Biochemical and Biophysical Research Communications
... FusA A3 also match well to those of TycB A3. However, analysis of the fusaricidins of E681 suggested that FusA A3 activates valine, isoleucine, and allo-isoleucine. The active site residues of FusA A5 perfectly match those of TycC A1 [13], ItuA A2, ItuB A2, ItuC A1 [17], MycA A2, MycB A2, MycC A2 [1 ...
... FusA A3 also match well to those of TycB A3. However, analysis of the fusaricidins of E681 suggested that FusA A3 activates valine, isoleucine, and allo-isoleucine. The active site residues of FusA A5 perfectly match those of TycC A1 [13], ItuA A2, ItuB A2, ItuC A1 [17], MycA A2, MycB A2, MycC A2 [1 ...
Tools for Comparing Bacterial Genomes
... lists several that we find useful. It is beyond the scope of this review to provide a detailed analysis of these methods, and the list is far from complete. The tools discussed here provide some interesting information on fundamental biological features and can be used to compare a few or large numb ...
... lists several that we find useful. It is beyond the scope of this review to provide a detailed analysis of these methods, and the list is far from complete. The tools discussed here provide some interesting information on fundamental biological features and can be used to compare a few or large numb ...
Solving the shugoshin puzzle
... is mediated by conserved proteins called shugoshins (Japanese for ’guardian spirit’) (reviewed in Ref. [3]). The role of shugoshins in mouse meiosis was recently analyzed [1]. Both mouse shugoshin proteins, Sgo1 and Sgo2, are ubiquitously expressed in proliferating cells, and Sgo2 expression is high ...
... is mediated by conserved proteins called shugoshins (Japanese for ’guardian spirit’) (reviewed in Ref. [3]). The role of shugoshins in mouse meiosis was recently analyzed [1]. Both mouse shugoshin proteins, Sgo1 and Sgo2, are ubiquitously expressed in proliferating cells, and Sgo2 expression is high ...
The Science of Psychology
... to aging that assumes older people are happier if they remain active in some way, such as volunteering or developing a hobby. • Cellular clock theory - based on the idea that cells only have so many times that they can reproduce; once that limit is reached, damaged cells begin to accumulate. Menu ...
... to aging that assumes older people are happier if they remain active in some way, such as volunteering or developing a hobby. • Cellular clock theory - based on the idea that cells only have so many times that they can reproduce; once that limit is reached, damaged cells begin to accumulate. Menu ...
Severe Combined Immunodeficiency (SCID)
... • There are several types of SCID. • The most common form is caused by a mutation in the SCIDX1 gene located on the X chromosome. ...
... • There are several types of SCID. • The most common form is caused by a mutation in the SCIDX1 gene located on the X chromosome. ...
Simplified global gene expression profiling
... unbiased, global transcript profiling by means of wholetranscriptome analysis (Figure 1). Ready-to-use research panels for gene expression analysis include the Ion AmpliSeq™ RNA Apoptosis Panel for gene expression profiling of 267 genes involved in the cellular apoptosis pathway, including genes ass ...
... unbiased, global transcript profiling by means of wholetranscriptome analysis (Figure 1). Ready-to-use research panels for gene expression analysis include the Ion AmpliSeq™ RNA Apoptosis Panel for gene expression profiling of 267 genes involved in the cellular apoptosis pathway, including genes ass ...
KAIE LOKK Comparative genome-wide DNA methylation
... The human genome contains about 29 million CpG dinucleotides where a cytosine base is followed by a guanine base. Cytosine in the CpG dinucleotide can exist in either a methylated or unmethylated state. DNA methyltransferase (DNMT) enzymes can add a methyl group to cytosine to form 5-methylcytosine ...
... The human genome contains about 29 million CpG dinucleotides where a cytosine base is followed by a guanine base. Cytosine in the CpG dinucleotide can exist in either a methylated or unmethylated state. DNA methyltransferase (DNMT) enzymes can add a methyl group to cytosine to form 5-methylcytosine ...
Do gametes woo? Evidence for non-random unions at
... embryonic development (preferential lethality). These examples of TRD probe the nature of Mendel’s First Law by illuminating genetic, molecular and cellular mechanisms that underlie meiosis, recombination, gametogenesis, and early development.1-3, 13, 32-36 Many of these ‘selfish genetic’ systems ar ...
... embryonic development (preferential lethality). These examples of TRD probe the nature of Mendel’s First Law by illuminating genetic, molecular and cellular mechanisms that underlie meiosis, recombination, gametogenesis, and early development.1-3, 13, 32-36 Many of these ‘selfish genetic’ systems ar ...
Forward to the special issue on Hox/Tale transcription factors in
... TALE proteins cannot be identified bioinformatically. This handicap would be at least somewhat alleviated by the ability to perform high-quality molecular biochemistry using antibodies in vivo and in cell culture; however, these reagents have been exceptionally difficult to generate, likely due to t ...
... TALE proteins cannot be identified bioinformatically. This handicap would be at least somewhat alleviated by the ability to perform high-quality molecular biochemistry using antibodies in vivo and in cell culture; however, these reagents have been exceptionally difficult to generate, likely due to t ...
Immobilization_Mecha..
... in ref 18. Briefly, 1.5 mL of 0.25 M HfOCl2·8H2O was added dropwise into 25 mL 5 M NH4OH and then annealed at 230 °C for 3 h in a sealed reaction vessel. Once the solution cooled to room temperature, it was centrifuged and rinsed with dH2O three times. At this point the particles were characterized w ...
... in ref 18. Briefly, 1.5 mL of 0.25 M HfOCl2·8H2O was added dropwise into 25 mL 5 M NH4OH and then annealed at 230 °C for 3 h in a sealed reaction vessel. Once the solution cooled to room temperature, it was centrifuged and rinsed with dH2O three times. At this point the particles were characterized w ...
Educational Items Section Chromosomes, Chromosome Anomalies Atlas of Genetics and Cytogenetics
... • Gametes with an extra autosome produce trisomic zygotes. The majority of trisomies are non-viable (e.g. trisomy 16) and a miscarriage occurs, sometimes so early that nothing is noticed. A few trisomies are more or less compatible with life, e.g. trisomies 21, 13, 18, and 8. • Nullosomic gametes (m ...
... • Gametes with an extra autosome produce trisomic zygotes. The majority of trisomies are non-viable (e.g. trisomy 16) and a miscarriage occurs, sometimes so early that nothing is noticed. A few trisomies are more or less compatible with life, e.g. trisomies 21, 13, 18, and 8. • Nullosomic gametes (m ...
Targeting gene expression to cones with human cone opsin
... all the promoters that lead to the successful cone transduction, cone GFP expression was most intense in the center of the bleb, and tapered to the margins where the relative number of transduced cells gradually decreased (Figures 4d and f). In addition, one eye of a dog affected by rcd1 was injecte ...
... all the promoters that lead to the successful cone transduction, cone GFP expression was most intense in the center of the bleb, and tapered to the margins where the relative number of transduced cells gradually decreased (Figures 4d and f). In addition, one eye of a dog affected by rcd1 was injecte ...
Genes, Chromosomes, and Numbers
... • A cell with two of each kind of chromosome is called a diploid cell and is said to contain a diploid, or 2n, number of chromosomes. (46 in humans) • Organisms produce gametes that contain one of each kind of chromosome. • A cell containing one of each kind of chromosome is called a haploid cell an ...
... • A cell with two of each kind of chromosome is called a diploid cell and is said to contain a diploid, or 2n, number of chromosomes. (46 in humans) • Organisms produce gametes that contain one of each kind of chromosome. • A cell containing one of each kind of chromosome is called a haploid cell an ...
10p proximal deletions from 10p11 and 10p12
... Each new version of the genome is often referred to as an ‘assembly’ or a ‘build’. Every few years a new assembly is released. The genetic information in this guide is based on the Genome Reference Consortium (GRC) human (h) genome assembly number 37 (GRCh37), which was released in 2009. Confusingly ...
... Each new version of the genome is often referred to as an ‘assembly’ or a ‘build’. Every few years a new assembly is released. The genetic information in this guide is based on the Genome Reference Consortium (GRC) human (h) genome assembly number 37 (GRCh37), which was released in 2009. Confusingly ...
Gene Section ETV6 (ets variant 6) Atlas of Genetics and Cytogenetics
... negative effect of the fusion protein over transcriptional repression mediated by wild-type ETV6. Thirty-three ETV6 partner genes have been identified. ...
... negative effect of the fusion protein over transcriptional repression mediated by wild-type ETV6. Thirty-three ETV6 partner genes have been identified. ...
Zygotic Lethal Mutations With Maternal Effect Phenotypes in
... the same strategy as described for 2K recombinants. The stocks used for these experiments were w; D FRT3',~zA/TM?, Sb and w; TM?, Sb/I,y. For Pelement lines that were proximal to thedominant marker D (which is inseparablefrom In(?L)h9D?-El; 7OCl?-D1), 10-20 individual lines were established since it ...
... the same strategy as described for 2K recombinants. The stocks used for these experiments were w; D FRT3',~zA/TM?, Sb and w; TM?, Sb/I,y. For Pelement lines that were proximal to thedominant marker D (which is inseparablefrom In(?L)h9D?-El; 7OCl?-D1), 10-20 individual lines were established since it ...
Bayesian Networks Classifiers for Gene-Expression Data
... IV contains the concluding remarks. II. BAYESIAN CLASSIFIERS FOR DNA MICROARRAY DATA ...
... IV contains the concluding remarks. II. BAYESIAN CLASSIFIERS FOR DNA MICROARRAY DATA ...
North Carolina End-Of-Course Coach for Biology
... A. By identifying the physical characteristics of someone with the disease B. By identifying parents as being carriers before they have children C. By identifying the presence of an extra copy of chromosome 21 D. By identifying chemical abnormalities in the blood ...
... A. By identifying the physical characteristics of someone with the disease B. By identifying parents as being carriers before they have children C. By identifying the presence of an extra copy of chromosome 21 D. By identifying chemical abnormalities in the blood ...
Association of MMP-3 (-1612 5A/6A) polymorphism with knee
... patients with knee osteoarthritis is not fully determined. To address this issue, we analyzed the influence of MMP-3 -1612 5A/6A polymorphism on the risk of knee OA in the Thai population. In this case–control study, our findings demonstrated that the percentage of the MMP-3 -1612 5A/ 6A polymorphis ...
... patients with knee osteoarthritis is not fully determined. To address this issue, we analyzed the influence of MMP-3 -1612 5A/6A polymorphism on the risk of knee OA in the Thai population. In this case–control study, our findings demonstrated that the percentage of the MMP-3 -1612 5A/ 6A polymorphis ...
PDF
... material Fig. S2B,D), which could be an indirect effect, but CDK9 has been reported to phosphorylate Ser5 in human cells (GloverCutter et al., 2009). Decreased Ser2-P after cdk-12 knockdown could be an indirect result of increased Pol II CTD phosphatase activity. Knockdown of the best characterized ...
... material Fig. S2B,D), which could be an indirect effect, but CDK9 has been reported to phosphorylate Ser5 in human cells (GloverCutter et al., 2009). Decreased Ser2-P after cdk-12 knockdown could be an indirect result of increased Pol II CTD phosphatase activity. Knockdown of the best characterized ...
Profile of Edward M. De Robertis - Howard Hughes Medical Institute
... follow in his father’s footsteps. “Consequently, I did not have to invest any energy in choosing a career,” he says. Students interested in biology were steered toward the field of medicine, so De Robertis went down that path. He earned a degree in medicine in 1971 from the University of Uruguay’s Sc ...
... follow in his father’s footsteps. “Consequently, I did not have to invest any energy in choosing a career,” he says. Students interested in biology were steered toward the field of medicine, so De Robertis went down that path. He earned a degree in medicine in 1971 from the University of Uruguay’s Sc ...
Unit 4, Lesson 10 Chromosomes and Genetics
... A. fragment of a chromosome attaches to its homologue –3. Inversion Fragment reattaches to its chrom. ???? Is placed their backwards Ladies and gentlemen, do our chromosomes change over time? What causes them to change? A change in the structure of the chromosome is a genetic mutation. There are t ...
... A. fragment of a chromosome attaches to its homologue –3. Inversion Fragment reattaches to its chrom. ???? Is placed their backwards Ladies and gentlemen, do our chromosomes change over time? What causes them to change? A change in the structure of the chromosome is a genetic mutation. There are t ...
A1 - 99 - University of Pittsburgh
... The CRISPR Mechanism Compared to Other Methods The CRISPR system is not without limitations; however, it still compares favorably to other genetic modification techniques. For example, retargeting Cas9 is simple to do, since only twenty base pairs of crRNA need to be changed [7]. Other methods of ge ...
... The CRISPR Mechanism Compared to Other Methods The CRISPR system is not without limitations; however, it still compares favorably to other genetic modification techniques. For example, retargeting Cas9 is simple to do, since only twenty base pairs of crRNA need to be changed [7]. Other methods of ge ...
ThermalAce™ DNA Polymerase
... Life Technologies has an exclusive license under US Patent No. 5,948,666, pending US patent applications and corresponding foreign patents and patent applications owned and licensed by Verenium Corporation to sell the ThermalAce™ enzyme to scientists for internal research purposes only, under the te ...
... Life Technologies has an exclusive license under US Patent No. 5,948,666, pending US patent applications and corresponding foreign patents and patent applications owned and licensed by Verenium Corporation to sell the ThermalAce™ enzyme to scientists for internal research purposes only, under the te ...
Enzymatic cleavage of RNA by RNA
... that are transcribed from DNA, namely transfer R N A (tRNA) and ribosomal RNA (rRNA) and many other minor species of R N A found in vivo that had no identifiable function prior to 1976, nor does it indicate that the information in DNA and R N A can be replicated as daughter D N A and R N A molecules ...
... that are transcribed from DNA, namely transfer R N A (tRNA) and ribosomal RNA (rRNA) and many other minor species of R N A found in vivo that had no identifiable function prior to 1976, nor does it indicate that the information in DNA and R N A can be replicated as daughter D N A and R N A molecules ...