Effects of turmeric (Curcuma longa) on the expression
... d and stated that turmeric might have some positive effects on liver enzymes that directly or indirectly reflect a healthier liver. The above findings demonstrate the possible mode of action of TMP as an antioxidant. SOD. Superoxide dismutase catalyzes the conversion of superoxide anions to hydrogen ...
... d and stated that turmeric might have some positive effects on liver enzymes that directly or indirectly reflect a healthier liver. The above findings demonstrate the possible mode of action of TMP as an antioxidant. SOD. Superoxide dismutase catalyzes the conversion of superoxide anions to hydrogen ...
A xylem-specific cellulose synthase gene from aspen (Populus
... plants were bent to create tension stress for various time intervals (from 4 to 40 h). Surprisingly, tension stress rapidly induced phloem-speci®c GUS expression (Figure 5), but did not cause an apparent change in GUS expression in the developing xylem (Figure 5b). Thus under a normal developmental ...
... plants were bent to create tension stress for various time intervals (from 4 to 40 h). Surprisingly, tension stress rapidly induced phloem-speci®c GUS expression (Figure 5), but did not cause an apparent change in GUS expression in the developing xylem (Figure 5b). Thus under a normal developmental ...
- bioRxiv
... copy number changes. In humans, reduction in gene dosage for many transcription factors leads to haploinsufficient developmental disorders [12]. Thus it is likely that genomic responses to alterations in gene copy number are important drivers of some human diseases and understanding these effects ma ...
... copy number changes. In humans, reduction in gene dosage for many transcription factors leads to haploinsufficient developmental disorders [12]. Thus it is likely that genomic responses to alterations in gene copy number are important drivers of some human diseases and understanding these effects ma ...
Mice homozygous for a targeted disruption of Hoxd-3
... Graham et al., 1989). These correlations suggest that the mouse Hox genes may also function during development as master switches specifying regional information along the anteroposterior axis of the mammalian embryo. Targeted mutational analysis of Hoxa-1, Hoxa-3, Hoxb-4 and Hoxc8 has supported thi ...
... Graham et al., 1989). These correlations suggest that the mouse Hox genes may also function during development as master switches specifying regional information along the anteroposterior axis of the mammalian embryo. Targeted mutational analysis of Hoxa-1, Hoxa-3, Hoxb-4 and Hoxc8 has supported thi ...
Temporal and Spatial Expression of Homeotic Genes Is Important for
... in Polycomb group (PcG) genes, which are negative transregulators of homeotic genes, did not cause the thoracic to abdominal MM-CBG pattern transformation although the number of MM-CBG in a few percent of embryos were partially reduced or abnormally patterned. Our results indicate that temporal and ...
... in Polycomb group (PcG) genes, which are negative transregulators of homeotic genes, did not cause the thoracic to abdominal MM-CBG pattern transformation although the number of MM-CBG in a few percent of embryos were partially reduced or abnormally patterned. Our results indicate that temporal and ...
Chapter 21
... An insertion sequence is a transposon that codes for the enzyme(s) needed for transposition flanked by short inverted terminal repeats. The target site at which a transposon is inserted is duplicated during the insertion process to form two repeats in direct orientation at the ends of the transposon ...
... An insertion sequence is a transposon that codes for the enzyme(s) needed for transposition flanked by short inverted terminal repeats. The target site at which a transposon is inserted is duplicated during the insertion process to form two repeats in direct orientation at the ends of the transposon ...
Genetic characterization of the mitochondrial DNA - (BORA)
... and ND6), cytochrome c oxidase subunits I – III (COI, COII and COIII), two rRNA genes (12S rRNA and 16S rRNA) and 22 tRNAs. Two copies of tRNA-Lys are present in the mtDNA of L. salmonis, while tRNA-Cys was not identified. Both DNA strands contain coding regions in the salmon louse, in contrast to t ...
... and ND6), cytochrome c oxidase subunits I – III (COI, COII and COIII), two rRNA genes (12S rRNA and 16S rRNA) and 22 tRNAs. Two copies of tRNA-Lys are present in the mtDNA of L. salmonis, while tRNA-Cys was not identified. Both DNA strands contain coding regions in the salmon louse, in contrast to t ...
Complete Laboratory PDF
... Since Alfred Sturtevant constructed the first genetic map of a Drosophila chromosome in 1913, new mutations have been mapped using his method of linkage analysis. Determining the map position of a new mutation – and its corresponding gene – consists of testing for linkage with a number of previously ...
... Since Alfred Sturtevant constructed the first genetic map of a Drosophila chromosome in 1913, new mutations have been mapped using his method of linkage analysis. Determining the map position of a new mutation – and its corresponding gene – consists of testing for linkage with a number of previously ...
Reduced penetrance in human inherited disease
... The most common genetic cause of familial and sporadic amyotrophic lateral silerosis (ALS) and frontotemporal dementia (FTD) is a massive GGGGCC hexanucleotide intronic repeat expansion mutation within C9 or F72. The mean age of onset was 57.9 years for ALS cases and 63.6 years for FTD. Age dependen ...
... The most common genetic cause of familial and sporadic amyotrophic lateral silerosis (ALS) and frontotemporal dementia (FTD) is a massive GGGGCC hexanucleotide intronic repeat expansion mutation within C9 or F72. The mean age of onset was 57.9 years for ALS cases and 63.6 years for FTD. Age dependen ...
Molecular Plant-Microbe Interactions
... probe on total genomic DNA of strain N33, we showed previously that this probe hybridized with a 4.1-kb EcoRI fragment (pJC1) coding potentially for the nodA gene (Cloutier et al. 1996b; Table 1). We have sequenced this 4.1-kb EcoRI fragment and showed that it encodes for nodF, nodE, and nodG genes ...
... probe on total genomic DNA of strain N33, we showed previously that this probe hybridized with a 4.1-kb EcoRI fragment (pJC1) coding potentially for the nodA gene (Cloutier et al. 1996b; Table 1). We have sequenced this 4.1-kb EcoRI fragment and showed that it encodes for nodF, nodE, and nodG genes ...
Differential Expression Analysis
... the list of genes in the multiple testing process. Making the list of genes shorter makes the multiple testing correction less severe. This may seem backwards. How do we eliminate genes from a test for differential expression without testing them? We use very crude measures that select only genes th ...
... the list of genes in the multiple testing process. Making the list of genes shorter makes the multiple testing correction less severe. This may seem backwards. How do we eliminate genes from a test for differential expression without testing them? We use very crude measures that select only genes th ...
Differential roles of TGIF family genes in mammalian reproduction Open Access
... TGIF2 shares similar DNA binding homeodomains to TGIF1, suggesting both proteins are likely to bind the same DNA sequence [4]. Human TGIF2 has 3 exons which have the highest homology with TGIF1. There are two alternative splicing forms of Tgif2 genes one of which contains a retained intron within th ...
... TGIF2 shares similar DNA binding homeodomains to TGIF1, suggesting both proteins are likely to bind the same DNA sequence [4]. Human TGIF2 has 3 exons which have the highest homology with TGIF1. There are two alternative splicing forms of Tgif2 genes one of which contains a retained intron within th ...
Deconstructing the Genome: DNA at High Resolution
... released from the nuclei of cells at specific sites. These welldefined cuts generate fragments suitable for manipulation and characterization. A restriction enzyme recognizes a specific sequence of bases anywhere within the genome and then severs two covalent bonds (one in each strand) in the sugar- ...
... released from the nuclei of cells at specific sites. These welldefined cuts generate fragments suitable for manipulation and characterization. A restriction enzyme recognizes a specific sequence of bases anywhere within the genome and then severs two covalent bonds (one in each strand) in the sugar- ...
MiRNA_GO_Meeting_August2015
... Direct curation of the roles of miRNAs is expected to improve miRNA functional analysis that has so far relied on indirect analysis of the gene targets’ functions “We show that the most commonly used functional enrichment test is inappropriate for the analysis of sets of genes targeted by miRNAs.” B ...
... Direct curation of the roles of miRNAs is expected to improve miRNA functional analysis that has so far relied on indirect analysis of the gene targets’ functions “We show that the most commonly used functional enrichment test is inappropriate for the analysis of sets of genes targeted by miRNAs.” B ...
Engineering a tRNA and aminoacyl-tRNA synthetase for the site
... To expand our ability to probe the relationship between protein structure and function, as well as engineer new proteins with altered properties, we earlier developed an in vitro method that makes it possible to site-specifically incorporate into proteins amino acids not specified in the genetic cod ...
... To expand our ability to probe the relationship between protein structure and function, as well as engineer new proteins with altered properties, we earlier developed an in vitro method that makes it possible to site-specifically incorporate into proteins amino acids not specified in the genetic cod ...
Patterns of gene action in plant development revealed by enhancer
... none of the KanRNAM R progeny carried the IAAH gene {data not shown}. These results indicate that both the Ds donor locus and the immobilized A c have been selected against, and that each of the KanRNAM R plants carried a si,~gle transposed Ds element at a new chromosomal site. In Figure 4A, the fre ...
... none of the KanRNAM R progeny carried the IAAH gene {data not shown}. These results indicate that both the Ds donor locus and the immobilized A c have been selected against, and that each of the KanRNAM R plants carried a si,~gle transposed Ds element at a new chromosomal site. In Figure 4A, the fre ...
E.coli
... 1. The analysis of genome organization and the identification of genes, particularly in organisms with large genome sizes (human DNA is 3 109 bp, for example) is difficult to use plasmid and bacteriophage vectors, since the relatively small size capacity of these vectors for cloned DNA means tha ...
... 1. The analysis of genome organization and the identification of genes, particularly in organisms with large genome sizes (human DNA is 3 109 bp, for example) is difficult to use plasmid and bacteriophage vectors, since the relatively small size capacity of these vectors for cloned DNA means tha ...
The β-Globin LCR is Not Necessary for an Open Chromatin
... LCR vital to transcription and regulation of β-globin locus LCR is necessary for normal levels of β-globin transcription LCR properties resemble those of enhancers Determines that LCR provides contributory rather then dominant functions for its native location Regulatory sequences in addition to the ...
... LCR vital to transcription and regulation of β-globin locus LCR is necessary for normal levels of β-globin transcription LCR properties resemble those of enhancers Determines that LCR provides contributory rather then dominant functions for its native location Regulatory sequences in addition to the ...
No Slide Title
... What is the benefit of genetic testing? Can anything be done to change risk /outcome? Evidence for screening in HNPCC: Cohort study of CRC screening – 15 yr F/U Subgroup of HNPCC carriers CRC in 8/44 with colonoscopy q3 years vs. 19/46 ...
... What is the benefit of genetic testing? Can anything be done to change risk /outcome? Evidence for screening in HNPCC: Cohort study of CRC screening – 15 yr F/U Subgroup of HNPCC carriers CRC in 8/44 with colonoscopy q3 years vs. 19/46 ...
Genome Rearrangements Caused by Depletion of Essential DNA
... DPB11, POL2, POL30, RFC2, and RFC5) caused increased illegitimate mating. DNA2, which functions in Okazaki fragment processing (Budd et al. 2000; Lee et al. 2000) and in DNA repair (Zhu et al. 2008) resulted in increased illegitimate mating, as did repression of the DNA repair genes NSE1 (Santa Mari ...
... DPB11, POL2, POL30, RFC2, and RFC5) caused increased illegitimate mating. DNA2, which functions in Okazaki fragment processing (Budd et al. 2000; Lee et al. 2000) and in DNA repair (Zhu et al. 2008) resulted in increased illegitimate mating, as did repression of the DNA repair genes NSE1 (Santa Mari ...
20Sexual Reproduction, Meiosis, and Genetic Recombination
... Because sexual reproduction combines genetic information from two different parents into a single offspring, at some point in its life cycle every sexually reproducing organism has cells that contain two copies of each type of chromosome, one inherited from each parent. The two members of each chrom ...
... Because sexual reproduction combines genetic information from two different parents into a single offspring, at some point in its life cycle every sexually reproducing organism has cells that contain two copies of each type of chromosome, one inherited from each parent. The two members of each chrom ...
Regulation of Stage I1 of Sporulation in Bacillus subtilis
... prevent further development. These are designated spoOA, spoOB, etc., and it has recently become apparent that most of them, possibly all, are expressed during vegetative growth (Losick et al., 1986; Yamashita et al., 1986) and therefore can be disregarded for our purposes. Sporulation from the deve ...
... prevent further development. These are designated spoOA, spoOB, etc., and it has recently become apparent that most of them, possibly all, are expressed during vegetative growth (Losick et al., 1986; Yamashita et al., 1986) and therefore can be disregarded for our purposes. Sporulation from the deve ...
Regulation of Stage I1 of Sporulation in Bacillus subtilis
... prevent further development. These are designated spoOA, spoOB, etc., and it has recently become apparent that most of them, possibly all, are expressed during vegetative growth (Losick et al., 1986; Yamashita et al., 1986) and therefore can be disregarded for our purposes. Sporulation from the deve ...
... prevent further development. These are designated spoOA, spoOB, etc., and it has recently become apparent that most of them, possibly all, are expressed during vegetative growth (Losick et al., 1986; Yamashita et al., 1986) and therefore can be disregarded for our purposes. Sporulation from the deve ...
Electrophoresis Revised
... Liquid is never drawn into the barrel of the micropipette itself. An appropriate tip should always be placed firmly on the end. Since the principle by which the micropipette works is the creation of a vacuum in the tip, causing liquid to be drawn up, it is critical that the tip be on tight enough to ...
... Liquid is never drawn into the barrel of the micropipette itself. An appropriate tip should always be placed firmly on the end. Since the principle by which the micropipette works is the creation of a vacuum in the tip, causing liquid to be drawn up, it is critical that the tip be on tight enough to ...
Nat. Struct. Biol. 8, 192-194.
... viewed as entry points for transcription factors which, once bound, can interact with the transcription complex by looping out intervening sequences9. More recently, enhancer-bound transcription factors have been shown tethered to proteins at the promoter region that are involved in histone modifica ...
... viewed as entry points for transcription factors which, once bound, can interact with the transcription complex by looping out intervening sequences9. More recently, enhancer-bound transcription factors have been shown tethered to proteins at the promoter region that are involved in histone modifica ...
Cancer epigenetics
Cancer epigenetics is the study of epigenetic modifications to the genome of cancer cells that do not involve a change in the nucleotide sequence. Epigenetic alterations are as important as genetic mutations in a cell’s transformation to cancer, and their manipulation holds great promise for cancer prevention, detection, and therapy. In different types of cancer, a variety of epigenetic mechanisms can be perturbed, such as silencing of tumor suppressor genes and activation of oncogenes by altered CpG island methylation patterns, histone modifications, and dysregulation of DNA binding proteins. Several medications which have epigenetic impact are now used in several of these diseases.