Heritability of X Chromosome-inactivation Phenotype in a Large
... 365 women, were found to have e80% of their lymphocytes with the same X chromosome active. Initially we found this observation surprising, but this estimate is similar to that reported by other investigators using either the AR methylation assay on total lymphocytes from normal females (3 [15%] of 2 ...
... 365 women, were found to have e80% of their lymphocytes with the same X chromosome active. Initially we found this observation surprising, but this estimate is similar to that reported by other investigators using either the AR methylation assay on total lymphocytes from normal females (3 [15%] of 2 ...
Brassinosteroids Rescue the Deficiency of CYP90, a Cytochrome
... negative regulators of light signaling because the developmental and molecular phenotypes of det, cop, and fus mutants are not altered by the hy mutations of photoreceptors (Quail et al., 1995). Nonetheless, because these mutations have severe pleiotropic effects, it is likely that the DET, COP, and ...
... negative regulators of light signaling because the developmental and molecular phenotypes of det, cop, and fus mutants are not altered by the hy mutations of photoreceptors (Quail et al., 1995). Nonetheless, because these mutations have severe pleiotropic effects, it is likely that the DET, COP, and ...
CHAPTER 13 Gene Mapping in Eukaryotes
... single X chromosome. Phenotype is carnation, non-bar eyes. b. Female parent carried two abnormal and cytologically distinct X chromosomes, with a genotype of + + / B car, and a phenotype of wide-bar red eyes. i. One X chromosome had a translocated fragment of Y chromosome. It carried the wild-type a ...
... single X chromosome. Phenotype is carnation, non-bar eyes. b. Female parent carried two abnormal and cytologically distinct X chromosomes, with a genotype of + + / B car, and a phenotype of wide-bar red eyes. i. One X chromosome had a translocated fragment of Y chromosome. It carried the wild-type a ...
Functional genomics of plant photosynthesis in
... protein interacts specifically with a U-rich translation element in a NAC2-dependent manner19. The NAC2 gene was cloned by complementation of the nac2 mutation with a cosmid library20, and found to encode a hydrophilic polypeptide with nine tetratricopeptide-like repeats (TPRs) in its C-terminal dom ...
... protein interacts specifically with a U-rich translation element in a NAC2-dependent manner19. The NAC2 gene was cloned by complementation of the nac2 mutation with a cosmid library20, and found to encode a hydrophilic polypeptide with nine tetratricopeptide-like repeats (TPRs) in its C-terminal dom ...
NIHMS103218-supplement-2
... mRNA bearing the missense variant(s) under investigation7. We identified a single partial zebrafish transcript that, upon reciprocal BLAST analysis, showed the highest amino acid similarity between zebrafish and human (73% similarity, 55% identity), to which we designed a splice-blocking morpholino ...
... mRNA bearing the missense variant(s) under investigation7. We identified a single partial zebrafish transcript that, upon reciprocal BLAST analysis, showed the highest amino acid similarity between zebrafish and human (73% similarity, 55% identity), to which we designed a splice-blocking morpholino ...
silicon nanowire biosensor for studying nuclear hormone receptor
... Estrogen receptors (ERs) are members of a superfamily of nuclear receptors that function as ligand-modulated transcriptional regulators. The ERs mainly function as a DNA binding transcription factor that regulates gene expression. They play a key role in many normal physiological processes, but prom ...
... Estrogen receptors (ERs) are members of a superfamily of nuclear receptors that function as ligand-modulated transcriptional regulators. The ERs mainly function as a DNA binding transcription factor that regulates gene expression. They play a key role in many normal physiological processes, but prom ...
Marfan syndrome in the third Millennium
... The deduced primary structure reveals a highly repetitive protein that contains essentially three repeated modules (figure 1): The first repeated module is the EGF-like module that is homologous to one found in the epidermal growth factor. These modules contain six cysteine residues that form three ...
... The deduced primary structure reveals a highly repetitive protein that contains essentially three repeated modules (figure 1): The first repeated module is the EGF-like module that is homologous to one found in the epidermal growth factor. These modules contain six cysteine residues that form three ...
Natural variation in monoterpene synthesis in kiwifruit
... Grierson, 2002) initiates rapid fruit ripening. During climacteric fruit ripening, autocatalytic ...
... Grierson, 2002) initiates rapid fruit ripening. During climacteric fruit ripening, autocatalytic ...
S1 Supporting Information
... The amplified 5.1 kb fragment was BglII digested and ligated with the 3.4 kb pyrG fragment to give plasmid pMAT768. A 5.5 kb replacement fragment harboring the pyrG gene flanked by 1.1 kb and 1.0 kb of sequences adjacent to 136157 was released from plasmid pMAT768 by PvuII digestion, amplified with ...
... The amplified 5.1 kb fragment was BglII digested and ligated with the 3.4 kb pyrG fragment to give plasmid pMAT768. A 5.5 kb replacement fragment harboring the pyrG gene flanked by 1.1 kb and 1.0 kb of sequences adjacent to 136157 was released from plasmid pMAT768 by PvuII digestion, amplified with ...
Ultrasound-triggered image-guided therapy
... gas exchange does take place in the lungs. Polymer-shelled microbubbles are easily prepared with a more narrow size distribution. This avoids significant accumulation in the lungs. Polymer shells are more rigid, leading to different acoustic characteristics from those of lipidshelled agents, governe ...
... gas exchange does take place in the lungs. Polymer-shelled microbubbles are easily prepared with a more narrow size distribution. This avoids significant accumulation in the lungs. Polymer shells are more rigid, leading to different acoustic characteristics from those of lipidshelled agents, governe ...
Interfering RNA
... • showing of antisense targets across mRNA may be sufficient, but not all antisense targets are open to siRNA • intron targets may not be active for siRNA but may be for antisense – identify all elements claimed and their support in the description – identify species explicitly or implicitly disclos ...
... • showing of antisense targets across mRNA may be sufficient, but not all antisense targets are open to siRNA • intron targets may not be active for siRNA but may be for antisense – identify all elements claimed and their support in the description – identify species explicitly or implicitly disclos ...
Depleting Gene Activities in Early Drosophila Embryos
... when expressed during oogenesis using an upstream activating sequence (UAS) and a maternal Gal4 driver, reproduced the phenotypes of Mat, Zyg, and Mat&Zyg genes (Ni et al. 2011). Using RNAi to study early embryonic phenotypes is an attractive strategy as it requires fewer and simpler crosses than th ...
... when expressed during oogenesis using an upstream activating sequence (UAS) and a maternal Gal4 driver, reproduced the phenotypes of Mat, Zyg, and Mat&Zyg genes (Ni et al. 2011). Using RNAi to study early embryonic phenotypes is an attractive strategy as it requires fewer and simpler crosses than th ...
Dissecting Gene Expression Changes Accompanying a Ploidy
... In any given environment, the fitness of an aneuploid appears to reflect a combination of these general negative impacts of aneuploidy along with any phenotypes associated with the particular pattern of chromosome (and hence gene) copy number change. With sufficiently strong selective pressure, the ...
... In any given environment, the fitness of an aneuploid appears to reflect a combination of these general negative impacts of aneuploidy along with any phenotypes associated with the particular pattern of chromosome (and hence gene) copy number change. With sufficiently strong selective pressure, the ...
Part 2 - Laboratory of Aquaculture & Artemia Reference Center
... This review claims attention of genomic researchers about a tiny crustacean Artemia. Apart from serving as livefeed in aquaulture industries, Artemia seems to be the ultimate model for several genomic puzzles. Genomic research on Artemia at the molecular level is still in its infancy and a complete ...
... This review claims attention of genomic researchers about a tiny crustacean Artemia. Apart from serving as livefeed in aquaulture industries, Artemia seems to be the ultimate model for several genomic puzzles. Genomic research on Artemia at the molecular level is still in its infancy and a complete ...
Huntingtin grabs a hammer: DNA repair in HD
... this, they used an extremely precise laser light beam to irradiate each nucleus, etching a stripe of DNA damage in its wake. Soon after, they observed the arrival of glowing huntingtin proteins along the injured swath. ATM proteins were congregated in the same place. When a drug was used to silence ...
... this, they used an extremely precise laser light beam to irradiate each nucleus, etching a stripe of DNA damage in its wake. Soon after, they observed the arrival of glowing huntingtin proteins along the injured swath. ATM proteins were congregated in the same place. When a drug was used to silence ...
PDF
... results provide strong support for the view that all melanoblasts are affected and the host tissue plays an important role in determining the pattern of spotting. However, there appear to be some indications that all melanoblasts may not be affected to the same degree. INTRODUCTION ...
... results provide strong support for the view that all melanoblasts are affected and the host tissue plays an important role in determining the pattern of spotting. However, there appear to be some indications that all melanoblasts may not be affected to the same degree. INTRODUCTION ...
Cloning of a Novel Na+-Dependent L
... transport upon the initial rates of [14C]serine uptake was investigated (Fig. 4). Serine uptake is a saturatable process displaying a hyperbolic curve. The kinetics of Lserine transport, by preparing a double-reciprocal plot of serine concentration versus initial serine uptakes, was also investigate ...
... transport upon the initial rates of [14C]serine uptake was investigated (Fig. 4). Serine uptake is a saturatable process displaying a hyperbolic curve. The kinetics of Lserine transport, by preparing a double-reciprocal plot of serine concentration versus initial serine uptakes, was also investigate ...
"Dual-coding Regions in Alternatively Spliced Human Genes". In
... Figure 1c, two tumour suppressor proteins p16INK4A and ARF are juxtaposed in this 30-kb locus: each has a unique first exon that splices to a common second exon, but in different reading frames. These two proteins have distinct biological functions: p16INK4A inhibits cdk4/6 activity, leading to RB hyp ...
... Figure 1c, two tumour suppressor proteins p16INK4A and ARF are juxtaposed in this 30-kb locus: each has a unique first exon that splices to a common second exon, but in different reading frames. These two proteins have distinct biological functions: p16INK4A inhibits cdk4/6 activity, leading to RB hyp ...
Meiosis Lecture - Mayfield City Schools
... halves the number of chromosome sets per cell from diploid (2n) to haploid (n) Meiosis II is called the equational division because the haploid cells divide to produce haploid daughter cells The mechanism of sister chromatid separation in meiosis II is identical to that in mitosis ...
... halves the number of chromosome sets per cell from diploid (2n) to haploid (n) Meiosis II is called the equational division because the haploid cells divide to produce haploid daughter cells The mechanism of sister chromatid separation in meiosis II is identical to that in mitosis ...
A small region on the X chromosome of Drosophila regulates a key
... the quality of the structures differentiated by them. These parameters are important, since, as discussed later, they can be used as an indirect measure of dosage compensation. The distribution of clones in head, thorax, and abdomen is shown in Figure 2. Proximal duplications were well tolerated. Ti ...
... the quality of the structures differentiated by them. These parameters are important, since, as discussed later, they can be used as an indirect measure of dosage compensation. The distribution of clones in head, thorax, and abdomen is shown in Figure 2. Proximal duplications were well tolerated. Ti ...
Combining Microarrays and Biological Knowledge for
... candidate networks obtained in Step3. In Step2, we use the greedy hill-climbing algorithm for learning networks. The details are shown in Imoto et al. [23]. Note that the proposed prior probability of the network can be used for other types of Bayesian network models, such as discrete Bayesian netwo ...
... candidate networks obtained in Step3. In Step2, we use the greedy hill-climbing algorithm for learning networks. The details are shown in Imoto et al. [23]. Note that the proposed prior probability of the network can be used for other types of Bayesian network models, such as discrete Bayesian netwo ...
Knockdown of Parhyale Ultrabithorax - IMBB
... developed a strategy to knock down gene function during Parhayle development using injection of siRNAs, a technique effective in several diverse animal taxa. To demonstrate the efficacy of this technique in Parhyale, we chose the Dll gene as a positive control. Dll and its vertebrate homologs, the D ...
... developed a strategy to knock down gene function during Parhayle development using injection of siRNAs, a technique effective in several diverse animal taxa. To demonstrate the efficacy of this technique in Parhyale, we chose the Dll gene as a positive control. Dll and its vertebrate homologs, the D ...
Effects of MethionineSulfoxide Reductase (Msr)
... that reduce free and bound oxidized methionine. Two forms of Msr - MsrA and MsrB - are specific for the S and R enantiomers of methionine sulfoxide, respectively. There are three wellcharacterized functions of Msr: It repairs oxidized methionine, acts as a catalytic antioxidant, and regulates certai ...
... that reduce free and bound oxidized methionine. Two forms of Msr - MsrA and MsrB - are specific for the S and R enantiomers of methionine sulfoxide, respectively. There are three wellcharacterized functions of Msr: It repairs oxidized methionine, acts as a catalytic antioxidant, and regulates certai ...
WEREWOLF, a Regulator of Root Hair Pattern
... reported previously (Lee and Schiefelbein, 1999), transcripts were also detectable in young leaves, shoot apices, adult rosette leaves, stems, and inflorescences, including floral buds and mature flowers (Fig. 3A). To inspect the spatial pattern of WER expression, WERp::GUS transgenic plants, in whi ...
... reported previously (Lee and Schiefelbein, 1999), transcripts were also detectable in young leaves, shoot apices, adult rosette leaves, stems, and inflorescences, including floral buds and mature flowers (Fig. 3A). To inspect the spatial pattern of WER expression, WERp::GUS transgenic plants, in whi ...
Tearing down barriers: understanding the
... flowering plants is still under debate (Mallet, 2007), although it can be predicted that autopolyploidy is the more frequent form of polyploidy because within-species mating is more frequent than interspecific mating (Hegarty and Hiscock, 2008). However, a strict classification proves to be complex, ...
... flowering plants is still under debate (Mallet, 2007), although it can be predicted that autopolyploidy is the more frequent form of polyploidy because within-species mating is more frequent than interspecific mating (Hegarty and Hiscock, 2008). However, a strict classification proves to be complex, ...