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Is there a code for protein–DNA recognition?
Is there a code for protein–DNA recognition?

... If the two distributions, P and Q, are similar in the high probability states then their relative entropy is close to zero. This formalisation makes clear the relation between the interaction energies and the specificity of a protein to certain DNA targets (‘‘DNA recognition’’). The lower the intera ...
Walk-thru of CAGE exercise
Walk-thru of CAGE exercise

... – Etc What if we want to compare two experiments? ...
Functional analysis of the regulatory region of a zein gene in
Functional analysis of the regulatory region of a zein gene in

... genes has led to the, identification of a typical regulatory region, in which two promoters, P1 and P2, lying approximately 1000 bases apart, determine the appearance of long and short zein transcripts [ 13]. On the basis of sequence homology and nuclear protein-binding sites, it has been suggested ...
Estimation of Circular DNA Size Using r
Estimation of Circular DNA Size Using r

... weight of about 85 kb (the nicked circular species remains in the well, as discussed above). The new 85-kb DNA is linear, as revealed by mobility characteristics (lack of altered migration path or pulse-time dependence) and sensitivity to exonuclease (not shown). These data show that the amplified c ...
Lab 9: Web Applications for Gene Family Evolution
Lab 9: Web Applications for Gene Family Evolution

... First, let's look at the plot of domains. There are three different classes of domains described in this plot. There are a bunch of transmembrane alpha-helices and several of these make up the ABC-transporter trans-membrane domains What is the “ABC tran”? Click on that link. This links to the Sanger ...
genome_mapping.pdf
genome_mapping.pdf

... number of certain repeats seen in nonSequencing of the human genome as part of coding regions correlate with development the Human Genome Project has led to the of cancer. discovery of sequence tagged sites (STSs) that are found throughout the human genome and can be reliably used as markers. STSs a ...
Chapter 13
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... However, Initiation Complex needs the help of other proteins, Activators, in order to assemble. Some Activators bind to promoter-proximal elements, others bind to enhancer elements, due to the sequence-specific DNA binding properties of their DNA binding domains. Activators' activation domains physi ...
Network (Reticulate) Evolution: Biology, Models, and
Network (Reticulate) Evolution: Biology, Models, and

... • Key Evolutionary Insight: Because all evolution is a product of change from one generation to the next, the information must initially change in some form of ...
Word Work File L_3.tmp - FacStaff Home Page for CBU
Word Work File L_3.tmp - FacStaff Home Page for CBU

... molecules, body defense, signaling between cells, chemical catalysts called enzymes, storage, and other functions. Proteins vary in their structure so they can perform specific functions. Proteins are large complex molecules, polymers of amino acids, joined by peptide bonds. These polymers are calle ...
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Sulfuricella denitrificans gen. nov., sp. nov., a sulfur

... Growth was observed at temperatures below 28 6C; optimum growth was observed at 22 6C. The pH range for growth was 6.0–9.0, and the optimum pH was 7.5–8.0. Optimum growth of the isolate was observed in medium without NaCl, and no growth was observed in medium containing more than 220 mM NaCl. The G+ ...
Word Work File L_293849362.tmp
Word Work File L_293849362.tmp

... molecules, body defense, signaling between cells, chemical catalysts called enzymes, storage, and other functions. Proteins vary in their structure so they can perform specific functions. Proteins are large complex molecules, polymers of amino acids, joined by peptide bonds. These polymers are calle ...
Bio II Ch 19 Eukaryotic Genomes
Bio II Ch 19 Eukaryotic Genomes

... shortens with each round of replication and they bind to proteins that protect the ends of chromosomes from degradation and fusion with other chromosomes. ...
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preparation for end of course biology exam
preparation for end of course biology exam

... The Corn snakes show variety in their skin color pattern. While the complete genetics of corn snake color are complex, the most common colors on normal corn snakes—red and black— are each coded by one gene. For the red gene, the allele for the presence of red pigment (R) is dominant and the allele f ...
Closely related proteins MBD2 and MBD3 play distinctive but
Closely related proteins MBD2 and MBD3 play distinctive but

... transcription stop site located in the ␤geo cassette, thus preventing transcription of the remainder of the Mbd2 gene. The resulting transcript can encode the N-terminal 183 amino acids of MBD2, but translation then stops in the middle of the methyl-CpG binding domain (Fig. 1a,2a). After transfectio ...
BioinformaIcs Journal Club
BioinformaIcs Journal Club

... This  special  issue  reflects  the  recent  advances  in  the  field  of   environmental   genomics   and   exposes   the   aPrac)ve   prospects  in  the  light  of  the  new,  rapidly-­‐evolving  tools  that   are   next   genera)on   seque ...
12–1 DNA
12–1 DNA

... information from one generation to the next. c. transformation does not affect bacteria. d. proteins transmit genetic information from one generation to the next. ...
PDF - Molecular Vision
PDF - Molecular Vision

... first year of life [1,2]. The incidence of RB worldwide is estimated at between 5,000 and 8,000 new cases per year, and although RB can occur at any age, this tumor occurs most often in preschool children (95% of cases diagnosed before 5 years of age) [3-5]. The primary genetic event associated with ...
Candy Shop! - hrsbstaff.ednet.ns.ca
Candy Shop! - hrsbstaff.ednet.ns.ca

... Making proteins in the cell is a lot like making candy in a factory! The boss of the Candy Factory, Frieda, sits in her office all day handing out recipe cards to messengers who go out to the various assembly stations on the factory floor and direct the assembly of ingredients that correspond to the ...
LINKAGE DATA Crosses were
LINKAGE DATA Crosses were

... (inositol-less) ...
Laboratory of Molecular Genetics, KNU
Laboratory of Molecular Genetics, KNU

... Viruses  Replicate by inserting their DNA into a host ...
MOTIFS MOTIFSMARTIFAMORIFSMOOTIFSMICIFC
MOTIFS MOTIFSMARTIFAMORIFSMOOTIFSMICIFC

... When a sequence motif appears in protein-coding regions, it may specify a "structural motif" of a protein. Short coding motifs in proteins include sites that label proteins for delivery to particular parts of a cell, or mark them for phosphorylation. ...
Linear DNA Low Efficiency Transfection by Liposome Can - if
Linear DNA Low Efficiency Transfection by Liposome Can - if

... when using the same amount of Lipofectamine. The AFM showed the condensate structures to be very different from those of the circular plasmid. Furthermore, during the electrophoresis there was no or very little retention of the linear DNA inside the agarose gel (Figure 2, lane 4). The incorporation ...
No Slide Title
No Slide Title

... biosynthetic pathways that might be required in free-living organisms – But remember about non-orthologous gene displacements! • Some lessons from bacterial genomics – Nearly half of ORFs are of unknown function – About 25% of all ORFs are unique to a particular species! • Suggests that many new pro ...
The Differential Killing of Genes by Inversions in Prokaryotic Genomes
The Differential Killing of Genes by Inversions in Prokaryotic Genomes

... from ftp://www.ncbi.nlm.nih.gov. The two pairs of genomes were chosen because, according to parameters of asymmetry in each of these genomes, the genes lying on the leading strand form a set distinct from the set of genes lying on the lagging strand. We have extracted amino acid sequences of ortholo ...
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Helitron (biology)

A helitron is a transposon found in eukaryotes that is thought to replicate by a so-called ""rolling-circle"" mechanism. This category of transposons was discovered by Vladimir Kapitonov and Jerzy Jurka in 2001. The rolling-circle process begins with a break being made at the terminus of a single strand of the helitron DNA. Transposase then sits at this break and at another break where the helitron targets as a migration site. The strand is then displaced from its original location at the site of the break and attached to the target break, forming a circlular heteroduplex. This heteroduplex is then resolved into a flat piece of DNA via replication. During the rolling-circle process, DNA can be replicated beyond the initial helitron sequence, resulting in the flanking regions of DNA being ""captured"" by the helitron as it moves to a new location.
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