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LBSC 708L Session 1
LBSC 708L Session 1

... nitric oxide reductases respectively. The NirI sequence corresponds to that of a membrane-bound protein with six transmembrane helices, a large periplasmic domain and cysteine-rich cytoplasmic domains that resemble the binding sites of [4Fe-4S] clusters in many ferredoxin-like proteins. NirX is solu ...
Pennisi E
Pennisi E

... been able to decipher another layer of "code" scattered in the arrangement of binding sites within the enhancer. This code is critical to directing patterns of differentiation in embryonic tissue, they reported in the 16 March Proceedings of the National Academy of Sciences. Dorsal, whose concentrat ...
Snapshots of RNA polymerase II transcription initiation
Snapshots of RNA polymerase II transcription initiation

... A basic understanding of interactions between basal factors has been established for a typical pol II promoter, but interesting exceptions to the rules may exist. The snRNA genes from higher eukaryotes use an alternative TBP-containing complex known as SNAPc (snRNA activating protein complex) to rec ...
`Genes` Like That, Who Needs an Environment?
`Genes` Like That, Who Needs an Environment?

... 4.1. The Protein-Based Key-Lock System. There is a significant correlation between the size of intergenic DNA—upstream, downstream, and within intronic regions—of ‘complex’ genes and the diversity of functions in development and cell differentiations. Complex genes are also more often located in gen ...
Chapter 17: From Gene to Protein
Chapter 17: From Gene to Protein

... 26. Explain what determines the primary structure of a protein and describe how a polypeptide must be modified before it becomes fully functional. 27. Describe what determines whether a ribosome will be free in the cytosol or attached to the rough endoplasmic reticulum. 28. Describe two properties o ...
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pdf

... NusG is the bacterial homolog of a family of conserved proteins involved in elongation. It is homologous to the large subunit of DSIF, which is an elongation factor in mammals. DSIF is the DRB-sensitivity inducing factor. Current studies implicate it in both negative and positive effects on elongati ...
Slide 1
Slide 1

... What makes RNA so powerful? • It can fold up • Some of its bases can catalyze chemical reactions • It is highly specific (i.e., complementary) tRNA ...
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Chap2 DNA RNA and Protein

... Proteolytic processing: e.g. cleavage of a polyprotein (VP) to form VP2 and VP4 (IBDV) ...
File - MRS. WILSON Science
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... Like DNA, RNA is a nucleic acid. It is made of nucleotides that consist of a phosphate group, a sugar, and a nitrogen-containing base. However, RNA differs in important ways from DNA: (1) RNA contains the sugar ribose, not deoxyribose; (2) RNA is made up of the nucleotides A, C, G, and uracil, U, wh ...
Gene Section NFATC2 (nuclear factor of activated T cells, cytoplasmic, calcineurin
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Managing people in sport organisations: A strategic human resource
Managing people in sport organisations: A strategic human resource

... Translation in Prokaryotes (A) Initiation of translation begins with the association of the small ribosome subunit with the Shine-Dalgarno sequence (S-D sequence) on the mRNA. Next, the initiator tRNA that reads AUG is charged with fMet. The charged initiator tRNA associates with the small ribosome ...
AP Biology 12
AP Biology 12

... Both prokaryotes and eukaryotes alter their patterns of gene expression in response to changes in environmental conditions. In multicellular eukaryotes, each cell type contains the same genome but expresses a different subset of genes. During development, gene expression must be carefully regulated ...
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From Gene to Protein

... • Elongation: three-step cycle that adds amino acids one by one to the initial amino acid, requires cooperation of ...
Foundations of Biology
Foundations of Biology

... Some of the general methods used to control expression in prokaryotes are used in eukaryotes, but nothing resembling operons is known Eukaryotic genes are controlled individually and each gene has specific control sequences preceding the transcription start site In addition to controlling transcript ...
Transcription Initiation
Transcription Initiation

... Some of the general methods used to control expression in prokaryotes are used in eukaryotes, but nothing resembling operons is known Eukaryotic genes are controlled individually and each gene has specific control sequences preceding the transcription start site In addition to controlling transcript ...
Chapter 17: Transcription, RNA Processing, and Translation
Chapter 17: Transcription, RNA Processing, and Translation

... 2.) Does RNA Polymerase require a primer? What is the name for the region of DNA that RNA Polymerases interact with during transcription initiation? 3.) What are the components that make up the bacterial RNA Polymerase Holoenzyme? What is the function of each component? 4.) What is the significance ...
From Gene to Protein
From Gene to Protein

... Many different roles! ...
Chapter 17: Transcription, RNA Processing, and Translation
Chapter 17: Transcription, RNA Processing, and Translation

... 2.) Does RNA Polymerase require a primer? What is the name for the region of DNA that RNA Polymerases interact with during transcription initiation? 3.) What are the components that make up the bacterial RNA Polymerase Holoenzyme? What is the function of each component? 4.) What is the significance ...
Chapter 18: Regulation of Gene Expression
Chapter 18: Regulation of Gene Expression

... controlling the levels and/or activities of specific gene products. • the gene product is either a protein or an RNA molecule • regulation can occur at any stage of gene expression which involves • accessibility of the gene itself (chromatin structure) • transcription & translation (if gene encodes ...
From Gene to Protein
From Gene to Protein

... Many different roles! ...
Transcription and Translation
Transcription and Translation

... • The ribosomal unit binds to mRNA where the code for met is located (AUG). The anticodon (UAC) of the tRNA matches the “start” codon on mRNA (AUG). ...
Special topics in electrical and systems engineering: Systems Biology
Special topics in electrical and systems engineering: Systems Biology

... Gene 1 ...
Regulation of Gene Expression
Regulation of Gene Expression

... • Gene transcription is controlled by regulatory proteins that bind to regulatory elements on DNA. The proteins usually either activate or repress transcription. • Regulation of transcription in prokaryotes typically involves an operon, such as the lac operon in E. coli. The lac operon is regulated ...
transcript - Mike Dyall
transcript - Mike Dyall

... ω - 11kDa, enzyme stability - restores denatured enzyme ...
Chapter 12
Chapter 12

... the aporepressor. The aporepressor becomes active only when a corepressor binds to it The corepressor inhibits transcription by activating the aporepressor ...
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Transcription factor



In molecular biology and genetics, a transcription factor (sometimes called a sequence-specific DNA-binding factor) is a protein that binds to specific DNA sequences, thereby controlling the rate of transcription of genetic information from DNA to messenger RNA. Transcription factors perform this function alone or with other proteins in a complex, by promoting (as an activator), or blocking (as a repressor) the recruitment of RNA polymerase (the enzyme that performs the transcription of genetic information from DNA to RNA) to specific genes.A defining feature of transcription factors is that they contain one or more DNA-binding domains (DBDs), which attach to specific sequences of DNA adjacent to the genes that they regulate. Additional proteins such as coactivators, chromatin remodelers, histone acetylases, deacetylases, kinases, and methylases, while also playing crucial roles in gene regulation, lack DNA-binding domains, and, therefore, are not classified as transcription factors.
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