Chapter 15 - HCC Learning Web
... Activity of the SRY gene triggers a cascade of biochemical, physiological, and anatomical features because it regulates many other genes. Other genes on the Y chromosome are necessary for the production of functional sperm. In the absence of these genes, an XY individual is male but does not p ...
... Activity of the SRY gene triggers a cascade of biochemical, physiological, and anatomical features because it regulates many other genes. Other genes on the Y chromosome are necessary for the production of functional sperm. In the absence of these genes, an XY individual is male but does not p ...
THE EFFECTS OF GENOTYPE AND CELL
... harderian glands, and in the nictitans, choroid, and retina of the eye. For the present investigation attention was centered on six tissues: hair bulbs, ear skin, harderian gland, nictitans, retina, and choroid. I n many mouse genotypes these six tissues are abundantly supplied with melanocytes, and ...
... harderian glands, and in the nictitans, choroid, and retina of the eye. For the present investigation attention was centered on six tissues: hair bulbs, ear skin, harderian gland, nictitans, retina, and choroid. I n many mouse genotypes these six tissues are abundantly supplied with melanocytes, and ...
β-Scruin, a homologue of the actin crosslinking protein scruin, is
... in 50% formamide, 50 mM NaPO 4, pH 6.8, 4× SET, 5× Denhardt’s and 100 µg/ml herring sperm DNA at 42°C for 2 hours. Hybridization was overnight in the same solution with either the α-scruin L1 clone or the β-scruin L3 clone insert labeled with [α-32P]dCTP using the Prime-It labeling kit (Stratagene, ...
... in 50% formamide, 50 mM NaPO 4, pH 6.8, 4× SET, 5× Denhardt’s and 100 µg/ml herring sperm DNA at 42°C for 2 hours. Hybridization was overnight in the same solution with either the α-scruin L1 clone or the β-scruin L3 clone insert labeled with [α-32P]dCTP using the Prime-It labeling kit (Stratagene, ...
Transport of proteins into and across the thylakoid membrane
... on the targeting signals have shown that both types contain the three domains described above, but DpHdependent routing is dependent on the presence of (at least) two particular determinants: a twin-arginine motif immediately before the hydrophobic domain and a highly hydrophobic residue two or thre ...
... on the targeting signals have shown that both types contain the three domains described above, but DpHdependent routing is dependent on the presence of (at least) two particular determinants: a twin-arginine motif immediately before the hydrophobic domain and a highly hydrophobic residue two or thre ...
The role of duplications in the evolution of genomes highlights the
... which genetic events are considered both in a phylogenetic framework and with regard to population genetics and environmental variables. In the mechanisms that generate adaptive and non-adaptive changes in genomes, segmental duplications (duplication of individual genes or genomic regions) and polyp ...
... which genetic events are considered both in a phylogenetic framework and with regard to population genetics and environmental variables. In the mechanisms that generate adaptive and non-adaptive changes in genomes, segmental duplications (duplication of individual genes or genomic regions) and polyp ...
Clustering approaches for temporal microarray gene expression data
... StepMiner is ideal for users interested in binary models of gene expression time courses. The downside is that binary models abstract from other features (essentially, we only isolate one feature—the change in expression level from low to high, or vice versa). Such is the case for most Feature-Based ...
... StepMiner is ideal for users interested in binary models of gene expression time courses. The downside is that binary models abstract from other features (essentially, we only isolate one feature—the change in expression level from low to high, or vice versa). Such is the case for most Feature-Based ...
Sense of smell- olfaction
... • Taste buds contain chemoreceptors called gustatory cells with cilia that project into taste pores bathed in saliva • Most taste buds are found in between papillae: elevated projections of differing ...
... • Taste buds contain chemoreceptors called gustatory cells with cilia that project into taste pores bathed in saliva • Most taste buds are found in between papillae: elevated projections of differing ...
antibody anarchy: a call to order
... sion in each new antibody product — assessing whether the signal subsides with the expression of the target gene. Such efforts are nascent, however, with only a tiny fraction of companies’ catalogues being subjected to validation. And not all companies disclose the specific conditions of testing, or ...
... sion in each new antibody product — assessing whether the signal subsides with the expression of the target gene. Such efforts are nascent, however, with only a tiny fraction of companies’ catalogues being subjected to validation. And not all companies disclose the specific conditions of testing, or ...
The E-Class PPR Protein MEF3 of Arabidopsis
... Fig. 3 Identification of the Arabidopsis thaliana MEF3 gene. (A) Introduction of the A. thaliana Col versions of the two candidate genes for PPR proteins in the mapped genomic window into Ler protoplasts shows differential effects. Sequence analysis of the atp4 cDNA shows that gene At1g06140 strongl ...
... Fig. 3 Identification of the Arabidopsis thaliana MEF3 gene. (A) Introduction of the A. thaliana Col versions of the two candidate genes for PPR proteins in the mapped genomic window into Ler protoplasts shows differential effects. Sequence analysis of the atp4 cDNA shows that gene At1g06140 strongl ...
C. elegans DAF-2 as a Model for Human Insulin Receptoropathies
... Modeling this phenotypic spectrum may require the identification of more subtle phenotypes than traditional screens allow. To fully understand the scope of IIS pathway mutants available in C. elegans, we interrogated WormBase (v245) for all known alleles in evolutionarily conserved IIS pathway genes ...
... Modeling this phenotypic spectrum may require the identification of more subtle phenotypes than traditional screens allow. To fully understand the scope of IIS pathway mutants available in C. elegans, we interrogated WormBase (v245) for all known alleles in evolutionarily conserved IIS pathway genes ...
Identification of C. elegans lin
... cDNA sequences with pVT2D sequences indicated that the corresponding mRNA is spliced from a primary transcript at conventional splice donor and acceptor sites within pVT2D that, for the most part, flank the pVTSal rescuing region (see legend to Figure 3). Therefore, it appears that the lin-4 gene li ...
... cDNA sequences with pVT2D sequences indicated that the corresponding mRNA is spliced from a primary transcript at conventional splice donor and acceptor sites within pVT2D that, for the most part, flank the pVTSal rescuing region (see legend to Figure 3). Therefore, it appears that the lin-4 gene li ...
Extensions of Mendelian Genetics
... For example, a gene that has been associated with breast cancer in women is BRCA1, and the protein it encodes is BRCA1. ...
... For example, a gene that has been associated with breast cancer in women is BRCA1, and the protein it encodes is BRCA1. ...
A rule-based kinetic model of RNA polymerase II C
... distinct site that may mediate its effect on elongation [16]. The dephosphorylation of Ser5 by Fcp1 after the termination of transcription, in vitro, can be explained by the lower specificity of Fcp1 for a ternary complex of DNA, RNAPII, TFIIH in comparison with that for free RNAPII [17]. Consequent ...
... distinct site that may mediate its effect on elongation [16]. The dephosphorylation of Ser5 by Fcp1 after the termination of transcription, in vitro, can be explained by the lower specificity of Fcp1 for a ternary complex of DNA, RNAPII, TFIIH in comparison with that for free RNAPII [17]. Consequent ...
Cockayne Syndrome group B protein interacts
... 6-pyrimidine-4-pyrimidone photoproducts). In addition to NER, CSB has also been implicated in base excision repair (30,31), transcription (32–35), chromatin maintenance and remodeling (36). However, whether CSB may play a role in telomere maintenance relevant to cancer and aging has not yet been cha ...
... 6-pyrimidine-4-pyrimidone photoproducts). In addition to NER, CSB has also been implicated in base excision repair (30,31), transcription (32–35), chromatin maintenance and remodeling (36). However, whether CSB may play a role in telomere maintenance relevant to cancer and aging has not yet been cha ...
Estimating complexity and adaptation in the embryo: a
... developmental stages might show distinct levels of positive or stabilizing selection, that could be related to inter-speci c divergence patterns proposed by the von Baer's laws or the hourglass model. The former states that the development of two species of a phylogenetic group would be very similar ...
... developmental stages might show distinct levels of positive or stabilizing selection, that could be related to inter-speci c divergence patterns proposed by the von Baer's laws or the hourglass model. The former states that the development of two species of a phylogenetic group would be very similar ...
ADPKD - Postępy Nauk Medycznych
... distinct (from ADPKD) gene mutation (gene PRKCSH; encoding hepatocystin). Similarly as in ADPKD, advancing age of the patient is a risk factor for liver – cyst growth and dysfunction (11). Colonic diverticula are quite common in adult ADPKD patients, however they are mainly asymptomatic. In cases of ...
... distinct (from ADPKD) gene mutation (gene PRKCSH; encoding hepatocystin). Similarly as in ADPKD, advancing age of the patient is a risk factor for liver – cyst growth and dysfunction (11). Colonic diverticula are quite common in adult ADPKD patients, however they are mainly asymptomatic. In cases of ...
Gene Section RAD52 (RAD52 homolog (S. cerevisiae)) Atlas of Genetics and Cytogenetics
... Interfering with the Phe-79 of hRAD52 was recently demonstrated to disrupt the RAD52-DNA interaction leading to an accumulation of DNA double-strand breaks (DSBs) particularly in BRCA1/2 deficient cells (Cramer-Morales et al., ...
... Interfering with the Phe-79 of hRAD52 was recently demonstrated to disrupt the RAD52-DNA interaction leading to an accumulation of DNA double-strand breaks (DSBs) particularly in BRCA1/2 deficient cells (Cramer-Morales et al., ...
Genetic Testing for Hereditary Breast and/or Ovarian Cancer
... factors in rare, but highly penetrant cancer syndromes that substantially increase the risk of breast cancer. Although rare, when taken together, mutations in these genes are thought to account for at least 5–10% of breast cancer diagnoses. Each of these genes, and the hereditary cancers they cause, ...
... factors in rare, but highly penetrant cancer syndromes that substantially increase the risk of breast cancer. Although rare, when taken together, mutations in these genes are thought to account for at least 5–10% of breast cancer diagnoses. Each of these genes, and the hereditary cancers they cause, ...
S0735109712013162_mmc1
... PON1 A common reduced function allele in PON1 (rs662), may be involved in clopidogrel bioactivation (17), though this observation has not been validated by others(15,18-20). Carriers of the minor allele of the rs662 variant in PON1 are overrepresented in one series of ST cases on clopidogrel (17) th ...
... PON1 A common reduced function allele in PON1 (rs662), may be involved in clopidogrel bioactivation (17), though this observation has not been validated by others(15,18-20). Carriers of the minor allele of the rs662 variant in PON1 are overrepresented in one series of ST cases on clopidogrel (17) th ...
- CSHL Institutional Repository
... an equational division instead of a reductional one, indicating that meiosis 1 is replaced by a mitotic division (Golubovskaya and Mashnenkov, 1975). In the el1 mutant, meiosis 2 is affected leading to the production of unreduced spores (Rhoades, 1956). Given the differences in form and function bet ...
... an equational division instead of a reductional one, indicating that meiosis 1 is replaced by a mitotic division (Golubovskaya and Mashnenkov, 1975). In the el1 mutant, meiosis 2 is affected leading to the production of unreduced spores (Rhoades, 1956). Given the differences in form and function bet ...
Transgenic mice: generation and husbandry
... e.g. a promoter can be attached to a reporter gene such as LacZ or GFP 2. examine the effects of overexpressing and misexpressing endogenous or foreign genes at specific times and locations in the animals 3 Study gene function ...
... e.g. a promoter can be attached to a reporter gene such as LacZ or GFP 2. examine the effects of overexpressing and misexpressing endogenous or foreign genes at specific times and locations in the animals 3 Study gene function ...
Comparison Between Transformation Efficiencies in Rod
... compromised of a number of additional mutations, potentially decreasing the strains’ transformation potential. Since the total difference in relative transformation efficiencies between the two strains tested (658.5 transformants/µg DNA) is much greater than the absolute uncertainty (40.8 transforma ...
... compromised of a number of additional mutations, potentially decreasing the strains’ transformation potential. Since the total difference in relative transformation efficiencies between the two strains tested (658.5 transformants/µg DNA) is much greater than the absolute uncertainty (40.8 transforma ...
Multicellular Organisms Part 3
... a……..……….. For example – there is an eye colour gene. But this might have a blue a…………….. and a brown a………….…… (two different forms of the same gene). Some alleles hide other alleles – these are d……………..……. alleles, and the ones that are hidden are r…………………………. If the brown eyed a……..………. was domina ...
... a……..……….. For example – there is an eye colour gene. But this might have a blue a…………….. and a brown a………….…… (two different forms of the same gene). Some alleles hide other alleles – these are d……………..……. alleles, and the ones that are hidden are r…………………………. If the brown eyed a……..………. was domina ...