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VDJ Recombination
VDJ Recombination

... effect in coding joint formation and not in signal joint formation, as well as its homology to proteins with hydrolase activity, Artemis was proposed to participate in opening the hairpin coding ends (11). This prediction was supported by in vitro studies performed in M. Lieber’s laboratory (14), wh ...


... AN2 is more related to plant MYB proteins than to the animal c-MYB, the prototype of this superfamily (Figure 3A). The protein with the highest similarity found in the databases is that encoded by the myb75 gene of Arabidopsis, a gene whose function is not known (Kranz et al., 1998). Because the maj ...
Excel spreadsheet
Excel spreadsheet

... Average fold change is calculate as average of HEL6hrX5/restX5 and HEL6hrX7/rest6hrX7. Average difference intensities less than 5 were considered indistiguishable from 5 for this calculation. A transcript was considered increased at 6 hours if the data satisifed the following queries. For a given tr ...
Fusion Detection using Archer Analysis
Fusion Detection using Archer Analysis

High mutation rates in human and ape pseudoautosomal genes
High mutation rates in human and ape pseudoautosomal genes

... two small pseudoautosomal regions (PARs) at both ends of the sex chromosomes (Cooke et al., 1985; Freije et al., 1992). The short arms (Xp/Yp) of the sex chromosomes contain the larger p-PAR, which is about 2.6 Mb in size (Brown, 1988; Petit et al., 1988). Chiasmata between X and Y chromosomes in th ...
The mitochondrial genome of the soybean cyst nematode
The mitochondrial genome of the soybean cyst nematode

... infest a number of indicator soybean cultivars. Genetic approaches for distinguishing H. glycines populations could provide a means of rapidly distinguishing these types. However, such genetic markers have not yet been developed. The mitochondrial genome of H. glycines may provide such genetic marke ...
Mendel and After - U3A Site Builder Home Page
Mendel and After - U3A Site Builder Home Page

... Linnaeus began to think the hitherto unthinkable: had God really made all these species in one creative episode or had he arranged things so that new species might arise by cross-breeding among an originally much smaller suite of primordial forms? This idea was not deemed heretical because cross-br ...
Mechanisms of fast and stringent search in homologous pairing of
Mechanisms of fast and stringent search in homologous pairing of

... Homologous pairing of DNA molecules is involved in many fundamental biological processes, including homologous recombination in meiosis, interaction between alleles on homologous chromosomes (transvection) [1], and homologous repair of double strand breaks [2]. Recent experiments have shown that dsD ...
Nematode genome evolution
Nematode genome evolution

... Most nematodes have haploid chromosome numbers of n=4–12 (Walton, 1959). The karyotypes of just ~300 species have been studied, but nematodes display a lot of karyotypic variation (Špakulová and Casanova, 2004). The lowest haploid number is n=1 in Parascaris univalens, but very high counts are seen ...
Natural infection of Run1-positive vines by naïve genotypes of
Natural infection of Run1-positive vines by naïve genotypes of

Oncomedicine Base Excision Repair Manipulation in Breast
Oncomedicine Base Excision Repair Manipulation in Breast

... chromatin remodeling. On the other side, BRCA2 gene is devoted to DNA recombination and repair processes [1, 3, 6, 25, 26, 27]. It is documented that BRCA1 or BRCA2 loss result into lack of DNA double-strand breaks repair by the error-free mechanism of homologous recombination (HR). The deficiency i ...
gene (Pun1? - UC Davis Plant Sciences
gene (Pun1? - UC Davis Plant Sciences

... – cap, major QTL on chromosome 7 (C. frutescens x C. annuum) F2 – No co-localization between predicted structural genes and variation in capsaicinoid content – cap is a regulator of the pathway or unknown structural gene? ...
DNA How the Molecule of Heredity Carries, Replicates, and
DNA How the Molecule of Heredity Carries, Replicates, and

... DNA stores information in the sequence of its bases. •Much of DNA’s sequence-specific information is accessible only when the double helix is unwound. •Proteins read the DNA sequence of nucleotides as the DNA helix unwinds. Proteins can either bind to a DNA sequence, or initiate the copying of it. ...
Identification of Short Motifs for Comparing Biological Sequences
Identification of Short Motifs for Comparing Biological Sequences

... [email protected] Abstract — Sequence comparison remains one of the main computational tools in bioinformatics research. It is an essential starting point for addressing many problems in bioinformatics; including problems associated with recognition and classification of organisms. Although sequence ...
SAMPLE LITERATURE Please refer to included weblink for correct
SAMPLE LITERATURE Please refer to included weblink for correct

... use GFP to fluorescently label blood vessel proteins so they can track blood vessel growth patterns and networks. Scientists also tag regulatory DNA sequences with the GFP coding sequence so they can observe patterns of when and where the gene is expressed. In this way, GFP can reveal the role these ...
Document
Document

... © 2005 Prentice Hall Inc. / A Pearson Education Company / Upper Saddle River, New Jersey 07458 ...
"Frontmatter". In: Plant Genomics and Proteomics
"Frontmatter". In: Plant Genomics and Proteomics

... complication is that rounds of polyploidization followed by a restructuring of a polyploid genome have frequently occurred during evolution. The restructuring of the genome has usually resulted in a loss of some of the additional DNA derived from the original polyploid event. Therefore, the detailed ...
The Effect of a Coat Colour-Associated Genes Polymorphism on
The Effect of a Coat Colour-Associated Genes Polymorphism on

... et al., 1999). Horses of roan phenotype are characterized by grey coat colour that results from blending the basic colour with white bristles in the thorax, neck, and partially limb areas. Roan coat colour in horses is a semi-dominant trait (Rnrn). The dominant homozygote (RnRn) is lethal in utero ( ...
University of Bucharest, Faculty of Biology, Molecular Biology Center
University of Bucharest, Faculty of Biology, Molecular Biology Center

... neutrophiles across membranes to destroy invading pathogens [6; 9; 10]. The molecular basis of BLAD is a single point mutation (A-G) at position 383 in the cDNA of the CD18 gene. This mutation results in a substitution of a glycine for an aspartic acid at position 128 in the D128G protein [2; 5; 8; ...
"An In Vitro Selection Protocol for Threose Nucleic Acid (TNA) Using
"An In Vitro Selection Protocol for Threose Nucleic Acid (TNA) Using

... forming antiparallel Watson-Crick duplex structures in a self-pairing mode, and can also cross-pair opposite complementary strands of DNA and RNA. The solution NMR structure of a self-complementary TNA duplex reveals that TNA adopts an A-form helical structure, which explains its ability to exchange ...
Chapter Outline
Chapter Outline

... • When mutations occur, modified DNA molecules are  transmitted to the offspring. • Over time, mutations accumulate and the DNA  sequence is changed; chromosomal rearrangements  may also occur. l • Molecular evolution underlies the evolution of  organisms. © John Wiley & Sons, Inc. ...
Accounting for Non-Genetic Factors Improves the Power of eQTL
Accounting for Non-Genetic Factors Improves the Power of eQTL

... other physiological and biological factors. In principle, when collecting gene expression data sets for eQTL, non-genetic factors should be controlled to be constant across all samples, but in practice this can only be achieved to a limited degree. Indeed, it is reasonable to expect that a substanti ...
Why do more divergent sequences produce smaller non
Why do more divergent sequences produce smaller non

... closely related species, and the estimates decay as a function of the estimated distance. Figures 1B and 1B’ show the estimated synonymous distance dS vs. estimated d and figures 1C and 1C’ shows the estimated nonsynonymous distance dN vs. estimated d. Note that estimates of dS and d are highly corr ...
Chapter 27 Phage Strategies
Chapter 27 Phage Strategies

... • This results in the ordered expression of groups of genes during phage infection. ...
BIOLOGY (THEORY) – 2008
BIOLOGY (THEORY) – 2008

... organisms if there is more storage than consumption, the biomass of a population would be higher at the end of a time period than at the beginning. The rate of increase in the biomass of heterotrophs per unit time area is called secondary productivity. Secondary productivity is generally limited by ...
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Helitron (biology)

A helitron is a transposon found in eukaryotes that is thought to replicate by a so-called ""rolling-circle"" mechanism. This category of transposons was discovered by Vladimir Kapitonov and Jerzy Jurka in 2001. The rolling-circle process begins with a break being made at the terminus of a single strand of the helitron DNA. Transposase then sits at this break and at another break where the helitron targets as a migration site. The strand is then displaced from its original location at the site of the break and attached to the target break, forming a circlular heteroduplex. This heteroduplex is then resolved into a flat piece of DNA via replication. During the rolling-circle process, DNA can be replicated beyond the initial helitron sequence, resulting in the flanking regions of DNA being ""captured"" by the helitron as it moves to a new location.
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