Abundant RNA editing sites of chloroplast protein
... argue that the editing system produces additional mutations to adapt to different physiological functions. However, this does not explain why RNA editing did not occur in some ancient predating parasitic organisms [25]. Although one model, constructive neutral evolution, proposed that the RNA editin ...
... argue that the editing system produces additional mutations to adapt to different physiological functions. However, this does not explain why RNA editing did not occur in some ancient predating parasitic organisms [25]. Although one model, constructive neutral evolution, proposed that the RNA editin ...
Exclusion of known corneal dystrophy genes in an autosomal
... underlying causative genetic mechanism in a three-generation pedigree affected with a unique anterior membrane corneal dystrophy characterized by early onset recurrent corneal erosions, small discrete focal opacities at the level of Bowman layer and anterior stroma, anterior stromal flecks, and prom ...
... underlying causative genetic mechanism in a three-generation pedigree affected with a unique anterior membrane corneal dystrophy characterized by early onset recurrent corneal erosions, small discrete focal opacities at the level of Bowman layer and anterior stroma, anterior stromal flecks, and prom ...
Tomé, S., Manley, K., Simard, J.P., Clark, G.W., Slean, M.M., Swami
... through an affected individual’s life with Huntington’s disease or myotonic dystrophy. Broad ranges of repeat instability arise between individuals with expanded repeats, suggesting the existence of modifiers of repeat instability. Mice with expanded CAG/CTG repeats show variable levels of instabili ...
... through an affected individual’s life with Huntington’s disease or myotonic dystrophy. Broad ranges of repeat instability arise between individuals with expanded repeats, suggesting the existence of modifiers of repeat instability. Mice with expanded CAG/CTG repeats show variable levels of instabili ...
Wolbachia–host interactions: connecting phenotype to genotype
... parasites of insects is becoming complicated as an increasing number of papers describe a richer picture of Wolbachia-mediated phenotypes in insects. The search for the molecular basis for this phenotypic variability has been greatly aided by the recent sequencing of several Wolbachia genomes. These ...
... parasites of insects is becoming complicated as an increasing number of papers describe a richer picture of Wolbachia-mediated phenotypes in insects. The search for the molecular basis for this phenotypic variability has been greatly aided by the recent sequencing of several Wolbachia genomes. These ...
Human RIF1 and protein phosphatase 1 stimulate DNA replication
... experiments. We find that RIF1 depletion mildly but reproducibly impairs licensing, and that this effect is rescued by induction of GFP-RIF1 but not GFP-RIF1pp1bs. This result is as predicted by our model, in which RIF1 promotes origin licensing by directing PP1 to dephosphorylate and stabilize ORC1 ...
... experiments. We find that RIF1 depletion mildly but reproducibly impairs licensing, and that this effect is rescued by induction of GFP-RIF1 but not GFP-RIF1pp1bs. This result is as predicted by our model, in which RIF1 promotes origin licensing by directing PP1 to dephosphorylate and stabilize ORC1 ...
Etude du régime alimentaire des carnivores par des techniques
... biodiversity. Thus, precise knowledge of their diet is a prerequisite for designing conservation strategies of these endangered species. Direct and indirect monitoring as well as invasive and non-invasive approaches that have been used to study the diet are either biased or have a low resolution. Th ...
... biodiversity. Thus, precise knowledge of their diet is a prerequisite for designing conservation strategies of these endangered species. Direct and indirect monitoring as well as invasive and non-invasive approaches that have been used to study the diet are either biased or have a low resolution. Th ...
Presence of Escherichia coli carrying the EAST1 toxin gene in farm
... E. coli strains than EAST1 17-2. Furthermore, strain O-42 seems to be more virulent than strain 17-2, which failed to induce diarrhea, when administered to volunteers [26]. This study indicated that EAST1 produced by EAEC strain O-42 could represent a potent toxic molecule whereas the toxin elaborat ...
... E. coli strains than EAST1 17-2. Furthermore, strain O-42 seems to be more virulent than strain 17-2, which failed to induce diarrhea, when administered to volunteers [26]. This study indicated that EAST1 produced by EAEC strain O-42 could represent a potent toxic molecule whereas the toxin elaborat ...
Wolbachia John H. Werren and Jeremy D. Bartos
... in Wolbachia could increase their utility as tools for the genetic manipulation of insect populations by increasing the potential for the introduction of desirable traits into Wolbachia [15, 16]. Recombination also complicates phylogenetic analysis of Wolbachia. The major phylogenetic subdivisions ( ...
... in Wolbachia could increase their utility as tools for the genetic manipulation of insect populations by increasing the potential for the introduction of desirable traits into Wolbachia [15, 16]. Recombination also complicates phylogenetic analysis of Wolbachia. The major phylogenetic subdivisions ( ...
Type I Factor XI11 Deficiency Is Caused By a
... Nucleotide sequence analysis. The amplified DNA samples were digested with restriction enzymes to generate the proper ends for ligation into sequencing vectors. The digested samples were applied to a 0.8% agarose gel, electroeluted, and then subcloned into M13mp18 or M13mp19 (GIBCO-BRL, Gathersburg, ...
... Nucleotide sequence analysis. The amplified DNA samples were digested with restriction enzymes to generate the proper ends for ligation into sequencing vectors. The digested samples were applied to a 0.8% agarose gel, electroeluted, and then subcloned into M13mp18 or M13mp19 (GIBCO-BRL, Gathersburg, ...
Resolving the Discrepancies Among Nucleic Acid Conformational
... approaches, designed to meet guidelines set by the nucleic acid community, permit rigorous comparative analyses of different three-dimensional structures, as well as allow for reconstruction of chain molecules at the base-pair level. The different computer programs, however, yield inconsistent descr ...
... approaches, designed to meet guidelines set by the nucleic acid community, permit rigorous comparative analyses of different three-dimensional structures, as well as allow for reconstruction of chain molecules at the base-pair level. The different computer programs, however, yield inconsistent descr ...
Product description P003-D1 MLH1-MSH2-v01 - MRC
... least 220 nt or 520 nt, respectively, in inversion positive DNA samples, which is much longer than the length requirements for other MLPA probes (60-80 nt). DNA samples in which both probes show a clear peak, as well as samples in which only a clear peak for the 265 nt probe (20091-L28216) is observ ...
... least 220 nt or 520 nt, respectively, in inversion positive DNA samples, which is much longer than the length requirements for other MLPA probes (60-80 nt). DNA samples in which both probes show a clear peak, as well as samples in which only a clear peak for the 265 nt probe (20091-L28216) is observ ...
The amelogenin gene
... protein is now well characterized from the data of amino acid sequences which have been shown to be at a high degree of homology between all species investigated to date. The gene structure of this protein has been demonstrated and it is confirmed that there are two amelogenin genes, one on the X.ch ...
... protein is now well characterized from the data of amino acid sequences which have been shown to be at a high degree of homology between all species investigated to date. The gene structure of this protein has been demonstrated and it is confirmed that there are two amelogenin genes, one on the X.ch ...
documentation in PDF format
... Uniprot - add identifiers for translated protein products from three UniProt -related databases (SWISSPROT, TREMBL and UniParc). Equivalent to --uniprot HGVS - generate HGVS identifiers for your input variants relative to the transcript coding sequence (HGVSc) and the protein sequence (HGVSp). Equival ...
... Uniprot - add identifiers for translated protein products from three UniProt -related databases (SWISSPROT, TREMBL and UniParc). Equivalent to --uniprot HGVS - generate HGVS identifiers for your input variants relative to the transcript coding sequence (HGVSc) and the protein sequence (HGVSp). Equival ...
Distribution and structural variation of the she pathogenicity island in
... A third putative virulence gene, pic, encoding a mucinase with haemagglutinin activity [7], is also carried on the PAI [1]. The complete nucleotide sequence and genetic organisation of the she PAI was determined recently and revealed that it has many of the features that are characteristic of PAIs f ...
... A third putative virulence gene, pic, encoding a mucinase with haemagglutinin activity [7], is also carried on the PAI [1]. The complete nucleotide sequence and genetic organisation of the she PAI was determined recently and revealed that it has many of the features that are characteristic of PAIs f ...
Deletions of NF1 gene and exons detected by multiplex ligation
... are small lesions, such as intraexonic deletions or insertions, splicing mutations, and nonsense or missense mutations.11 15–17 In these cases, the intrafamilial and interfamilial clinical variability of all symptoms is marked, precluding any prognosis regarding patient outcome even if the disease-c ...
... are small lesions, such as intraexonic deletions or insertions, splicing mutations, and nonsense or missense mutations.11 15–17 In these cases, the intrafamilial and interfamilial clinical variability of all symptoms is marked, precluding any prognosis regarding patient outcome even if the disease-c ...
Hormesis - Illinois Institute of Technology
... BEIR-VII says: in order for a dose threshold to exist, there has to be totally error-free DNA damage response and repair Others would argue with that! Intelligent and thoughtful professionals are involved in crafting these responses; but the final conclusions might still be seen as politically motiv ...
... BEIR-VII says: in order for a dose threshold to exist, there has to be totally error-free DNA damage response and repair Others would argue with that! Intelligent and thoughtful professionals are involved in crafting these responses; but the final conclusions might still be seen as politically motiv ...
Sequence dependence of isothermal DNA amplification via EXPAR
... is one of the leading methods used to identify DNA sequences recognized by certain proteins, such as transcription factor binding sites (30,31), splice sites, and translational start sites (32). The standard PWM approach relies on the assumption that each position in the DNA sequence contributes ind ...
... is one of the leading methods used to identify DNA sequences recognized by certain proteins, such as transcription factor binding sites (30,31), splice sites, and translational start sites (32). The standard PWM approach relies on the assumption that each position in the DNA sequence contributes ind ...
mic.sgmjournals.org
... amino acid residues such as epimerization, heterocyclization, oxidation, formylation, reduction or N-methylation may also be included in the module (Lautru & Challis, 2004; Marahiel et al., 1997; Sieber & Marahiel, 2005). Microcystins typically contain the unusual non-proteinogenic amino acid Nmethy ...
... amino acid residues such as epimerization, heterocyclization, oxidation, formylation, reduction or N-methylation may also be included in the module (Lautru & Challis, 2004; Marahiel et al., 1997; Sieber & Marahiel, 2005). Microcystins typically contain the unusual non-proteinogenic amino acid Nmethy ...
Tandem Genetic Duplications in Phage and Bacteria
... Before discussing experimental data, it is important to consider the behavior and formal genetic aspects of tandem duplications. These considerations lead to predic tions that are borne out by the experimental data. The reasons tandem duplications generally cause no loss of function can be seen in ...
... Before discussing experimental data, it is important to consider the behavior and formal genetic aspects of tandem duplications. These considerations lead to predic tions that are borne out by the experimental data. The reasons tandem duplications generally cause no loss of function can be seen in ...
Commentary: A century of Mendelism: on Johannsen`s genotype
... question. Johannsen opposed such preformationist notions. He also opposed Weismann’s chromosomal theory, which suggested ‘that discrete particles of the chromosomes are “bearers” of special organizing functions in the mechanism of ontogenesis, a chromatin representative of an organ or a group of tis ...
... question. Johannsen opposed such preformationist notions. He also opposed Weismann’s chromosomal theory, which suggested ‘that discrete particles of the chromosomes are “bearers” of special organizing functions in the mechanism of ontogenesis, a chromatin representative of an organ or a group of tis ...
lecture - Berkeley MCB
... “Up until now, it had seemed reasonable to postulate that constitutive mutants synthesized an endogenous inducer which was absent in inducible cells. The results described here suggest an exactly opposite hypothesis. The facts can be explained by the supposition that the i gene determines (via an en ...
... “Up until now, it had seemed reasonable to postulate that constitutive mutants synthesized an endogenous inducer which was absent in inducible cells. The results described here suggest an exactly opposite hypothesis. The facts can be explained by the supposition that the i gene determines (via an en ...
Ensembl variation resources Open Access Database
... information is used to filter out wrongly mapped reads, and variants with more than two alleles for one strain/ individual are discarded. For individuals or strains with a read coverage of greater than 3, a SNP will be reported if at least two reads have the minor allele. Ensembl also examines the r ...
... information is used to filter out wrongly mapped reads, and variants with more than two alleles for one strain/ individual are discarded. For individuals or strains with a read coverage of greater than 3, a SNP will be reported if at least two reads have the minor allele. Ensembl also examines the r ...
Chapter 4 - DORAS
... 2001). The uptake systems for these compounds by free-living rhizobia have been shown to consist of TonB-dependent outer membrane haem specific receptors and inner membrane haem ABC transporters. In S. meliloti 242 an outer membrane receptor, ShmR, specific for haem uptake has been identified (Batti ...
... 2001). The uptake systems for these compounds by free-living rhizobia have been shown to consist of TonB-dependent outer membrane haem specific receptors and inner membrane haem ABC transporters. In S. meliloti 242 an outer membrane receptor, ShmR, specific for haem uptake has been identified (Batti ...