PowerPoint - 埼玉医科大学総合医療センター 内分泌・糖尿病内科
... Transcription factor 7-like 2 (T-cell specific, HMG-box) also known as TCF7L2 or TCF4 is a protein acting as a transcription factor. In humans this protein is encoded by the TCF7L2 gene. A variant of the protein is linked to higher risk to develop type 2 diabetes. ...
... Transcription factor 7-like 2 (T-cell specific, HMG-box) also known as TCF7L2 or TCF4 is a protein acting as a transcription factor. In humans this protein is encoded by the TCF7L2 gene. A variant of the protein is linked to higher risk to develop type 2 diabetes. ...
Transcription, RNA Processing, and
... designated “-1” (there is no 0); numbering continues -1, 2, etc. in the upstream direction ...
... designated “-1” (there is no 0); numbering continues -1, 2, etc. in the upstream direction ...
DNA Transcription & Translation
... • The word transcribe means “to copy”. During transcription, the genetic information code is copied into a single strand of mRNA. mRNA is known as “messenger” RNA because it carries the DNA code or message out of the nucleus and into the cytoplasm. • DNA cannot travel out of the nucleus but RNA can. ...
... • The word transcribe means “to copy”. During transcription, the genetic information code is copied into a single strand of mRNA. mRNA is known as “messenger” RNA because it carries the DNA code or message out of the nucleus and into the cytoplasm. • DNA cannot travel out of the nucleus but RNA can. ...
Document
... A transcription factor (sometimes called a sequence-specific DNAbinding factor) is a protein that binds to specific DNA sequences, thereby controlling the flow (or transcription) of genetic information from DNA to mRNA. Transcription factors perform this function alone or with other proteins in a co ...
... A transcription factor (sometimes called a sequence-specific DNAbinding factor) is a protein that binds to specific DNA sequences, thereby controlling the flow (or transcription) of genetic information from DNA to mRNA. Transcription factors perform this function alone or with other proteins in a co ...
Chapter 17 - TeacherWeb
... A transcription factor (sometimes called a sequence-specific DNAbinding factor) is a protein that binds to specific DNA sequences, thereby controlling the flow (or transcription) of genetic information from DNA to mRNA. Transcription factors perform this function alone or with other proteins in a co ...
... A transcription factor (sometimes called a sequence-specific DNAbinding factor) is a protein that binds to specific DNA sequences, thereby controlling the flow (or transcription) of genetic information from DNA to mRNA. Transcription factors perform this function alone or with other proteins in a co ...
From DNA to Protein: Genotype to Phenotype Reading Assignments
... • Certain hereditary diseases in humans have been found to be caused by a defective enzyme. y • These observations supported the one one-gene, one one--polypeptide hypothesis. ...
... • Certain hereditary diseases in humans have been found to be caused by a defective enzyme. y • These observations supported the one one-gene, one one--polypeptide hypothesis. ...
Chapter 2
... In this dissertation we frequently refer to the HGVS Nomenclature and when doing so we have a clear subset of its rules in mind. Usually, we will restrict ourselves to so-called genomic descriptions, i.e., descriptions based upon a genomic sequence, e.g. a chromosome, without any additional annotati ...
... In this dissertation we frequently refer to the HGVS Nomenclature and when doing so we have a clear subset of its rules in mind. Usually, we will restrict ourselves to so-called genomic descriptions, i.e., descriptions based upon a genomic sequence, e.g. a chromosome, without any additional annotati ...
E. coli
... binding of ribosomes to the RNA maintains transcript stability and promotes efficient translation. This bacterial translation system gives efficient expression of either prokaryotic or eukaryotic gene products in a short amount of time. For the highest protein yield and the best initiation fidelity, ...
... binding of ribosomes to the RNA maintains transcript stability and promotes efficient translation. This bacterial translation system gives efficient expression of either prokaryotic or eukaryotic gene products in a short amount of time. For the highest protein yield and the best initiation fidelity, ...
Gene Expression Overview
... RNA gene or non-coding RNA gene: RNA molecule that is not translated into a protein. Noncoding RNA genes produce transcripts that exert their function without ever producing proteins. Non-coding RNA genes include transfer RNA (tRNA) and ribosomal RNA (rRNA), small RNAs such as snoRNAs, microRNAs, si ...
... RNA gene or non-coding RNA gene: RNA molecule that is not translated into a protein. Noncoding RNA genes produce transcripts that exert their function without ever producing proteins. Non-coding RNA genes include transfer RNA (tRNA) and ribosomal RNA (rRNA), small RNAs such as snoRNAs, microRNAs, si ...
RNA Viruses
... a nested set of RNAs - all share short 5’ sequence and a 7 base sequence but have unique AUG site and share 3’ end of genome • May be produced by jumping polymerase - 7 base sequence in various parts of genome – Get recombinant viruses with mixed infections – DI particles are common ...
... a nested set of RNAs - all share short 5’ sequence and a 7 base sequence but have unique AUG site and share 3’ end of genome • May be produced by jumping polymerase - 7 base sequence in various parts of genome – Get recombinant viruses with mixed infections – DI particles are common ...
Document
... What chromosomal events convert protooncogenes to dominantly acting oncogenes • Point mutations (e.g., RAS) • Deletion mutations (e.g., RTKs) • Chromosomal translocations that produce novel fusion proteins (e.g., Bcr-Abl) • Chromosomal translocation to juxtapose a strong promoter upstream and the p ...
... What chromosomal events convert protooncogenes to dominantly acting oncogenes • Point mutations (e.g., RAS) • Deletion mutations (e.g., RTKs) • Chromosomal translocations that produce novel fusion proteins (e.g., Bcr-Abl) • Chromosomal translocation to juxtapose a strong promoter upstream and the p ...
A quantitative modeling of protein
... We may be able to use heterogeneous experimental data to reveal the underlying mechanisms of differential binding of transcription factor to cis-regulatory region. ...
... We may be able to use heterogeneous experimental data to reveal the underlying mechanisms of differential binding of transcription factor to cis-regulatory region. ...
Nongenic transcription, gene regulation and action at a distance
... but not other genes with powerful upstream activation sequences (e.g. TEF1 and TEF2) (Bi and Broach, 1999), CHA1 – which flanks the HML mating-type locus – becomes a robust barrier when induced by serine (Donze and Kamakaka, 2001), and inverting the β-globin LCR destroys much of its activity (Tanimo ...
... but not other genes with powerful upstream activation sequences (e.g. TEF1 and TEF2) (Bi and Broach, 1999), CHA1 – which flanks the HML mating-type locus – becomes a robust barrier when induced by serine (Donze and Kamakaka, 2001), and inverting the β-globin LCR destroys much of its activity (Tanimo ...
No Slide Title
... turn, phosphorylates tyrosine residues on the cytoplasmic tail of the receptor. These phosphorylated tyrosines serve as docking sites for the Src Homology-2 (SH-2) domain of the STAT protein, and JAK catalyzes the tyrosine phosphorylation of the receptor-bound STAT. Phosphorylation of STAT at a cons ...
... turn, phosphorylates tyrosine residues on the cytoplasmic tail of the receptor. These phosphorylated tyrosines serve as docking sites for the Src Homology-2 (SH-2) domain of the STAT protein, and JAK catalyzes the tyrosine phosphorylation of the receptor-bound STAT. Phosphorylation of STAT at a cons ...
Gene Section CREB3L2 (cAMP responsive element binding
... induced substance (OASIS) DNA binding and basic leucine zipper dimerization (B-ZIP) family of transcription factors, together with CREB3L1 (also known as OASIS), CREB3L3, CREB3 and CREB3L4. ...
... induced substance (OASIS) DNA binding and basic leucine zipper dimerization (B-ZIP) family of transcription factors, together with CREB3L1 (also known as OASIS), CREB3L3, CREB3 and CREB3L4. ...
POSITIVE REGULATION – THE ARA OPERON
... -CAP is a symmetrical dimer of two identical subunits -when bound to cAMP (low glucose, high cAMP), CAP is active and binds to a specific palindrome found upstream of genes that are controlled by catabolite repression -consensus: 5’-AAATGTGATCT-AGATCACATTT-3’ -DNA binding mediated by a HTH present i ...
... -CAP is a symmetrical dimer of two identical subunits -when bound to cAMP (low glucose, high cAMP), CAP is active and binds to a specific palindrome found upstream of genes that are controlled by catabolite repression -consensus: 5’-AAATGTGATCT-AGATCACATTT-3’ -DNA binding mediated by a HTH present i ...
Gene Section THBS1 (thrombospondin-1) Atlas of Genetics and Cytogenetics in Oncology and Haematology
... transcription of THBS1 stimulated by serum. Transcription is regulated by c-Jun/AP-1 in cooperation with the repressor Yin Yang-1 (YY-1) and by p53. USF2 mediates glucose-induced TSP1 transcription. Id1 represses transcription. The ATF-1 transcription factor also down-regulates transcription of TSP1 ...
... transcription of THBS1 stimulated by serum. Transcription is regulated by c-Jun/AP-1 in cooperation with the repressor Yin Yang-1 (YY-1) and by p53. USF2 mediates glucose-induced TSP1 transcription. Id1 represses transcription. The ATF-1 transcription factor also down-regulates transcription of TSP1 ...
The Molecular Genetics of Gene Expression
... Most polypeptide chains fold correctly as they exit the ribosome: they pass through a tunnel in the large ribosomal subunit that is long enough to include about 35 amino acids Emerging from the tunnel, protein enters into a sort of cradle formed by a protein associated with the ribosome: it provides ...
... Most polypeptide chains fold correctly as they exit the ribosome: they pass through a tunnel in the large ribosomal subunit that is long enough to include about 35 amino acids Emerging from the tunnel, protein enters into a sort of cradle formed by a protein associated with the ribosome: it provides ...
Fig. 17.1 Levels at which gene expression can be controlled in
... • What evidence has shown the role of chromosome packaging and histone proteins in gene regulation? • What role does DNA methylation play? • What are DNA binding motifs in transcription factor proteins? • What are enhancers and silencers? • How does RNA processing and stability contribute to gene re ...
... • What evidence has shown the role of chromosome packaging and histone proteins in gene regulation? • What role does DNA methylation play? • What are DNA binding motifs in transcription factor proteins? • What are enhancers and silencers? • How does RNA processing and stability contribute to gene re ...
Promoter identification
... Promoters of housekeeping genes are easier to predict, but housekeeping genes are not regulated that strongly. So if biologist wants to up- or down-regulate the expression and you tell him he has CpG island promoter, he is usually not happy. • non-CpG islands correspond to tissue-specific expression ...
... Promoters of housekeeping genes are easier to predict, but housekeeping genes are not regulated that strongly. So if biologist wants to up- or down-regulate the expression and you tell him he has CpG island promoter, he is usually not happy. • non-CpG islands correspond to tissue-specific expression ...
Transcription
... initially synthesized‐‐a cut‐and‐paste job called RNA splicing. The average length of a transcription unit along a eukaryotic DNA molecule is about 8,000 nucleotides, so the primary RNA transcript is also that long. But it takes only about 1,200 nucleotides to code for an average‐sized protein of ...
... initially synthesized‐‐a cut‐and‐paste job called RNA splicing. The average length of a transcription unit along a eukaryotic DNA molecule is about 8,000 nucleotides, so the primary RNA transcript is also that long. But it takes only about 1,200 nucleotides to code for an average‐sized protein of ...
Chapter 2 DNA, RNA, Transcription and Translation I. DNA
... Proteolytic processing: e.g. cleavage of a polyprotein (VP) to form VP2 and VP4 (IBDV) ...
... Proteolytic processing: e.g. cleavage of a polyprotein (VP) to form VP2 and VP4 (IBDV) ...
Embryology
... Another group of paracrine signaling molecules important during development are neurotransmitters, including serotonin and norepinephrine, that act as ligands and bind to receptors just as proteins do. ...
... Another group of paracrine signaling molecules important during development are neurotransmitters, including serotonin and norepinephrine, that act as ligands and bind to receptors just as proteins do. ...
LBSC 708L Session 1
... nitric oxide reductases respectively. The NirI sequence corresponds to that of a membrane-bound protein with six transmembrane helices, a large periplasmic domain and cysteine-rich cytoplasmic domains that resemble the binding sites of [4Fe-4S] clusters in many ferredoxin-like proteins. NirX is solu ...
... nitric oxide reductases respectively. The NirI sequence corresponds to that of a membrane-bound protein with six transmembrane helices, a large periplasmic domain and cysteine-rich cytoplasmic domains that resemble the binding sites of [4Fe-4S] clusters in many ferredoxin-like proteins. NirX is solu ...
Transcription factor
In molecular biology and genetics, a transcription factor (sometimes called a sequence-specific DNA-binding factor) is a protein that binds to specific DNA sequences, thereby controlling the rate of transcription of genetic information from DNA to messenger RNA. Transcription factors perform this function alone or with other proteins in a complex, by promoting (as an activator), or blocking (as a repressor) the recruitment of RNA polymerase (the enzyme that performs the transcription of genetic information from DNA to RNA) to specific genes.A defining feature of transcription factors is that they contain one or more DNA-binding domains (DBDs), which attach to specific sequences of DNA adjacent to the genes that they regulate. Additional proteins such as coactivators, chromatin remodelers, histone acetylases, deacetylases, kinases, and methylases, while also playing crucial roles in gene regulation, lack DNA-binding domains, and, therefore, are not classified as transcription factors.