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PROTEIN SYNTHESIS AND PROCESSING Protein biosynthesis is
PROTEIN SYNTHESIS AND PROCESSING Protein biosynthesis is

... released. This whole complex of processes is carried out by the ribosome, formed of two main chains of RNA, called ribosomal RNA (rRNA), and more than 50 different proteins. The ribosome latches onto the end of an mRNA molecule and moves along it, capturing loaded tRNA molecules and joining togethe ...
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... Extranodal nasal-type Natural Killer/T-cell lymphoma (NKTL) • Distinct clinicopathologic entity most commonly ...
Topic 3 The Chemistry of Life - wfs
Topic 3 The Chemistry of Life - wfs

... 3. The exposed bases of each strand are then paired with an available nucleotide by complementary base pairing. The result is two strands where only one was first present. 4. DNA polymerase is an enzyme that allows the connection between nucleotides lined up by basepairing. 5. This replication is ca ...
Protein Synthesis PowerPoint
Protein Synthesis PowerPoint

... – turning DNA’s code into messenger RNA  TRANSLATION – turning mRNA into an amino acid chain = PROTEIN ...
10 Useful RNA Facts
10 Useful RNA Facts

... 4. There are several types of RNA, including transfer RNA (tRNA), messenger RNA (mRNA), and ribosomal RNA (rRNA). RNA performs many functions in an organism, such as coding, decoding, regulating, and expressing genes. ...
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... Complex gene regulation in eukaryotes is what makes differentiation so the can specialize in structure and ...
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... Transpositional site-specific recombination Conservative site-specific recombinatinon ...
transcription
transcription

... 3. More multimeric regulatory proteins 4. Transcription is separated from translation in both space and time ...
Ways to get from plant genomes to phenomes: via
Ways to get from plant genomes to phenomes: via

... of Toronto, Canada). Out of the 6,000 yeast genes, 5,000 have been shown to be non-essential in a genome-wide single-gene-knockout project, but double mutants of these non-essential genes often have lethal phenotypes (synthetic lethal phenotypes). SGA analysis allows the identification of genetic in ...
Vaccines and Antivirals - Cal State L.A. - Cal State LA
Vaccines and Antivirals - Cal State L.A. - Cal State LA

... is similar to that of hybrid arrested translation. • A single stranded RNA or DNA moles that is complementary to a viral mRNA is made. • It will combine, by complementary base-pairing, with the mRNA to block translation of the mRNA into a protein product • Hence an essential viral protein is not mad ...
Ch. 17: From Gene to Protein
Ch. 17: From Gene to Protein

...  Prokaryotes bind to RNA Poly directly.  Eukaryotes bind to transcription factors that bind to DNA. ...
RNA Structure and Function
RNA Structure and Function

... yet still be used. It is analogous to a “reference book” within a library. The information must be copied from the master copy to be removed from the protective location and used in a remote location. 3. The information is contained within the order of nitrogenous bases along the RNA strand. The sug ...
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... eukaryotic in cytoplasm Initiation, elongation, termination phase with specific factors ...
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origin of genes, the genetic code, and genomes

... The genetic code may have arisen through a link ...
Lecture 3 - Transcription (student)
Lecture 3 - Transcription (student)

... • Mutant strains were produced via x-rays – Result: Descendents could NOT grow on medium • they could no longer produce all essential compounds to sustain life ...
transfer RNA
transfer RNA

... At this point the newly formed RNA is a “PremRNA”, and must be modified before its proteinbuilding instructions can be put to use. A cap binding protein complex (CBC) forms at the 5’ end which is needed when the mRNA is exported from the nucleus. To the 3’ end, a poly-tail of about 100 to 300 nucle ...
View/Open - JEWLScholar@MTSU
View/Open - JEWLScholar@MTSU

... •Not all genes in the genome are expressed in every cell. •Regulation of gene expression can occur at many levels including transcription, splicing, nuclear export, RNA decay, and translation. •Alternative mRNA splicing, which is a common gene regulation mechanism in eukaryotes, occurs when one gene ...
Non-coding RNAs
Non-coding RNAs

... Genomes are databases sensitive to invasion by viruses (foreign nucleic acids). In recent years, a defense mechanism has been discovered, which turns out to be conserved among eukaryotes. The system can be compared to the immune system in several ways: It has specificity against foreign elements and ...
Lecture 6
Lecture 6

... • Statistical analysis of the rates of homologous recombination of several different genes could determine their order on a certain chromosome, and information from many such experiments could be combined to create a genetic map specifying the rough location of known genes relative to each other. • ...
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Where do pumpkins come from?
Where do pumpkins come from?

... • Translational regulatory proteins – recognize sequences in mRNA and inhibit translation (sometimes at the start codon) • Antisense RNA – a RNA strand that is complementary to mRNA binds to the mRNA and keeps it from being translated ...
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... then induced and macronuclear differentiation analyzed by DAPI-staining. These cells enter the polytenization stage but later stages of macronuclear development (DNA poor stage, macronucleus in the second amplification phase) were morphologically not detectable. In these exconjugants the old macronu ...
AP Biology Discussion Notes
AP Biology Discussion Notes

... • Be able to decode the message in messenger RNA (mRNA) • Be able to name and describe the two major steps of protein synthesis (how proteins are made) • Be able to list the molecules & structures involved in Transcription & Translation. ...
Transcription
Transcription

... • The flow of genetic information: • The expression of genetic information is achieved ultimately via proteins, particularly the enzymes that catalyse the reactions of metabolism. Proteins are condensation heteropolymers synthesized from amino acids, of which 20 are used in natural proteins. • gene ...
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Translation

... A processed mRNA ready for translation: microRNAs inhibit translation by binding to the 3’ end of mRNA ...
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RNA interference



RNA interference (RNAi) is a biological process in which RNA molecules inhibit gene expression, typically by causing the destruction of specific mRNA molecules. Historically, it was known by other names, including co-suppression, post-transcriptional gene silencing (PTGS), and quelling. Only after these apparently unrelated processes were fully understood did it become clear that they all described the RNAi phenomenon. Andrew Fire and Craig C. Mello shared the 2006 Nobel Prize in Physiology or Medicine for their work on RNA interference in the nematode worm Caenorhabditis elegans, which they published in 1998.Two types of small ribonucleic acid (RNA) molecules – microRNA (miRNA) and small interfering RNA (siRNA) – are central to RNA interference. RNAs are the direct products of genes, and these small RNAs can bind to other specific messenger RNA (mRNA) molecules and either increase or decrease their activity, for example by preventing an mRNA from producing a protein. RNA interference has an important role in defending cells against parasitic nucleotide sequences – viruses and transposons. It also influences development.The RNAi pathway is found in many eukaryotes, including animals, and is initiated by the enzyme Dicer, which cleaves long double-stranded RNA (dsRNA) molecules into short double-stranded fragments of ~20 nucleotide siRNAs. Each siRNA is unwound into two single-stranded RNAs (ssRNAs), the passenger strand and the guide strand. The passenger strand is degraded and the guide strand is incorporated into the RNA-induced silencing complex (RISC). The most well-studied outcome is post-transcriptional gene silencing, which occurs when the guide strand pairs with a complementary sequence in a messenger RNA molecule and induces cleavage by Argonaute, the catalytic component of the RISC complex. In some organisms, this process spreads systemically, despite the initially limited molar concentrations of siRNA.RNAi is a valuable research tool, both in cell culture and in living organisms, because synthetic dsRNA introduced into cells can selectively and robustly induce suppression of specific genes of interest. RNAi may be used for large-scale screens that systematically shut down each gene in the cell, which can help to identify the components necessary for a particular cellular process or an event such as cell division. The pathway is also used as a practical tool in biotechnology, medicine and insecticides.
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