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lecture4(GS351)
lecture4(GS351)

... • Switches control transcription (which take the form of DNA sequence) - Called regulatory elements (RE’s) or enhancers - Adjoin the promoter region, but can be quite distant • Regulators, which take the form of proteins that bind the DNA, operate the switches - Called transcription factors (TF’s) • ...
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... mutation from each parent in both copies of a particular gene and develops a health condition. If the child inherits only one copy of the gene with the mutation, he/she will be a carrier of the condition but will not develop it. When 2 parents are carriers of the same mutation, their children have a ...
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... d) v-src, for example, is similar to a ‘normal’ gene in chickens. The major difference is that the ‘normal’ chicken gene (denoted c-src, where c = cellular) possesses introns, whereas v-src (the homologue in the virus) does not possess introns (and is a mutant allele) (i) This suggests that v-src (a ...
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... Mutation may occur spontaneously, or be induced by chemicals (e.g. colchicines ), radiations (e.g. X-rays and UV) and biological factors (e.g. viruses). Mutation may involve change in the number of chromosomes, e.g. polyploidy changes in chromosome structure, changes in DNA structure Sub-tot ...
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Vectors in gene therapy

Gene therapy utilizes the delivery of DNA into cells, which can be accomplished by several methods, summarized below. The two major classes of methods are those that use recombinant viruses (sometimes called biological nanoparticles or viral vectors) and those that use naked DNA or DNA complexes (non-viral methods).
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