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1548 Tn Gene Is Borne by Composite Transposon Aminoglycoside
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... resistant to amikacin, streptomycin-spectinomycin, sulfonamides, trimethoprim, neomycin, and chloramphenicol. By contrast, in the K802N recipient, the loss of resistance (i) to amikacin, streptomycin-spectinomycin, sulfonamides, and trimethoprim secondary to excision of Tn1548, (ii) to neomycin due ...
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... of discrete, double-strand breaks caused by nuclease digestion of chromatin. • These correspond to discrete regions of substantially altered chromatin structure – In some cases they lack nucleosomes ...
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... expand the original set, and increase recall. • Some rules with lower confidence get a lower weight in the ranking step. ...
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Helitron (biology)

A helitron is a transposon found in eukaryotes that is thought to replicate by a so-called ""rolling-circle"" mechanism. This category of transposons was discovered by Vladimir Kapitonov and Jerzy Jurka in 2001. The rolling-circle process begins with a break being made at the terminus of a single strand of the helitron DNA. Transposase then sits at this break and at another break where the helitron targets as a migration site. The strand is then displaced from its original location at the site of the break and attached to the target break, forming a circlular heteroduplex. This heteroduplex is then resolved into a flat piece of DNA via replication. During the rolling-circle process, DNA can be replicated beyond the initial helitron sequence, resulting in the flanking regions of DNA being ""captured"" by the helitron as it moves to a new location.
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