpression affects muscle cell differentiation. Alkaline phosphatase (AP) activity, a marker of endoderm differentiation (Fig. 4I) was detected in embryos developed from eggs injected ...
... a high dose of Cs-HNF3 mRNA was injected, the expression of AChE was suppressed (Fig. 4F), indicating that HNF-3 overexpression affects muscle cell differentiation. Alkaline phosphatase (AP) activity, a marker of endoderm differentiation (Fig. 4I) was detected in embryos developed from eggs injected ...
The amphioxus hairy family: differential fate after duplication.
... and in somatic sex determination. In Tribolium, only a role during segmentation has been suggested for its single hairy gene. On the contrary, hairy genes are expressed in many places in vertebrate embryos and have been implicated in numerous functions, such as somitogenesis, neurogenesis, and endoc ...
... and in somatic sex determination. In Tribolium, only a role during segmentation has been suggested for its single hairy gene. On the contrary, hairy genes are expressed in many places in vertebrate embryos and have been implicated in numerous functions, such as somitogenesis, neurogenesis, and endoc ...
Gene Section EXT2 (exostoses (multiple) 2) Atlas of Genetics and Cytogenetics
... Location: 11p11-p12 ...
... Location: 11p11-p12 ...
Protein expression pattern in cerebellum of Cav2.1 mutant, tottering
... products were detected in the fractions that did not include cDNA (data not shown). Histological observation of protein expression patterns in the cerebellum of tottering-6j mice We have used cresyl violet staining to check the gross morphology and cytoarchitecture. The gross morphology (data not sh ...
... products were detected in the fractions that did not include cDNA (data not shown). Histological observation of protein expression patterns in the cerebellum of tottering-6j mice We have used cresyl violet staining to check the gross morphology and cytoarchitecture. The gross morphology (data not sh ...
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... termini of histones H3 and H4 (15). Combined immunofluorescence and in situ-hybridization experiments have shown that telomeres are clustered and that Rap1p, Sir3p, and Sir4p colocalize with telomeric foci in wild-type cells (9). Immunoprecipitation and cross-linking data confirm that Sir3p, Sir4p, ...
... termini of histones H3 and H4 (15). Combined immunofluorescence and in situ-hybridization experiments have shown that telomeres are clustered and that Rap1p, Sir3p, and Sir4p colocalize with telomeric foci in wild-type cells (9). Immunoprecipitation and cross-linking data confirm that Sir3p, Sir4p, ...
Full Text - The International Journal of Developmental Biology
... In the mouse. the initial distribution of the Pax2gene transcripts is in postmitotic cells on both sides of the sulcus limitans of the neural tube, and later in the intermediate zone of the spinal cord, myelencephalon and metencephalon (Names at af., 1990; Asano and Gruss. 1992). Pax2 is also expres ...
... In the mouse. the initial distribution of the Pax2gene transcripts is in postmitotic cells on both sides of the sulcus limitans of the neural tube, and later in the intermediate zone of the spinal cord, myelencephalon and metencephalon (Names at af., 1990; Asano and Gruss. 1992). Pax2 is also expres ...
Chromatin Signature Identifies Monoallelic Gene Expression Across
... different ChIP-Seq datasets. To note, in this context, the use of quantile rank is equivalent to quantile normalization, but without requiring a reference dataset. Consequently, the newly trained classifier can be readily applied to other datasets with gene2body signal expressed as quantile-rank, eve ...
... different ChIP-Seq datasets. To note, in this context, the use of quantile rank is equivalent to quantile normalization, but without requiring a reference dataset. Consequently, the newly trained classifier can be readily applied to other datasets with gene2body signal expressed as quantile-rank, eve ...
Modeling Fragile X Syndrome Using Human Pluripotent Stem Cells
... Despite the tight correlation between transcriptional inactivation and chromatin compaction, the precise mechanism governing the silencing of FMR1 is not fully understood. In addition, it remains unclear when FMR1 gene inactivation takes place during embryo development. Previous reports related to t ...
... Despite the tight correlation between transcriptional inactivation and chromatin compaction, the precise mechanism governing the silencing of FMR1 is not fully understood. In addition, it remains unclear when FMR1 gene inactivation takes place during embryo development. Previous reports related to t ...
Horizontal Gene Transfer between Bacteria
... ‘Genetic material’ refers to any fraction of the genome (DNA or RNA), usually a gene or part thereof, which can include coding and/or non-coding sequences. ‘Organism’, as used here, includes cellular organism or replication competent virus. ‘Reproduction’ refers to the generation of offspring sexual ...
... ‘Genetic material’ refers to any fraction of the genome (DNA or RNA), usually a gene or part thereof, which can include coding and/or non-coding sequences. ‘Organism’, as used here, includes cellular organism or replication competent virus. ‘Reproduction’ refers to the generation of offspring sexual ...
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... changed in Sd embryos. First, the amount of Pax-1 mRNA was compared to that of M 5, one of the β-tubulin gene isotypes, using RNase protection analysis (data not shown). The M 5 gene is a component of the cytoskeleton, which is expressed in a ubiquitous manner (Wang et al., 1986). While no significa ...
... changed in Sd embryos. First, the amount of Pax-1 mRNA was compared to that of M 5, one of the β-tubulin gene isotypes, using RNase protection analysis (data not shown). The M 5 gene is a component of the cytoskeleton, which is expressed in a ubiquitous manner (Wang et al., 1986). While no significa ...
Gene prediction and Genome Annotation
... • RNA seq reads are often very noisy, with reads aligning allover the genome • RNA seq detect sense and antisense transcripts, protein-encoding or not • Only stranded reads can tell for sure in which sense they should apply • Small read length of RNA seq leads to virtual transcripts, but are they (a ...
... • RNA seq reads are often very noisy, with reads aligning allover the genome • RNA seq detect sense and antisense transcripts, protein-encoding or not • Only stranded reads can tell for sure in which sense they should apply • Small read length of RNA seq leads to virtual transcripts, but are they (a ...
Complete Sequence of the Mitochondrial DNA of
... is unusually variable. Complete mitochondrial gene organizations have been determined for five molluscan species (representing three different classes): the blue mussel Mytilus edulis, of the class Bivalvia (Hoffmann, Boore, and Brown 1992); the black chiton Katharina tunicata, of the class Polyplac ...
... is unusually variable. Complete mitochondrial gene organizations have been determined for five molluscan species (representing three different classes): the blue mussel Mytilus edulis, of the class Bivalvia (Hoffmann, Boore, and Brown 1992); the black chiton Katharina tunicata, of the class Polyplac ...
MCB317 Topic 10, part 4, A Story of Txn Sp14
... Secondary screen to identify possible txn factors ...
... Secondary screen to identify possible txn factors ...
Identification of lineage-specific zygotic transcripts in early
... in early embryonic transcription. For example, a maternally supplied transcription factor, SKN-1, is required for the specification of the mesendodermal precursor EMS in the 4-cell stage embryo (Bowerman et al., 1992). When EMS divides, it gives rise to a mesoderm-restricted precursor, MS, and an en ...
... in early embryonic transcription. For example, a maternally supplied transcription factor, SKN-1, is required for the specification of the mesendodermal precursor EMS in the 4-cell stage embryo (Bowerman et al., 1992). When EMS divides, it gives rise to a mesoderm-restricted precursor, MS, and an en ...
CTLA-4 gene expression is influenced by promoter and
... cells and certain T-cell phenotypes. One explanation for this would be that mechanisms other than genotype contribute to the regulation of CTLA-4 cell-surface expression, and that these mechanisms are differentially operative in various T-cell subpopulations. Indeed, two recent studies have demonstr ...
... cells and certain T-cell phenotypes. One explanation for this would be that mechanisms other than genotype contribute to the regulation of CTLA-4 cell-surface expression, and that these mechanisms are differentially operative in various T-cell subpopulations. Indeed, two recent studies have demonstr ...
Adaptation of Sucrose Metabolism in the Escherichia coli Wild
... Finally, we isolated and characterized mutants with chromosomal and plasmid-borne mutations that grow faster on sucrose than the wild type. Analysis of such adaptational mutations provided evidence that the basal expression level of cscB or the transport activity of the sucrose permease in the wildt ...
... Finally, we isolated and characterized mutants with chromosomal and plasmid-borne mutations that grow faster on sucrose than the wild type. Analysis of such adaptational mutations provided evidence that the basal expression level of cscB or the transport activity of the sucrose permease in the wildt ...
Discussion paper - Office of the Gene Technology Regulator
... “to protect the health and safety of people, and to protect the environment, by identifying risks posed by or as a result of gene technology, and by managing those risks through regulating certain dealings with GMOs.”4 Australia’s gene technology regulatory scheme was set up in 2000 in response to a ...
... “to protect the health and safety of people, and to protect the environment, by identifying risks posed by or as a result of gene technology, and by managing those risks through regulating certain dealings with GMOs.”4 Australia’s gene technology regulatory scheme was set up in 2000 in response to a ...
The relationship between higher‑order chromatin structure and
... input chromatin fractions to a human chromosome 22q genomic array consisting of overlapping sequencing tiling path clones [21]. The average resolution of this array is 78 kb, but it contains regions where the clones are even smaller than the size of the chromatin fibres being examined (∼20 kb). The ...
... input chromatin fractions to a human chromosome 22q genomic array consisting of overlapping sequencing tiling path clones [21]. The average resolution of this array is 78 kb, but it contains regions where the clones are even smaller than the size of the chromatin fibres being examined (∼20 kb). The ...