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Foundations of Biology

... 3’AGTTCAG-TAC-TGA-ACA-CCA-TCA-ACT-GATCATC5’ 5’AGUC-AUG-ACU-UGU-GGU-AGU-UGA-CUAGAAA3’ ...
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... How is transcription different than replication? 1. Only one strand of DNA is transcribed so only one strand of mRNA is produced 2. The mRNA is released, it does not stay attached to the DNA 3. Many copies of mRNA can be made from a single gene in a short period of time ...
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... bypass • when highly processive semiconservative DNA replication is arrested at DNA lesions ...
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... order and overall chromosome organization have diverged greatly between humans and mice. According to rough estimates, a total of about 180 break-and-rejoin events have occurred in the human and mouse lineages since these two species last shared a common ancestor. In the process, although the number ...
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... There are several types of mutation: DELETION (a base is lost) INSERTION (an extra base is inserted) Deletion and insertion may cause what’s called a FRAMESHIFT, meaning the reading “frame” changes, changing the amino acid sequence. SUBSTITUTION (one base is substituted for another) If a substitutio ...
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... • Earlier, scientists thought that one gene equals one mRNA equals one protein, but the reality is much more complicated. They now know that one gene can be read out in portions that are spliced and diced to generate a variety of mRNAs and that subsequent processing of the newly made proteins that ...
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... to 0.15 events per generation, depending on the mutational pressure µ. However, it is still theoretically possible to create a gene “from scratch” or to duplicate a coding sequence without its promoter and letting it diverge before expressing it. Therefore, the genome should continue to grow, althou ...
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... exchange between molecules with extended sequence homology. For example, transformation and conjugation between related bacterial strains. Site-specific recombination refers to DNA recombination between molecules that shared limited regions of sequence homology. ...
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... BONUS 1) In humans, blue eyes are inherited as a recessive autosomal trait and color blindness is an X-linked recessive trait. A woman with blue eyes and normal color vision whose father was color blind marries a man who also has normal color vision. He has brown eyes, but his mother had blue eyes. ...
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... mutations, however, may be associated with a loss of function. In some cases, two copies of a gene are required for normal function, so that removing a single copy leads to mutant phenotype. Such genes are referred to as haplo-insufficient. In other cases, mutations in one allele may lead to a struc ...
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... D. Chemist Erwin Chargaff added to evidence that DNA is genetic material for cells by explaining the great diversity that can occur in DNA by the varying amounts of DNA’s four nitrogenous bases within a species. 1. Remember, DNA consists of a nitrogenous base (which can be adenine (A), thymine (T), ...
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... Assume that in humans the allele for brown eyes (B) is dominant over the allele for blue eyes (b). A blue-eyed man, both of whose parents had brown eyes, marries a brown-eyed woman. They have one child who has blue eyes. What are the genotypes of the man, his parents, his wife and the child? ...
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...  94% of bases in single scaffold  5602 protein-coding genes identified  Error rate per read = 1.04%  Error with coverage > 20X is zero  Slight bias toward high gene coverage ...
CTEGD Symposium, UGA, Athens, May 2011
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... users to combine datasets while building a search strategy. Multistep searches strategies are built one step at a time choosing from more than 100 searches. The latest EuPathDB release debuts a search for DNA motifs and a method of combining searches based on relative genomic location. This new oper ...
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Non-coding DNA

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