In vivo resistance to CPT
... resistance was achieved after 25 passages in nude mice treated with several cycles of 27 mg/kg/dx5 CPT-11 every 21 days and was revertible after 15 passages without treatment. Cross-resistance existed to the topoisomerase I inhibitor topotecan, but not to cyclophosphamide and cisplatin. Common mecha ...
... resistance was achieved after 25 passages in nude mice treated with several cycles of 27 mg/kg/dx5 CPT-11 every 21 days and was revertible after 15 passages without treatment. Cross-resistance existed to the topoisomerase I inhibitor topotecan, but not to cyclophosphamide and cisplatin. Common mecha ...
Gene Section REG4 (regenerating gene type IV) Atlas of Genetics and Cytogenetics
... Genetics, Dept Medical Information, UMR 8125 CNRS, University of Poitiers, CHU Poitiers Hospital, F86021 Poitiers, France (JLH, SS) Published in Atlas Database: August 2003 Online updated version: http://AtlasGeneticsOncology.org/Genes/REGIVID485.html DOI: 10.4267/2042/38012 This work is licensed un ...
... Genetics, Dept Medical Information, UMR 8125 CNRS, University of Poitiers, CHU Poitiers Hospital, F86021 Poitiers, France (JLH, SS) Published in Atlas Database: August 2003 Online updated version: http://AtlasGeneticsOncology.org/Genes/REGIVID485.html DOI: 10.4267/2042/38012 This work is licensed un ...
Eukaryotic Gene Regulation
... b. Determination of a cell occurs due to molecular changes. Once a cell differentiates, it expresses genes based on what kind of cell it is/what kind of tissue it makes up. Thus, they only express genes for _____________________________. i. These proteins are found only in a specific cell type. ii. ...
... b. Determination of a cell occurs due to molecular changes. Once a cell differentiates, it expresses genes based on what kind of cell it is/what kind of tissue it makes up. Thus, they only express genes for _____________________________. i. These proteins are found only in a specific cell type. ii. ...
2368AOS1-genefunctiongenesinaction2
... Some genes are only active during the embryonic period whilst others such as Huntington’s disease are only expressed in the phenotype only when the individual is well into adulthood. Some genes are only active in certain tissues (eg. Genes that produce insulin are only active in the pancreas). ...
... Some genes are only active during the embryonic period whilst others such as Huntington’s disease are only expressed in the phenotype only when the individual is well into adulthood. Some genes are only active in certain tissues (eg. Genes that produce insulin are only active in the pancreas). ...
Gene Section AF15q14 (ALL1 fused gene from 15q14) in Oncology and Haematology
... t(11;15)(q23;q14)/acute non lymphocytic leukemia (ANLL) --> MLL/AF15q14 ...
... t(11;15)(q23;q14)/acute non lymphocytic leukemia (ANLL) --> MLL/AF15q14 ...
Linking gene expression mentions to anatomical
... • Results range across: – 28,000 different genes (top: TNF) – 3,900 different anatomical locations (top: T cells). – 240,000 different gene/location combinations (60% mentioned once) ...
... • Results range across: – 28,000 different genes (top: TNF) – 3,900 different anatomical locations (top: T cells). – 240,000 different gene/location combinations (60% mentioned once) ...
NUS Presentation Title 2006
... 05 science/Figures/schematic/annotated.network.darker/schematic.png ...
... 05 science/Figures/schematic/annotated.network.darker/schematic.png ...
TB1 - BIOCHEM, Broyles
... Zinc finger (Cys-Cys and Cys-His), e.g. TFIIIA or GATA-1 (a protein involved in regulation of human globin genes) Leucine zipper – a class of trans-acting factor with a special motif for interacting with other proteins as well as DNA Helix-loop-helix (HLH) or basic helix-loop-helix (bHLH) o Ci ...
... Zinc finger (Cys-Cys and Cys-His), e.g. TFIIIA or GATA-1 (a protein involved in regulation of human globin genes) Leucine zipper – a class of trans-acting factor with a special motif for interacting with other proteins as well as DNA Helix-loop-helix (HLH) or basic helix-loop-helix (bHLH) o Ci ...
Organization of Genes Differs in Prokaryotic and Eukaryotic DNA
... By beginning of 21st century, completed sequencing, entire genomes of viruses, bacteria & budding yeast S. cerevisiae, D. melanogaster, and humans - sequencing data revealed large portion of genomes of higher eukaryotes -----more 95% human chromosomal DNA non-coding -regions similar but not identic ...
... By beginning of 21st century, completed sequencing, entire genomes of viruses, bacteria & budding yeast S. cerevisiae, D. melanogaster, and humans - sequencing data revealed large portion of genomes of higher eukaryotes -----more 95% human chromosomal DNA non-coding -regions similar but not identic ...
Supplementary Figure and Table Legends (doc 22K)
... A table of pair-wise Pearson correlation values between samples based on the log2 expression ratio shows sample correlation. High correlation coefficients between biological replicates are highlighted in green, and those correlation coefficients outside of biological replicates are highlighted in b ...
... A table of pair-wise Pearson correlation values between samples based on the log2 expression ratio shows sample correlation. High correlation coefficients between biological replicates are highlighted in green, and those correlation coefficients outside of biological replicates are highlighted in b ...
From Gene to Protein
... They protect mRNA from hydrolytic enzymes. They help ribosomes attach to the 5ʹ′ end. ...
... They protect mRNA from hydrolytic enzymes. They help ribosomes attach to the 5ʹ′ end. ...
Eukaryotic Transcription
... Basic Principles of Transcription • Transcription is the synthesis of RNA under the direction of DNA • Transcription produces messenger RNA (mRNA) • In a eukaryotic cell, the nuclear envelope separates transcription from translation • Eukaryotic RNA transcripts are modified through RNA processing t ...
... Basic Principles of Transcription • Transcription is the synthesis of RNA under the direction of DNA • Transcription produces messenger RNA (mRNA) • In a eukaryotic cell, the nuclear envelope separates transcription from translation • Eukaryotic RNA transcripts are modified through RNA processing t ...
Modeling DNA Sequenc..
... by regulatory genes, i.e. genes that express transcription factors Development events are not discrete and the regulatory networks that control development are often connected to other networks that control prior and surrounding processes in both the spatial and temporal domains The model used for t ...
... by regulatory genes, i.e. genes that express transcription factors Development events are not discrete and the regulatory networks that control development are often connected to other networks that control prior and surrounding processes in both the spatial and temporal domains The model used for t ...
Hox
... Codes for a DNA binding segment (aa sequence) in the transcription factor. The transcription factors activate structural genes. Structural genes produce structures appropriate for that location. Mutations in Hox genes result in inappropriate structures for that ...
... Codes for a DNA binding segment (aa sequence) in the transcription factor. The transcription factors activate structural genes. Structural genes produce structures appropriate for that location. Mutations in Hox genes result in inappropriate structures for that ...
What is a gene?
... • genes for individual enzymes of one pathway are often located far apart in the genome ...
... • genes for individual enzymes of one pathway are often located far apart in the genome ...
Gene Section CLDN6 (claudin 6) Atlas of Genetics and Cytogenetics
... associated with higher mortality rate in the diffuse- vs the intestinal-type gastric adenocarcinoma after a 2year follow-up (Rendón-Huerta et al., 2010). Claudin-6 expression is closely related to gastric carcinogenesis, and their detection is a useful prognostic marker in gastric adenocarcinoma. Cl ...
... associated with higher mortality rate in the diffuse- vs the intestinal-type gastric adenocarcinoma after a 2year follow-up (Rendón-Huerta et al., 2010). Claudin-6 expression is closely related to gastric carcinogenesis, and their detection is a useful prognostic marker in gastric adenocarcinoma. Cl ...
Transcription
... d. Genes that perform similar functions are scattered around the genome and must be coordinated. e. Transcription regulator sequences can be great distances from the genes they regulate. f. Cell specialization means that specific sets of genes are activated or inactivated depending on cell type. ...
... d. Genes that perform similar functions are scattered around the genome and must be coordinated. e. Transcription regulator sequences can be great distances from the genes they regulate. f. Cell specialization means that specific sets of genes are activated or inactivated depending on cell type. ...
Supplementary Information Text
... core motif5, 6. Promoter choice appears to determine the splicing of a particular or variable exon to the first constant region exon, in that the splice donor site of the transcribed variable exon is used in cis-splicing3. Each neuron appears to express a distinct combination of protocadherin ge ...
... core motif5, 6. Promoter choice appears to determine the splicing of a particular or variable exon to the first constant region exon, in that the splice donor site of the transcribed variable exon is used in cis-splicing3. Each neuron appears to express a distinct combination of protocadherin ge ...